메뉴 건너뛰기




Volumn 3, Issue 4, 2013, Pages 394-401

Therapeutics for HIV-1 reactivation from latency

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTIRETROVIRUS AGENT; AZACITIDINE; BELINOSTAT; BRYOSTATIN 1; DISULFIRAM; GIVINOSTAT; HETEROCHROMATIN PROTEIN 1; HEXAMETHYLENEBISACETAMIDE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITOR; HOST FACTOR; INTERFERON REGULATORY FACTOR 1; METHYLTRANSFERASE INHIBITOR; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; OXAMFLATIN; PANOBINOSTAT; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; PROTEIN KINASE C ACTIVATOR; ROMIDEPSIN; VALPROIC ACID; VORINOSTAT;

EID: 84885075354     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2013.06.001     Document Type: Review
Times cited : (28)

References (81)
  • 1
    • 73549089480 scopus 로고    scopus 로고
    • Current status and challenges of antiretroviral research and therapy
    • Esté JA, Cihlar T: Current status and challenges of antiretroviral research and therapy. Antiviral Res 2010, 85:25-33.
    • (2010) Antiviral Res , vol.85 , pp. 25-33
    • Esté, J.A.1    Cihlar, T.2
  • 2
    • 0028792184 scopus 로고
    • In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
    • Chun TW, Finzi D, Margolick J, Chadwick K, Schwartz D, Siliciano RF: In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency. Nat Med 1995, 1:1284-1290.
    • (1995) Nat Med , vol.1 , pp. 1284-1290
    • Chun, T.W.1    Finzi, D.2    Margolick, J.3    Chadwick, K.4    Schwartz, D.5    Siliciano, R.F.6
  • 3
    • 84866498069 scopus 로고    scopus 로고
    • Redefining the viral reservoirs that prevent HIV-1 eradication
    • The authors propose definitions for key terms in eradication research and viral reservoirs
    • Eisele E, Siliciano RF: Redefining the viral reservoirs that prevent HIV-1 eradication. Immunity 2012, 37:377-388. The authors propose definitions for key terms in eradication research and viral reservoirs.
    • (2012) Immunity , vol.37 , pp. 377-388
    • Eisele, E.1    Siliciano, R.F.2
  • 4
    • 84155162676 scopus 로고    scopus 로고
    • Low-level viraemia on HAART: Significance and management
    • Doyle T, Geretti AM: Low-level viraemia on HAART: significance and management. Curr Opin Infect Dis 2012, 25:17-25.
    • (2012) Curr Opin Infect Dis , vol.25 , pp. 17-25
    • Doyle, T.1    Geretti, A.M.2
  • 6
    • 57749177930 scopus 로고    scopus 로고
    • Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips
    • Rong L, Perelson AS: Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips. Math Biosci 2009, 217:77-87.
    • (2009) Math Biosci , vol.217 , pp. 77-87
    • Rong, L.1    Perelson, A.S.2
  • 7
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    • This seminal paper dissects, for the first time, the nature of HIV-1 reservoir among different CD4 subsets and demonstrates that two principal mechanisms are responsible for the maintenance of these reservoirs
    • Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, Boucher G, Boulassel MR, Ghattas G, Brenchley JM et al.: HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 2009, 15:893-900. This seminal paper dissects, for the first time, the nature of HIV-1 reservoir among different CD4 subsets and demonstrates that two principal mechanisms are responsible for the maintenance of these reservoirs.
    • (2009) Nat Med , vol.15 , pp. 893-900
    • Chomont, N.1    El-Far, M.2    Ancuta, P.3    Trautmann, L.4    Procopio, F.A.5    Yassine-Diab, B.6    Boucher, G.7    Boulassel, M.R.8    Ghattas, G.9    Brenchley, J.M.10
  • 9
    • 84864345953 scopus 로고    scopus 로고
    • Towards an HIV cure: A global scientific strategy
    • A comprehensive analysis from 'The International AIDS Society Scientific Working Group on HIV Cure' of major hurdles that scientific community faces in looking for a HIV cure. The paper also describes the seven key priorities identified by the IAS for HIV cure research
    • Deeks SG, Autran B, Berkhout B, Benkirane M, Chun TW, Churchill M, Di Mascio M, Katlama C, Lafeuillade A, Landay A et al.: Towards an HIV cure: A global scientific strategy. Nat Rev Immunol 2012, 12:607-614. A comprehensive analysis from 'The International AIDS Society Scientific Working Group on HIV Cure' of major hurdles that scientific community faces in looking for a HIV cure. The paper also describes the seven key priorities identified by the IAS for HIV cure research.
