Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: Involvement of nonsterol isoprenoid biosynthesis inhibition

Molecular and Cellular Neuroscience

Volumn 17, Issue 2, 2001, Pages 329-341

  García Román, Natalia ^a   Álvarez, Alberto M ^b   Toro, María J ^a   Montes, Agustín ^a   Lorenzo, María J ^a,c  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOPRENOID; MEVINOLIN; PRAVASTATIN; PROTEIN BCL 2; PROTEIN BCL X; RAS PROTEIN; RHO FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL IMMORTALIZATION; CELL METABOLISM; CONTROLLED STUDY; DRUG EFFECT; NERVE CELL GROWTH; NERVE CELL NECROSIS; NEUROBLAST; NEUROTOXICITY; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0035114219     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.2000.0904     Document Type: Article

References (54)

1. Insomnia, lovastatin and isoprene
2. Inhibitors of hydroxymethylglutaryl coenzyme A reductase for treating hypercholesterolaemia
3. Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis
4. Neuronal apoptosis
5. Signal transduction: Three paths to stress relief
6. Sterol metabolism in fetal, newborn and suckled lambs and their response to cholesterol after weaning
7. Apoptotic features of selective neuronal death in ischemia, epilepsy and gpl20 toxicity
8. Role of cholesterol metabolism in cell growth
9. Features of apoptotic cells measured by flow cytometry
10. The Bcl-2 family of proteins, and the regulation of neuronal survival
11. A new approach for the electrophoretic detection of apoptosis
12. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway
13. Effects of a competitive inhibitor (mevinolin) of 3-hydroxy-3-methylglutaryl coenzyme A reductase on human and bovine endothelial cells, fibroblast and smooth muscle cells in vitro
14. Regulation of intracellular actin polymerization by prenylated cellular proteins
15. Role of Rho A activation in the growth and morphology of a murine prostate turmor cell line
16. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
17. Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain
18. Prenyl proteins in eukaryotic cells: A new type of membrane anchor
19. Regulation of the mevalonate pathway
20. Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death
21. 3-Hydroxy-3-methylglutaryl coenzyme A reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
22. Global ischemia induces apoptosis-associated genes in hippocampus
23. Release from G1 growth arrest by transforming growth factor beta 1 requires cellular ras activity
24. Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells
25. Cholesterol for synthesis of myelin is made locally, not imported into brain
26. Regulation of sterol synthesis in developing brains of normal and jimpy mice
27. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevilonin, a competitive inhibitor of the reductase
28. Role of Rho protein in lovastatin-induced breakdown of actin cytoskeleton
29. Apoptosis, oncosis, and necrosis: An overview of cell death
30. Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: Relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis
31. Inhibition by compactin demonstrates a requirement of isoprenoid metabolism for long-term potentiation in rat hippocampal slices
32. Tissue-selective acute effects of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase on cholesterol biosynthesis in lens
33. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
34. Thyroid hormone receptor/c-erbA: Control of commitment and differentiation in the neuronal/chromaffin progenitor line PC12
35. H2MG-CoA reductase inhibitor-induced L6 myoblast cell death: Involvement of the phosphatidylinositol 3-kinase pathway
36. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
37. Cholesterol metabolism in the RSH/Smith-Lemli-Opitz syndrome: Summary of an NICHD conference
38. Lovastatin-induced apoptosis in prostate stromal cells
39. An in vitro study of the effects of lovastatin on human fetal brain cells
40. Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells
41. Pharmacological control of the mevalonate pathway: Effect on arterial smooth muscle cell proliferation
42. Mitogen-activated protein kinase pathways
43. Comparative effects of pravastatin and lovastatin on nightime sleep and daytime performance
44. Abnormal cholesterol biosynthesis in the Smith-Lemli-Opitz syndrome
45. Decreased expression of bcl-2 and bcl-x mRNA coincides with apoptosis following intracerebral administration of 3-nitropopionic acid
46. Simvastatin inhibits the division and induces neurite-like outgrowth in PC12 cells
47. Relative lipophilicities, solubilities, and structure-phamacological considerations of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors pravastatin, lovastatin, mevastatin, and simvastatin
48. Role of cholesterogenesis and isoprenoid synthesis in DNA replication and cell growth
49. Sterol synthesis in vivo in 18 tissues of the squirrell monkey, guinea pig, rabbit, hamster and rat
50. New developments in lipid-lowering therapy: The role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase
51. Preferential utilization of newly synthesized cholesterol for brain growth in neonatal lambs
52. Rho family members: Activators of MAP kinase cascades
53. ras activated, AP-1-dependent pathway
54. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis