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Volumn 85, Issue 17, 2011, Pages 9078-9089

Epigenetic silencing of HIV-1 by the histone H3 Lysine 27 methyltransferase enhancer of Zeste 2

Author keywords

[No Author keywords available]

Indexed keywords

3 DEAZANEPLANOCIN A; BIX 01294; CHETOCIN; HISTONE H3; HISTONE LYSINE METHYLTRANSFERASE; LYSINE; METHYLTRANSFERASE; POLYCOMB GROUP PROTEIN; POLYCOMB REPRESSIVE COMPLEX 2 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR EZH2; TRIMETHYL HISTONE LYSINE 27; UNCLASSIFIED DRUG;

EID: 80052287096     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00836-11     Document Type: Article
Times cited : (222)

References (80)
  • 1
    • 60849127627 scopus 로고    scopus 로고
    • Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid
    • Archin, N. M., et al. 2009. Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid. AIDS Res. Hum. Retrovir. 25:207-212.
    • (2009) AIDS Res. Hum. Retrovir. , vol.25 , pp. 207-212
    • Archin, N.M.1
  • 2
    • 70249100307 scopus 로고    scopus 로고
    • Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors
    • Archin, N. M., et al. 2009. Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors. AIDS 23:1799-1806.
    • (2009) AIDS , vol.23 , pp. 1799-1806
    • Archin, N.M.1
  • 3
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein, B. E., et al. 2006. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125:315-326.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1
  • 4
    • 70049090006 scopus 로고    scopus 로고
    • CpG methylation controls reactivation of HIV from latency
    • Blazkova, J., et al. 2009. CpG methylation controls reactivation of HIV from latency. PLoS Pathog. 5:e1000554.
    • (2009) PLoS Pathog. , vol.5
    • Blazkova, J.1
  • 6
    • 33646882068 scopus 로고    scopus 로고
    • Polycomb complexes repress developmental regulators in murine embryonic stem cells
    • Boyer, L. A., et al. 2006. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441:349-353.
    • (2006) Nature , vol.441 , pp. 349-353
    • Boyer, L.A.1
  • 7
    • 69249214157 scopus 로고    scopus 로고
    • Analysis of HIV-1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy
    • Brennan, T. P., et al. 2009. Analysis of HIV-1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy. J. Virol. 83:8470-8481.
    • (2009) J. Virol. , vol.83 , pp. 8470-8481
    • Brennan, T.P.1
  • 8
    • 1942503942 scopus 로고    scopus 로고
    • The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3
    • Cao, R., and Y. Zhang. 2004. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr. Opin. Genet. Dev. 14:155-164.
    • (2004) Curr. Opin. Genet. Dev. , vol.14 , pp. 155-164
    • Cao, R.1    Zhang, Y.2
  • 9
    • 79957912993 scopus 로고    scopus 로고
    • EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis
    • Cheng, A. S., et al. 2011. EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis. Cancer Res. 71:4028-4039.
    • (2011) Cancer Res. , vol.71 , pp. 4028-4039
    • Cheng, A.S.1
  • 10
    • 70349464819 scopus 로고    scopus 로고
    • p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1
    • Cherrier, T., et al. 2009. p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1. Oncogene 28:3380-3389.
    • (2009) Oncogene , vol.28 , pp. 3380-3389
    • Cherrier, T.1
  • 11
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    • Chomont, N., et al. 2009. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat. Med. 15:893-900.
    • (2009) Nat. Med. , vol.15 , pp. 893-900
    • Chomont, N.1
  • 12
    • 0032555117 scopus 로고    scopus 로고
    • Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection
    • Chun, T.-W., et al. 1998. Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection. Proc. Natl. Acad. Sci. U. S. A. 95:8869-8873.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 8869-8873
    • Chun, T.-W.1
  • 14
    • 27644524761 scopus 로고    scopus 로고
    • HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    • Chun, T. W., et al. 2005. HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J. Clin. Invest. 115:3250-3255.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3250-3255
    • Chun, T.W.1
  • 15
    • 36048945927 scopus 로고    scopus 로고
    • HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription
    • Contreras, X., M. Barboric, T. Lenasi, and B. M. Peterlin. 2007. HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription. PLoS Pathog. 3:1459-1469.