    • (2012) Nat Rev Immunol , vol.12 , pp. 607-614
    • Deeks, S.G.1    Autran, B.2    Berkhout, B.3    Benkirane, M.4    Chun, T.W.5    Churchill, M.6    Di, M.M.7    Katlama, C.8    Lafeuillade, A.9    Landay, A.10
  • 14
    • 84878873135 scopus 로고    scopus 로고
    • Targeting HIV latency: Pharmacologic strategies toward eradication
    • drudis.2012.12.008. pii: S1359- 6446(12)00431-X (Dec 25, Epub ahead of print)
    • Xing S, Siliciano RF: Targeting HIV latency: pharmacologic strategies toward eradication. Drug Discov Today 2012 http://dx.doi.org/10.1016/jdrudis. 2012.12.008. pii: S1359- 6446(12)00431-X (Dec 25, Epub ahead of print).
    • (2012) Drug Discov Today
    • Xing, S.1    Siliciano, R.F.2
  • 16
    • 84873738644 scopus 로고    scopus 로고
    • Attacking the HIV reservoir from the immune and viral perspective
    • Massanella M, Martinez-Picado J, Blanco J: Attacking the HIV reservoir from the immune and viral perspective. Curr HIV/AIDS Rep 2013, 10:33-41.
    • (2013) Curr HIV/AIDS Rep , vol.10 , pp. 33-41
    • Massanella, M.1    Martinez-Picado, J.2    Blanco, J.3
  • 17
    • 68649099762 scopus 로고    scopus 로고
    • HIV integration site distributions in resting and activated CD4+ T cells infected in culture
    • Brady T, Agosto LM, Malani N, Berry CC, O'Doherty U, Bushman F: HIV integration site distributions in resting and activated CD4+ T cells infected in culture. AIDS 2009, 23:1461-1471.
    • (2009) AIDS , vol.23 , pp. 1461-1471
    • Brady, T.1    Agosto, L.M.2    Malani, N.3    Berry, C.C.4    O'doherty, U.5    Bushman, F.6
  • 20
    • 84873032782 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms involved in the establishment of HIV-1 latency
    • Donahue DA, Wainberg MA: Cellular and molecular mechanisms involved in the establishment of HIV-1 latency. Retrovirology 2013, 10:11 http://dx.doi.org/10.1186/1742-4690-10-11.
    • (2013) Retrovirology , vol.10 , pp. 11
    • Donahue, D.A.1    Wainberg, M.A.2
  • 21
    • 79954441735 scopus 로고    scopus 로고
    • The molecular biology of HIV latency: Breaking and restoring the Tat-dependent transcriptional circuit
    • Karn J: The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit. Curr Opin HIV AIDS 2011, 6:4-11.
    • (2011) Curr Opin HIV AIDS , vol.6 , pp. 4-11
    • Karn, J.1
  • 22
    • 65349193781 scopus 로고    scopus 로고
    • A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression
    • Keedy KS, Archin NM, Gates AT, Espeseth A, Hazuda DJ, Margolis DM: A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression. J Virol 2009, 83:4749-4756.
    • (2009) J Virol , vol.83 , pp. 4749-4756
    • Keedy, K.S.1    Archin, N.M.2    Gates, A.T.3    Espeseth, A.4    Hazuda, D.J.5    Margolis, D.M.6
  • 23
    • 79954437524 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and HIV latency
    • 0b013e328341242d
    • Margolis DM: Histone deacetylase inhibitors and HIV latency. Curr Opin HIV AIDS 2011, 6:25-29 http://dx.doi.org/10.1097/COH.0b013e328341242d.
    • (2011) Curr Opin HIV AIDS , vol.6 , pp. 25-29
    • Margolis, D.M.1
  • 24
    • 84864911121 scopus 로고    scopus 로고
    • HIV-1, interferon and the interferon regulatory factor system: An interplay between induction, antiviral responses and viral evasion
    • Marsili G, Remoli AL, Sgarbanti M, Perrotti E, Fragale A, Battistini A: HIV-1, interferon and the interferon regulatory factor system: An interplay between induction, antiviral responses and viral evasion. Cytokine Growth Factor Rev 2012, 23:255-270.
