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Volumn 48, Issue 2, 2013, Pages 308-314

Statins, Bcl-2, and apoptosis: Cell death or cell protection?

Author keywords

Alzheimer's disease; Apoptosis; Bcl 2; Cancer; Cholesterol; Isoprenoids; Neurodegeneration; Neuroprotection; Statins

Indexed keywords

ATORVASTATIN; DEXAMETHASONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PROTEIN BAX; PROTEIN BCL 2; SIMVASTATIN;

EID: 84885324882     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8496-5     Document Type: Conference Paper
Times cited : (82)

References (69)
  • 2
    • 0036118915 scopus 로고    scopus 로고
    • Pleiotropic effects of HMG-CoA reductase inhibitors
    • 12002257 10.1007/s003950200000 1:CAS:528:DC%2BD38XjtFSgsrw%3D
    • Werner N, Nickenig G, Laufs U (2002) Pleiotropic effects of HMG-CoA reductase inhibitors. Basic Res Cardiol 97:105-116
    • (2002) Basic Res Cardiol , vol.97 , pp. 105-116
    • Werner, N.1    Nickenig, G.2    Laufs, U.3
  • 3
    • 10644286120 scopus 로고    scopus 로고
    • Pleiotropic effects of statins
    • 10.1146/annurev.pharmtox.45.120403.095748
    • Liao JK, Laufs U (2004) Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 45:89-118
    • (2004) Annu Rev Pharmacol Toxicol , vol.45 , pp. 89-118
    • Liao, J.K.1    Laufs, U.2
  • 4
    • 0036239832 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors and the malignant cell: The statin family of drugs as triggers of tumor-specific apoptosis
    • 11960327 10.1038/sj.leu.2402476 1:CAS:528:DC%2BD38XjvFGnurY%3D
    • Wong WWL, Dimitroulakos J, Minden MD, Penn LZ (2002) HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis. Leukemia 16:508-519
    • (2002) Leukemia , vol.16 , pp. 508-519
    • Wong, W.W.L.1    Dimitroulakos, J.2    Minden, M.D.3    Penn, L.Z.4
  • 5
    • 33645047418 scopus 로고    scopus 로고
    • The role of statins in cancer therapy
    • 16549815 10.1634/theoncologist.11-3-306 1:CAS:528:DC%2BD28XhtFKlsbzL
    • Hindler K, Cleeland CS, Rivera E, Collard CD (2006) The role of statins in cancer therapy. Oncologist 11:306-315
    • (2006) Oncologist , vol.11 , pp. 306-315
    • Hindler, K.1    Cleeland, C.S.2    Rivera, E.3    Collard, C.D.4
  • 7
    • 34547860418 scopus 로고    scopus 로고
    • Cholesterol-lowering drugs and Alzheimer's disease
    • 10.2217/17460875.2.4.423 1:CAS:528:DC%2BD2sXosVShurk%3D
    • Eckert GP, Muller WE, Wood WG (2007) Cholesterol-lowering drugs and Alzheimer's disease. Future Lipidol 2:423-432
    • (2007) Future Lipidol , vol.2 , pp. 423-432
    • Eckert, G.P.1    Muller, W.E.2    Wood, W.G.3
  • 8
    • 77953185965 scopus 로고    scopus 로고
    • Statins and neuroprotection: A prescription to move the field forward
    • 10.1111/j.1749-6632.2010.05188.x
    • Wood WG, Eckert GP, Igbavboa U, Muller WE (2010) Statins and neuroprotection: a prescription to move the field forward. Ann NY Acad Sci 1197:1-8
    • (2010) Ann NY Acad Sci , vol.1197 , pp. 1-8
    • Wood, W.G.1    Eckert, G.P.2    Igbavboa, U.3    Muller, W.E.4
  • 9
    • 0024414217 scopus 로고
    • Comparison of dexamethasone and lovastatin (mevinolin) as growth inhibitors in cultures of T-cell derived human acute leukemia lines (CEM)
    • 2586143 10.1016/0145-2126(89)90040-4 1:CAS:528:DyaK3cXjtVegtA%3D%3D
    • Bansal N, Houle AG, Melnykovych G (1989) Comparison of dexamethasone and lovastatin (mevinolin) as growth inhibitors in cultures of T-cell derived human acute leukemia lines (CEM). Leuk Res 13:875-882
