Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells

Molecular Neurobiology

Volumn 41, Issue 2-3, 2010, Pages 384-391

  Butterick, Tammy A ^a   Igbavboa, Urule ^a   Eckert, Gunter P ^b   Sun, Grace Y ^c   Weisman, Gary A ^c   Müller, Walter E ^b   Wood, W Gibson ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b GOETHE UNIVERSITY   (Germany)

^c University of Missouri   (United States)

Author keywords

Alzheimer's disease; Apoptosis; Bcl 2; Endothelin 1; Neuroprotection; NFAT; Simvastatin; Statins

Indexed keywords

CHOLESTEROL; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; PROTEIN BCL 2; SIMVASTATIN; TRANSCRIPTION FACTOR NFAT3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NFATC1 PROTEIN, HUMAN; NFATC3 PROTEIN, HUMAN; NFATC4 PROTEIN, HUMAN; PROTEIN BINDING; TRANSCRIPTION FACTOR NFAT;

CELL NUCLEUS; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SPACE; NERVE CELL; NEUROBLASTOMA CELL; NEUROPROTECTION; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; UPREGULATION; DRUG EFFECTS; GENETICS; METABOLISM; TUMOR CELL LINE;

CELL LINE, TUMOR; ENDOTHELIN-1; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; NFATC TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; SIMVASTATIN;

EID: 77955087261     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12035-010-8122-8     Document Type: Conference Paper

References (36)

