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Volumn 1771, Issue 2, 2007, Pages 164-176

c-Jun N-terminal protein kinase signalling pathway mediates lovastatin-induced rat brain neuroblast apoptosis

Author keywords

Apoptosis; Bim; JNK; Nervous system; p38 MAPK; Statins

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; MEVALONIC ACID; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

EID: 33846799237     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2006.12.002     Document Type: Article
Times cited : (25)

References (65)
  • 1
    • 0021363725 scopus 로고
    • Role of cholesterol metabolism in cell growth
    • Chen H.W. Role of cholesterol metabolism in cell growth. Fed. Proc. 43 (1984) 126-130
    • (1984) Fed. Proc. , vol.43 , pp. 126-130
    • Chen, H.W.1
  • 2
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein J.L., and Brown M.S. Regulation of the mevalonate pathway. Nature 343 (1990) 425-429
    • (1990) Nature , vol.343 , pp. 425-429
    • Goldstein, J.L.1    Brown, M.S.2
  • 3
    • 0028216631 scopus 로고
    • Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins
    • Grunler J., Ericsson J., and Dallner G. Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins. Biochim. Biophys. Acta 1212 (1994) 259-277
    • (1994) Biochim. Biophys. Acta , vol.1212 , pp. 259-277
    • Grunler, J.1    Ericsson, J.2    Dallner, G.3
  • 5
    • 0036192275 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation
    • Blanco-Colio L.M., Villa A., Ortego M., Hernández-Presa M.A., Pascual A., Plaza J.J., and Egido J. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. Atherosclerosis 161 (2002) 17-26
    • (2002) Atherosclerosis , vol.161 , pp. 17-26
    • Blanco-Colio, L.M.1    Villa, A.2    Ortego, M.3    Hernández-Presa, M.A.4    Pascual, A.5    Plaza, J.J.6    Egido, J.7
  • 7
    • 0037446216 scopus 로고    scopus 로고
    • Inhibition of pancreatic stellate cell activation by the hydroxymethylglutaryl coenzyme A reductase inhibitor lovastatin
    • Jaster R., Brock P., Sparmann G., Emmrich J., and Liebe S. Inhibition of pancreatic stellate cell activation by the hydroxymethylglutaryl coenzyme A reductase inhibitor lovastatin. Biochem. Pharmacol. 65 (2003) 1295-1303
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1295-1303
    • Jaster, R.1    Brock, P.2    Sparmann, G.3    Emmrich, J.4    Liebe, S.5
  • 8
    • 7544219925 scopus 로고    scopus 로고
    • Effect of statins and farnesyltransferase inhibitors on the development and progression of cancer
    • Graaf M.R., Richel D.J., van Noorden C.J.F., and Guchelarr H.J. Effect of statins and farnesyltransferase inhibitors on the development and progression of cancer. Cancer Treat. Rev. 30 (2004) 609-641
    • (2004) Cancer Treat. Rev. , vol.30 , pp. 609-641
    • Graaf, M.R.1    Richel, D.J.2    van Noorden, C.J.F.3    Guchelarr, H.J.4
  • 9
    • 5644290906 scopus 로고    scopus 로고
    • Simvastatin induces proliferation inhibition and apoptosis in C6 glioma cells via c-jun N-terminal kinase
    • Koyuturk M., Ersoz M., and Altiok N. Simvastatin induces proliferation inhibition and apoptosis in C6 glioma cells via c-jun N-terminal kinase. Neurosci. Lett. 370 (2004) 212-217
    • (2004) Neurosci. Lett. , vol.370 , pp. 212-217
    • Koyuturk, M.1    Ersoz, M.2    Altiok, N.3
  • 10
    • 0842326546 scopus 로고    scopus 로고
    • Cerivastatin-induced apoptosis of human aortic smooth muscle cells through partial inhibition of basal activation of extracellular signal-regulated kinases
    • Takata R., Fukasawa S., Hara T., Nakajima H., Yamashina A., Yanase N., and Nizuguchi J. Cerivastatin-induced apoptosis of human aortic smooth muscle cells through partial inhibition of basal activation of extracellular signal-regulated kinases. Cardiovasc. Pathol. 13 (2004) 41-48
