-
1
-
-
48249134364
-
HIV vaccine research: The way forward
-
Fauci, A. S. et al. HIV vaccine research: the way forward. Science 321, 530-532 (2008).
-
(2008)
Science
, vol.321
, pp. 530-532
-
-
Fauci, A.S.1
-
2
-
-
0033592967
-
HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
-
Davey, R. T. Jr et al. HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. Proc. Natl Acad. Sci. USA 96, 15109-15114 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 15109-15114
-
-
Davey Jr., R.T.1
-
3
-
-
0043069555
-
Toxicity of antiretroviral therapy and implications for drug development
-
Carr, A. Toxicity of antiretroviral therapy and implications for drug development. Nature Rev. Drug Discov. 2, 624-634 (2003).
-
(2003)
Nature Rev. Drug Discov.
, vol.2
, pp. 624-634
-
-
Carr, A.1
-
4
-
-
33845286853
-
Adherence to HAART: A systematic review of developed and developing nation patient-reported barriers and facilitators
-
Mills, E. J. et al. Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators. PLoS Med. 3, 2039-2064 (2006).
-
(2006)
PLoS Med.
, vol.3
, pp. 2039-2064
-
-
Mills, E.J.1
-
5
-
-
0041827389
-
High levels of adherence do not prevent accumulation of HIV drug resistance mutations
-
Bangsberg, D. R. et al. High levels of adherence do not prevent accumulation of HIV drug resistance mutations. AIDS 17, 1925-1932 (2003).
-
(2003)
AIDS
, vol.17
, pp. 1925-1932
-
-
Bangsberg, D.R.1
-
6
-
-
0036720438
-
Persistence of wild-type virus and lack of temporal structure in the latent reservoir for human immunodeficiency virus type 1 in pediatric patients with extensive antiretroviral exposure
-
Ruff, C. T. et al. Persistence of wild-type virus and lack of temporal structure in the latent reservoir for human immunodeficiency virus type 1 in pediatric patients with extensive antiretroviral exposure. J. Virol. 76, 9481-9492 (2002).
-
(2002)
J. Virol.
, vol.76
, pp. 9481-9492
-
-
Ruff, C.T.1
-
7
-
-
33745245733
-
Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating cd4 t cells
-
Bailey, J. R. et al. Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4 T cells. J. Virol. 80, 6441-6457 (2006).
-
(2006)
J. Virol.
, vol.80
, pp. 6441-6457
-
-
Bailey, J.R.1
-
8
-
-
67249121143
-
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
-
Dinoso, J. B. et al. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc. Natl Acad. Sci. USA 160, 9403-9408 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.160
, pp. 9403-9408
-
-
Dinoso, J.B.1
-
9
-
-
70350148394
-
Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs
-
Coiras, M., Lopez-Huertas, M. R., Perez-Olmeda, M. & Alcami, J. Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs. Nature Rev. 7, 798-812 (2009).
-
(2009)
Nature Rev.
, vol.7
, pp. 798-812
-
-
Coiras, M.1
Lopez-Huertas, M.R.2
Perez-Olmeda, M.3
Alcami, J.4
-
10
-
-
0032953920
-
Latent infection of CD4 t cells provides a mechanism for lifelong persistence of hiv-1 even in patients on effective combination therapy
-
Finzi, D. et al. Latent infection of CD4 T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nature Med. 5, 512-517 (1999).
-
(1999)
Nature Med.
, vol.5
, pp. 512-517
-
-
Finzi, D.1
-
11
-
-
62249095476
-
The challenge of finding a cure for HIV infection
-
Richman, D. D. et al. The challenge of finding a cure for HIV infection. Science 323, 1304-1307 (2009).
-
(2009)
Science
, vol.323
, pp. 1304-1307
-
-
Richman, D.D.1
-
12
-
-
0037178320
-
Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial)
-
Stellbrink, H-J. et al. Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial). AIDS 16, 1479-1487 (2002).
-
(2002)
AIDS
, vol.16
, pp. 1479-1487
-
-
Stellbrink, H.-J.1
-
13
-
-
0035026749
-
OKT3 and IL-2 treatment for purging of the latent HIV-1 reservoir in vivo results in selective long-lasting CD41 T cell depletion
-
Van Praag, R. M. E. et al. OKT3 and IL-2 treatment for purging of the latent HIV-1 reservoir in vivo results in selective long-lasting CD41 T cell depletion. J. Clin. Immunol. 21, 218-226 (2001).
-
(2001)
J. Clin. Immunol.
, vol.21
, pp. 218-226
-
-
Van Praag, R.M.E.1
-
14
-
-
0035892120
-
Prostratin: Activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART
-
Kulkosky, J. et al. Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood 98, 3006-3015 (2001).