1. Tobert JA (2003) Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev 2:517-526
2. Law MR, Wald NJ, Rudnicka AR (2003) Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. Br Med J 326:1-7
3. Nassief A, Marsh JD (2008) Statin therapy for stroke prevention. Stroke 39:1042-1048
4. Eckert GP, Wood WG, Müller WE (2005) Statins: drugs for Alzheimer's diseasé J Neural Transm 112:1057-1071
5. Wahner AD, Bronstein JM, Bordelon YM, Ritz B (2008) Statin use and the risk of Parkinson disease. Neurology 70:1418-1422
6. Neuhaus O, Hartung HP (2007) Evaluation of atorvastatin and simvastatin for treatment of multiple sclerosis. Expert Rev Neurother 7:547-556
7. Tapia-Perez JH, Sanchez-Aguilar M, Torres-Corzo JG, Gordillo-Moscoso AG, Martinez-Perez P, Madeville P, Cruz-Mendoza E, Chalita-Williams J (2008) Effect of rosuvastatin on amnesia and disorientation after traumatic brain injury (NCT003229758). J Neurotrauma 25:1011-1017
8. Eckert GP, Hooff GP, Strandjord DM, Igbavboa U, Volmer DA, Müller WE, Wood WG (2009) Regulation of the brain isoprenoids farnesyl-and geranylgeranylpyrophosphate is altered in male Alzheimer patients. Neurobiol Dis 35:251-257
9. Tringali G, Vairano M, Dello Russo C, Preziosi P, Navarra P (2004) Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. Neurosci Lett 354:107-110
10. Bösel J, Gandor F, Harms C, Synowitz M, Harms U, Djoufack P, Megow D, Dirnagl U, Hörtnagl H, Finks KB, Endres M (2005) Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. J Neurochem 92:1386-1398
11. Johnson-Anuna LN, Eckert GP, Franke C, Igbavboa U, Müller WE, Wood WG (2007) Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. J Neuro-chem 101:77-86
12. Brown MS, Goldstein JL (1980) Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. J Lipid Res 21:505-517
13. Johnson-Anuna LN, Eckert GP, Keller JH, Igbavboa U, Franke C, Fechner T, Schubert-Zsilavecz M, Karas M, Müller WE, Wood WG (2005) Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex. J Pharmacol Exp Ther 312:786-793
14. Franke C, Nöldner M, Abdel-Kader R, Johnson-Anuna LN, Wood WG, Müller WE, Eckert GP (2007) Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment. Neurobiol Dis 25:438-445
15. Kakita T, Hasegawa K, Iwai-Kanai E, Adachi S, Morimoto T, Wada H, Kawamura T, Yanazume T, Sasayama S (2001) Calcineurin pathway is required for endothelin-1-mediated protection against oxidant stress-induced apoptosis in cardiac myocytes. Circ Res 88:1239-1246
16. Kawamura T, Ono K, Morimoto T, Akao M, Iwai-Kanai E, Wada H, Sowa N, Kita T, Hasegawa K (2004) Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes. Circ Res 94:1492-1499
17. Groth RD, Mermelstein PG (2008) NFAT-dependent gene expression in the nervous system: a critical mediator of neurotrophin-induced plasticity. In: Dudek SM (ed) Transcriptional regulation by neuronal activity. Springer, New York, pp 187-208
18. Schwartz N, Schohl A, Ruthazer ES (2009) Neural activity regulates synaptic properties and dendritic structure in vivo through calcineurin/NFAT signaling. Neuron 62:655-669
19. Benedito AB, Lehtinen M, Massol R, Lopes UG, Kirchhausen T, Rao A, Bonni A (2005) The transcription factor NFAT3 mediates neuronal survival. J Biol Chem 280:2818-2825
20. Luoma JI, Zirpel L (2008) Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS. J Neurosci 28:3159-3169
21. Hasselblatt M, Kamrowski-Kruck H, Jensen N, Schilling L, Kratzin H, Sirén AL, Ehrenreich H (1998) ETA and ETB antagonists synergistically increase extracellular endothelin-1 levels in primary rat astrocyte cultures. Brain Res 785:253-261
22. Oukka M, Ho IC, de la Brousse FC, Hoey T, Grusby MJ, Glimcher LH (1998) The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity 9:295-304
23. Nilsson LM, Sun ZW, Nilsson J, Nordström I, Chen YW, Molkentin JD, Wide-Swensson D, Hellstand P, Lydrup ML, Gomez MF (2007) Novel blocker of NFAT activation inhibits
24. IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation. Am J Physiol Cell Physiol 292:C1167-C1178
25. Haynes WG, Webb DJ (1998) Endothelin as a regulator of cardiovascular function in health and disease. J Hypertens 16:1081-1098
26. Chauhan A, Hahn S, Gartner S, Pardo CA, Netesan SK, McArthur J, Nath A (2007) Molecular programming of endothelin-1 in HIV-infected brain: role of TAT in up-regulation of ET-1 and its inhibition by statins. FASEB J 21:777-789
27. Hernandez-Perera O, Perez-Sala D, Navarro-Antolin J, Sanchez-Pascuala R, Hernandez G, Diaz C, Lamas S (1998) Effects of the 3-hydroxy-3-methylglutaryl- CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest 101:2711-2719
28. Ohkita M, Sugii M, Ka Y, Kitamura A, Mori T, Hayashi T, Takaoka M, Matsumura Y (2006) Differential effects of different statins on endothelin-1 gene expression and endothelial NOS phosphorylation in porcine aortic endothelial cells. Exp Biol Med 231:772-776
29. Wood WG, Eckert GP, Igbavboa U, Müller WE (2010) Statins and neuroprotection: a prescription to move the field forward. Ann NY Acad Sci in press
30. Vacca F, Bagnato A, Catt KJ, Tecce R (2000) Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells. Cancer Res 60:5310-5317
31. Wu H, Peisley A, Graef IA, Crabtree GR (2007) NFAT signaling and the invention of vertebrates. Trends Cell Biol 17:251-260
32. Macian F (2005) NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 5:472-484
33. Ghribi O, Herman MM, Spaulding NK, Savory J (2002) Lithium inhibits aluminum-induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl-2 decrease, Bax elevation and caspase-3 activation. J Neurochem 82:137-145
34. Youdim MB, Arraf Z (2004) Prevention of MPTP (N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvement of Bcl-2 and Bax. Neuropharmacology 46:1130-1140
35. Wei H, Leeds PR, Qian Y, Wei W, Chen R, Chuang D (2000) Beta-amyloid peptide-induced death of PC12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment. Eur J Pharmacol 392:117-123
36. Graef IA, Chen F, Crabtree GR (2001) NFAT signaling in vertebrate development. Curr Opin Genet Dev 11:505-512