    • (1989) Leuk Res , vol.13 , pp. 875-882
    • Bansal, N.1    Houle, A.G.2    Melnykovych, G.3
  • 10
    • 0028307941 scopus 로고
    • Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells
    • 8147861 10.1006/bbrc.1994.1359
    • Pérez-Sala D, Mollinedo F (1994) Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells. Biochem Biophys Res Commun 199:1209-1215
    • (1994) Biochem Biophys Res Commun , vol.199 , pp. 1209-1215
    • Pérez-Sala, D.1    Mollinedo, F.2
  • 11
    • 0028596288 scopus 로고
    • Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells
    • 7811252 10.1006/bbrc.1994.2861 1:CAS:528:DyaK2MXivV2rtbo%3D
    • Jones KD, Couldwell WT, Hinton DR, Su Y, He S, Anker L, Law RE (1994) Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells. Biochem Biophys Res Commun 205:1681-1687
    • (1994) Biochem Biophys Res Commun , vol.205 , pp. 1681-1687
    • Jones, K.D.1    Couldwell, W.T.2    Hinton, D.R.3    Su, Y.4    He, S.5    Anker, L.6    Law, R.E.7
  • 12
    • 0032499798 scopus 로고    scopus 로고
    • Ha-rasVal12 oncogene increases susceptibility of NIH/3T3 cells to lovastatin
    • 9675086 10.1006/bbrc.1998.8911 1:CAS:528:DyaK1cXks1ertbo%3D
    • Chang MY, Jan MS, Won SJ, Liu HS (1998) Ha-rasVal12 oncogene increases susceptibility of NIH/3T3 cells to lovastatin. Biochem Biophys Res Commun 248:62-68
    • (1998) Biochem Biophys Res Commun , vol.248 , pp. 62-68
    • Chang, M.Y.1    Jan, M.S.2    Won, S.J.3    Liu, H.S.4
  • 14
    • 41849115563 scopus 로고    scopus 로고
    • Statins inhibit proliferation and induce apoptosis in Barett's esophageal adenocarcinoma cells
    • 18371146 10.1111/j.1572-0241.2007.01773.x 1:CAS:528:DC%2BD1cXls1CqsL0%3D
    • Ogunwobi OO, Beales IL (2008) Statins inhibit proliferation and induce apoptosis in Barett's esophageal adenocarcinoma cells. Am J Gastroenterol 103:825-837
    • (2008) Am J Gastroenterol , vol.103 , pp. 825-837
    • Ogunwobi, O.O.1    Beales, I.L.2
  • 15
    • 0031918223 scopus 로고    scopus 로고
    • Bcl-2 family: Regulators of cell death
    • 9597135 10.1146/annurev.immunol.16.1.395 1:CAS:528:DyaK1cXislyntLs%3D
    • Chao DT, Korsmeyer SJ (1998) Bcl-2 family: regulators of cell death. Annu Rev Immunol 16:395-419
    • (1998) Annu Rev Immunol , vol.16 , pp. 395-419
    • Chao, D.T.1    Korsmeyer, S.J.2
  • 16
    • 1442359840 scopus 로고    scopus 로고
    • Bcl-2 family regulation of neuronal development and neurodegeneration
    • 14996503 10.1016/j.bbamcr.2003.10.013 1:CAS:528:DC%2BD2cXhslWnsro%3D
    • Akhtar RS, Ness JM, Roth KA (2004) Bcl-2 family regulation of neuronal development and neurodegeneration. Biochim Biophys Acta 1644:189-203
    • (2004) Biochim Biophys Acta , vol.1644 , pp. 189-203
    • Akhtar, R.S.1    Ness, J.M.2    Roth, K.A.3
  • 17
    • 7744224359 scopus 로고    scopus 로고
    • Regulation of mitochondrial membrane permeabilization by Bcl-2 family proteins and caspases
    • 15530776 10.1016/j.ceb.2004.09.009 1:CAS:528:DC%2BD2cXpsVOrtbs%3D
    • Breckenridge DG, Xue D (2004) Regulation of mitochondrial membrane permeabilization by Bcl-2 family proteins and caspases. Curr Opin Cell Biol 16:647-652
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 647-652
    • Breckenridge, D.G.1    Xue, D.2
  • 18
    • 33745953139 scopus 로고    scopus 로고
    • Bcl-2 in the crosshairs: Tipping the balance of life and death
    • 16763614 10.1038/sj.cdd.4401992 1:CAS:528:DC%2BD28XmvFaiurs%3D