    • (2012) Cytokine Growth Factor Rev , vol.23 , pp. 255-270
    • Marsili, G.1    Remoli, A.L.2    Sgarbanti, M.3    Perrotti, E.4    Fragale, A.5    Battistini, A.6
  • 26
    • 79951837401 scopus 로고    scopus 로고
    • Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase- 2 activity in human myeloid dendritic cells
    • Fragale A, Stellacci E, Ilari R, Remoli AL, Lanciotti A, Perrotti E, Shytaj I, Orsatti R, Lawrence HR, Lawrence NJ et al.: Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase- 2 activity in human myeloid dendritic cells. J Immunol 2011, 186:1951-1962.
    • (2011) J Immunol , vol.186 , pp. 1951-1962
    • Fragale, A.1    Stellacci, E.2    Ilari, R.3    Remoli, A.L.4    Lanciotti, A.5    Perrotti, E.6    Shytaj, I.7    Orsatti, R.8    Lawrence, H.R.9    Lawrence, N.J.10
  • 29
    • 28544437589 scopus 로고    scopus 로고
    • Characterization of two candidate genes, NCoA3 and IRF8, potentially involved in the control of HIV-1 latency
    • Munier S, Delcroix-Genete D, Carthagé na L, Gumez A, Hazan U: Characterization of two candidate genes, NCoA3 and IRF8, potentially involved in the control of HIV-1 latency. Retrovirology 2005, 2:73.
    • (2005) Retrovirology , vol.2 , pp. 73
    • Munier, S.1    Delcroix-Genete, D.2    Carthagé, N.L.3    Gumez, A.4    Hazan, U.5
  • 31
    • 77952767617 scopus 로고    scopus 로고
    • Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294
    • Imai K, Togami H, Okamoto T: Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294. J Biol Chem 2010, 285:16538-16545.
    • (2010) J Biol Chem , vol.285 , pp. 16538-16545
    • Imai, K.1    Togami, H.2    Okamoto, T.3
  • 32
    • 80052287096 scopus 로고    scopus 로고
    • Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2
    • Friedman J, Cho WK, Chu CK, Keedy KS, Archin NM, Margolis DM, Karn J: Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2. J Virol 2011, 85:9078-9089.
    • (2011) J Virol , vol.85 , pp. 9078-9089
    • Friedman, J.1    Cho, W.K.2    Chu, C.K.3    Keedy, K.S.4    Archin, N.M.5    Margolis, D.M.6    Karn, J.7
  • 35
    • 84861314042 scopus 로고    scopus 로고
    • Paucity of HIV DNA methylation in latently infected, resting CD4+ T cells from infected individuals receiving antiretroviral therapy
    • Blazkova J, Murray D, Justement JS, Funk EK, Nelson AK, Moir S, Chun TW, Fauci AS: Paucity of HIV DNA methylation in latently infected, resting CD4+ T cells from infected individuals receiving antiretroviral therapy. J Virol 2012, 86:5390-5392.
    • (2012) J Virol , vol.86 , pp. 5390-5392
    • Blazkova, J.1    Murray, D.2    Justement, J.S.3    Funk, E.K.4    Nelson, A.K.5    Moir, S.6    Chun, T.W.7    Fauci, A.S.8
  • 36
    • 84875485322 scopus 로고    scopus 로고
    • Lost in transcription: Molecular mechanisms that control HIV latency
    • Taube R, Peterlin M: Lost in transcription: molecular mechanisms that control HIV latency. Viruses 2013, 5:902-927.
    • (2013) Viruses , vol.5 , pp. 902-927
    • Taube, R.1    Peterlin, M.2
  • 37
    • 84871977941 scopus 로고    scopus 로고
    • Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells
    • Budhiraja S, Famiglietti M, Bosque A, Planelles V, Rice AP: Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells. J Virol 2013, 87:1211-1220.