    • (2007) PLoS Pathog. , vol.3 , pp. 1459-1469
    • Contreras, X.1    Barboric, M.2    Lenasi, T.3    Peterlin, B.M.4
  • 16
    • 65449148344 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells
    • Contreras, X., et al. 2009. Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells. J. Biol. Chem. 284:6782-6789.
    • (2009) J. Biol. Chem. , vol.284 , pp. 6782-6789
    • Contreras, X.1
  • 17
    • 0033592967 scopus 로고    scopus 로고
    • HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
    • Davey, R. T., Jr., et al. 1999. HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. Proc. Natl. Acad. Sci. U. S. A. 96:15109-15114.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 15109-15114
    • Davey Jr., R.T.1
  • 18
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso, J. B., et al. 2009. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc. Natl. Acad. Sci. U. S. A. 106:9403-9408.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 9403-9408
    • Dinoso, J.B.1
  • 19
    • 33846506800 scopus 로고    scopus 로고
    • Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency
    • du Chene, I., et al. 2007. Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency. EMBO J. 26:424-435.
    • (2007) EMBO J. , vol.26 , pp. 424-435
    • du Chene, I.1
  • 20
    • 78751595020 scopus 로고    scopus 로고
    • Polycomb preferentially targets stalled promoters of coding and noncoding transcripts
    • Enderle, D., et al. 2011. Polycomb preferentially targets stalled promoters of coding and noncoding transcripts. Genome Res. 21:216-226.
    • (2011) Genome Res. , vol.21 , pp. 216-226
    • Enderle, D.1
  • 21
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi, D., et al. 1997. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278:1295-1300.
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1
  • 22
    • 70350494322 scopus 로고    scopus 로고
    • Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
    • Fiskus, W., et al. 2009. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood 114:2733-2743.
    • (2009) Blood , vol.114 , pp. 2733-2743
    • Fiskus, W.1
  • 24
    • 24344466882 scopus 로고    scopus 로고
    • DNA methylation and histone modifications: teaming up to silence genes
    • Fuks, F. 2005. DNA methylation and histone modifications: teaming up to silence genes. Curr. Opin. Genet. Dev. 15:490-495.
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , pp. 490-495
    • Fuks, F.1
  • 25
    • 30644474460 scopus 로고    scopus 로고
    • Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9
    • Greiner, D., T. Bonaldi, R. Eskeland, E. Roemer, and A. Imhof. 2005. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat. Chem. Biol. 1:143-145.
    • (2005) Nat. Chem. Biol. , vol.1 , pp. 143-145
    • Greiner, D.1    Bonaldi, T.2    Eskeland, R.3    Roemer, E.4    Imhof, A.5
  • 26
    • 77954688337 scopus 로고    scopus 로고
    • The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes
    • Gunther, T., and A. Grundhoff. 2010. The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes. PLoS Pathog. 6:e1000935.
    • (2010) PLoS Pathog. , vol.6
    • Gunther, T.1    Grundhoff, A.2
  • 28
    • 2642523580 scopus 로고    scopus 로고
    • Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes
    • Han, Y., et al. 2004. Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes. J. Virol. 78:6122-6133.
    • (2004) J. Virol. , vol.78 , pp. 6122-6133
    • Han, Y.1
  • 29
    • 48649085472 scopus 로고    scopus 로고
    • Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough
    • Han, Y., et al. 2008. Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. Cell Host Microbe 4:134-146.
    • (2008) Cell Host Microbe , vol.4 , pp. 134-146
    • Han, Y.1
  • 30
    • 77952767617 scopus 로고    scopus 로고
    • Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294
    • Imai, K., H. Togami, and T. Okamoto. 2010. Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294. J. Biol. Chem. 285:16538-16545.
