메뉴 건너뛰기




Volumn 13, Issue 5, 2012, Pages 291-296

Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: Results from a multicentre randomized clinical study

Author keywords

CD4 T cells; Highly active antiretroviral therapy; HIV; Reservoir; Valproic acid

Indexed keywords

ANTIRETROVIRUS AGENT; VALPROATE SEMISODIUM; VALPROIC ACID;

EID: 84859424538     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/j.1468-1293.2011.00975.x     Document Type: Article
Times cited : (96)

References (21)
  • 1
    • 78549235738 scopus 로고    scopus 로고
    • Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication
    • Chun TW, Justement JS, Murray D etal. Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication. AIDS 2010; 24: 2803-2808.
    • (2010) AIDS , vol.24 , pp. 2803-2808
    • Chun, T.W.1    Justement, J.S.2    Murray, D.3
  • 2
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi D, Hermankova M, Pierson T etal. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997; 278: 1295-1300.
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1    Hermankova, M.2    Pierson, T.3
  • 3
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano JD, Kajdas J, Finzi D etal. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med 2003; 9: 727-728.
    • (2003) Nat Med , vol.9 , pp. 727-728
    • Siliciano, J.D.1    Kajdas, J.2    Finzi, D.3
  • 4
    • 30444431914 scopus 로고    scopus 로고
    • NF-kappa GWC. B p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation
    • Williams SA, Chen LF, Kwon H, Ruiz-Jarabo CM, Verdin E, NF-kappa GWC. B p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J 2006; 25: 139-149.
    • (2006) EMBO J , vol.25 , pp. 139-149
    • Williams, S.A.1    Chen, L.F.2    Kwon, H.3    Ruiz-Jarabo, C.M.4    Verdin, E.5
  • 5
    • 77249123298 scopus 로고    scopus 로고
    • Mechanisms of HIV latency: an emerging picture of complexity
    • Margolis DM. Mechanisms of HIV latency: an emerging picture of complexity. Curr HIV/AIDS Rep 2010; 7: 37-43.
    • (2010) Curr HIV/AIDS Rep , vol.7 , pp. 37-43
    • Margolis, D.M.1
  • 6
    • 35148858784 scopus 로고    scopus 로고
    • c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter
    • Jiang G, Espeseth A, Hazuda DJ, Margolis DM. c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. J Virol 2007; 81: 10914-10923.
    • (2007) J Virol , vol.81 , pp. 10914-10923
    • Jiang, G.1    Espeseth, A.2    Hazuda, D.J.3    Margolis, D.M.4
  • 7
    • 4143089463 scopus 로고    scopus 로고
    • Administration of HDAC inhibitors to reactivate HIV-1 expression in latent cellular reservoirs: implications for the development of therapeutic strategies
    • Demonté D, Quivy V, Colette Y, Van Lint C. Administration of HDAC inhibitors to reactivate HIV-1 expression in latent cellular reservoirs: implications for the development of therapeutic strategies. Biochem Pharmacol 2004; 68: 1231-1238.
    • (2004) Biochem Pharmacol , vol.68 , pp. 1231-1238
    • Demonté, D.1    Quivy, V.2    Colette, Y.3    Van Lint, C.4
  • 8
    • 2942586974 scopus 로고    scopus 로고
    • Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression
    • Ylisastigui L, Archin NM, Lehrman G, Bosch RJ, Margolis DM. Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression. AIDS 2004; 18: 1101-1108.
    • (2004) AIDS , vol.18 , pp. 1101-1108
    • Ylisastigui, L.1    Archin, N.M.2    Lehrman, G.3    Bosch, R.J.4    Margolis, D.M.5
  • 9
    • 23744500093 scopus 로고    scopus 로고
    • Depletion of latent HIV-1 infection in vivo: a proof-of-concept study
    • Lehrman G, Hogue IB, Palmer S etal. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet 2005; 366: 549-555.
    • (2005) Lancet , vol.366 , pp. 549-555
    • Lehrman, G.1    Hogue, I.B.2    Palmer, S.3
  • 10
    • 23744456548 scopus 로고    scopus 로고
    • Valproic acid: a potential role in treating latent HIV infection
    • Routy JP. Valproic acid: a potential role in treating latent HIV infection. Lancet 2005; 366: 523-524.
    • (2005) Lancet , vol.366 , pp. 523-524
    • Routy, J.P.1
  • 11
    • 33746721508 scopus 로고    scopus 로고
    • No change to HIV-1 latency with valproate therapy
