Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor

Biochemical Pharmacology

Volumn 86, Issue 6, 2013, Pages 824-835

  Banerjee, Monimoy ^a   Chen, Taosheng ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Drug metabolism; Molecular docking; Natural product derivative; PXR

Indexed keywords

CYTOCHROME P450 3A4; NATURAL PRODUCT; PREGNANE X RECEPTOR; RIFAMPICIN; TRYPTOPHAN;

ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; INTESTINE CELL; LIGAND BINDING; MOLECULAR DOCKING; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RECEPTOR BINDING; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION;

EID: 84885183440     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.07.023     Document Type: Article

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