Involvement of Chk1-Cdc25A-cyclin A/CDk2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells

European Journal of Pharmacology

Volumn 670, Issue 2-3, 2011, Pages 356-364

  Tu, Yong Sheng ^a,b   Kang, Xiao Long ^a   Zhou, Jia Guo ^a   Lv, Xiao Fei ^a   Tang, Yong Bo ^a   Guan, Yong Yuan ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cdc25A; Chk1; Cyclin dependent kinase 2; S phase arrest; Simvastatin

Indexed keywords

CASPASE 3; CASPASE 9; CHECKPOINT KINASE 1; CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYTOCHROME C; PROTEIN BCL 2; PROTEIN TYROSINE PHOSPHATASE; SIMVASTATIN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; MYELOMA CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; WESTERN BLOTTING;

APOPTOSIS; CASPASE 3; CASPASE 9; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; CYTOCHROMES C; DOWN-REGULATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MITOCHONDRIA; MULTIPLE MYELOMA; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; S PHASE CELL CYCLE CHECKPOINTS; SIGNAL TRANSDUCTION; SIMVASTATIN;

EID: 80755153113     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.09.031     Document Type: Article

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