Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein

Journal of Biological Chemistry

Volumn 287, Issue 43, 2012, Pages 36609-36616

  Bartholomeeusen, Koen ^a   Xiang, Yanhui ^a   Fujinaga, Koh ^a   Peterlin, B Matija ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL DOMAINS; CELLULAR ACTIVATION; ELONGATION COMPLEX; ELONGATION FACTOR; EUKARYOTIC GENES; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACIDS; NUCLEAR RIBONUCLEOPROTEIN; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; RAPID RELEASE; REASSEMBLY; RNA POLYMERASE II; SIGNALING CASCADES; TRANSCRIPTIONAL BLOCKADE;

ELONGATION; LEAD COMPOUNDS; ORGANIC ACIDS; RNA; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

JQ1; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; PROTEIN INHIBITOR; RNA POLYMERASE II; SMALL NUCLEAR RIBONUCLEOPROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRD4; TRANSCRIPTION FACTOR HEXIM1; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN IMMUNODEFICIENCY VIRUS; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TUMOR GROWTH; VIRUS ACTIVATION; VIRUS TRANSCRIPTION;

ACETAMIDES; AZEPINES; CELL LINE; GENE KNOCKDOWN TECHNIQUES; HIV-1; HUMANS; NUCLEAR PROTEINS; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA POLYMERASE II; RNA-BINDING PROTEINS; TRANSCRIPTION ELONGATION, GENETIC; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ELONGATION FACTORS; TRIAZOLES; ULTRAVIOLET RAYS; VIRAL PROTEINS;

EID: 84867760525     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.410746     Document Type: Article

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