    • Walensky LD (2006) Bcl-2 in the crosshairs: tipping the balance of life and death. Cell Death Differ 13:1339-1350
    • (2006) Cell Death Differ , vol.13 , pp. 1339-1350
    • Walensky, L.D.1
  • 20
    • 33846946439 scopus 로고    scopus 로고
    • Cellular demolition and the rules of engagement
    • 17289967 10.1126/science.1138870 1:CAS:528:DC%2BD2sXhvVChtbw%3D
    • Youle RJ (2007) Cellular demolition and the rules of engagement. Science 315:776-778
    • (2007) Science , vol.315 , pp. 776-778
    • Youle, R.J.1
  • 22
    • 79954420768 scopus 로고    scopus 로고
    • Rosuvastatin induces apoptosis in CD4(+)CD28(null) T cells in patients with acute coronary syndromes
    • 20852871 10.1007/s00392-010-0225-8 1:CAS:528:DC%2BC3MXhsFGntr4%3D
    • Link A, Selejan S, Hewera L, Walter F, Nickenig G, Böhm M (2011) Rosuvastatin induces apoptosis in CD4(+)CD28(null) T cells in patients with acute coronary syndromes. Clin Res Cardiol 100:147-158
    • (2011) Clin Res Cardiol , vol.100 , pp. 147-158
    • Link, A.1    Selejan, S.2    Hewera, L.3    Walter, F.4    Nickenig, G.5    Böhm, M.6
  • 24
    • 0035114219 scopus 로고    scopus 로고
    • Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: Involvement of nonsterol isoprenoid biosynthesis inhibition
    • 11178870 10.1006/mcne.2000.0904
    • Garcia-Román N, Alvarez AM, Toro MJ, Lorenzo MJ (2001) Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. Mol Cell Neurosci 17:329-341
    • (2001) Mol Cell Neurosci , vol.17 , pp. 329-341
    • Garcia-Román, N.1    Alvarez, A.M.2    Toro, M.J.3    Lorenzo, M.J.4
  • 25
    • 0037792165 scopus 로고    scopus 로고
    • Bcl-xl overexpression protects from apoptosis induced by HMG-CoA reductase inhibitors in murine tubular cells
    • 12787408 10.1046/j.1523-1755.2003.00080.x 1:CAS:528:DC%2BD3sXlsFeksro%3D
    • Blanco-Colio LM, Justo P, Daehn I, Lorz C, Ortiz A, Egido J (2003) Bcl-xl overexpression protects from apoptosis induced by HMG-CoA reductase inhibitors in murine tubular cells. Kidney Int 64:181-191
    • (2003) Kidney Int , vol.64 , pp. 181-191
    • Blanco-Colio, L.M.1    Justo, P.2    Daehn, I.3    Lorz, C.4    Ortiz, A.5    Egido, J.6
  • 26
    • 33846896918 scopus 로고    scopus 로고
    • Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: Role of IkappaBalpha kinase and TGF-beta-activated kinase-1
    • 17277159 1:CAS:528:DC%2BD2sXht1Cnsb4%3D
    • Ahn KS, Sethi G, Aggarwal BB (2007) Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. J Immunol 178:2507-2516
    • (2007) J Immunol , vol.178 , pp. 2507-2516
    • Ahn, K.S.1    Sethi, G.2    Aggarwal, B.B.3
  • 27
    • 47049103366 scopus 로고    scopus 로고
    • Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice
    • 18521906 10.1002/ijc.23593 1:CAS:528:DC%2BD1cXovFWmu7g%3D
    • Cho SJ, Kim JS, Kim JM, Lee JY, Jung HC, Song IS (2008) Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer 123:951-957
    • (2008) Int J Cancer , vol.123 , pp. 951-957
    • Cho, S.J.1    Kim, J.S.2    Kim, J.M.3    Lee, J.Y.4    Jung, H.C.5    Song, I.S.6
  • 28
    • 84866169732 scopus 로고    scopus 로고
    • Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis
    • 22974127 10.1186/1471-2407-12-409 1:CAS:528:DC%2BC3sXitVaisg%3D%3D
    • Goc A, Kochuparambil ST, Al-Husein B, Al-Azayzih A, Mohammad S, Somanath PR (2012) Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis. BMC Cancer 12:409
    • (2012) BMC Cancer , vol.12 , pp. 409