    • (2010) J. Biol. Chem. , vol.285 , pp. 16538-16545
    • Imai, K.1    Togami, H.2    Okamoto, T.3
  • 31
    • 55949083820 scopus 로고    scopus 로고
    • HIV rebounds from latently infected cells, rather than from continuing low-level replication
    • Joos, B., et al. 2008. HIV rebounds from latently infected cells, rather than from continuing low-level replication. Proc. Natl. Acad. Sci. U. S. A. 105:16725-16730.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 16725-16730
    • Joos, B.1
  • 32
    • 0037446948 scopus 로고    scopus 로고
    • HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
    • Jordan, A., D. Bisgrove, and E. Verdin. 2003. HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J. 22:1868-1877.
    • (2003) EMBO J. , vol.22 , pp. 1868-1877
    • Jordan, A.1    Bisgrove, D.2    Verdin, E.3
  • 33
    • 78649807567 scopus 로고    scopus 로고
    • Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA
    • Kaneko, S., et al. 2010. Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev. 24:2615-2620.
    • (2010) Genes Dev. , vol.24 , pp. 2615-2620
    • Kaneko, S.1
  • 34
    • 77953107585 scopus 로고    scopus 로고
    • Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2
    • Kanhere, A., et al. 2010. Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol. Cell 38:675-688.
    • (2010) Mol. Cell , vol.38 , pp. 675-688
    • Kanhere, A.1
  • 35
    • 79954441735 scopus 로고    scopus 로고
    • The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit
    • Karn, J. 2011. The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit. Curr. Opin. HIV AIDS 6:4-11.
    • (2011) Curr. Opin. HIV AIDS , vol.6 , pp. 4-11
    • Karn, J.1
  • 37
    • 33747605357 scopus 로고    scopus 로고
    • Recruitment of TFIIH to the HIV LTR is a ratelimiting step in the emergence of HIV from latency
    • Kim, Y. K., et al. 2006. Recruitment of TFIIH to the HIV LTR is a ratelimiting step in the emergence of HIV from latency. EMBO J. 25:3596-3604.
    • (2006) EMBO J. , vol.25 , pp. 3596-3604
    • Kim, Y.K.1
  • 38
    • 79960342414 scopus 로고    scopus 로고
    • T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway
    • Kim, Y. K., U. Mbonye, J. Hokello, and J. Karn. 2011. T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway. J. Mol. Biol. 410:896-916.
    • (2011) J. Mol. Biol. , vol.410 , pp. 896-916
    • Kim, Y.K.1    Mbonye, U.2    Hokello, J.3    Karn, J.4
  • 39
    • 0030939152 scopus 로고    scopus 로고
    • The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells
    • Kinoshita, S., et al. 1997. The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells. Immunity 6:235-244.
    • (1997) Immunity , vol.6 , pp. 235-244
    • Kinoshita, S.1
  • 40
    • 0036532202 scopus 로고    scopus 로고
    • Histone methylation in transcriptional control
    • Kouzarides, T. 2002. Histone methylation in transcriptional control. Curr. Opin. Genet. Dev. 12:198-209.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 198-209
    • Kouzarides, T.1
  • 41
    • 24744462507 scopus 로고    scopus 로고
    • EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells
    • Koyanagi, M., et al. 2005. EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells. J. Biol. Chem. 280:31470-31477.
    • (2005) J. Biol. Chem. , vol.280 , pp. 31470-31477
    • Koyanagi, M.1
  • 42
    • 55449105221 scopus 로고    scopus 로고
    • Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
    • Ku, M., et al. 2008. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet. 4:e1000242.
    • (2008) PLoS Genet. , vol.4
    • Ku, M.1
  • 43
    • 0036337415 scopus 로고    scopus 로고
    • Direct and quantitative single-cell analysis of human immunodeficiency virus type 1 reactivation from latency
    • Kutsch, O., E. N. Benveniste, G. M. Shaw, and D. N. Levy. 2002. Direct and quantitative single-cell analysis of human immunodeficiency virus type 1 reactivation from latency. J. Virol. 76:8776-8786.
    • (2002) J. Virol. , vol.76 , pp. 8776-8786
    • Kutsch, O.1    Benveniste, E.N.2    Shaw, G.M.3    Levy, D.N.4
  • 44
    • 0037111831 scopus 로고    scopus 로고
    • Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
    • Kuzmichev, A., K. Nishioka, H. Erdjument-Bromage, P. Tempst, and D. Reinberg. 2002. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16:2893-2905.