    • (2013) J Virol , vol.87 , pp. 1211-1220
    • Budhiraja, S.1    Famiglietti, M.2    Bosque, A.3    Planelles, V.4    Rice, A.P.5
  • 39
    • 80655146232 scopus 로고    scopus 로고
    • RelA Ser276 phosphorylation-coupled Lys310 acetylation controls transcriptional elongation of inflammatory cytokines in respiratory syncytial virus infection
    • Brasier AR, Tian B, Jamaluddin M, Kalita MK, Garofalo RP, Lu M: RelA Ser276 phosphorylation-coupled Lys310 acetylation controls transcriptional elongation of inflammatory cytokines in respiratory syncytial virus infection. J Virol 2011, 85:11752-11769.
    • (2011) J Virol , vol.85 , pp. 11752-11769
    • Brasier, A.R.1    Tian, B.2    Jamaluddin, M.3    Kalita, M.K.4    Garofalo, R.P.5    Lu, M.6
  • 41
    • 84861393144 scopus 로고    scopus 로고
    • Kinase control prevents HIV-1 reactivation in spite of high levels of induced NF-kappaB activity
    • Wolschendorf F, Bosque A, Shishido T, Duverger A, Jones J, Planelles V, Kutsch O: Kinase control prevents HIV-1 reactivation in spite of high levels of induced NF-kappaB activity. J Virol 2012, 86:4548-4558.
    • (2012) J Virol , vol.86 , pp. 4548-4558
    • Wolschendorf, F.1    Bosque, A.2    Shishido, T.3    Duverger, A.4    Jones, J.5    Planelles, V.6    Kutsch, O.7
  • 42
    • 58149487612 scopus 로고    scopus 로고
    • Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29
    • Zhou M, Huang K, Jung KJ, Cho WK, Klase Z, Kashanchi F, Pise-Masison CA, Brady JN: Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29. J Virol 2009, 83:1036-1044.
    • (2009) J Virol , vol.83 , pp. 1036-1044
    • Zhou, M.1    Huang, K.2    Jung, K.J.3    Cho, W.K.4    Klase, Z.5    Kashanchi, F.6    Pise-Masison, C.A.7    Brady, J.N.8
  • 44
    • 84874410182 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors (HDACIs): Multitargeted anticancer agents
    • Ververis K, Hiong A, Karagiannis TC, Licciardi PV: Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents. Biologics 2013, 7:47-60.
    • (2013) Biologics , vol.7 , pp. 47-60
    • Ververis, K.1    Hiong, A.2    Karagiannis, T.C.3    Licciardi, P.V.4
  • 45
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • This paper constitute the proof-of-concept that a single dose of the HDAC inhibitor Vorinistat can disrupt latent infection within a detectable proportion of the reservoir of latent resting CD4+T cells in patients on c-ART
    • Archin NM, Liberty AL, Kashuba AD, Choudhary SK, Kuruc JD, Crooks AM, Parker DC, Anderson EM, Kearney MF, Strain MC et al.: Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 2012, 487:482-485. This paper constitute the proof-of-concept that a single dose of the HDAC inhibitor Vorinistat can disrupt latent infection within a detectable proportion of the reservoir of latent resting CD4+T cells in patients on c-ART.
    • (2012) Nature , vol.487 , pp. 482-485
    • Archin, N.M.1    Liberty, A.L.2    Kashuba, A.D.3    Choudhary, S.K.4    Kuruc, J.D.5    Crooks, A.M.6    Parker, D.C.7    Anderson, E.M.8    Kearney, M.F.9    Strain, M.C.10
  • 46
    • 84859424538 scopus 로고    scopus 로고
    • Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: Results from a multicentre randomized clinical study
    • Large cross-over study showing that the weak HDAC inhibitor valproic acid is ineffective in reducing the resting CD4 reservoir in virally suppressed patients
    • Routy JP, Tremblay CL, Angel JB, Trottier B, Rouleau D, Baril JG, Harris M, Trottier S, Singer J, Chomont N et al.: Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study. HIV Med 2012, 13:291-296. Large cross-over study showing that the weak HDAC inhibitor valproic acid is ineffective in reducing the resting CD4 reservoir in virally suppressed patients.
    • (2012) HIV Med , vol.13 , pp. 291-296
    • Routy, J.P.1    Tremblay, C.L.2    Angel, J.B.3    Trottier, B.4    Rouleau, D.5    Baril, J.G.6    Harris, M.7    Trottier, S.8    Singer, J.9    Chomont, N.10
  • 47
    • 77951670390 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro
    • Matalon S, Palmer BE, Nold MF, Furlan A, Kassu A, Fossati G, Mascagni P, Dinarello CA: The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro. J Acquir Immune Defic Syndr 2010, 54:1-9.