    • Goc, A.1    Kochuparambil, S.T.2    Al-Husein, B.3    Al-Azayzih, A.4    Mohammad, S.5    Somanath, P.R.6
  • 29
    • 84655169258 scopus 로고    scopus 로고
    • Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes
    • 22080086 10.1016/j.freeradbiomed.2011.10.449 1:CAS:528: DC%2BC38XitlygtQ%3D%3D
    • Kwak HB, Thalacker-Mercer A, Anderson EJ, Lin CT, Kane DA, Lee NS, Cortright RN, Bamman MM, Neufer PD (2012) Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes. Free Radic Biol Med 52:198-207
    • (2012) Free Radic Biol Med , vol.52 , pp. 198-207
    • Kwak, H.B.1    Thalacker-Mercer, A.2    Anderson, E.J.3    Lin, C.T.4    Kane, D.A.5    Lee, N.S.6    Cortright, R.N.7    Bamman, M.M.8    Neufer, P.D.9
  • 30
    • 0036192275 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation
    • 11882313 10.1016/S0021-9150(01)00613-X 1:CAS:528:DC%2BD38XhslWhtrw%3D
    • Blanco-Colio LM, Villa A, Ortego M, Hernández-Presa MA, Pascual A, Plaza JJ, Egido J (2002) 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. Atherosclerosis 161:17-26
    • (2002) Atherosclerosis , vol.161 , pp. 17-26
    • Blanco-Colio, L.M.1    Villa, A.2    Ortego, M.3    Hernández-Presa, M.A.4    Pascual, A.5    Plaza, J.J.6    Egido, J.7
  • 31
    • 0036045450 scopus 로고    scopus 로고
    • The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells
    • 12094262 10.1038/sj.leu.2402501
    • van de Donk NW, Kamphuis MM, Lokhorst HM, Bloem AC (2002) The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells. Leukemia 16:1362-1371
    • (2002) Leukemia , vol.16 , pp. 1362-1371
    • Van De Donk, N.W.1    Kamphuis, M.M.2    Lokhorst, H.M.3    Bloem, A.C.4
  • 32
    • 1842457774 scopus 로고    scopus 로고
    • Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells
    • 15030401 10.1111/j.1471-4159.2004.02319.x 1:CAS:528:DC%2BD2cXjtValtrg%3D
    • Jiang Z, Zheng X, Lytle RA, Higashikubo R, Rich KM (2004) Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells. J Neurochem 89:168-178
    • (2004) J Neurochem , vol.89 , pp. 168-178
    • Jiang, Z.1    Zheng, X.2    Lytle, R.A.3    Higashikubo, R.4    Rich, K.M.5
  • 34
    • 33749637920 scopus 로고    scopus 로고
    • RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation
    • 16470222 10.1038/sj.cdd.4401873
    • Fromigué O, Haÿ E, Modrowski D, Bouvet S, Jacquel A, Auberger P, Marie PJ (2006) RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. Cell Death Differ 13:1845-1856
    • (2006) Cell Death Differ , vol.13 , pp. 1845-1856
    • Fromigué, O.1    Haÿ, E.2    Modrowski, D.3    Bouvet, S.4    Jacquel, A.5    Auberger, P.6    Marie, P.J.7
  • 35
  • 36
    • 44449100667 scopus 로고    scopus 로고
    • Simvastatin induces apoptosis in human breast cancer cells in a NKkappaB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa
    • 18031796 10.1016/j.thromres.2007.09.017
    • Aberg M, Wickström M, Siegbahn A (2008) Simvastatin induces apoptosis in human breast cancer cells in a NKkappaB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa. Thromb Res 122:191-202
    • (2008) Thromb Res , vol.122 , pp. 191-202
    • Aberg, M.1    Wickström, M.2    Siegbahn, A.3
  • 37
    • 80755153113 scopus 로고    scopus 로고
    • Involvement of Chk1-Cdc25A-cyclin A/CDK2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells
    • 10.1016/j.ejphar.2011.09.031
    • Tu YS, Kang XL, Zhou JG, Lv XF, Tang YB, Guan YY (2013) Involvement of Chk1-Cdc25A-cyclin A/CDK2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells. Eur J Pharmacol 670:356-364
    • (2013) Eur J Pharmacol , vol.670 , pp. 356-364
    • Tu, Y.S.1    Kang, X.L.2    Zhou, J.G.3    Lv, X.F.4    Tang, Y.B.5    Guan, Y.Y.6
  • 39
  • 41
    • 33846439745 scopus 로고    scopus 로고
    • Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment
    • 17157514 10.1016/j.nbd.2006.10.004 1:CAS:528:DC%2BD2sXpvVKktA%3D%3D
    • Franke C, Nöldner M, Abdel-Kader R, Johnson-Anuna LN, Wood WG, Muller WE, Eckert GP (2007) Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment. Neurobiol Dis 25:438-445
    • (2007) Neurobiol Dis , vol.25 , pp. 438-445
    • Franke, C.1    Nöldner, M.2    Abdel-Kader, R.3    Johnson-Anuna, L.N.4    Wood, W.G.5    Muller, W.E.6    Eckert, G.P.7
  • 42
    • 55549136009 scopus 로고    scopus 로고
    • Effects of simvastatin on neuroprotection and modulation of Bcl-2 and BAX in the rat quinolinic acid model of Huntington's disease
    • 1:CAS:528:DC%2BD1cXhtlyiurnF
    • Patassini S, Giampà C, Martorana A, Bernardi G, Fusco FR (2008) Effects of simvastatin on neuroprotection and modulation of Bcl-2 and BAX in the rat quinolinic acid model of Huntington's disease. Neurosci Res 448:166-169
    • (2008) Neurosci Res , vol.448 , pp. 166-169
    • Patassini, S.1    Giampà, C.2    Martorana, A.3    Bernardi, G.4    Fusco, F.R.5
  • 43
    • 80051783999 scopus 로고    scopus 로고
    • In vivo cardioprotection by pitavastatin from ischemic-reperfusion injury through suppression of IKK/NF-κB and upregulation of pAkt-e-NOS
    • 21654332 10.1097/FJC.0b013e31822002a6 1:CAS:528:DC%2BC3MXhtVWjtLfN
    • Malik S, Sharma AK, Bharti S, Nepal S, Bhatia J, Nag TC, Narang R, Arya DS (2011) In vivo cardioprotection by pitavastatin from ischemic-reperfusion injury through suppression of IKK/NF-κB and upregulation of pAkt-e-NOS. J Cardiovasc Pharmacol 58:199-206
    • (2011) J Cardiovasc Pharmacol , vol.58 , pp. 199-206
    • Malik, S.1    Sharma, A.K.2    Bharti, S.3    Nepal, S.4    Bhatia, J.5    Nag, T.C.6    Narang, R.7    Arya, D.S.8
  • 44
    • 84873124916 scopus 로고    scopus 로고
    • Pleiotropic effects of simvastatin are associated with mitigation of apoptotic component of cell death upon lethal myocardial reperfusion-induced injury
    • 23130901
    • Rajtík T, Carnická S, Szobi A, Mesároš ová L, Mát'uš M, Svec P, Ravingerová T, Adameová A (2012) Pleiotropic effects of simvastatin are associated with mitigation of apoptotic component of cell death upon lethal myocardial reperfusion-induced injury. Physiol Res 61(S2):S33-S41
    • (2012) Physiol Res , vol.61 , Issue.S2
    • Rajtík, T.1    Carnická, S.2    Szobi, A.3    Mesároš ová, L.4    Mát'Uš, M.5    Svec, P.6    Ravingerová, T.7    Adameová, A.8
  • 45
    • 84857782055 scopus 로고    scopus 로고
    • Simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p(53), Bcl-2 and Bcl-xL
    • 22038096 10.1007/s10557-011-6347-z 1:CAS:528:DC%2BC38XivFOku7w%3D
    • Qin W, Lu Y, Zhan C, Shen T, Dou L, Man Y, Wang S, Xiao C, Bian Y, Li J (2012) Simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p(53), Bcl-2 and Bcl-xL. Cardiovasc Drugs Ther 26:23-30
    • (2012) Cardiovasc Drugs Ther , vol.26 , pp. 23-30
    • Qin, W.1    Lu, Y.2    Zhan, C.3    Shen, T.4    Dou, L.5    Man, Y.6    Wang, S.7    Xiao, C.8    Bian, Y.9    Li, J.10
  • 46
    • 79952625581 scopus 로고    scopus 로고
    • Does atorvastatin induce aortic smooth muscle cell apoptosis in vivo?