-
(2001)
Blood
, vol.98
, pp. 3006-3015
-
-
Kulkosky, J.1
-
15
-
-
0036315848
-
Effects of prostratin on T-cell activation and human immunodeficiency virus latency
-
Korin, Y. D., Brooks, D. G., Brown, S., Korotzer, A. & Zack, J. A. Effects of prostratin on T-cell activation and human immunodeficiency virus latency. J. Virol. 76, 8118-8123 (2002).
-
(2002)
J. Virol.
, vol.76
, pp. 8118-8123
-
-
Korin, Y.D.1
Brooks, D.G.2
Brown, S.3
Korotzer, A.4
Zack, J.A.5
-
17
-
-
43249122214
-
Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV
-
Wender, P. A., Kee, J-M. & Warrington, J. M. Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV. Science 320, 649-652 (2008).
-
(2008)
Science
, vol.320
, pp. 649-652
-
-
Wender, P.A.1
Kee, J.-M.2
Warrington, J.M.3
-
18
-
-
0020408957
-
Isolation and structure of bryostatin 1
-
Pettit, G. R. et al. Isolation and structure of bryostatin 1. J. Am. Chem. Soc. 104, 6846-6848 (1982).
-
(1982)
J. Am. Chem. Soc.
, vol.104
, pp. 6846-6848
-
-
Pettit, G.R.1
-
19
-
-
0346096818
-
Bryostatin-1: A novel PKC inhibitor in clinical development
-
Kortmansky, J. & Schwartz, G. K. Bryostatin-1: a novel PKC inhibitor in clinical development. Cancer Invest. 21, 924-936 (2003).
-
(2003)
Cancer Invest.
, vol.21
, pp. 924-936
-
-
Kortmansky, J.1
Schwartz, G.K.2
-
20
-
-
0035984562
-
The chemistry and biology of the bryostatin antitumour macrolides
-
Hale, K. J., Hummersone, M. G., Manaviazar, S. & Frigerio, M. The chemistry and biology of the bryostatin antitumour macrolides. Nat. Prod. Rep. 19, 413-453 (2002).
-
(2002)
Nat. Prod. Rep.
, vol.19
, pp. 413-453
-
-
Hale, K.J.1
Hummersone, M.G.2
Manaviazar, S.3
Frigerio, M.4
-
21
-
-
3342934646
-
Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice
-
Etcheberrigaray, R. et al. Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice. Proc. Natl Acad. Sci. USA 101, 11141-11146 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 11141-11146
-
-
Etcheberrigaray, R.1
-
22
-
-
0025004457
-
Direct and cytokinemediated activation of protein kinase c induces human immunodeficiency virus expression in chronically infected promonocytic cells
-
Kinter, A. L., Poli, G., Maury,W., Folks, T. M. & Fauci, A. S. Direct and cytokinemediated activation of protein kinase C induces human immunodeficiency virus expression in chronically infected promonocytic cells. J. Virol. 64, 4306-4312 (1990).
-
(1990)
J. Virol.
, vol.64
, pp. 4306-4312
-
-
Kinter, A.L.1
Mauryw, P.G.2
Folks, T.M.3
Fauci, A.S.4
-
23
-
-
0027336298
-
Go 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level- producing reservoir cells in vitro
-
Quatsha, K. A., Rudolph, C., Marme, D., Schachtele, C. & May, W. S. Go 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. Proc. Natl Acad. Sci. USA 90, 4674-4676 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 4674-4676
-
-
Quatsha, K.A.1
Rudolph, C.2
Marme, D.3
Schachtele, C.4
May, W.S.5
-
24
-
-
77955287402
-
Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner
-
Mehla, R. et al. Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner. PLoS One 5, e11160 (2010).
-
(2010)
PLoS One
, vol.5
-
-
Mehla, R.1
-
25
-
-
67749124516
-
Phase II study of bryostatin 1 and vincristine for aggressive non- Hodgkin lymphoma relapsing after an autologous stem cell transplant
-
Barr, P. M. et al. Phase II study of bryostatin 1 and vincristine for aggressive non- Hodgkin lymphoma relapsing after an autologous stem cell transplant. Am. J. Hematol. 84, 484-487 (2009).
-
(2009)
Am. J. Hematol.
, vol.84
, pp. 484-487
-
-
Barr, P.M.1
-
26
-
-
0026093899
-
The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices
-
Schaufelberger, D. E. et al. The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices. J. Nat. Prod. 54, 1265-1270 (1991).
-
(1991)
J. Nat. Prod.
, vol.54
, pp. 1265-1270
-
-
Schaufelberger, D.E.1
-
27
-
-
78349307964
-
Bryostatins: Biological context and biotechnological prospects
-
Trindade-Silva, A. E., Lim-Fong, G. E., Sharp, K. H. & Haygood, M. G. Bryostatins: biological context and biotechnological prospects. Curr. Opin. Biotechnol. 21, 834-842 (2010).
