Neuropsychiatric symptoms in Korean patients with Alzheimer's disease: Exploratory factor analysis and confirmatory factor analysis of the neuropsychiatric inventory

Dementia and Geriatric Cognitive Disorders

Volumn 29, Issue 1, 2010, Pages 82-87

  Kang, Hyo Shin ^a   Ahn, Inn Sook ^a   Kim, Ji Hae ^b   Kim, Doh Kwan ^a,b  

^a Samsung Medical Center   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

Alzheimer's disease; Confirmatory factor analysis; Exploratory factor analysis; Neuropsychiatric symptoms; Subsyndromes

Indexed keywords

AGED; AGGRESSION; AGITATION; ALZHEIMER DISEASE; ANXIETY; APATHY; APPETITE DISORDER; ARTICLE; CONFIRMATORY FACTOR ANALYSIS; CONTROLLED STUDY; DELUSION; DEPRESSION; DYSPHORIA; EATING DISORDER; EUPHORIA; EXPERIMENTAL MODEL; EXPLORATORY FACTOR ANALYSIS; FACTORIAL ANALYSIS; FEMALE; HALLUCINATION; HUMAN; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MENTAL INSTABILITY; MOTOR DYSFUNCTION; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NEUROLOGIC DISEASE; NEUROPSYCHIATRIC INVENTORY; PRIORITY JOURNAL; SLEEP DISORDER; SOUTH KOREA; SYMPTOMATOLOGY;

AFFECT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BEHAVIOR; DATA INTERPRETATION, STATISTICAL; FACTOR ANALYSIS, STATISTICAL; FEMALE; HUMANS; HYPERKINESIS; LIKELIHOOD FUNCTIONS; MALE; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; REPUBLIC OF KOREA;

EID: 75549092013     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000264629     Document Type: Article

References (29)