    • (2004) Cardiovasc. Pathol. , vol.13 , pp. 41-48
    • Takata, R.1    Fukasawa, S.2    Hara, T.3    Nakajima, H.4    Yamashina, A.5    Yanase, N.6    Nizuguchi, J.7
  • 11
    • 4644261860 scopus 로고    scopus 로고
    • Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukaemia cells to lovastatin-induced apoptosis
    • Wu J., Wong W.W., Khosravi F., Minden M.D., and Penn L.Z. Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukaemia cells to lovastatin-induced apoptosis. Cancer Res. 64 (2004) 6461-6468
    • (2004) Cancer Res. , vol.64 , pp. 6461-6468
    • Wu, J.1    Wong, W.W.2    Khosravi, F.3    Minden, M.D.4    Penn, L.Z.5
  • 12
    • 0242493030 scopus 로고    scopus 로고
    • All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells
    • Kaneta S., Satoh K., Kano S., Kanda M., and Ichihara K. All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells. Atheroscleoris 17 (2003) 237-243
    • (2003) Atheroscleoris , vol.17 , pp. 237-243
    • Kaneta, S.1    Satoh, K.2    Kano, S.3    Kanda, M.4    Ichihara, K.5
  • 13
    • 0018747136 scopus 로고
    • Developmental changes in the distribution of 3-hydroxy-3-methylglutaryl coenzyme A reductase among subcellular fractions of rat brain
    • Maltese W.A., and Volpe J.J. Developmental changes in the distribution of 3-hydroxy-3-methylglutaryl coenzyme A reductase among subcellular fractions of rat brain. J. Neurochem. 33 (1979) 107-115
    • (1979) J. Neurochem. , vol.33 , pp. 107-115
    • Maltese, W.A.1    Volpe, J.J.2
  • 14
    • 0020533584 scopus 로고
    • Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster and rat
    • Spady D.K., and Dietschy J.M. Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster and rat. J. Lipids Res. 24 (1983) 303-315
    • (1983) J. Lipids Res. , vol.24 , pp. 303-315
    • Spady, D.K.1    Dietschy, J.M.2
  • 15
    • 0028876634 scopus 로고
    • Sterol metabolism in fetal, newborn and suckled lambs and their response to cholesterol after weaning
    • Cavender C.P., Turley S.D., and Dietschy J.M. Sterol metabolism in fetal, newborn and suckled lambs and their response to cholesterol after weaning. Am. J. Physiol. 269 (1995) E331-E340
    • (1995) Am. J. Physiol. , vol.269
    • Cavender, C.P.1    Turley, S.D.2    Dietschy, J.M.3
  • 16
    • 1842714901 scopus 로고    scopus 로고
    • Central nervous system and limb anomalies in case reports of first-trimester statin exposure
    • Edison R.J., and Muenke M. Central nervous system and limb anomalies in case reports of first-trimester statin exposure. N. Engl. J. Med. 350 (2004) 1579-1582
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1579-1582
    • Edison, R.J.1    Muenke, M.2
  • 17
    • 17144429420 scopus 로고    scopus 로고
    • Mechanistic epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins
    • Edison R.J., and Muenke M. Mechanistic epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins. Am. J. Med. Genet. 131A (2004) 287-298
    • (2004) Am. J. Med. Genet. , vol.131 A , pp. 287-298
    • Edison, R.J.1    Muenke, M.2
  • 18
    • 0032973711 scopus 로고    scopus 로고
    • Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death
    • Michikawa M., and Yanagisawa K. Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. J. Neurochem. 72 (1999) 2278-2285
    • (1999) J. Neurochem. , vol.72 , pp. 2278-2285
    • Michikawa, M.1    Yanagisawa, K.2
  • 19
    • 0034655467 scopus 로고    scopus 로고
    • Geranylgeranyl-pirophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition
    • Tanaka T., Tatsuno I., Uchida D., Moroo I., Morio H., Nakamura S., Noguchi Y., Yasuda T., Kitagawa M., Saito Y., and Hirai A. Geranylgeranyl-pirophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. J. Neurosci. 20 (2000) 2852-2859