    • 20951229 10.1016/j.vph.2010.10.001 1:CAS:528:DC%2BC3MXjtFKis7Y%3D
    • Doyon M, Hale TM, Huot-Marchand JE, Wu R, de Champlain J, DeBlois D (2011) Does atorvastatin induce aortic smooth muscle cell apoptosis in vivo? Vascul Pharmacol 54:5-12
    • (2011) Vascul Pharmacol , vol.54 , pp. 5-12
    • Doyon, M.1    Hale, T.M.2    Huot-Marchand, J.E.3    Wu, R.4    De Champlain, J.5    Deblois, D.6
  • 47
    • 33947213317 scopus 로고    scopus 로고
    • Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein
    • 17241114 10.1111/j.1471-4159.2006.04375.x 1:CAS:528:DC%2BD2sXksFSqsLc%3D
    • Johnson-Anuna LN, Eckert GP, Franke C, Igbavboa U, Muller WE, Wood WG (2007) Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. J Neurochem 101:77-86
    • (2007) J Neurochem , vol.101 , pp. 77-86
    • Johnson-Anuna, L.N.1    Eckert, G.P.2    Franke, C.3    Igbavboa, U.4    Muller, W.E.5    Wood, W.G.6
  • 48
    • 40949118011 scopus 로고    scopus 로고
    • Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2
    • 18221360 10.1111/j.1538-7836.2008.02913.x 1:CAS:528:DC%2BD1cXltFCqs7c%3D
    • Xu SZ, Zhong W, Watson NM, Dickerson E, Wake JD, Lindow SW, Newton CJ, Atkin SL (2008) Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2. J Thromb Haemost 6:692-700
    • (2008) J Thromb Haemost , vol.6 , pp. 692-700
    • Xu, S.Z.1    Zhong, W.2    Watson, N.M.3    Dickerson, E.4    Wake, J.D.5    Lindow, S.W.6    Newton, C.J.7    Atkin, S.L.8
  • 49
    • 81855173610 scopus 로고    scopus 로고
    • Atorvastatin prevents mesenchymal stem cells from hypoxia and serum-free injury through activating AMP-activated protein kinase
    • 20832877 10.1016/j.ijcard.2010.08.047
    • Dong Q, Yang Y, Song L, Qian H, Xu Z (2011) Atorvastatin prevents mesenchymal stem cells from hypoxia and serum-free injury through activating AMP-activated protein kinase. Int J Cardiol 153:311-316
    • (2011) Int J Cardiol , vol.153 , pp. 311-316
    • Dong, Q.1    Yang, Y.2    Song, L.3    Qian, H.4    Xu, Z.5
  • 50
    • 84862932134 scopus 로고    scopus 로고
    • Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling
    • 1:CAS:528:DC%2BC38XkvFerug%3D%3D
    • Zhao XH, Xu ZR, Zhang Q, Yang YM (2012) Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling. Mol Med Report 5:483-488
    • (2012) Mol Med Report , vol.5 , pp. 483-488
    • Zhao, X.H.1    Xu, Z.R.2    Zhang, Q.3    Yang, Y.M.4
  • 51
    • 84859110726 scopus 로고    scopus 로고
    • Mechanisms involved in cardioprotective effects of pravastatin administered during reoxygenation in human myocardium in vitro
    • 22343498 10.1097/ALN.0b013e31824be77c 1:CAS:528:DC%2BC38Xktlehs7w%3D
    • Lemoine S, Allouche S, Coulbault L, Cornet V, Massetti M, Galera P, Géard J-L, Hanouz J-L (2012) Mechanisms involved in cardioprotective effects of pravastatin administered during reoxygenation in human myocardium in vitro. Anesthesiology 116:824-833
    • (2012) Anesthesiology , vol.116 , pp. 824-833
    • Lemoine, S.1    Allouche, S.2    Coulbault, L.3    Cornet, V.4    Massetti, M.5    Galera, P.6    Géard, J.-L.7    Hanouz, J.-L.8
  • 52
    • 84858661389 scopus 로고    scopus 로고
    • Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of Bcl-2 gene expression
    • 22134829 1:CAS:528:DC%2BC38XlslKhsr4%3D
    • Spampanato C, De Maria S, Sarnataro M, Giordano E, Zanfardino M, Baiano S, Carteni M, Morelli F (2012) Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of Bcl-2 gene expression. Int J Oncol 40:935-941
    • (2012) Int J Oncol , vol.40 , pp. 935-941
    • Spampanato, C.1    De Maria, S.2    Sarnataro, M.3    Giordano, E.4    Zanfardino, M.5    Baiano, S.6    Carteni, M.7    Morelli, F.8
  • 53
    • 67649781671 scopus 로고    scopus 로고
    • Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients
    • 19464372 10.1016/j.nbd.2009.05.005 1:CAS:528:DC%2BD1MXotFCgt7g%3D
    • Eckert GP, Hooff GP, Strandjord DM, Igbavboa U, Volmer DA, Muller WE, Wood WG (2009) Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients. Neurobiol Dis 35:251-257
    • (2009) Neurobiol Dis , vol.35 , pp. 251-257
    • Eckert, G.P.1    Hooff, G.P.2    Strandjord, D.M.3    Igbavboa, U.4    Volmer, D.A.5    Muller, W.E.6    Wood, W.G.7
  • 54
    • 0036280932 scopus 로고    scopus 로고
    • Pleiotropic effects of statins: Lipid reduction and beyond
    • 11932263 10.1210/jc.87.4.1451 1:CAS:528:DC%2BD38XivFKlsb0%3D
    • Mcfarlane SI, Muniyappa R, Francisco R, Sowers JR (2002) Pleiotropic effects of statins: lipid reduction and beyond. J Clin Endocrinol Metab 87:1451-1458
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1451-1458
    • McFarlane, S.I.1    Muniyappa, R.2    Francisco, R.3    Sowers, J.R.4
  • 55
    • 22244452701 scopus 로고    scopus 로고
    • Statins: Drugs for Alzheimer's disease?