1. Aalten P, de Vugt ME, Lousberg R, Korten E, Jaspers N, Senden B, Jolles J, Verhey FR: Behavioral problems in dementia: a factor analysis of the neuropsychiatric inventory. Dement Geriatr Cogn Disord 2003; 15: 99-105.
2. Steinberg M, Tschanz JT, Corcoran C, Steffens DC, Norton MC, Lyketsos CG, Breitner JC: The persistence of neuropsychiatric symptoms in dementia: the Cache County Study. Int J Geriatr Psychiatry 2004; 19: 19-26. (Pubitemid 38180688)
3. Finkel S: The significance of the behavioral and psychological symptoms of dementia. Clinician 1998; 16: 33-42.
4. Kaufer DI, Cummings JL, Christine D, Bray T, Castellon S, Masterman D, Macmillan A, Ketchel P, DeKosky ST: Assessing the impact of neuropsychiatric symptoms in Alzheimer's disease: the Neuropsychiatric Inventory Caregiver Distress Scale. J Am Geriatr Soc 1998; 46: 210-215.
5. Burns A: The burden of Alzheimer's disease. Int J Neuropsychopharmacol 2000; 3: 31-38.
6. Chan DC, Kasper JD, Black BS, Ravins PV: Presence of behavioral and psychological symptoms predicts nursing home placement in community-dwelling elders with cognitive impairment in univariate but not multivariate analysis. J Gerontol A Biol Sci Med Sci 2003; 58: 548-554.
7. Frisoni GB, Rozzini L, Gozzetti A, Binetti G, Zanetti O, Bianchetti A, Trabucchi M, Cummings JL: Behavioral syndromes in Alzheimer's disease: description and correlates. Dement Geriatr Cogn Disord 1999; 10: 130-138.
8. Fuh JL, Liu CK, Mega MS, Wang SJ, Cummings JL: Behavioral disorders and caregivers' reaction in Taiwanese patients with Alzheimer's disease. Int Psychogeriatr 2001; 13: 121-128.
9. Benoit M, Staccini P, Brocker P, Benhamidat T, Bertogliati C, Lechowski L, Tortrat D, Robert PH: Behavioral and psychologic symptoms in Alzheimer's disease: results of the REAL.FR study. Rev Med Interne 2003; 24: 319-324.
10. Mirakhur A, Craig D, Hart DJ, McIlroy SP, Passmore AP: Behavioural and psychological syndromes in Alzheimer's disease. Int J Geriatr Psychiatry 2004; 19: 1035-1039.
11. Matsui T, Nakaaki S, Murata Y, Sato J, Shinagawa Y, Tatsumi H, Furukawa TA: Determinants of the quality of life in Alzheimer's disease patients as assessed by the Japanese version of the Quality of Life-Alzheimer's Disease scale. Dement Geriatr Cogn Disord 2006; 21: 182-191.
12. Aalten P, Verhey F, Boziki M, Bullock R, Byrne EJ, Camus V, Caputo M, Collins D, de Deyn PP, Elina K, Frisoni GB, Girtler N, Holmes C, Hurt C, Marriot A, Mecocci P, Nobili F, Ousset PJ, Reynish E, Salmon E, Tsolaki M, Vellas B, Robert PH: Neuropsychiatric syndromes in dementia: results from the European Alzheimer Disease Consortium (EADC). Part 1. Dement Geriatr Cogn Disord 2007; 24: 457-463.
13. Hollingworth P, Hamshere ML, Moskvina V, Dowzell K, Moore PJ, Foy C, Archer N, Lynch A, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, Owen MJ, Williams J: Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease. J Am Geriatr Soc 2006; 54: 1348-1354.
14. Chow TW, Liu CK, Fuh JL, Leung VP, Tai CT, Chen LW, Wang SJ, Chiu HF, Lam LC, Chen QL, Cummings JL: Neuropsychiatric symptoms of Alzheimer's disease differ in Chinese and American patients. Int J Geriatr Psychiatry 2002; 17: 22-28.
15. Fuh JL, Mega MS, Binetti G, Wang SJ, Magni E, Cummings JL: A transcultural study of agitation in dementia. J Geriatr Psychiatry Neurol 2002; 15: 171-174.
16. Fuh JL, Lam L, Hirono N, Senanarong V, Cummings JL: Neuropsychiatric inventory workshop: behavioral and psychologic symptoms of dementia in Asia. Alzheimer Dis Assoc Disord 2006; 20: 314-317.
17. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Standlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944.
18. Cummings JL, Mega M, Gray K, Rosenberg- Thompson S, Carusi DA, Gornbein J: The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308-2314.
19. Choi SH, Na DL, Kwon HM, Yoon SJ, Jeong JH, Ha CK: The Korean version of the Neuropsychiatric Inventory: a scoring tool for neuropsychiatric disturbance in dementia patients. J Korean Med Sci 2000; 15: 609-615.
20. Folstein MF, Folstein SE, McHugh PR: 'Mini- Mental State': a practical method for grading the mental state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
21. Kang YW, Na DL, Hahn S: A validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients. J Korean Neurol Assoc 1997; 15: 300-307.
22. Kim TY, Kim SY, Kim EG, Kim JW, Park KW, Sung SM, Sohn TH, Ann KS, Yoo BG, Yoon SJ, Yoon SM, Lee SC, Cheong HK, Choi MS, Hong TY, Busan Gyeongnam Dementia Association: The differences of behavioral and psychological symptoms in the patients of Alzheimer's disease and vascular dementia. J Korean Neurol Assoc 2006; 24: 458-464.
23. Sultzer DL, Mahler ME, Mandelkern MA, Cummings JL, van Gorp WG, Hinkin CH, Berisford MA: The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer's disease. J Neuropsychiatry Clin Neurosci 1995; 7: 476-484.
24. Hope T, Keene J, Fairburn C, McShane R, Jacoby R: Behaviour changes in dementia. 2. Are there behavioral syndromes? Int J Geriatr Psychiatry 1997; 12: 1074-1078.
25. Levy ML, Cummings JL, Fairbanks LA, Bravi D, Calvani M, Carta A: Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer's disease. Am J Psychiatry 1996; 153: 1438-1443.
26. Starkstein SE, Ingram L, Garau ML, Mizrahi R: On the overlap between apathy and depression in dementia. J Neurol Neurosurg Psychiatry 2005; 76: 1070-1074.
27. Aalten P, Verhey F, Boziki M, Brugnolo A, Bullock R, Byrne EJ, Camus V, Caputo M, Collins D, de Deyn PP, Elina K, Frisoni GB, Girtler N, Holmes C, Hurt C, Marriott A, Mecocci P, Nobili F, Ousset PJ, Reynish E, Salmon E, Tsolaki M, Vellas B, Robert PH: Consistency of neuropsychiatric syndromes across dementias: results from the European Alzheimer Disease Consortium (EADC). Part 2. Dement Geriatr Cogn Disord 2008; 25: 1-8.
28. Gauthier S, Wirth Y, Mobius HJ: Effects of memantine on behavioural symptoms in Alzheimer's disease patients: an analysis of the Neuropsychiatric Inventory (NPI) data of two randomised, controlled studies. Int J Geriatr Psychiatry 2005; 20: 459-464.
29. Herrmann N, Rabheru K, Wang J, Binder C: Galantamine treatment of problematic behavior in Alzheimer's disease: post-hoc analysis of pooled data from three large trials. Am J Geriatr Psychiatry 2005; 13: 527-534.