Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression

FEBS Letters

Volumn 585, Issue 7, 2011, Pages 1103-1111

  Victoriano, Ann Florence B ^a,b   Imai, Kenichi ^a   Togami, Hiroaki ^a   Ueno, Takaharu ^a   Asamitsu, Kaori ^a   Suzuki, Takayoshi ^c   Miyata, Naoki ^c   Ochiai, Kuniyasu ^d   Okamoto, Takashi ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b The Japan Foundation   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

^d NIHON UNIVERSITY   (Japan)

Author keywords

Chromatin remodeling; Histone deacetylase; Histone deacetylase inhibitor; HIV transcription; HIV 1; Viral latency

Indexed keywords

HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITOR; NCH 51; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; GENE EXPRESSION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION; VIRUS ATTENUATION; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS REPLICATION;

ACETYLATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; GENE EXPRESSION REGULATION, VIRAL; GENE KNOCKDOWN TECHNIQUES; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HISTONES; HIV-1; HL-60 CELLS; HUMANS; NUCLEOSOMES; PROMOTER REGIONS, GENETIC; SP1 TRANSCRIPTION FACTOR; SULFHYDRYL COMPOUNDS; TERMINAL REPEAT SEQUENCES; TRANSCRIPTIONAL ACTIVATION; VIRUS LATENCY; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79953251644     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.03.017     Document Type: Article

References (47)

