Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling

Pharmacology and Therapeutics

Volumn 140, Issue 2, 2013, Pages 186-199

  Sessler, Tamas ^a   Healy, Sandra ^a   Samali, Afshin ^a   Szegezdi, Eva ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Apoptosis; Crystal structure; Death domain; Death receptor; FADD; Posttranslational modification

Indexed keywords

ADAPTOR PROTEIN; CASPASE 8; CYCLIC AMP DEPENDENT PROTEIN KINASE; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DEATH RECEPTOR; DEATH RECEPTOR 3; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DEATH RECEPTOR 6; EDAR RECEPTOR; FAS LIGAND; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIN RECEPTOR P75; PROTEIN P75; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; BIOLOGICAL FUNCTIONS; BLOOD CLOTTING; CAPPING PHENOMENON; CELL DEATH; CLADISTICS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; GLYCOSYLATION; HUMAN; IMMUNE RESPONSE; IMMUNOSURVEILLANCE; INTRACELLULAR SIGNALING; LIGAND BINDING; MITOCHONDRIAL MEMBRANE; NERVE FIBER GROWTH; NONHUMAN; PALMITOYLATION; PHENOTYPE; PHOSPHORYLATION; PHYLOGENY; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; STEREOSPECIFICITY; STRESS; TISSUE DIFFERENTIATION; TISSUE REGENERATION;

ACIDIC SPHINGOMYELINASE; ALPS; APOPTOSIS; ASM; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; C-JUN N-TERMINAL KINASE; CELLULAR FLICE INHIBITORY PROTEIN; CELLULAR INHIBITOR OF APOPTOSIS PROTEIN; CFLIP; CIAP; CRD; CRYSTAL STRUCTURE; CYSTEINE RICH DOMAIN; DD; DEATH DOMAIN; DEATH EFFECTOR DOMAIN; DEATH RECEPTOR; DEATH-INDUCING SIGNALLING COMPLEX; DED; DISC; DR; ECTODYSPLASIN A; ECTODYSPLASIN A RECEPTOR; EDA (EDA-A1); EDAR; EDAR-ASSOCIATED DEATH DOMAIN; EDARADD; FADD; FAS ASSOCIATED DEATH DOMAIN CONTAINING PROTEIN; FAS RECEPTOR LIGAND; FASL; IKK; INHIBITOR OF KAPPA B KINASE; INHIBITOR OF KAPPA-B PROTEIN; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE; IRAK; IΚB; JNK; MAPK; MITOGEN ACTIVATED PROTEIN KINASE; NF-ΚB; NUCLEAR FACTOR-KB; P53-INDUCED DEATH DOMAIN; P75 NEUROTROPHIN RECEPTOR; P75(NTR); PARP; PHOSPHATIDYLINOSITOL 3-KINASE; PI3K; PIDD; PLAD; POLY ADP RIBOSE POLYMERASE; POSTTRANSLATIONAL MODIFICATION; PRE-LIGAND ASSEMBLY DOMAIN; PYD; PYRIN DOMAINS; RECEPTOR INTERACTING PROTEIN KINASE 1; RIP1 (RIPK1); SM; SPHINGOMYELINASE; TAB2; TAK1-BINDING PROTEIN 2; TL1A; TNF; TNF RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR; TNF-LIKE LIGAND 1A; TNFR1 (P55); TRADD; TRAF; TRAIL (APO2L); TUMOUR NECROSIS FACTOR; TUMOUR NECROSIS FACTOR RECEPTOR 1; TUMOUR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND;

ANIMALS; APOPTOSIS; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; HUMANS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, DEATH DOMAIN; SIGNAL TRANSDUCTION;

EID: 84885178155     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.06.009     Document Type: Review

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