-
(2010)
Curr. Opin. Biotechnol.
, vol.21
, pp. 834-842
-
-
Trindade-Silva, A.E.1
Lim-Fong, G.E.2
Sharp, K.H.3
Haygood, M.G.4
-
28
-
-
0025053566
-
Synthesis of bryostatin 7
-
Kageyama, M. et al. Synthesis of bryostatin 7. J. Am. Chem. Soc. 112, 7407-7408 (1990).
-
(1990)
J. Am. Chem. Soc.
, vol.112
, pp. 7407-7408
-
-
Kageyama, M.1
-
29
-
-
0033603858
-
Total synthesis of bryostatin 2
-
Evans, D. A. et al. Total synthesis of bryostatin 2. J. Am. Chem. Soc. 121, 7540-7552 (1999).
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 7540-7552
-
-
Evans, D.A.1
-
30
-
-
0034600771
-
Total synthesis of bryostatin 3
-
Ohmori, K. et al. Total synthesis of bryostatin 3. Angew. Chem. Int. Ed. 39, 2290-2294 (2000).
-
(2000)
Angew. Chem. Int. Ed.
, vol.39
, pp. 2290-2294
-
-
Ohmori, K.1
-
31
-
-
57049128884
-
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
-
Trost, B. M. & Dong, G. Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches. Nature 456, 485-488 (2008).
-
(2008)
Nature
, vol.456
, pp. 485-488
-
-
Trost, B.M.1
Dong, G.2
-
32
-
-
79851469995
-
Total synthesis of bryostatin 1
-
Keck, G. E., Poudel, Y. B., Cummins, T. J., Rudra, A. & Covel, J. A. Total synthesis of bryostatin 1. J. Am. Chem. Soc. 133, 744-747 (2011).
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 744-747
-
-
Keck, G.E.1
Poudel, Y.B.2
Cummins, T.J.3
Rudra, A.4
Covel, J.A.5
-
33
-
-
79959240700
-
Total synthesis of bryostatin 9
-
Wender, P. A. & Schrier, A. J. Total synthesis of bryostatin 9. J. Am. Chem. Soc. 133, 9228-9231 (2011).
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 9228-9231
-
-
Wender, P.A.1
Schrier, A.J.2
-
34
-
-
80052308782
-
Total synthesis of bryostatin 7 via C-C bond-forming hydrogenation
-
Lu, Y., Woo, S. & Krische, M. J. Total synthesis of bryostatin 7 via C-C bond-forming hydrogenation. J. Am. Chem. Soc. 133, 13876-13879 (2011).
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 13876-13879
-
-
Lu, Y.1
Woo, S.2
Krische, M.J.3
-
35
-
-
0000852678
-
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C
-
Wender, P. A. et al. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc. Natl Acad. Sci. USA 85, 7197-7201 (1988).
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 7197-7201
-
-
Wender, P.A.1
-
37
-
-
79953882436
-
Translating nature's library: The bryostatins and function-oriented synthesis
-
Wender, P. A., Loy, B. A. & Schrier, A. J. Translating nature's library: the bryostatins and function-oriented synthesis. Isr. J. Chem. 51, 453-472 (2011).
-
(2011)
Isr. J. Chem.
, vol.51
, pp. 453-472
-
-
Wender, P.A.1
Loy, B.A.2
Schrier, A.J.3
-
38
-
-
38949138457
-
Function-oriented syn thesis, step economy, and drug design
-
Wender, P. A., Verma, V. A., Paxton, T. J. & Pillow, T. H. Function-oriented synthesis, step economy, and drug design. Acc. Chem. Res. 41, 40-49 (2008).
-
(2008)
Acc. Chem. Res.
, vol.41
, pp. 40-49
-
-
Wender, P.A.1
Verma, V.A.2
Paxton, T.J.3
Pillow, T.H.4
-
39
-
-
0032513707
-
Synthesis of the first members of a new class of biologically active bryostatin analogues
-
Wender, P. A. et al. Synthesis of the first members of a new class of biologically active bryostatin analogues. J. Am. Chem. Soc. 120, 4534-4535 (1998).
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 4534-4535
-
-
Wender, P.A.1
-
40
-
-
0037146084
-
The practical synthesis of a novel and highly potent analogue of bryostatin
-
Wender, P. A. et al. The practical synthesis of a novel and highly potent analogue of bryostatin. J. Am. Chem. Soc. 124, 13648-13649 (2002).
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 13648-13649
-
-
Wender, P.A.1
-
41
-
-
44349096284
-
Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy
-
Wender, P. A., DeChristopher, B. A. & Schrier, A. J. Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy. J. Am. Chem. Soc. 130, 6658-6659 (2008).