1. J.D. Graci, J.M. Colacino, S.W. Peltz, J.P. Dougherty, and Z. Gu HIV type-1 latency: targeted induction of proviral reservoirs Antivir. Chem. Chemother. 19 2009 177 187
2. N.M. Archin, and D.M. Margolis Attacking latent HIV provirus: from mechanism to therapeutic strategies Curr. Opin. HIV AIDS 1 2006 134 140
3. T.W. Chun, R.T. Davey Jr., D. Engel, H.C. Lane, and A.S. Fauci Re-emergence of HIV after stopping therapy Nature 401 1999 874 875 (Pubitemid 129516777)
4. T.W. Chun, R.T. Davey Jr., M. Ostrowski, J. Shawn Justement, D. Engel, J.I. Mullins, and A.S. Fauci Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy Nat. Med. 6 2000 757 761 (Pubitemid 30469423)
5. D.D. Ho, T.R. Rota, and M.S. Hirsch Infection of monocyte/macrophages by human T lymphotropic virus type III J. Clin. Invest. 77 1986 1712 1715 (Pubitemid 16047120)
6. T.W. Chun, L. Carruth, D. Finzi, X. Shen, J.A. DiGiuseppe, H. Taylor, M. Hermankova, K. Chadwick, J. Margolick, T.C. Quinn, and Y.H. Kuo Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection Nature 38 1997 183 188 (Pubitemid 27209433)
7. K. Imai, and T. Okamoto Transcriptional repression of human immunodeficiency virus type 1 by AP-4 J. Biol. Chem. 281 2006 12495 12505 (Pubitemid 43855336)
8. K. Imai, H. Togami, and T. Okamoto Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294 J. Biol. Chem. 285 2010 16538 16545
9. M. Lusic, A. Marcello, A. Cereseto, and M. Giacca Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter EMBO J. 22 2003 6550 6561 (Pubitemid 38009602)
10. C. Marban, S. Suzanne, F. Dequiedt, S. de Walque, L. Redel, C. Van Lint, D. Aunis, and O. Rohr Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing EMBO J. 26 2007 412 423 (Pubitemid 46160942)
11. C. Van Lint, S. Emiliani, M. Ott, and E. Verdin Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation EMBO J. 15 1996 1112 1120 (Pubitemid 26077840)
12. J.J. Coull, F. Romerio, J.M. Sun, J.L. Volker, K.M. Galvin, J.R. Davis, Y. Shi, U. Hansen, and D.M. Margolis The human factors YY1 and LSF repress the human immunodeficiency virus type-1 long terminal repeat via recruitment of histone deacetylase 1 J. Virol. 74 2000 6790 6799 (Pubitemid 30470662)
13. G. He, and D.M. Margolis Counter regulation of chromatin deacetylation and histone deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 Repressor YY1 and HIV-1 Activator Tat Mol. Cell. Biol. 22 2002 2965 2973 (Pubitemid 34437455)
14. G. Jiang, A. Espeseth, D.J. Hazuda, and D.M. Margolis C-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter J. Virol. 81 2007 10914 10923 (Pubitemid 47536066)
15. S.A. Williams, L.F. Chen, H. Kwon, C.M. Ruiz-Jarabo, E. Verdin, and W.C. Greene NF-κB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation EMBO J. 25 2006 139 149 (Pubitemid 43077303)
16. V. Quivy, E. Adam, Y. Collette, D. Demonte, A. Chariot, C. Vanhulle, B. Berkhout, R. Castellano, Y. de Launoit, and A. Burny Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-κB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies J. Virol. 76 2002 11091 11103 (Pubitemid 35176225)
17. X. Contreras, M. Schweneker, C.-S. Chen, J.M. McCune, S.G. Deeks, J. Martin, and B.M. Peterlin Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells J. Biol. Chem. 284 2009 6782 6789
18. N.M. Archin, A. Espeseth, D. Parker, M. Cheema, D. Hazuda, and D.M. Margolis Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid AIDS Res. Hum. Retro. 25 2009 207 212
19. D. Demonte, V. Quivy, Y. Colette, and C. Van Lint Administration of HDAC inhibitors to reactivate HIV-1 expression in latent cellular reservoirs: implications for the development of therapeutic strategies Biochem. Pharmacol. 6 2004 1231 1238 (Pubitemid 39094289)
20. J.D. Siliciano, J. Lai, M. Callender, E. Pitt, H. Zhang, J.B. Nargolick, J.E. Gallant, J. Confrancesco, R.D. Moore, S.J. Gange, and R.F. Siliciano Stability of the latent reservoir for HIV-1 in patients receiving valproic acid J. Infect. Dis. 195 2007 833 836 (Pubitemid 46363928)
21. N. Sagot-Lerolle, A. Lamine, M.L. Chaix, F. Boufassa, J.P. Aboulker, D. Costagliola, C. Goujard, C. Pallier, J.F. Delfraissy, O. Lambotte the ANRS EP39 study Prolonged valproic acid treatment does not reduce the size of latent reservoir AIDS 22 2008 1125 1129
22. N.A. Archin, J.J. Eron, S. Palmer, A. Hartmann-Duff, J.A. Martinson, A. Wiegand, N. Bandarenko, J.L. Schmitz, R.J. Bosch, A.L. Landay, J.M. Coffin, and D.M. Margolis Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells AIDS 22 2008 1131 1135
23. N.M. Archin, M. Cheema, D. Parker, A. Wiegand, R.J. Bosch, J.M. Coffin, J. Eron, M. Cohen, and D.M. Margolis Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection PLoS ONE 5 2010 e9390
24. T. Suzuki, Y. Nagano, A. Kouketsu, A. Matsuura, S. Maruyama, M. Kurotaki, H. Nakagawa, and N. Miyata Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates J. Med. Chem. 48 2005 1019 1032 (Pubitemid 40270446)
