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Fas small interfering RNA reduces motoneuron death in amyotrophic lateral sclerosis mice
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The authors use intrathecal micropumps to administer siRNA to Fas to mutant SOD1 mice. They observe not only a complete return of the Fas/NO pathway to normal activation levels but also significant neuroprotection of motor neurons and prolongation of lifespan. The effects are particularly striking given that Fas siRNA was only administered for a limited time. These results are currently the strongest evidence for a role of Fas signaling in disease onset and progression in ALS. They will need to be confirmed using similar approaches in other ALS models, and by the use of mouse genetics to fully evaluate the protective effect of Fas/FasL depletion.
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Locatelli F., Corti S., Papadimitriou D., Fortunato F., Del Bo R., Donadoni C., Nizzardo M., Nardini M., Salani S., Ghezzi S., et al. Fas small interfering RNA reduces motoneuron death in amyotrophic lateral sclerosis mice. Ann Neurol 62 (2007) 81-92. The authors use intrathecal micropumps to administer siRNA to Fas to mutant SOD1 mice. They observe not only a complete return of the Fas/NO pathway to normal activation levels but also significant neuroprotection of motor neurons and prolongation of lifespan. The effects are particularly striking given that Fas siRNA was only administered for a limited time. These results are currently the strongest evidence for a role of Fas signaling in disease onset and progression in ALS. They will need to be confirmed using similar approaches in other ALS models, and by the use of mouse genetics to fully evaluate the protective effect of Fas/FasL depletion.
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(2007)
Ann Neurol
, vol.62
, pp. 81-92
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Locatelli, F.1
Corti, S.2
Papadimitriou, D.3
Fortunato, F.4
Del Bo, R.5
Donadoni, C.6
Nizzardo, M.7
Nardini, M.8
Salani, S.9
Ghezzi, S.10
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37
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34247276120
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Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis
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Kiaei M., Kipiani K., Calingasan N.Y., Wille E., Chen J., Heissig B., Rafii S., Lorenzl S., and Beal M.F. Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis. Exp Neurol 205 (2007) 74-81
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(2007)
Exp Neurol
, vol.205
, pp. 74-81
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Kiaei, M.1
Kipiani, K.2
Calingasan, N.Y.3
Wille, E.4
Chen, J.5
Heissig, B.6
Rafii, S.7
Lorenzl, S.8
Beal, M.F.9
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38
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42649107468
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Tissue inhibitor of metalloproteinases-3 (TIMP-3) expression is increased during serum deprivation-induced neuronal apoptosis in vitro and in the G93A mouse model of amyotrophic lateral sclerosis: a potential modulator of Fas-mediated apoptosis
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Lee J.K., Shin J.H., Suh J., Choi I.S., Ryu K.S., and Gwag B.J. Tissue inhibitor of metalloproteinases-3 (TIMP-3) expression is increased during serum deprivation-induced neuronal apoptosis in vitro and in the G93A mouse model of amyotrophic lateral sclerosis: a potential modulator of Fas-mediated apoptosis. Neurobiol Dis 30 (2008) 174-185
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(2008)
Neurobiol Dis
, vol.30
, pp. 174-185
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Lee, J.K.1
Shin, J.H.2
Suh, J.3
Choi, I.S.4
Ryu, K.S.5
Gwag, B.J.6
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39
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33947363215
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Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis
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This paper provides two types of evidence for a role for Fas receptor in neurodegeneration in ALS model mice. First, the authors show increased expression in SOD mice of Fas and its downstream signaling intermediates, and report that Fas-FADD interactions are intensified at one stage of the disease. In addition, they report that lithium can prevent neurodegeneration and lead to modest increases in lifespan of SOD1 mice. Lithium also strongly inhibits the expression of Fas and FADD, though it still needs to be determined whether this underlies its neuroprotective activity.
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Shin J.H., Cho S.I., Lim H.R., Lee J.K., Lee Y.A., Noh J.S., Joo I.S., Kim K.W., and Gwag B.J. Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis. Mol Pharmacol 71 (2007) 965-975. This paper provides two types of evidence for a role for Fas receptor in neurodegeneration in ALS model mice. First, the authors show increased expression in SOD mice of Fas and its downstream signaling intermediates, and report that Fas-FADD interactions are intensified at one stage of the disease. In addition, they report that lithium can prevent neurodegeneration and lead to modest increases in lifespan of SOD1 mice. Lithium also strongly inhibits the expression of Fas and FADD, though it still needs to be determined whether this underlies its neuroprotective activity.
