메뉴 건너뛰기




Volumn 157, Issue 6, 2009, Pages 962-973

Statins inhibit the growth of variant human embryonic stem cells and cancer cells in vitr

Author keywords

Apoptosis; Cell proliferation; Isoprenoids; Pluripotency; Statins; Stem cells

Indexed keywords

COMPACTIN; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; GLUCOSE REGULATED PROTEIN 94; GROWTH DIFFERENTIATION FACTOR 3; GROWTH FACTOR; ISOPRENOID; MEVINOLIN; OCTAMER TRANSCRIPTION FACTOR 4; PRAVASTATIN; PROTEIN BAX; SIMVASTATIN; STAGE SPECIFIC EMBRYO ANTIGEN 4; SURVIVIN; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

EID: 70350346624     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00241.x     Document Type: Article
Times cited : (46)

References (44)
  • 1
    • 27144510277 scopus 로고    scopus 로고
    • Stem cells, asymmetric division and cancer
    • DOI 10.1038/ng1005-1027, PII N10051027
    • Clevers H (2005). Stem cells, asymmetric division and cancer. Nat Genet 37: 1027-1028. (Pubitemid 41486650)
    • (2005) Nature Genetics , vol.37 , Issue.10 , pp. 1027-1028
    • Clevers, H.1
  • 2
    • 0037840242 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: A randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group
    • Collins R, Armitage J, Parish S, Sleigh P, Peto R (2003). Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet 361 (9374): 2005-2016.
    • (2003) Lancet , vol.361 , Issue.9374 , pp. 2005-2016
    • Collins, R.1    Armitage, J.2    Parish, S.3    Sleigh, P.4    Peto, R.5
  • 3
    • 0035132669 scopus 로고    scopus 로고
    • Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apop-tosis: Therapeutic implications
    • Dimitroulakos J, Ye LY, Benzaquen M, Moore MJ, Kamel-Reid S, Freed-man MH et al. (2001). Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apop-tosis: therapeutic implications. Clin Cancer Res 7: 158-167.
    • (2001) Clin Cancer Res , vol.7 , pp. 158-167
    • Dimitroulakos, J.1    Ye, L.Y.2    Benzaquen, M.3    Moore, M.J.4    Kamel-Reid, S.5    Freed-Man, M.H.6
  • 4
    • 0032851111 scopus 로고    scopus 로고
    • Sterols and isoprenoids: Signaling molecules derived from the cholesterol biosynthetic pathway
    • Edwards PA, Ericsson J (1999). Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Ann Rev Biochem 68: 157-185.
    • (1999) Ann Rev Biochem , vol.68 , pp. 157-185
    • Edwards, P.A.1    Ericsson, J.2
  • 5
    • 27644473695 scopus 로고    scopus 로고
    • Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma
    • Ezeh UI, Turek PJ, Reijo RA, Clark AT (2005). Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 104 (10): 2255-2265.
    • (2005) Cancer , vol.104 , Issue.10 , pp. 2255-2265
    • Ezeh, U.I.1    Turek, P.J.2    Reijo, R.A.3    Clark, A.T.4
  • 6
    • 36448989350 scopus 로고    scopus 로고
    • Comparative evaluation of the effects of statins on human stem and cancer cells in vitro
    • Gauthaman K, Richards M, Wong J, Bongso A (2007). Comparative evaluation of the effects of statins on human stem and cancer cells in vitro. Reprod BioMed Online 15 (5): 566-581.
    • (2007) Reprod BioMed Online , vol.15 , Issue.5 , pp. 566-581
    • Gauthaman, K.1    Richards, M.2    Wong, J.3    Bongso, A.4
  • 7
    • 2942641691 scopus 로고    scopus 로고
    • Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis
    • Gniadecki R (2004). Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis. Biochem Biophys Res Commun 320: 165-169.
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 165-169
    • Gniadecki, R.1
  • 8
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein JL, Brown MS (1990). Regulation of the mevalonate pathway. Nature 343: 425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 9
    • 0036463405 scopus 로고    scopus 로고
    • A matter of life and death
    • Green DR, Evan GI (2002). A matter of life and death. Cancer Cell 1: 19-30.
    • (2002) Cancer Cell , vol.1 , pp. 19-30
    • Green, D.R.1    Evan, G.I.2
  • 10
    • 19444376167 scopus 로고    scopus 로고
    • Statins and cancer-beyond the 'one drug, one disease' model
    • Hawk E, Viner JL (2005). Statins and cancer-beyond the 'one drug, one disease' model. N Engl J Med 352: 2238-2239.
    • (2005) N Engl J Med , vol.352 , pp. 2238-2239
    • Hawk, E.1    Viner, J.L.2
  • 12
    • 1842479021 scopus 로고    scopus 로고
    • The 'brainy side' of human embryonic stem cells
    • Hornstein E, Benvenisty N (2004). The 'brainy side' of human embryonic stem cells. J Neurosci Res 76: 169-173.