    • (2010) J Acquir Immune Defic Syndr , vol.54 , pp. 1-9
    • Matalon, S.1    Palmer, B.E.2    Nold, M.F.3    Furlan, A.4    Kassu, A.5    Fossati, G.6    Mascagni, P.7    Dinarello, C.A.8
  • 48
    • 79957933972 scopus 로고    scopus 로고
    • Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat)
    • Furlan A, Monzani V, Reznikov LL, Leoni F, Fossati G, Modena D, Mascagni P, Dinarello CA: Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat). Mol Med 2011, 17:353-362.
    • (2011) Mol Med , vol.17 , pp. 353-362
    • Furlan, A.1    Monzani, V.2    Reznikov, L.L.3    Leoni, F.4    Fossati, G.5    Modena, D.6    Mascagni, P.7    Dinarello, C.A.8
  • 50
    • 79959337704 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases: Correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells
    • The authors highlight the importance of HDAC3 in HIV-1 latency
    • Huber K, Doyon G, Plaks J, Fyne E, Mellors JW, Sluis-Cremer N: Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells. J Biol Chem 2011, 286:22211-22218. The authors highlight the importance of HDAC3 in HIV-1 latency.
    • (2011) J Biol Chem , vol.286 , pp. 22211-22218
    • Huber, K.1    Doyon, G.2    Plaks, J.3    Fyne, E.4    Mellors, J.W.5    Sluis-Cremer, N.6
  • 51
    • 84855233016 scopus 로고    scopus 로고
    • Histonedeacetylase inhibitor oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells
    • Yin H, Zhang Y, Zhou X, Zhu H: Histonedeacetylase inhibitor oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells. Mol Biol Rep 2011, 38:5071-5078.
    • (2011) Mol Biol Rep , vol.38 , pp. 5071-5078
    • Yin, H.1    Zhang, Y.2    Zhou, X.3    Zhu, H.4
  • 54
    • 84855448173 scopus 로고    scopus 로고
    • HDAC inhibitors: Modulating leukocyte differentiation, survival, proliferation and inflammation
    • Sweet MJ, Shakespear MR, Kamal NA, Fairlie D: HDAC inhibitors: modulating leukocyte differentiation, survival, proliferation and inflammation. Immunol Cell Biol 2012, 90:14-22.
    • (2012) Immunol Cell Biol , vol.90 , pp. 14-22
    • Sweet, M.J.1    Shakespear, M.R.2    Kamal, N.A.3    Fairlie, D.4
  • 55
    • 76949108202 scopus 로고    scopus 로고
    • Th17 and regulatory T cells: Implications for AIDS pathogenesis
    • Kanwar B, Favre D, McCune JM: Th17 and regulatory T cells: implications for AIDS pathogenesis. Curr Opin HIV AIDS 2010, 5:151-157.
    • (2010) Curr Opin HIV AIDS , vol.5 , pp. 151-157
    • Kanwar, B.1    Favre, D.2    McCune, J.M.3
  • 56
    • 80855148233 scopus 로고    scopus 로고
    • The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response
    • Bernhard W, Barreto K, Saunders A, Dahabieh MS, Johnson P, Sadowski I: The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response. FEBS Lett 2011, 585:3549-3554.
    • (2011) FEBS Lett , vol.585 , pp. 3549-3554
    • Bernhard, W.1    Barreto, K.2    Saunders, A.3    Dahabieh, M.S.4    Johnson, P.5    Sadowski, I.6
  • 57
    • 84864286769 scopus 로고    scopus 로고
    • Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4(+) T cells from HIV-1-infected HAART-treated patients
    • Bouchat S, Gatot JS, Kabeya K, Cardona C, Colin L, Herbein G, De Wit S, Clumeck N, Lambotte O, Rouzioux C et al.: Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4(+) T cells from HIV-1-infected HAART-treated patients. AIDS 2012, 26:1473-1482.