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 6658-6659
-
-
Wender, P.A.1
Dechristopher, B.A.2
Schrier, A.J.3
-
42
-
-
79955553260
-
Design, syn thesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity
-
Wender, P. A. et al. Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity. Proc. Natl Acad. Sci. USA 108, 6721-6726 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 6721-6726
-
-
Wender, P.A.1
-
43
-
-
34250902930
-
Targeting the protein kinase C family: Are we there yet?
-
Mackay, H. J. & Twelves, C. J. Targeting the protein kinase C family: are we there yet? Nature Rev. Cancer 7, 554-562 (2007).
-
(2007)
Nature Rev. Cancer
, vol.7
, pp. 554-562
-
-
MacKay, H.J.1
Twelves, C.J.2
-
44
-
-
84863224510
-
'Picolog' a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo
-
DeChristopher, B. A., Fan, A. C., Felsher, D. W. & Wender, P. A. 'Picolog', a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo. Oncotarget 3, 58-66 (2012).
-
(2012)
Oncotarget
, vol.3
, pp. 58-66
-
-
Dechristopher, B.A.1
Fan, A.C.2
Felsher, D.W.3
Wender, P.A.4
-
45
-
-
64449084409
-
A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Ab-induced biomarker abnormality on cultured fibroblasts
-
Khan, T. K., Nelson, T. J., Verma, V. A., Wender, P. A. & Alkon, D. L. A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Ab-induced biomarker abnormality on cultured fibroblasts. Neurobiol. Dis. 34, 332-339 (2009).
-
(2009)
Neurobiol. Dis.
, vol.34
, pp. 332-339
-
-
Khan, T.K.1
Nelson, T.J.2
Verma, V.A.3
Wender, P.A.4
Alkon, D.L.5
-
46
-
-
78149419134
-
Prins-type macrocyclizations as an efficient ring-closing strategy in natural product synthesis
-
Crane, E. A. & Scheidt, K. A. Prins-type macrocyclizations as an efficient ring-closing strategy in natural product synthesis. Angew. Chem. Int. Ed. 49, 8316-8326 (2010).
-
(2010)
Angew. Chem. Int. Ed.
, vol.49
, pp. 8316-8326
-
-
Crane, E.A.1
Scheidt, K.A.2
-
47
-
-
30444448361
-
Soluble lanthanide salts (LnCl3 .2LiCl) for the improved addition of organomagnesium reagents to carbonyl compounds
-
Krasovskiy, A., Kopp, F. & Knochel, P. Soluble lanthanide salts (LnCl3 .2LiCl) for the improved addition of organomagnesium reagents to carbonyl compounds. Angew. Chem. Int. Ed. 45, 497-500 (2006).
-
(2006)
Angew. Chem. Int. Ed.
, vol.45
, pp. 497-500
-
-
Krasovskiy, A.1
Kopp, F.2
Knochel, P.3
-
48
-
-
74049131691
-
Establishment and maintenance of hiv latency: Model systems and opportunities for intervention
-
Marsden, M. D. & Zack, J. A. Establishment and maintenance of HIV latency: model systems and opportunities for intervention. Future Virol. 5, 97-109 (2010).
-
(2010)
Future Virol.
, vol.5
, pp. 97-109
-
-
Marsden, M.D.1
Zack, J.A.2
-
49
-
-
0037446948
-
HIV reproducibly establishes a latent infection after acute infection in T cells in vitro
-
Jordan, A., Bisgrove, D. & Verdin, E. HIV reproducibly establishes a latent infection after acute infection in T cells in vitro. EMBO J. 22, 1868-1877 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 1868-1877
-
-
Jordan, A.1
Bisgrove, D.2
Verdin, E.3
-
50
-
-
4744359117
-
Prostratin antagonizes HIV latency by activating NF-kB
-
Williams, S. A. et al. Prostratin antagonizes HIV latency by activating NF-kB. J. Biol. Chem. 279, 42008-42017 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 42008-42017
-
-
Williams, S.A.1
-
51
-
-
79953689313
-
Activation of latent HIV using drug-loaded nanoparticles
-
Kovochich, M., Marsden, M. D. & Zack, J. A. Activation of latent HIV using drug-loaded nanoparticles. PLoS One 6, e18270 (2011).
-
(2011)
PLoS One
, vol.6
-
-
Kovochich, M.1
Marsden, M.D.2
Zack, J.A.3
-
52
-
-
0141567539
-
Molecular characterization, reactivation, and depletion of latent HIV
-
Brooks, D. G. et al. Molecular characterization, reactivation, and depletion of latent HIV. Immunity 19, 413-423 (2003).
-
(2003)
Immunity
, vol.19
, pp. 413-423
-
-
Brooks, D.G.1
|