    • (2004) J Neurosci Res , vol.76 , pp. 169-173
    • Hornstein, E.1    Benvenisty, N.2
  • 13
    • 34948891467 scopus 로고    scopus 로고
    • Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infracted rat hearts
    • Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK et al. (2007). Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infracted rat hearts. Nat Biotechnol 25 (9): 1015-1024.
    • (2007) Nat Biotechnol , vol.25 , Issue.9 , pp. 1015-1024
    • Laflamme, M.A.1    Chen, K.Y.2    Naumova, A.V.3    Muskheli, V.4    Fugate, J.A.5    Dupras, S.K.6
  • 14
    • 34547202193 scopus 로고    scopus 로고
    • Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranayl gera-nylation
    • Lee MH, Cho YS, Han YM (2007). Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranayl gera-nylation. Stem Cells 25 (7): 1654-1663.
    • (2007) Stem Cells , vol.25 , Issue.7 , pp. 1654-1663
    • Lee, M.H.1    Cho, Y.S.2    Han, Y.M.3
  • 15
    • 0037309378 scopus 로고    scopus 로고
    • A novel anti-inflammatory role for simvastatin in inflammatory arthritis
    • Leung BP, Sattar N, Crilly A, Prach M, McCarey DW, Payne H et al. (2003). A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J Immunol 170: 1524-1530.
    • (2003) J Immunol , vol.170 , pp. 1524-1530
    • Leung, B.P.1    Sattar, N.2    Crilly, A.3    Prach, M.4    McCarey, D.W.5    Payne, H.6
  • 18
    • 0033584938 scopus 로고    scopus 로고
    • Integrin-dependent leukocyte adhesion involves gera-nylgeranylated protein(s)
    • Li L, Patty M, Nicholas LK, Bailey R, Hamilton AD, Sebti SM et al. (1999). Integrin-dependent leukocyte adhesion involves gera-nylgeranylated protein(s). J Biol Chem 274: 33334-33340.
    • (1999) J Biol Chem , vol.274 , pp. 33334-33340
    • Li, L.1    Patty, M.2    Nicholas, L.K.3    Bailey, R.4    Hamilton, A.D.5    Sebti, S.M.6
  • 19
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) method
    • Livak KJ, Schmittgen TD (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 21
    • 0025649688 scopus 로고
    • Post-translational modification of proteins by isoprenoids in mammalian cells
    • Maltese WA (1990). Post-translational modification of proteins by isoprenoids in mammalian cells. FASEB J 4: 3319-3328.
    • (1990) FASEB J , vol.4 , pp. 3319-3328
    • Maltese, W.A.1
  • 22
    • 0037057629 scopus 로고    scopus 로고
    • Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
    • Marsden VS, O'Connor L, O'Reilly LA, Silke J, Metcalf D, Ekert PG et al. (2002). Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature 419: 634-637.
    • (2002) Nature , vol.419 , pp. 634-637
    • Marsden, V.S.1    O'Connor, L.2    O'Reilly, L.A.3    Silke, J.4    Metcalf, D.5    Ekert, P.G.6
  • 23
    • 18844442326 scopus 로고    scopus 로고
    • Statins and cholesterol lowering after a cancer diagnosis: Why not?
    • Moyad MA, Merrick GS (2005). Statins and cholesterol lowering after a cancer diagnosis: why not? Urol Oncol 23: 49-55.
    • (2005) Urol Oncol , vol.23 , pp. 49-55
    • Moyad, M.A.1    Merrick, G.S.2
  • 25
    • 0027166048 scopus 로고
    • Bcl-2 heterodimers in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai ZN, Milliman CL, Korsmeyer SJ (1993). Bcl-2 heterodimers in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 26
    • 33745008414 scopus 로고    scopus 로고
    • Characterization of a new NIH-registered variant human embryonic stem cell line, BG01V: A tool for human embryonic stem cell research
    • Plaia TW, Josephson R, Liu Y, Zeng X, Ording C, Toumadje A et al. (2006). Characterization of a new NIH-registered variant human embryonic stem cell line, BG01V: a tool for human embryonic stem cell research. Stem Cells 24: 531-546.
    • (2006) Stem Cells , vol.24 , pp. 531-546
    • Plaia, T.W.1    Josephson, R.2    Liu, Y.3    Zeng, X.4    Ording, C.5    Toumadje, A.6
  • 28
    • 0033529171 scopus 로고    scopus 로고
    • Lovastatin-mediated G1 arrest is through inhibition of the protea-some, independent of hydroxymethyl glutaryl-CoA reductase
    • Rao S, Porter DC, Chen X, Herliczek T, Lowe M, Keyomarsi K (1999). Lovastatin-mediated G1 arrest is through inhibition of the protea-some, independent of hydroxymethyl glutaryl-CoA reductase. Proc Natl Acad Sci USA 96: 7797-7802.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7797-7802
    • Rao, S.1    Porter, D.C.2    Chen, X.3    Herliczek, T.4    Lowe, M.5    Keyomarsi, K.6
  • 29
    • 31844436074 scopus 로고    scopus 로고
    • Rho/ROCK pathway as a target of tumor therapy