    • Steel A, Clark S, Teo I etal. No change to HIV-1 latency with valproate therapy. AIDS 2006; 20: 1681-1682.
    • (2006) AIDS , vol.20 , pp. 1681-1682
    • Steel, A.1    Clark, S.2    Teo, I.3
  • 12
    • 33847642822 scopus 로고    scopus 로고
    • Stability of the latent reservoir for HIV-1 in patients receiving valproic acid
    • Siliciano JD, Lai J, Callender M etal. Stability of the latent reservoir for HIV-1 in patients receiving valproic acid. J Infect Dis 2007; 195: 833-836.
    • (2007) J Infect Dis , vol.195 , pp. 833-836
    • Siliciano, J.D.1    Lai, J.2    Callender, M.3
  • 13
    • 50949096673 scopus 로고    scopus 로고
    • Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir
    • Sagot-Lerolle N, Lamine A, Chaix ML etal. Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir. AIDS 2008; 22: 1125-1129.
    • (2008) AIDS , vol.22 , pp. 1125-1129
    • Sagot-Lerolle, N.1    Lamine, A.2    Chaix, M.L.3
  • 14
    • 50949131800 scopus 로고    scopus 로고
    • Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells
    • Archin NM, Eron JJ, Palmer S etal. Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells. AIDS 2008; 22: 1131-1135.
    • (2008) AIDS , vol.22 , pp. 1131-1135
    • Archin, N.M.1    Eron, J.J.2    Palmer, S.3
  • 15
    • 77949592502 scopus 로고    scopus 로고
    • Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection
    • Archin NM, Cheema M, Parker D etal. Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection. PLoS ONE 2010; 5: e9390.
    • (2010) PLoS ONE , vol.5
    • Archin, N.M.1    Cheema, M.2    Parker, D.3
  • 16
    • 34447322319 scopus 로고    scopus 로고
    • Immunophenotypic patterns of CD8+ T cell subsets expressing CD8alphaalpha and IL-7Ralpha in viremic, aviremic and slow progressor HIV-1-infected subjects
    • Boulassel MR, Mercier F, Gilmore N, Routy JP. Immunophenotypic patterns of CD8+ T cell subsets expressing CD8alphaalpha and IL-7Ralpha in viremic, aviremic and slow progressor HIV-1-infected subjects. Clin Immunol 2007; 124: 149-157.
    • (2007) Clin Immunol , vol.124 , pp. 149-157
    • Boulassel, M.R.1    Mercier, F.2    Gilmore, N.3    Routy, J.P.4
  • 17
    • 0034458743 scopus 로고    scopus 로고
    • Marked differences in quantity of infectious human immunodeficiency virus type 1 detected in persons with controlled plasma viremia by a simple enhanced culture method
    • Tremblay CL, Giguel F, Merrill DP etal. Marked differences in quantity of infectious human immunodeficiency virus type 1 detected in persons with controlled plasma viremia by a simple enhanced culture method. J Clin Microbiol 2000; 38: 4246-4248.
    • (2000) J Clin Microbiol , vol.38 , pp. 4246-4248
    • Tremblay, C.L.1    Giguel, F.2    Merrill, D.P.3
  • 18
    • 70350148394 scopus 로고    scopus 로고
    • Understanding HIV latency provides clues for the eradication of long-term reservoirs
    • Coiras M, López-Huertas MR, Pérez-Olmeda M, Alcamí J. Understanding HIV latency provides clues for the eradication of long-term reservoirs. Nat Microbiol 2009; 7: 798-812.
    • (2009) Nat Microbiol , vol.7 , pp. 798-812
    • Coiras, M.1    López-Huertas, M.R.2    Pérez-Olmeda, M.3    Alcamí, J.4
  • 19
    • 75649108956 scopus 로고    scopus 로고
    • No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy
    • Gandhi RT, Bosch RJ, Aga E etal. No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy. J Infect Dis 2010; 201: 293-296.
    • (2010) J Infect Dis , vol.201 , pp. 293-296
    • Gandhi, R.T.1    Bosch, R.J.2    Aga, E.3
  • 20
    • 77956856393 scopus 로고    scopus 로고
    • The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial
    • e1000321.
    • Gandhi RT, Zheng L, Bosch RJ etal. The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial. PLoS Med 2010; 7: e1000321.
    • (2010) PLoS Med , vol.7
    • Gandhi, R.T.1    Zheng, L.2    Bosch, R.J.3
  • 21
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    • Chomont N, El-Far M, Ancuta P etal. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 2009; 15: 893-900.
    • (2009) Nat Med , vol.15 , pp. 893-900
    • Chomont, N.1    El-Far, M.2    Ancuta, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.