The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

Nucleic Acids Research

Volumn 41, Issue 1, 2013, Pages 277-287

  Li, Zichong ^a   Guo, Jia ^b   Wu, Yuntao ^b   Zhou, Qiang ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GEORGE MASON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BET BROMODOMAIN INHIBITOR; ENZYME ACTIVATOR; JQ1; NUCLEAR PROTEIN; PROSTRATIN; PROTEIN BRD4; PROTEIN INHIBITOR; RNA POLYMERASE II; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG MECHANISM; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; LEUKEMIA CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION; TRANSACTIVATION; VIRUS LATENCY; VIRUS TRANSCRIPTION;

ANTI-HIV AGENTS; AZEPINES; CYCLIN-DEPENDENT KINASE 9; HELA CELLS; HIV; HUMANS; JURKAT CELLS; NUCLEAR PROTEINS; PHORBOL ESTERS; PHOSPHORYLATION; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROMOTER REGIONS, GENETIC; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA POLYMERASE II; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSCRIPTIONAL ELONGATION FACTORS; TRIAZOLES; VIRUS LATENCY;

EID: 84871725205     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks976     Document Type: Article

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