    • (2000) J. Neurosci. , vol.20 , pp. 2852-2859
    • Tanaka, T.1    Tatsuno, I.2    Uchida, D.3    Moroo, I.4    Morio, H.5    Nakamura, S.6    Noguchi, Y.7    Yasuda, T.8    Kitagawa, M.9    Saito, Y.10    Hirai, A.11
  • 20
    • 1842510494 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis
    • Schulz J.G., Bosel J., Stoeckel M., Megow D., Dirnagl U., and Endres M. HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. J. Neurochem. 89 (2004) 24-32
    • (2004) J. Neurochem. , vol.89 , pp. 24-32
    • Schulz, J.G.1    Bosel, J.2    Stoeckel, M.3    Megow, D.4    Dirnagl, U.5    Endres, M.6
  • 21
    • 0035114219 scopus 로고    scopus 로고
    • Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition
    • García-Román N., Álvarez A.M., Toro M.J., Montes A., and Lorenzo M.J. Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. Mol. Cell Neurosci. 17 (2001) 329-341
    • (2001) Mol. Cell Neurosci. , vol.17 , pp. 329-341
    • García-Román, N.1    Álvarez, A.M.2    Toro, M.J.3    Montes, A.4    Lorenzo, M.J.5
  • 22
    • 0038012640 scopus 로고    scopus 로고
    • In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS
    • Lossi L., and Merighi A. In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS. Prog. Neurobiol. 69 (2003) 287-312
    • (2003) Prog. Neurobiol. , vol.69 , pp. 287-312
    • Lossi, L.1    Merighi, A.2
  • 25
    • 0033970158 scopus 로고    scopus 로고
    • JNK and p38 stress kinases-degenerative effectors of signal-transduction-cascades in the nervous system
    • Mielke K., and Herdegen T. JNK and p38 stress kinases-degenerative effectors of signal-transduction-cascades in the nervous system. Prog. Neurobiol. 61 (2000) 45-60
    • (2000) Prog. Neurobiol. , vol.61 , pp. 45-60
    • Mielke, K.1    Herdegen, T.2
  • 26
    • 0035033952 scopus 로고    scopus 로고
    • Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38
    • Harper S.J., and LoGrasso P. Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38. Cell. Signal. 13 (2001) 299-310
    • (2001) Cell. Signal. , vol.13 , pp. 299-310
    • Harper, S.J.1    LoGrasso, P.2
  • 27
    • 23944466208 scopus 로고    scopus 로고
    • Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage
    • Waetzig V., and Herdegen T. Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage. Trends Pharmacol. Sci. 26 (2005) 455-461
    • (2005) Trends Pharmacol. Sci. , vol.26 , pp. 455-461
    • Waetzig, V.1    Herdegen, T.2
  • 28
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., Dickens M., Raingeaud J., Davis R.J., and Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270 (1995) 1326-1331
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 29
    • 0032937879 scopus 로고    scopus 로고
    • Withdrawal of survival factors results in activation of JNK pathway in neuronal cells leading to Fas Ligand induction and cell death
    • Le-Niculescu H., Bonfoco E., Kasuya Y., Claret F.-X., Green D.R., and Karin M. Withdrawal of survival factors results in activation of JNK pathway in neuronal cells leading to Fas Ligand induction and cell death. Mol. Cell. Biol. 19 (1999) 751-763
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 751-763
    • Le-Niculescu, H.1    Bonfoco, E.2    Kasuya, Y.3    Claret, F.-X.4    Green, D.R.5    Karin, M.6
  • 30
    • 0347296357 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase pathways during the death of PC12 cells is dependent on the state of differentiation
    • Lambeng N., Willaime-Morawek S., Mariani J., Ruberg M., and Brugg B. Activation of mitogen-activated protein kinase pathways during the death of PC12 cells is dependent on the state of differentiation. Mol. Brain Res. 111 (2003) 52-60
    • (2003) Mol. Brain Res. , vol.111 , pp. 52-60
    • Lambeng, N.1    Willaime-Morawek, S.2    Mariani, J.3    Ruberg, M.4    Brugg, B.5