    • (2012) AIDS , vol.26 , pp. 1473-1482
    • Bouchat, S.1    Gatot, J.S.2    Kabeya, K.3    Cardona, C.4    Colin, L.5    Herbein, G.6    De Wit, S.7    Clumeck, N.8    Lambotte, O.9    Rouzioux, C.10
  • 58
    • 77957730576 scopus 로고    scopus 로고
    • Cell line-dependent variability in HIV activation employing DNMT inhibitors
    • Fernandez G, Zeichner SL: Cell line-dependent variability in HIV activation employing DNMT inhibitors. Virol J 2010, 7:266-276.
    • (2010) Virol J , vol.7 , pp. 266-276
    • Fernandez, G.1    Zeichner, S.L.2
  • 59
    • 84873824788 scopus 로고    scopus 로고
    • (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1
    • Laska MJ, Nissen KK, Nexø BA: (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1. PLoS ONE 2013, 8:e53895.
    • (2013) PLoS ONE , vol.8
    • Laska, M.J.1    Nissen, K.K.2    Nexoslash3    , B.A.4
  • 60
    • 79551652566 scopus 로고    scopus 로고
    • Activation of latent HIV-1 expression by protein kinase C agonists, A novel therapeutic approach to eradicate HIV-1 reservoirs
    • Sanchez-Duffhues G, Vo MQ, Perez M, Calzado MA, Moreno S, Appendino G, Muñ oz E: Activation of latent HIV-1 expression by protein kinase C agonists. A novel therapeutic approach to eradicate HIV-1 reservoirs. Curr Drug Targets 2011, 12:348-356.
    • (2011) Curr Drug Targets , vol.12 , pp. 348-356
    • Sanchez-Duffhues, G.1    Vo, M.Q.2    Perez, M.3    Calzado, M.A.4    Moreno, S.5    Appendino, G.6    Muñ, O.E.7
  • 63
    • 78249282605 scopus 로고    scopus 로고
    • Bryostatin-1 synergizes with histone deacetylase inhibitors to reactivate HIV-1 from latency
    • Perez M, de Vinuesa AG, Sanchez-Duffhues G et al.: Bryostatin-1 synergizes with histone deacetylase inhibitors to reactivate HIV-1 from latency. Curr HIV Res 2010, 8:418-429.
    • (2010) Curr HIV Res , vol.8 , pp. 418-429
    • Perez, M.1    De Vinuesa, A.G.2    Sanchez-Duffhues, G.3
  • 64
    • 84877895204 scopus 로고    scopus 로고
    • HDAC inhibitors that release positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription
    • Mar 28, Epub ahead of print
    • Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM: HDAC inhibitors that release positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription. J Biol Chem 2013. (Mar 28, Epub ahead of print).
    • (2013) J Biol Chem
    • Bartholomeeusen, K.1    Fujinaga, K.2    Xiang, Y.3    Peterlin, B.M.4
  • 65
    • 84866842026 scopus 로고    scopus 로고
    • Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro
    • The paper describes the successful chemical synthesis of a new family of designed bryostatin analogs that are up to 1000-fold more potent in inducing latent HIV expression than prostratin
    • DeChristopher BA, Loy BA, Marsden MD, Schrier AJ, Zack JA, Wender PA: Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro. Nat Chem 2012, 4:705-710. The paper describes the successful chemical synthesis of a new family of designed bryostatin analogs that are up to 1000-fold more potent in inducing latent HIV expression than prostratin.
    • (2012) Nat Chem , vol.4 , pp. 705-710
    • Dechristopher, B.A.1    Loy, B.A.2    Marsden, M.D.3    Schrier, A.J.4    Zack, J.A.5    Wender, P.A.6
  • 66
    • 84862295855 scopus 로고    scopus 로고
    • Phase II trial of bryostatin-1 in combination with cisplatin in patients with recurrent or persistent epithelial ovarian cancer: A California cancer consortium study
    • Morgan RJ Jr, Leong L, Chow W, Gandara D, Frankel P, Garcia A, Lenz HJ, Doroshow JH: Phase II trial of bryostatin-1 in combination with cisplatin in patients with recurrent or persistent epithelial ovarian cancer: A California cancer consortium study. Invest New Drugs 2012, 30:723-728.