25. T. Sanda, T. Okamoto, Y. Uchida, H. Nakagawa, S. Iida, S. Kayukawa, T. Suzuki, T. Oshizawa, T. Suzuki, N. Miyata, and R. Ueda Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells Leukemia 21 2007 2344 2353 (Pubitemid 350011707)
26. + cell model of chronic infection J. Virol. 65 1991 46 55
27. T. Folks, D.M. Powell, M.M. Lightfoote, S. Benn, M.A. Martin, and A.S. Fauci Induction of HTLV-III/LAV from a nonvirus-producing T-cell line: implications for latency Science 231 1986 600 602 (Pubitemid 16088942)
28. K.A. Clouse, D. Powell, I. Washington, G. Poli, K. Strebel, W. Farrar, P. Barstad, J. Kovacs, A.S. Fauci, and T.M. Folks Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone J. Immunol. 142 1989 431 438 (Pubitemid 19039959)
29. K. Imai, K. Ochiai, and T. Okamoto Reactivation of latent HIV-1 infection by the periodontopathic bacterium Porphyromonas gingivalis involves histone modification J. Immunol. 182 2009 3688 3695
30. X. Wei, J.M. Decker, H. Liu, Z. Zhang, R.B. Arani, J.M. Kilby, M.S. Saag, X. Wu, G.M. Shaw, and J.C. Kappes Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy Antimicrob. Agents Chemother. 46 2002 1896 1905 (Pubitemid 34535213)
31. C.M. Finnegan, S.S. Rawat, A. Puri, J.M. Wang, F.W. Ruscetti, and R. Blumenthal Ceramide, a target for antiretroviral therapy Proc. Natl. Acad. Sci. USA 101 2004 15452 15457 (Pubitemid 39441562)
32. N. Takada, T. Sanda, H. Okamoto, J.P. Yang, K. Asamtisu, L. Sarol, G. Kimura, H. Uranishi, T. Tetsuka, and T. Okamoto RelA-associated inhibitor blocks transcription of human Immunodeficiency virus type 1 by inhibiting NF-κB and Sp1 actions J. Virol. 76 2002 8019 8030 (Pubitemid 34809056)
33. A.F.B. Victoriano, K. Asamitsu, Y. Hibi, K. Imai, N.G. Barzaga, and T. Okamoto Inhibition of human immunodeficiency virus type-1 replication in latently infected cells by a novel IκB kinase inhibitor Antimicrob. Agents Chemother. 50 2006 547 555 (Pubitemid 43190965)
34. J.C. Burnett, K. Miller-Jensen, P.S. Shah, A.P. Arkin, and D.V. Schaffer Control of stochastic gene expression by host factors at the HIV promoter PLoS Pathog. 5 2009 e1000260
35. B.S. Sørensen, J. Sinding, A.H. Andersen, J. Alsner, P.B. Jensen, and O. Westergaard Mode of action of topoisomerase II-targeting agents at a specific DNA sequence: uncoupling the DNA binding, cleavage and religation events J. Mol. Biol. 228 1992 778 786 (Pubitemid 23017269)
36. J.C. Burnett, K. Lim, A. Calafi, J.J. Rossi, D.V. Schaffer, and A.P. Arkin Combinatorial latency reactivation for HIV-1 subtypes and variants J. Virol. 84 2010 5958 5974
37. G. Lehrman, I.B. Hogue, S. Palmer, C. Jennings, C.A. Spina, A. Wiegand, A.L. Landay, R.W. Coombs, D.D. Richman, J.W. Mellors, and J.W. Coffin Depletion of latent HIV-1 infection in vivo: a proof-of-concept study Lancet 366 2005 549 554
38. Blume, S.W., Snyder, R.C., Ray, R., Thomas, S., Koller, C.A. and Miller, D.M. (1991) Mithramycin inhibits Sp1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. J. Clin. Invest. 88, 1613-1621.
39. E. Verdin, P. Paras Jr., and C. Van Lint Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation EMBO J. 12 1993 3249 3259 (Pubitemid 23232756)
40. C. Marban, L. Redel, S. Suzanne, C. Van Lint, D. Lecestre, S. Chasserot-Golaz, M. Leid, D. Aunis, E. Schaeffer, and O. Rohr COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells Nucleic Acids Res. 33 2005 2318 2331 (Pubitemid 41439899)
41. J.C. Burnett, K. Miller-Jensen, P.S. Shah, A.P. Arkin, and D.V. Schaffer Control of stochastic gene expression by host factors at the HIV promoter PLoS Pathog. 5 2009 e1000260
42. H.-J. Sun, X. Xu, X.-L. Wang, L. Wei, F. Li, J. Lu, and B.-Q. Huang Transcription factors Ets2 and Sp1 act synergistically with histone acetyltransferase p300 in activating human Interleukin-12 p40 promoter Acta Biochim. Biophys. Sin. 38 2006 194 200
43. T. Suzuki, A. Kimura, R. Nagai, and M. Horikoshi Regulation of interaction of the acetyltransferase region of p300 and the DNA-binding domain of Sp1 on and through DNA binding Genes Cells 5 2000 29 41 (Pubitemid 30095679)
44. S.K. Choudhary, N.M. Archin, and D.M. Margolis Hexamethylbisacetamide and disruption of human immunodeficiency virus type 1 latency in CD4(+) T cells J. Infect. Dis. 197 2008 1162 1170 (Pubitemid 351590052)
45. B. Majello, G. Napolitano, P. De Luca, and L. Lania Recruitment of human TBP selectively activates RNA Polymerase II TATA-dependent promoters J. Biol. Chem. 273 1998 16509 16516 (Pubitemid 28311435)
46. H. Xiao, J.D. Friesen, and J.T. Lis Recruiting TATA-binding protein to a promoter: transcriptional activation without an upstream activator Mol. Cell. Biol. 15 1995 5757 5761
47. N.Y. Tan, and L.M. Khachigian Sp1 phosphorylation and its regulation of gene transcription Mol. Cell. Biol. 29 2009 2483 2488