  • 31
    • 4143083990 scopus 로고    scopus 로고
    • Distinct requirements for p38α and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death
    • Cao J., Semenova M.M., Solovyan V.T., Han J., and Coffey E.L.T. Distinct requirements for p38α and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. J. Biol. Chem. 279 (2004) 35903-35913
    • (2004) J. Biol. Chem. , vol.279 , pp. 35903-35913
    • Cao, J.1    Semenova, M.M.2    Solovyan, V.T.3    Han, J.4    Coffey, E.L.T.5
  • 32
    • 0038400952 scopus 로고    scopus 로고
    • c-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis
    • Willaime-Moravek S., Brami-Cherrier K., Mariani J., Caboche J., and Brugg B. c-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis. Neuroscience 119 (2003) 387-397
    • (2003) Neuroscience , vol.119 , pp. 387-397
    • Willaime-Moravek, S.1    Brami-Cherrier, K.2    Mariani, J.3    Caboche, J.4    Brugg, B.5
  • 34
    • 12844251358 scopus 로고    scopus 로고
    • Identification of ASK1, MKK4, JNK, c-Jun and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis
    • Kim S.D., Moon C.K., Eun S.-Y., Ryu P.D., and Jo S.A. Identification of ASK1, MKK4, JNK, c-Jun and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis. Biochem. Biophys. Res. Commun. 328 (2005) 326-334
    • (2005) Biochem. Biophys. Res. Commun. , vol.328 , pp. 326-334
    • Kim, S.D.1    Moon, C.K.2    Eun, S.-Y.3    Ryu, P.D.4    Jo, S.A.5
  • 35
    • 0034281386 scopus 로고    scopus 로고
    • Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun-N-terminal protein kinase 3 and p38 mitogen-activated protein kinase
    • Namgung U., and Xia Z. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun-N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. J. Neurosci. 20 (2000) 6442-6451
    • (2000) J. Neurosci. , vol.20 , pp. 6442-6451
    • Namgung, U.1    Xia, Z.2
  • 36
    • 0032568994 scopus 로고    scopus 로고
    • Apoptosis of cerebellar granule cells induced by serum withdrawal, glutamate or beta-amyloid, is independent of Jun kinase or p38 mitogen activated protein kinase activation
    • Gunn-Moore F.J., and Tavare J.M. Apoptosis of cerebellar granule cells induced by serum withdrawal, glutamate or beta-amyloid, is independent of Jun kinase or p38 mitogen activated protein kinase activation. Neurosci. Lett. 250 (1998) 53-56
    • (1998) Neurosci. Lett. , vol.250 , pp. 53-56
    • Gunn-Moore, F.J.1    Tavare, J.M.2
  • 37
    • 0032032404 scopus 로고    scopus 로고
    • Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons
    • Eilers A., Whitfield J., Babij C., Rubin L.L., and Ham J. Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons. J. Neurosci. 18 (1998) 1713-1724
    • (1998) J. Neurosci. , vol.18 , pp. 1713-1724
    • Eilers, A.1    Whitfield, J.2    Babij, C.3    Rubin, L.L.4    Ham, J.5
  • 38
    • 0033556356 scopus 로고    scopus 로고
    • A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK independent induction of apoptosis by cytosine arabinoside
    • Anderson C.N.G., and Tolkovsky A.M. A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK independent induction of apoptosis by cytosine arabinoside. J. Neurosci. 19 (1999) 664-673
    • (1999) J. Neurosci. , vol.19 , pp. 664-673
    • Anderson, C.N.G.1    Tolkovsky, A.M.2
  • 39
    • 0033595764 scopus 로고    scopus 로고
    • Neuronal activity dependent cell survival mediated by transcription factor MEF2
    • Mao Z., Bonni A., Xia F., Nadal-Vicens M., and Greenberg M.E. Neuronal activity dependent cell survival mediated by transcription factor MEF2. Science 286 (1999) 785-790
    • (1999) Science , vol.286 , pp. 785-790
    • Mao, Z.1    Bonni, A.2    Xia, F.3    Nadal-Vicens, M.4    Greenberg, M.E.5
  • 40
    • 0032479977 scopus 로고    scopus 로고
    • Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation
    • Leppa S., Saffrich R., Ansorge W., and Bohmann D. Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation. EMBO J. 17 (1998) 4404-4413
    • (1998) EMBO J. , vol.17 , pp. 4404-4413
    • Leppa, S.1    Saffrich, R.2    Ansorge, W.3    Bohmann, D.4
  • 41
    • 0032544550 scopus 로고    scopus 로고
    • Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells
    • Morooka T., and Nishida E. Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells. J. Biol. Chem. 273 (1998) 24285-24288
    • (1998) J. Biol. Chem. , vol.273 , pp. 24285-24288
    • Morooka, T.1    Nishida, E.2
  • 43
    • 0031972678 scopus 로고    scopus 로고
    • Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons
    • Watson A., Eliers A., Lallemand D., Kyriakis J., Rubin L.L., and Ham J. Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J. Neurosci. 18 (1998) 751-762
    • (1998) J. Neurosci. , vol.18 , pp. 751-762
    • Watson, A.1    Eliers, A.2    Lallemand, D.3    Kyriakis, J.4    Rubin, L.L.5    Ham, J.6
  • 44
    • 0029954311 scopus 로고    scopus 로고
    • Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement of new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species
    • Schulz J.B., Weller M., and Klockgether T. Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement of new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species. J. Neurosci. 16 (1996) 4696-4706
    • (1996) J. Neurosci. , vol.16 , pp. 4696-4706
    • Schulz, J.B.1    Weller, M.2    Klockgether, T.3
  • 45
    • 0029012476 scopus 로고
    • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • Ham J., Babij C., Whitfield J., Pfarr C.M., Lallemand D., Yaniv M., and Rubin L.L. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14 (1995) 927-939
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1    Babij, C.2    Whitfield, J.3    Pfarr, C.M.4    Lallemand, D.5    Yaniv, M.6    Rubin, L.L.7
  • 47
    • 0035851204 scopus 로고    scopus 로고
    • BH3-only Bcl-2 Family Members are co-ordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons
    • Harris C.A., and Jonhson Jr. E.M. BH3-only Bcl-2 Family Members are co-ordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons. J. Biol. Chem. 276 (2001) 37754-37760
    • (2001) J. Biol. Chem. , vol.276 , pp. 37754-37760
    • Harris, C.A.1    Jonhson Jr., E.M.2
  • 48
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: molecular mechanisms and functional consequences
    • Zhang F.L., and Casey P.J. Protein prenylation: molecular mechanisms and functional consequences. Ann. Rev. Biochem. 65 (1996) 241-269
    • (1996) Ann. Rev. Biochem. , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2
  • 49
    • 0019140920 scopus 로고
    • Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevilonin, a competitive inhibitor of the reductase
    • Kita T., Brown M.S., and Goldstein J.L. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevilonin, a competitive inhibitor of the reductase. J. Clin. Invest. 66 (1980) 1094-1100
    • (1980) J. Clin. Invest. , vol.66 , pp. 1094-1100
    • Kita, T.1    Brown, M.S.2    Goldstein, J.L.3
  • 50
    • 0027483360 scopus 로고
    • Thyroid hormone receptor/c-erbA: control of commitment and differentiation in the neuronal/chromaffin progenitor line PC12
    • Muñoz A., Wrighton C., Seliger B., Bernal J., and Beug H. Thyroid hormone receptor/c-erbA: control of commitment and differentiation in the neuronal/chromaffin progenitor line PC12. J. Cell Biol. 121 (1993) 423-438
    • (1993) J. Cell Biol. , vol.121 , pp. 423-438
    • Muñoz, A.1    Wrighton, C.2    Seliger, B.3    Bernal, J.4    Beug, H.5
  • 51
    • 0035152487 scopus 로고    scopus 로고
    • Cell-permeable peptide inhibitors of JNK. Novel blockers of beta-cell death