    • 15682268 10.1007/s00702-004-0273-1 1:CAS:528:DC%2BD2MXmtVSgu7k%3D
    • Eckert GP, Wood WG, Muller WE (2005) Statins: drugs for Alzheimer's disease? J Neural Transm 112:1057-1071
    • (2005) J Neural Transm , vol.112 , pp. 1057-1071
    • Eckert, G.P.1    Wood, W.G.2    Muller, W.E.3
  • 56
    • 84868146096 scopus 로고    scopus 로고
    • Isoprenoids and related pharmacological interventions: Potential application in Alzheimer's disease
    • 22418893 10.1007/s12035-012-8253-1 1:CAS:528:DC%2BC38XhtlGmsLbJ
    • Li L, Zhang W, Cheng S, Cao D (2012) Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease. Mol Neurobiol 46:64-77
    • (2012) Mol Neurobiol , vol.46 , pp. 64-77
    • Li, L.1    Zhang, W.2    Cheng, S.3    Cao, D.4
  • 58
    • 2942659875 scopus 로고    scopus 로고
    • Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes
    • 15117818 10.1161/01.RES.0000129701.14494.52 1:CAS:528: DC%2BD2cXksF2ltrY%3D
    • Kawamura T, Ono K, Morimoto T, Akao M, Iwai-Kanai E, Wada H, Sowa N, Kita T, Hasegawa K (2004) Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes. Circ Res 94:1492-1499
    • (2004) Circ Res , vol.94 , pp. 1492-1499
    • Kawamura, T.1    Ono, K.2    Morimoto, T.3    Akao, M.4    Iwai-Kanai, E.5    Wada, H.6    Sowa, N.7    Kita, T.8    Hasegawa, K.9
  • 59
    • 77955087261 scopus 로고    scopus 로고
    • Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells
    • 20369390 10.1007/s12035-010-8122-8 1:CAS:528:DC%2BC3cXmsFSqt74%3D
    • Butterick TA, Igbavboa U, Eckert GP, Sun GY, Weisman GA, Muller WE, Wood WG (2010) Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells. Mol Neurobiol 41:384-391
    • (2010) Mol Neurobiol , vol.41 , pp. 384-391
    • Butterick, T.A.1    Igbavboa, U.2    Eckert, G.P.3    Sun, G.Y.4    Weisman, G.A.5    Muller, W.E.6    Wood, W.G.7
  • 60
    • 0033451446 scopus 로고    scopus 로고
    • Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis
    • 10652602 1:CAS:528:DC%2BD3cXmvF2lsA%3D%3D
    • Park WH, Lee YY, Kim ES, Seol JG, Jung CW, Lee CC, Kim BK (1999) Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis. Anticancer Res 19:3133-3140
    • (1999) Anticancer Res , vol.19 , pp. 3133-3140
    • Park, W.H.1    Lee, Y.Y.2    Kim, E.S.3    Seol, J.G.4    Jung, C.W.5    Lee, C.C.6    Kim, B.K.7
  • 61
  • 62
    • 2942571658 scopus 로고    scopus 로고
    • Class-specific pro-apoptotic effects of statins on human vascular endothelial cells
    • 15160275 10.1007/s00392-004-0081-5
    • Mück AO, Seeger H, Wallwiener D (2004) Class-specific pro-apoptotic effects of statins on human vascular endothelial cells. Z Kardiol 93:398-402
    • (2004) Z Kardiol , vol.93 , pp. 398-402
    • Mück, A.O.1    Seeger, H.2    Wallwiener, D.3
  • 63
    • 2442434564 scopus 로고    scopus 로고
    • Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors
    • 15163549 10.1016/j.bcp.2004.02.037 1:CAS:528:DC%2BD2cXkt1Sktbk%3D
    • Kubota T, Fujisaki K, Itoh Y, Yano T, Sendo T, Oishi R (2004) Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors. Biochem Pharmacol 67:2175-2186