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(2007)
Mol Pharmacol
, vol.71
, pp. 965-975
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Shin, J.H.1
Cho, S.I.2
Lim, H.R.3
Lee, J.K.4
Lee, Y.A.5
Noh, J.S.6
Joo, I.S.7
Kim, K.W.8
Gwag, B.J.9
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40
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33751256823
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Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice
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Petri S., Kiaei M., Wille E., Calingasan N.Y., and Flint Beal M. Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice. J Neurol Sci 251 (2006) 44-49
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(2006)
J Neurol Sci
, vol.251
, pp. 44-49
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Petri, S.1
Kiaei, M.2
Wille, E.3
Calingasan, N.Y.4
Flint Beal, M.5
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41
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41149124406
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Lithium delays progression of amyotrophic lateral sclerosis
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•].
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•].
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(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2052-2057
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Fornai, F.1
Longone, P.2
Cafaro, L.3
Kastsiuchenka, O.4
Ferrucci, M.5
Manca, M.L.6
Lazzeri, G.7
Spalloni, A.8
Bellio, N.9
Lenzi, P.10
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42
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33746072956
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The matrix metalloproteinases inhibitor Ro 28-2653 [correction of Ro 26-2853] extends survival in transgenic ALS mice
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Lorenzl S., Narr S., Angele B., Krell H.W., Gregorio J., Kiaei M., Pfister H.W., and Beal M.F. The matrix metalloproteinases inhibitor Ro 28-2653 [correction of Ro 26-2853] extends survival in transgenic ALS mice. Exp Neurol 200 (2006) 166-171
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(2006)
Exp Neurol
, vol.200
, pp. 166-171
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Lorenzl, S.1
Narr, S.2
Angele, B.3
Krell, H.W.4
Gregorio, J.5
Kiaei, M.6
Pfister, H.W.7
Beal, M.F.8
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43
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15944379637
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Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis
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Dewil M., Schurmans C., Starckx S., Opdenakker G., Van Den Bosch L., and Robberecht W. Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis. Neuroreport 16 (2005) 321-324
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(2005)
Neuroreport
, vol.16
, pp. 321-324
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Dewil, M.1
Schurmans, C.2
Starckx, S.3
Opdenakker, G.4
Van Den Bosch, L.5
Robberecht, W.6
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44
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33947512432
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Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice
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Yamamoto M., Kiyota T., Horiba M., Buescher J.L., Walsh S.M., Gendelman H.E., and Ikezu T. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol 170 (2007) 680-692
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(2007)
Am J Pathol
, vol.170
, pp. 680-692
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Yamamoto, M.1
Kiyota, T.2
Horiba, M.3
Buescher, J.L.4
Walsh, S.M.5
Gendelman, H.E.6
Ikezu, T.7
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45
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33646575557
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Inhibition of Fas-mediated apoptosis through administration of soluble Fas receptor improves functional outcome and reduces posttraumatic axonal degeneration after acute spinal cord injury
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Ackery A., Robins S., and Fehlings M.G. Inhibition of Fas-mediated apoptosis through administration of soluble Fas receptor improves functional outcome and reduces posttraumatic axonal degeneration after acute spinal cord injury. J Neurotrauma 23 (2006) 604-616
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(2006)
J Neurotrauma
, vol.23
, pp. 604-616
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Ackery, A.1
Robins, S.2
Fehlings, M.G.3
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46
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21844470751
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Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation
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Martin L.J., Chen K., and Liu Z. Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. J Neurosci 25 (2005) 6449-6459
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(2005)
J Neurosci
, vol.25
, pp. 6449-6459
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Martin, L.J.1
Chen, K.2
Liu, Z.3
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47
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34250799663
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FLIP(L) protects neurons against in vivo ischemia and in vitro glucose deprivation-induced cell death
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Taoufik E., Valable S., Muller G.J., Roberts M.L., Divoux D., Tinel A., Voulgari-Kokota A., Tseveleki V., Altruda F., Lassmann H., et al. FLIP(L) protects neurons against in vivo ischemia and in vitro glucose deprivation-induced cell death. J Neurosci 27 (2007) 6633-6646
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(2007)
J Neurosci
, vol.27
, pp. 6633-6646
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Taoufik, E.1
Valable, S.2
Muller, G.J.3
Roberts, M.L.4
Divoux, D.5
Tinel, A.6
Voulgari-Kokota, A.7
Tseveleki, V.8
Altruda, F.9
Lassmann, H.10
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48
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41149179522
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Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS
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Luoma J.I., and Zirpel L. Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS. J Neurosci 28 (2008) 3159-3169
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(2008)
J Neurosci
, vol.28
, pp. 3159-3169
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Luoma, J.I.1
