Structure of the Fas/FADD complex: A conditional death domain complex mediating signaling by receptor clustering

Cell Cycle

Volumn 8, Issue 17, 2009, Pages 2723-2727

  Salvesen, Guy S ^a   Riedl, Stefan J ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Conditional complex; Death domains; DISC; Receptor clustering; Structure

Indexed keywords

DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN;

APOPTOSIS; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW;

EID: 69749117596     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.17.9399     Document Type: Review

References (46)

1. Park HH, Lo YC, Lin SC, Wang L, Yang JK, Wu H. The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu Rev Immunol 2007; 25:561-586 (Pubitemid 46697917)
2. Park SM, Schickel R, Peter ME. Nonapoptotic functions of FADD-binding death receptors and their signaling molecules. Curr Opin Cell Biol 2005; 17:610-616 (Pubitemid 41540410)
3. Stehlik C, Dorfleutner A. COPs and POPs: modulators of inflammasome activity. J Immunol 2007; 179:7993-7998
4. Wilson NS, Dixit V, Ashkenazi A. Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat Immunol 2009; 10:348-355
5. Yu JW, Shi Y. FLIP and the death effector domain family. Oncogene 2008; 27:6216-6227
6. Ashkenazi A, Dixit VM. Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 1999; 11:255-260 (Pubitemid 29164042)
7. Peter ME, Krammer PH. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 2003; 10:26-35.
8. Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008; 9:231-241
9. Gloire G, Charlier E, Piette J. Regulation of CD95/APO-1/Fas-induced apoptosis by protein phosphatases. Biochem Pharmacol 2008; 76:1451-1458
10. Chaigne-Delalande B, Moreau JF, Legembre P. Rewinding the DISC. Arch Immunol Ther Exp (Warsz) 2008; 56:9-14.
11. Feig C, Tchikov V, Schutze S, Peter ME. Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling. EMBO J 2007; 26:221-231 (Pubitemid 46094713)
12. Gajate C, Gonzalez-Camacho F, Mollinedo F. Lipid raft connection between extrinsic and intrinsic apoptotic pathways. Biochem Biophys Res Commun 2009; 380:780-784
13. Hueber AO, Bernard AM, Herincs Z, Couzinet A, He HT. An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes. EMBO Rep 2002; 3:190-196 (Pubitemid 34213499)
14. Lee KH, Feig C, Tchikov V, Schickel R, Hallas C, Schutze S, et al. The role of receptor internalization in CD95 signaling. EMBO J 2006; 25:1009-1023 (Pubitemid 43372115)
15. Legembre P, Daburon S, Moreau P, Ichas F, de Giorgi F, Moreau JF, Taupin JL. Amplification of Fas-mediated apoptosis in type II cells via microdomain recruitment. Mol Cell Biol 2005; 25:6811-6820 (Pubitemid 41023251)
16. Legembre P, Daburon S, Moreau P, Moreau JF, Taupin JL. Modulation of Fas-mediated apoptosis by lipid rafts in T lymphocytes. J Immunol 2006; 176:716-720 (Pubitemid 43099665)
17. Mollinedo F, Gajate C. Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy. Drug Resist Updat 2006; 9:51-73. (Pubitemid 43928806)
18. Muppidi JR, Siegel RM. Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death. Nat Immunol 2004; 5:182-189
19. Fesik SW. Insights into programmed cell death through structural biology. Cell 2000; 103:273-282
20. Carrington PE, Sandu C, Wei Y, Hill JM, Morisawa G, Huang T, et al. The structure of FADD and its mode of interaction with procaspase-8. Mol Cell 2006; 22:599-610. (Pubitemid 43817600)
21. Sandu C, Morisawa G, Wegorzewska I, Huang T, Arechiga AF, Hill JM, et al. FADD self-association is required for stable interaction with an activated death receptor. Cell Death Differ 2006; 13:2052-2061 (Pubitemid 44742688)
22. Werner MH, Wu C, Walsh CM. Emerging roles for the death adaptor FADD in death receptor avidity and cell cycle regulation. Cell Cycle 2006; 5:2332-2338 (Pubitemid 44785841)