    • (2004) Biochem Pharmacol , vol.67 , pp. 2175-2186
    • Kubota, T.1    Fujisaki, K.2    Itoh, Y.3    Yano, T.4    Sendo, T.5    Oishi, R.6
  • 64
    • 10344264968 scopus 로고    scopus 로고
    • Inhibitory effect of statins on the proliferation of human breast cancer cells
    • 15624286 10.5414/CPP42695
    • Mück AO, Seeger H, Wallwiener D (2004) Inhibitory effect of statins on the proliferation of human breast cancer cells. Int J Clin Pharmacol Ther 42:695-700
    • (2004) Int J Clin Pharmacol Ther , vol.42 , pp. 695-700
    • Mück, A.O.1    Seeger, H.2    Wallwiener, D.3
  • 65
    • 34948895062 scopus 로고    scopus 로고
    • Inhibition of Barret's adenocarcinoma cell growth by simvastatin: Involvement of COX-2 and apoptosis-related proteins
    • 17901590
    • Konturek PC, Burnat G, Hahn EG (2007) Inhibition of Barret's adenocarcinoma cell growth by simvastatin: involvement of COX-2 and apoptosis-related proteins. J Physiol Pharmacol 58:141-148
    • (2007) J Physiol Pharmacol , vol.58 , pp. 141-148
    • Konturek, P.C.1    Burnat, G.2    Hahn, E.G.3
  • 66
    • 34547109890 scopus 로고    scopus 로고
    • Survivin down-regulation plays a crucial role in 3-hydroxy-3- methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer
    • 17472962 10.1074/jbc.M610350200 1:CAS:528:DC%2BD2sXntFWktLg%3D
    • Kaneko R, Tsuji N, Asanuma K, Tanabe H, Kobayashi D, Watanabe N (2007) Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer. J Biol Chem 282:19273-19281
    • (2007) J Biol Chem , vol.282 , pp. 19273-19281
    • Kaneko, R.1    Tsuji, N.2    Asanuma, K.3    Tanabe, H.4    Kobayashi, D.5    Watanabe, N.6
  • 67
    • 70350346624 scopus 로고    scopus 로고
    • Statins inhibit the growth of variant human embryonic stem cells and cancer cells in vitro but not normal human embryonic stem cells
    • 19438511 10.1111/j.1476-5381.2009.00241.x 1:CAS:528:DC%2BD1MXhtVChu7bO
    • Gauthaman K, Manasi N, Bongso A (2009) Statins inhibit the growth of variant human embryonic stem cells and cancer cells in vitro but not normal human embryonic stem cells. Br J Pharmacol 157:962-973
    • (2009) Br J Pharmacol , vol.157 , pp. 962-973
    • Gauthaman, K.1    Manasi, N.2    Bongso, A.3
  • 68
    • 74449092398 scopus 로고    scopus 로고
    • Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis
    • 20043868 10.1016/j.bbrc.2009.12.077 1:CAS:528:DC%2BC3cXhtVaru74%3D
    • Lee SK, Kim YC, Song SB, Kim YS (2010) Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. Biochem Biophys Res Commun 391:1592-1597
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1592-1597
    • Lee, S.K.1    Kim, Y.C.2    Song, S.B.3    Kim, Y.S.4
  • 69
    • 78649423169 scopus 로고    scopus 로고
    • Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway
    • 21250597 1:CAS:528:DC%2BC3MXisFagtbc%3D
    • Zhang W, Wu J, Zhou L, Xie HY, Zheng SS (2010) Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol 48:1167-1174
    • (2010) Indian J Exp Biol , vol.48 , pp. 1167-1174
    • Zhang, W.1    Wu, J.2    Zhou, L.3    Xie, H.Y.4    Zheng, S.S.5


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