Mechanisms of inhibitory effects of cerivastatin on rat vascular smooth muscle cell growth

Journal of Cardiovascular Pharmacology

Volumn 40, Issue 2, 2002, Pages 277-287

  Igarashi, Masahiko ^a   Yamaguchi, Hiroshi ^a   Hirata, Akihiko ^a   Tsuchiya, Hiromi ^a   Ohnuma, Hiroshi ^a   Tominaga, Makoto ^a   Daimon, Makoto ^a   Kato, Takeo ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cerivastatin; MAP kinase; Mevalonate; Vascular smooth muscle cells

Indexed keywords

CASPASE 3; CELL NUCLEUS ANTIGEN; CERIVASTATIN; DNA FRAGMENT; HISTONE; MEVALONIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BCL 2; PROTEIN KINASE; PROTEIN KINASE B; S6 KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PYRIDINE DERIVATIVE;

AMINO TERMINAL SEQUENCE; ANGIOPLASTY; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL CULTURE; CELL GROWTH; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DOSE RESPONSE; ENZYME ACTIVITY; MALE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; RESTENOSIS; SIGNAL TRANSDUCTION; STARVATION; VASCULAR SMOOTH MUSCLE; ANALYSIS OF VARIANCE; ANIMAL; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; METABOLISM; SPRAGUE DAWLEY RAT;

ANALYSIS OF VARIANCE; ANIMAL; APOPTOSIS; CELLS, CULTURED; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MUSCLE, SMOOTH, VASCULAR; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; ANIMALS;

EID: 0035988163     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200208000-00013     Document Type: Article

References (52)

1. Randomized trial of cholesterol lowering in 4,444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
2. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
3. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
4. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study
5. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
6. Statin trials and goals of cholesterol-lowering therapy
7. Antiatherothrombic properties of statins: Implications for cardiovascular event reduction
8. The antithrombic effect of statins
9. Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation
10. Molecular bases of the acute coronary syndromes
11. The pathogenesis of atherosclerosis - An update
12. HMG CoA reductase inhibitors: In vivo effects on carotid intimal thickening in normocholesterolemic rabbits
13. Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors: Comparison with other human cell types
14. Direct vascular effects of HMG-CoA reductase inhibitors
15. Suppression of neointimal thickening by a newly developed HMG-CoA reductase inhibitor, BAYw6228, and its inhibitory effect on vascular smooth muscle cell growth
16. Pioglitazone reduces smooth muscle cell density of rat carotid arterial intima induced by balloon catheterization
17. Nifedipine suppresses neointimal thickening by its inhibitory effect on vascular smooth muscle cell growth via a MEK-ERK pathway coupling with Pyk2
18. Protein measurement with the folin phenol reagent
19. Diabetes mellitus induces accelerated growth of aortic smooth muscle cells: Association with overexpression of PDGF β-receptors
20. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways
21. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
22. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
23. Protective effect of nifedipine against cytotoxicity and intracellular calcium alterations induced by acetaminophen in rat hepatocyte cultures
24. Cholesterol reduction in cardiovascular disease: Clinical benefits and possible mechanism
25. Vastatins inhibit tissue factor in cultured human macrophage
26. Effects of fluvastatin on leukocyte-endothelial cell adhesion in hypercholesterolemic rats
27. Effect of pravastatin on cardiovascular reactivity to norepinephrine and angiotensin II in patients with hypercholesterolemia and systemic hypertension
28. Simvastatin, an HMG- coenzyme A reductase inhibitor, improves endothelial function within 1 month
29. Inhibition of thromboxane biosynthesis and platelet function by simbastatin in type IIa hypercholesterolemia
30. + antiport in human platelets: A novel mechanism enhancing platelet activity in hypercholesterolemia
31. Effects of cerivastatin on human arterial smooth muscle cell proliferation and migration in transfilter cocultures
32. The MAPK signaling cascade
33. Role of transactivation of EGF receptor in signaling by G-protein-coupled receptors
34. Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP) kinase cascades
35. Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration
36. Insulin activates p38 mitogen-activated protein (MAP) kinase via a MAP kinase kinase (MKK) 3/MKK 6 pathway in vascular smooth muscle cells
37. Regulation and function of the JNK subgroup of MAP kinases
38. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
39. PI3K: Downstream AKTion blocks apoptosis
40. Protein kinases as mediators of phosphoinositide 3-kinase signaling
41. Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt
42. The 70-kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1
43. Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression
44. 411 in vascular smooth muscle cells: Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt
45. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
46. Activation of c-Jun N-terminal kinase antagonizes an antiapoptotic action of bcl-2
47. Phosphorylation and regulation of Raf by Akt (protein kinase B)
48. Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV
49. Repeated balloon injury of rat aorta. A model of neointima with attenuated inhibition by heparin
50. Cell replication in the arterial wall: Activation of signaling pathway following in vivo injury
51. Induction of apoptosis and inhibition of migration of inflammatory and vascular wall cells by cerivastatin
52. Lipophilic statins induce apoptosis of human vascular smooth muscle cells