Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner

PLoS ONE

Volumn 5, Issue 6, 2010, Pages

  Mehla, Rajeev ^a   Bivalkar Mehla, Shalmali ^a   Zhang, Ruonan ^a   Handy, Indhira ^a   Albrecht, Helmut ^a   Giri, Shailendra ^b   Nagarkatti, Prakash ^a   Nagarkatti, Mitzi ^a   Chauhan, Ashok ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; BRYOSTATIN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; ROTTLERIN; ADENYLATE KINASE; BRYOSTATIN 1; PROTEIN KINASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; LATENT VIRUS INFECTION; LYMPHOCYTE; MONOCYTE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STRESS; T LYMPHOCYTE ACTIVATION; VIROGENESIS; VIRUS CELL INTERACTION; VIRUS LOAD; VIRUS REACTIVATION; CELL CULTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; PHYSIOLOGY; VIRUS LATENCY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADENYLATE KINASE; BRYOSTATINS; CELLS, CULTURED; HIV INFECTIONS; HIV-1; HUMANS; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; VIRUS LATENCY;

EID: 77955287402     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011160     Document Type: Article

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