23. Scott FL, Stec B, Pop C, Dobaczewska MK, Lee JJ, Monosov E, et al. The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature 2009; 457:1019-1022
24. Huang B, Eberstadt M, Olejniczak ET, Meadows RP, Fesik SW. NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain. Nature 1996; 384:638-641 (Pubitemid 27021516)
25. Bogan AA, Thorn KS. Anatomy of hot spots in protein interfaces. J Mol Biol 1998; 280:1-9.
26. Clackson T, Wells JA. A hot spot of binding energy in a hormone-receptor interface. Science 1995; 267:383-386
27. Reichmann D, Rahat O, Cohen M, Neuvirth H, Schreiber G. The molecular architecture of protein-protein binding sites. Curr Opin Struct Biol 2007; 17:67-76. (Pubitemid 46240815)
28. Roisman LC, Jaitin DA, Baker DP, Schreiber G. Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site. J Mol Biol 2005; 353:271-281 (Pubitemid 41356611)
29. Qin H, Srinivasula SM, Wu G, Fernandes-Alnemri T, Alnemri ES, Shi Y. Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature 1999; 399:549-557 (Pubitemid 29279168)
30. Ferguson BJ, Esposito D, Jovanovic J, Sankar A, Driscoll PC, Mehmet H. Biophysical and cell-based evidence for differential interactions between the death domains of CD95/Fas and FADD. Cell Death Differ 2007; 14:1717-1719 (Pubitemid 47278858)
31. Park HH, Logette E, Raunser S, Cuenin S, Walz T, Tschopp J, Wu H. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell 2007; 128:533-546 (Pubitemid 46198901)
32. Xiao T, Towb P, Wasserman SA, Sprang SR. Three-dimensional structure of a complex between the death domains of Pelle and Tube. Cell 1999; 99:545-555
33. Danot O, Marquenet E, Vidal-Ingigliardi D, Richet E. Wheel of Life, Wheel of Death: A Mechanistic Insight into Signaling by STAND Proteins. Structure 2009; 17:172-182
34. Riedl SJ, Salvesen GS. The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 2007; 8:405-413
35. Yu X, Acehan D, Menetret JF, Booth CR, Ludtke SJ, Riedl SJ, et al. A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Structure 2005; 13:1725-1735 (Pubitemid 41571836)
36. Pop C, Timmer J, Sperandio S, Salvesen GS. The apoptosome activates caspase-9 by dimerization. Mol Cell 2006; 22:269-275
37. Tinel A, Janssens S, Lippens S, Cuenin S, Logette E, Jaccard B, et al. Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NFkappaB pathway. EMBO J 2007; 26:197-208. (Pubitemid 46094711)
38. Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995; 81:505-512
39. Itoh N, Nagata S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 1993; 268:10932-10937 (Pubitemid 23162276)
40. Martin DA, Zheng L, Siegel RM, Huang B, Fisher GH, Wang J, et al. Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia. Proc Natl Acad Sci USA 1999; 96:4552-4557 (Pubitemid 29190374)
41. Vaishnaw AK, Orlinick JR, Chu JL, Krammer PH, Chao MV, Elkon KB. The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations. J Clin Invest 1999; 103:355-363
42. Chen G, Shaw MH, Kim YG, Nunez G. NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol 2009; 4:365-398
43. Netea MG, van de Veerdonk FL, Kullberg BJ, Van der Meer JW, Joosten LA. The role of NLRs and TLRs in the activation of the inflammasome. Expert Opin Biol Ther 2008; 8:1867-1872
44. Petrilli V, Dostert C, Muruve DA, Tschopp J. The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 2007; 19:615-622 (Pubitemid 350236810)
45. Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W, et al. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 2007; 14:1590-1604 (Pubitemid 47278845)
46. Ye Z, Ting JP. NLR, the nucleotide-binding domain leucine-rich repeat containing gene family. Curr Opin Immunol 2008; 20:3-9.