    • Bonny C., Oberson A., Negri S., Sauser C., and Schorderet D.F. Cell-permeable peptide inhibitors of JNK. Novel blockers of beta-cell death. Diabetes 50 (2001) 77-82
    • (2001) Diabetes , vol.50 , pp. 77-82
    • Bonny, C.1    Oberson, A.2    Negri, S.3    Sauser, C.4    Schorderet, D.F.5
  • 52
    • 1842457774 scopus 로고    scopus 로고
    • Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells
    • Jiang Z., Zheng X., Lytle R.A., Higashikubo R., and Rich K.M. Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells. J. Neurochem. 89 (2004) 168-178
    • (2004) J. Neurochem. , vol.89 , pp. 168-178
    • Jiang, Z.1    Zheng, X.2    Lytle, R.A.3    Higashikubo, R.4    Rich, K.M.5
  • 54
    • 24144493681 scopus 로고    scopus 로고
    • Lovastatin inhibits the growth and survival pathway of phosphoinositide 3-kinase/protein kinase B in immortalized rat brain neuroblasts
    • Cerezo-Guisado M.I., García-Marín L.J., Lorenzo M.J., and Bragado M.J. Lovastatin inhibits the growth and survival pathway of phosphoinositide 3-kinase/protein kinase B in immortalized rat brain neuroblasts. J. Neurochem. 94 (2005) 1277-1287
    • (2005) J. Neurochem. , vol.94 , pp. 1277-1287
    • Cerezo-Guisado, M.I.1    García-Marín, L.J.2    Lorenzo, M.J.3    Bragado, M.J.4
  • 55
    • 0033524740 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun-N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons
    • Shimoke K., Yamagishi S., Yamada M., Ikeuchi T., and Hatanaka H. Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun-N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. Dev. Brain Res. 112 (1999) 245-253
    • (1999) Dev. Brain Res. , vol.112 , pp. 245-253
    • Shimoke, K.1    Yamagishi, S.2    Yamada, M.3    Ikeuchi, T.4    Hatanaka, H.5
  • 57
    • 0029145073 scopus 로고
    • Rho family members: activators of MAP kinase cascades
    • Vojtek A.B., and Cooper J.A. Rho family members: activators of MAP kinase cascades. Cell 82 (1995) 527-529
    • (1995) Cell , vol.82 , pp. 527-529
    • Vojtek, A.B.1    Cooper, J.A.2
  • 58
    • 0031057656 scopus 로고    scopus 로고
    • Bcl-2 gene family in the nervous system
    • Merry D.E., and Korsmeyer S.J. Bcl-2 gene family in the nervous system. Annu. Rev. Neurosci. 20 (1997) 245-267
    • (1997) Annu. Rev. Neurosci. , vol.20 , pp. 245-267
    • Merry, D.E.1    Korsmeyer, S.J.2
  • 61
    • 4544255383 scopus 로고    scopus 로고
    • The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim alters transient focal cerebral ischemia
    • Okuno S., Saito A., Hayashi T., and Chan P.H. The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim alters transient focal cerebral ischemia. J. Neurosci. 24 (2004) 7879-7887
    • (2004) J. Neurosci. , vol.24 , pp. 7879-7887
    • Okuno, S.1    Saito, A.2    Hayashi, T.3    Chan, P.H.4
  • 62
    • 31344437880 scopus 로고    scopus 로고
    • Okadaic acid induces JNK activation, Bim overexpression and mitochondrial dysfunction in cultured rat cortical neurons
    • Yoon S., Choi J., Yoon J., Huh J.-W., and Kim D. Okadaic acid induces JNK activation, Bim overexpression and mitochondrial dysfunction in cultured rat cortical neurons. Neurosci. Let. 394 (2006) 190-195
    • (2006) Neurosci. Let. , vol.394 , pp. 190-195
    • Yoon, S.1    Choi, J.2    Yoon, J.3    Huh, J.-W.4    Kim, D.5
  • 65
    • 0346749450 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity
    • Zacco A., Togo J., Spence K., Ellis A., Lloyd D., Furlong S., and Piser T. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J. Neurosci. 23 (2003) 11104-11111
    • (2003) J. Neurosci. , vol.23 , pp. 11104-11111
    • Zacco, A.1    Togo, J.2    Spence, K.3    Ellis, A.4    Lloyd, D.5    Furlong, S.6    Piser, T.7


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