    • (2002) Genes Dev. , vol.16 , pp. 2893-2905
    • Kuzmichev, A.1    Nishioka, K.2    Erdjument-Bromage, H.3    Tempst, P.4    Reinberg, D.5
  • 45
    • 67749137595 scopus 로고    scopus 로고
    • The polycomb group protein Bmi1 binds to the herpes simplex virus 1 latent genome and maintains repressive histone marks during latency
    • Kwiatkowski, D. L., H. W. Thompson, and D. C. Bloom. 2009. The polycomb group protein Bmi1 binds to the herpes simplex virus 1 latent genome and maintains repressive histone marks during latency. J. Virol. 83:8173-8181.
    • (2009) J. Virol. , vol.83 , pp. 8173-8181
    • Kwiatkowski, D.L.1    Thompson, H.W.2    Bloom, D.C.3
  • 46
    • 23744500093 scopus 로고    scopus 로고
    • Depletion of latent HIV-1 infection in vivo: a proof-of-concept study
    • Lehrman, G., et al. 2005. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet 366:549-555.
    • (2005) Lancet , vol.366 , pp. 549-555
    • Lehrman, G.1
  • 47
    • 48649089113 scopus 로고    scopus 로고
    • Transcriptional interference antagonizes proviral gene expression to promote HIV latency
    • Lenasi, T., X. Contreras, and B. M. Peterlin. 2008. Transcriptional interference antagonizes proviral gene expression to promote HIV latency. Cell Host Microbe 4:123-133.
    • (2008) Cell Host Microbe , vol.4 , pp. 123-133
    • Lenasi, T.1    Contreras, X.2    Peterlin, B.M.3
  • 48
    • 33745684269 scopus 로고    scopus 로고
    • Retroviral DNA integration: viral and cellular determinants of target-site selection
    • Lewinski, M. K., et al. 2006. Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog. 2:e60.
    • (2006) PLoS Pathog. , vol.2
    • Lewinski, M.K.1
  • 49
    • 76749083433 scopus 로고    scopus 로고
    • Jarid2 and PRC2, partners in regulating gene expression
    • Li, G., et al. 2010. Jarid2 and PRC2, partners in regulating gene expression. Genes Dev. 24:368-380.
    • (2010) Genes Dev. , vol.24 , pp. 368-380
    • Li, G.1
  • 50
    • 77649123174 scopus 로고    scopus 로고
    • Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway
    • Lu, F., W. Stedman, M. Yousef, R. Renne, and P. M. Lieberman. 2010. Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway. J. Virol. 84:2697-2706.
    • (2010) J. Virol. , vol.84 , pp. 2697-2706
    • Lu, F.1    Stedman, W.2    Yousef, M.3    Renne, R.4    Lieberman, P.M.5
  • 51
    • 0347624643 scopus 로고    scopus 로고
    • Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter
    • Lusic, M., A. Marcello, A. Cereseto, and M. Giacca. 2003. Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. EMBO J. 22:6550-6561.
    • (2003) EMBO J. , vol.22 , pp. 6550-6561
    • Lusic, M.1    Marcello, A.2    Cereseto, A.3    Giacca, M.4
  • 52
    • 33746021681 scopus 로고    scopus 로고
    • The SWI/SNF chromatin-remodeling complex is a cofactor for tat transactivation of the HIV promoter
    • Mahmoudi, T., et al. 2006. The SWI/SNF chromatin-remodeling complex is a cofactor for tat transactivation of the HIV promoter. J. Biol. Chem. 281:19960-19968.
    • (2006) J. Biol. Chem. , vol.281 , pp. 19960-19968
    • Mahmoudi, T.1
  • 53
    • 33846536395 scopus 로고    scopus 로고
    • Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing
    • Marban, C., et al. 2007. Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing. EMBO J. 26:412-423.
    • (2007) EMBO J. , vol.26 , pp. 412-423
    • Marban, C.1
  • 54
    • 77249123298 scopus 로고    scopus 로고
    • Mechanisms of HIV latency: an emerging picture of complexity
    • Margolis, D. M. 2010. Mechanisms of HIV latency: an emerging picture of complexity. Curr. HIV/AIDS Rep. 7:37-43.