Zirpel, L.2
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49
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24344455580
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Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease
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Landau A.M., Luk K.C., Jones M.L., Siegrist-Johnstone R., Young Y.K., Kouassi E., Rymar V.V., Dagher A., Sadikot A.F., and Desbarats J. Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease. J Exp Med 202 (2005) 575-581
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(2005)
J Exp Med
, vol.202
, pp. 575-581
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Landau, A.M.1
Luk, K.C.2
Jones, M.L.3
Siegrist-Johnstone, R.4
Young, Y.K.5
Kouassi, E.6
Rymar, V.V.7
Dagher, A.8
Sadikot, A.F.9
Desbarats, J.10
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50
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33646255922
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Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha
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Sriram K., Matheson J.M., Benkovic S.A., Miller D.B., Luster M.I., and O'Callaghan J.P. Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha. FASEB J 20 (2006) 670-682
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(2006)
FASEB J
, vol.20
, pp. 670-682
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Sriram, K.1
Matheson, J.M.2
Benkovic, S.A.3
Miller, D.B.4
Luster, M.I.5
O'Callaghan, J.P.6
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51
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50249118029
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A novel juxtamembrane domain in TNF receptor superfamily molecules activates Rac1 and controls neurite growth
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Ruan W., Lee C.T., and Desbarats J. A novel juxtamembrane domain in TNF receptor superfamily molecules activates Rac1 and controls neurite growth. Mol Biol Cell 19 (2008) 3192-3202
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(2008)
Mol Biol Cell
, vol.19
, pp. 3192-3202
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Ruan, W.1
Lee, C.T.2
Desbarats, J.3
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52
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34548388779
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A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells
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Thornhill P.B., Cohn J.B., Drury G., Stanford W.L., Bernstein A., and Desbarats J. A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells. FEBS Lett 581 (2007) 4455-4462
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(2007)
FEBS Lett
, vol.581
, pp. 4455-4462
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Thornhill, P.B.1
Cohn, J.B.2
Drury, G.3
Stanford, W.L.4
Bernstein, A.5
Desbarats, J.6
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53
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34948894931
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Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
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Wagner K.W., Punnoose E.A., Januario T., Lawrence D.A., Pitti R.M., Lancaster K., Lee D., von Goetz M., Yee S.F., Totpal K., et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med 13 (2007) 1070-1077
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(2007)
Nat Med
, vol.13
, pp. 1070-1077
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Wagner, K.W.1
Punnoose, E.A.2
Januario, T.3
Lawrence, D.A.4
Pitti, R.M.5
Lancaster, K.6
Lee, D.7
von Goetz, M.8
Yee, S.F.9
Totpal, K.10
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54
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33744964514
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Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury
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Tsuruma K., Nakagawa T., Morimoto N., Minami M., Hara H., Uehara T., and Nomura Y. Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury. J Biol Chem 281 (2006) 11397-11404
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(2006)
J Biol Chem
, vol.281
, pp. 11397-11404
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Tsuruma, K.1
Nakagawa, T.2
Morimoto, N.3
Minami, M.4
Hara, H.5
Uehara, T.6
Nomura, Y.7
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55
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45249110462
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Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apoptosis of dentate granule neurons
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This study investigates the role of TNF in neuronal damage induced by neuroinflammation. The toxin trimethyltin was known to induce a microglial response and an increase in TNFα, and is shown to induce cell death of hippocampal neurons. Genetic ablation of TNFR1 and/or TNFR2, or the use of antibodies to TNFα, both provide significant protection against the effects of toxin treatment.
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Harry G.J., Lefebvre d'Hellencourt C., McPherson C.A., Funk J.A., Aoyama M., and Wine R.N. Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apoptosis of dentate granule neurons. J Neurochem 106 (2008) 281-298. This study investigates the role of TNF in neuronal damage induced by neuroinflammation. The toxin trimethyltin was known to induce a microglial response and an increase in TNFα, and is shown to induce cell death of hippocampal neurons. Genetic ablation of TNFR1 and/or TNFR2, or the use of antibodies to TNFα, both provide significant protection against the effects of toxin treatment.
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(2008)
J Neurochem
, vol.106
, pp. 281-298
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Harry, G.J.1
Lefebvre d'Hellencourt, C.2
McPherson, C.A.3
Funk, J.A.4
Aoyama, M.5
Wine, R.N.6
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56
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33645123006
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Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha
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Sriram K., Miller D.B., and O'Callaghan J.P. Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha. J Neurochem 96 (2006) 706-718
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(2006)
J Neurochem
, vol.96
, pp. 706-718
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Sriram, K.1
Miller, D.B.2
O'Callaghan, J.P.3
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