Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR

Journal of Biological Chemistry

Volumn 288, Issue 19, 2013, Pages 13655-13668

  Li, Hao ^a   Redinbo, Matthew R ^c   Venkatesh, Madhukumar ^a   Ekins, Sean ^d   Chaudhry, Anik ^a   Bloch, Nicolin ^a,e   Negassa, Abdissa ^a   Mukherjee, Paromita ^b   Kalpana, Ganjam ^b   Mani, Sridhar ^a,b  

^a Department of Medicine ^*  (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c University of North Carolina at Chapel Hill   (United States)

^d University of North Carolina ^*  (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC METHODS; HIGH-THROUGHPUT SCREENS; NUCLEAR RECEPTORS; PREGNANE X RECEPTORS; SURFACE BINDING SITES; SURFACE RESIDUES;

BIOCHEMISTRY; BIOLOGY;

YEAST;

GLUTAMINE; KETOCONAZOLE; PHENYLALANINE; PREGNANE X RECEPTOR; SERINE;

AMINO ACID SEQUENCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GAIN OF FUNCTION MUTATION; HUMAN; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION; TWO HYBRID SYSTEM; VOLTAGE CLAMP;

ANTAGONIST; DRUG DEVELOPMENT; DRUG METABOLISM; KETOCONAZOLE; MUTAGENESIS; NUCLEAR RECEPTORS; PREGNANE X RECEPTOR; PROTEIN DRUG INTERACTIONS; PROTEOMICS; YEAST TWO-HYBRID;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; ANTIFUNGAL AGENTS; BINDING SITES; CELL LINE; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; DRUG RESISTANCE, FUNGAL; HUMANS; KETOCONAZOLE; MOLECULAR DOCKING SIMULATION; MUTAGENESIS; ONCOGENE PROTEIN PP60(V-SRC); PROTEIN BINDING; RECEPTORS, STEROID; RECOMBINANT PROTEINS; RIFAMPIN; SACCHAROMYCES CEREVISIAE; TRANSCRIPTIONAL ACTIVATION; TWO-HYBRID SYSTEM TECHNIQUES; XENOBIOTICS;

EID: 84877702152     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.455485     Document Type: Article

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