    • (2010) Curr. HIV/AIDS Rep. , vol.7 , pp. 37-43
    • Margolis, D.M.1
  • 55
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • Margueron, R., and D. Reinberg. 2011. The Polycomb complex PRC2 and its mark in life. Nature 469:343-349.
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 56
    • 67649371461 scopus 로고    scopus 로고
    • DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
    • Miranda, T. B., et al. 2009. DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol. Cancer Ther. 8:1579-1588.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1579-1588
    • Miranda, T.B.1
  • 57
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini, L., et al. 1996. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263-267.
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1
  • 58
    • 0035891288 scopus 로고    scopus 로고
    • 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes
    • Nguyen, V. T., T. Kiss, A. A. Michels, and O. Bensaude. 2001. 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature 414:322-325.
    • (2001) Nature , vol.414 , pp. 322-325
    • Nguyen, V.T.1    Kiss, T.2    Michels, A.A.3    Bensaude, O.4
  • 59
    • 77949414371 scopus 로고    scopus 로고
    • JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
    • Pasini, D., et al. 2010. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464:306-310.
    • (2010) Nature , vol.464 , pp. 306-310
    • Pasini, D.1
  • 60
    • 57349090221 scopus 로고    scopus 로고
    • Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency
    • Pearson, R., et al. 2008. Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency. J. Virol. 82:12291-12303.
    • (2008) J. Virol. , vol.82 , pp. 12291-12303
    • Pearson, R.1
  • 61
    • 0035873747 scopus 로고    scopus 로고
    • Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation
    • Raaphorst, F. M., et al. 2001. Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation. J. Immunol. 166:5925-5934.
    • (2001) J. Immunol. , vol.166 , pp. 5925-5934
    • Raaphorst, F.M.1
  • 62
    • 62249095476 scopus 로고    scopus 로고
    • The challenge of finding a cure for HIV infection
    • Richman, D. D., et al. 2009. The challenge of finding a cure for HIV infection. Science 323:1304-1307.
    • (2009) Science , vol.323 , pp. 1304-1307
    • Richman, D.D.1
  • 63
    • 0036310641 scopus 로고    scopus 로고
    • Selective interactions between vertebrate Polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins
    • Sewalt, R. G., et al. 2002. Selective interactions between vertebrate Polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins. Mol. Cell. Biol. 22:5539-5553.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5539-5553
    • Sewalt, R.G.1
  • 64
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano, J. D., et al. 2003. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat. Med. 9:727-728.
    • (2003) Nat. Med. , vol.9 , pp. 727-728
    • Siliciano, J.D.1
  • 65
    • 73149085280 scopus 로고    scopus 로고
    • Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells
    • Sun, F., et al. 2009. Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells. Mol. Cancer Ther. 8:3191-3202.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 3191-3202
    • Sun, F.1
  • 66
    • 80052252127 scopus 로고    scopus 로고
    • Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes
    • 29 March [Epub ahead of print.]
    • Tae, S., et al. 29 March 2011. Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes. Nucleic Acids Res. [Epub ahead of print.]
    • (2011) Nucleic Acids Res.
    • Tae, S.1
  • 67
    • 77957673318 scopus 로고    scopus 로고
    • Epigenetic analysis of KSHV latent and lytic genomes
    • Toth, Z., et al. 2010. Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog. 6:e1001013.
    • (2010) PLoS Pathog. , vol.6
    • Toth, Z.1
  • 68
    • 34948839944 scopus 로고    scopus 로고
    • Facultative heterochromatin: is there a distinctive molecular signature? Mol
    • Trojer, P., and D. Reinberg. 2007. Facultative heterochromatin: is there a distinctive molecular signature? Mol. Cell 28:1-13.
    • (2007) Cell , vol.28 , pp. 1-13
    • Trojer, P.1    Reinberg, D.2
  • 69
    • 77954633050 scopus 로고    scopus 로고
    • HIV persistence and the prospect of long-term drugfree remissions for HIV-infected individuals
    • Trono, D., et al. 2010. HIV persistence and the prospect of long-term drugfree remissions for HIV-infected individuals. Science 329:174-180.