    • Rattan R, Giri S, Singh AK, Singh I (2006). Rho/ROCK pathway as a target of tumor therapy. J Neurosci Res 83 (2): 243-255.
    • (2006) J Neurosci Res , vol.83 , Issue.2 , pp. 243-255
    • Rattan, R.1    Giri, S.2    Singh, A.K.3    Singh, I.4
  • 30
    • 0034101804 scopus 로고    scopus 로고
    • Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
    • Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A (2000). Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 18: 399-404.
    • (2000) Nat Biotechnol , vol.18 , pp. 399-404
    • Reubinoff, B.E.1    Pera, M.F.2    Fong, C.Y.3    Trounson, A.4    Bongso, A.5
  • 31
    • 0346250854 scopus 로고    scopus 로고
    • The Transcriptome Profile of Human Embryonic Stem Cells as Defined by SAGE
    • Richards M, Tan SP, Tan JH, Chan WK, Bongso A (2004). The tran-scriptome profile of human embryonic stem cells as defined by SAGE. Stem Cells 22: 51-64. (Pubitemid 38018781)
    • (2004) Stem Cells , vol.22 , Issue.1 , pp. 51-64
    • Richards, M.1    Tan, S.-P.2    Tan, J.-H.3    Chan, W.-K.4    Bongso, A.5
  • 33
    • 34247898958 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells towards a pancreatic cell fate
    • Shim JH, Kim SE, Woo DH, Kim SK, Oh CH, McKay R et al. (2007). Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 50: 1228-1238.
    • (2007) Diabetologia , vol.50 , pp. 1228-1238
    • Shim, J.H.1    Kim, S.E.2    Woo, D.H.3    Kim, S.K.4    Oh, C.H.5    McKay, R.6
  • 35
    • 0038638343 scopus 로고    scopus 로고
    • In vitro osteogenic differentiation of human ES cells
    • Sottile V, Thomson A, McWhir J (2003). In vitro osteogenic differentiation of human ES cells. Cloning Stem Cells 5: 149-155.
    • (2003) Cloning Stem Cells , vol.5 , pp. 149-155
    • Sottile, V.1    Thomson, A.2    McWhir, J.3
  • 37
    • 1842765431 scopus 로고    scopus 로고
    • Intensive statin therapy-a sea change in cardiovascular prevention
    • Topol EJ (2004). Intensive statin therapy-a sea change in cardiovascular prevention. N Engl J Med 350: 1562-1564.
    • (2004) N Engl J Med , vol.350 , pp. 1562-1564
    • Topol, E.J.1
  • 38
    • 0242290258 scopus 로고    scopus 로고
    • P21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases
    • Ukomadu C, Dutta A (2003). p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases. J Biol Chem 278: 43586-43594.
    • (2003) J Biol Chem , vol.278 , pp. 43586-43594
    • Ukomadu, C.1    Dutta, A.2
  • 39
    • 0028814860 scopus 로고
    • Different effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on sterol synthesis in various human cell types
    • van Vliet AK, van Thiel GC, Huisman RH, Moshage H, Yap SH, Cohen LH (1995). Different effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on sterol synthesis in various human cell types. Biochim Biophys Acta 1254: 105-111.
    • (1995) Biochim Biophys Acta , vol.1254 , pp. 105-111
    • Van Vliet, A.K.1    Van Thiel, G.C.2    Huisman, R.H.3    Moshage, H.4    Yap, S.H.5    Cohen, L.H.6
  • 40
    • 0034930259 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2
    • Wachtershauser A, Akoglu B, Stein J (2001). HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Carcinogenesis 22: 1061-1067.
    • (2001) Carcinogenesis , vol.22 , pp. 1061-1067
    • Wachtershauser, A.1    Akoglu, B.2    Stein, J.3
  • 42
    • 0036118915 scopus 로고    scopus 로고
    • Pleiotropic effects of HMG-CoA reductase inhibitors
    • Werner N, Nickenig G, Laufs U (2002). Pleiotropic effects of HMG-CoA reductase inhibitors. Basic Res Cardiol 97: 105-116.
    • (2002) Basic Res Cardiol , vol.97 , pp. 105-116
    • Werner, N.1    Nickenig, G.2    Laufs, U.3
  • 43
    • 8644286440 scopus 로고    scopus 로고
    • Presence of functional gap junctions in human embryonic stem cells
    • Wong RC, Pébay A, Nguyen LT, Koh KL, Pera MF (2004). Presence of functional gap junctions in human embryonic stem cells. Stem Cells 22: 883-889.
    • (2004) Stem Cells , vol.22 , pp. 883-889
    • Wong, R.C.1    Pébay, A.2    Nguyen, L.T.3    Koh, K.L.4    Pera, M.F.5
  • 44
    • 38349004470 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in Parkinsonian rats
    • Yang D, Zhang Z, Oldenberg M, Ayala M, Zhang S (2008). Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in Parkinsonian rats. Stem Cells 26: 55-63.
    • (2008) Stem Cells , vol.26 , pp. 55-63
    • Yang, D.1    Zhang, Z.2    Oldenberg, M.3    Ayala, M.4    Zhang, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.