    • (2012) Invest New Drugs , vol.30 , pp. 723-728
    • Morgan Jr., R.J.1    Leong, L.2    Chow, W.3    Gandara, D.4    Frankel, P.5    Garcia, A.6    Lenz, H.J.7    Doroshow, J.H.8
  • 67
    • 36048945927 scopus 로고    scopus 로고
    • HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription
    • DOI 10.1371/journal.ppat.0030146
    • Contreras X, Barboric M, Lenasi T, Peterlin BM: HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription. PLoS Pathog 2007, 3:1459-1469. (Pubitemid 350085610)
    • (2007) PLoS Pathogens , vol.3 , Issue.10 , pp. 1459-1469
    • Contreras, X.1    Barboric, M.2    Lenasi, T.3    Peterlin, B.M.4
  • 68
  • 69
    • 70449377960 scopus 로고    scopus 로고
    • Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation
    • Yang HC, Sifei X, Liang S, O'Connell K, Dinoso J, Shen A, Zhou Y, Shrum CK, Han Y, Liu JO et al.: Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. J Clin Invest 2009, 119:3473-3486.
    • (2009) J Clin Invest , vol.119 , pp. 3473-3486
    • Yang, H.C.1    Sifei, X.2    Liang, S.3    O'connell, K.4    Dinoso, J.5    Shen, A.6    Zhou, Y.7    Shrum, C.K.8    Han, Y.9    Liu, J.O.10
  • 70
    • 61749088806 scopus 로고    scopus 로고
    • Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA
    • Huang B, Yang XD, Zhou MM, Ozato K, Chen LF: Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol 2009, 29:1375-1387.
    • (2009) Mol Cell Biol , vol.29 , pp. 1375-1387
    • Huang, B.1    Yang, X.D.2    Zhou, M.M.3    Ozato, K.4    Chen, L.F.5
  • 71
    • 84867758122 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a novel strategy for reactivation of HIV-1
    • These different groups provided evidences that BRD4 may represent a new 'druggable' target to reverse latency
    • Banerjee C, Archin N, Michaels D, Belkina AC, Denis GV, Bradner J, Sebastiani P, Margolis DM, Montano M: BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol 2012, 92:1147-1154. These different groups provided evidences that BRD4 may represent a new 'druggable' target to reverse latency.
    • (2012) J Leukoc Biol , vol.92 , pp. 1147-1154
    • Banerjee, C.1    Archin, N.2    Michaels, D.3    Belkina, A.C.4    Denis, G.V.5    Bradner, J.6    Sebastiani, P.7    Margolis, D.M.8    Montano, M.9
  • 73
    • 84867760525 scopus 로고    scopus 로고
    • Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein
    • Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM: Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein. J Biol Chem 2012, 287:36609-36616.
    • (2012) J Biol Chem , vol.287 , pp. 36609-36616
    • Bartholomeeusen, K.1    Xiang, Y.2    Fujinaga, K.3    Peterlin, B.M.4
  • 74
    • 84871725205 scopus 로고    scopus 로고
    • The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation
    • Li Z, Guo J, Wu Y, Zhou Q: The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Nucleic Acids Res 2013, 41:277-287.
    • (2013) Nucleic Acids Res , vol.41 , pp. 277-287
    • Li, Z.1    Guo, J.2    Wu, Y.3    Zhou, Q.4
  • 77
    • 84872393902 scopus 로고    scopus 로고
    • Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog (PTEN)
    • Doyon G, Zerbato J, Mellors JW, Sluis-Cremer N: Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog (PTEN). AIDS 2013, 27:F7-F11.
    • (2013) AIDS , vol.27
    • Doyon, G.1    Zerbato, J.2    Mellors, J.W.3    Sluis-Cremer, N.4
  • 78
    • 84862907673 scopus 로고    scopus 로고
    • Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
    • Xing S, Bhat S, Shroff NS, Zhang H, Lopez JA, Margolick JB, Liu JO, Siliciano RF: Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation. J Antimicrob Chemother 2012, 67:398-403.
    • (2012) J Antimicrob Chemother , vol.67 , pp. 398-403
    • Xing, S.1    Bhat, S.2    Shroff, N.S.3    Zhang, H.4    Lopez, J.A.5    Margolick, J.B.6    Liu, J.O.7    Siliciano, R.F.8
  • 81
    • 84876420870 scopus 로고    scopus 로고
    • Curing HIV: Lessons from cancer therapy
    • Mitsuyasu R: Curing HIV: lessons from cancer therapy. Curr Opin HIV AIDS 2013, 8:224-229.
    • (2013) Curr Opin HIV AIDS , vol.8 , pp. 224-229
    • Mitsuyasu, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.