    • (2010) Science , vol.329 , pp. 174-180
    • Trono, D.1
  • 70
    • 77954572735 scopus 로고    scopus 로고
    • Long noncoding RNA as modular scaffold of histone modification complexes
    • Tsai, M. C., et al. 2010. Long noncoding RNA as modular scaffold of histone modification complexes. Science 329:689-693.
    • (2010) Science , vol.329 , pp. 689-693
    • Tsai, M.C.1
  • 71
    • 37149031062 scopus 로고    scopus 로고
    • CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency
    • Tyagi, M., and J. Karn. 2007. CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency. EMBO J. 26:4985-4995.
    • (2007) EMBO J. , vol.26 , pp. 4985-4995
    • Tyagi, M.1    Karn, J.2
  • 72
    • 77953313393 scopus 로고    scopus 로고
    • Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction
    • Tyagi, M., R. J. Pearson, and J. Karn. 2010. Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction. J. Virol. 84:6425-6437.
    • (2010) J. Virol. , vol.84 , pp. 6425-6437
    • Tyagi, M.1    Pearson, R.J.2    Karn, J.3
  • 73
    • 32844459336 scopus 로고    scopus 로고
    • The Polycomb group protein EZH2 directly controls DNA methylation
    • Vire, E., et al. 2006. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 439:871-874.
    • (2006) Nature , vol.439 , pp. 871-874
    • Vire, E.1
  • 74
    • 77954734865 scopus 로고    scopus 로고
    • Antiretroviral therapy and management of HIV infection
    • Volberding, P. A., and S. G. Deeks. 2010. Antiretroviral therapy and management of HIV infection. Lancet 376:49-62.
    • (2010) Lancet , vol.376 , pp. 49-62
    • Volberding, P.A.1    Deeks, S.G.2
  • 75
    • 30444431914 scopus 로고    scopus 로고
    • NF-ΚB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation
    • Williams, S. A., et al. 2006. NF-ΚB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J. 25:139-149.
    • (2006) EMBO J. , vol.25 , pp. 139-149
    • Williams, S.A.1
  • 76
    • 34249810678 scopus 로고    scopus 로고
    • Sustained induction of NF-ΚB is required for efficient expression of latent human immunodeficiency virus type 1
    • Williams, S. A., H. Kwon, L. F. Chen, and W. C. Greene. 2007. Sustained induction of NF-ΚB is required for efficient expression of latent human immunodeficiency virus type 1. J. Virol. 81:6043-6056.
    • (2007) J. Virol. , vol.81 , pp. 6043-6056
    • Williams, S.A.1    Kwon, H.2    Chen, L.F.3    Greene, W.C.4
  • 77
    • 75649134998 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma
    • Yamaguchi, J., et al. 2010. Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma. Cancer Sci. 101:355-362.
    • (2010) Cancer Sci. , vol.101 , pp. 355-362
    • Yamaguchi, J.1
  • 78
    • 0035891271 scopus 로고    scopus 로고
    • The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription
    • Yang, Z., Q. Zhu, K. Luo, and Q. Zhou. 2001. The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription. Nature 414:317-22.
    • (2001) Nature , vol.414 , pp. 317-22
    • Yang, Z.1    Zhu, Q.2    Luo, K.3    Zhou, Q.4
  • 79
    • 2942586974 scopus 로고    scopus 로고
    • Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression
    • Ylisastigui, L., N. M. Archin, G. Lehrman, R. J. Bosch, and D. M. Margolis. 2004. Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression. AIDS 18:1101-1108.
    • (2004) AIDS , vol.18 , pp. 1101-1108
    • Ylisastigui, L.1    Archin, N.M.2    Lehrman, G.3    Bosch, R.J.4    Margolis, D.M.5
  • 80
    • 10044266854 scopus 로고    scopus 로고
    • Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription
    • Zhou, M., et al. 2004. Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription. J. Virol. 78:13522-13533.
    • (2004) J. Virol. , vol.78 , pp. 13522-13533
    • Zhou, M.1


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