High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor

Journal of Biological Chemistry

Volumn 286, Issue 24, 2011, Pages 21083-21091

  Micheva Viteva, Sofiya ^a,c,d   Kobayashi, Yoshifumi ^a   Edelstein, Leonard C ^a   Pacchia, Annmarie L ^a,e   Lee, Hui Ling Rose ^a,c   Graci, Jason D ^b   Breslin, Jamie ^b   Phelan, Bradley D ^a,c   Miller, Leia K ^a,c   Colacino, Joseph M ^b   Gu, Zhengxian ^b   Ron, Yacov ^a,c   Peltz, Stuart W ^b   Dougherty, Joseph P ^a,c  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b PTC THERAPEUTICS   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d LOS ALAMOS NATIONAL LABORATORY   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRALS; CELL LINES; CELL-BASED; HIGH-THROUGHPUT; HIGH-THROUGHPUT SCREENING; HISTONE DEACETYLASES; MRNA EXPRESSION; NUCLEAR FACTOR OF ACTIVATED T-CELLS; PERSISTENT INFECTION; PHARMACOLOGICAL PROPERTIES; PROOF OF CONCEPT; SMALL MOLECULES; SYSTEM MODELING; T CELL PROLIFERATION; T CELLS; VIRAL CLEARANCE;

CELL CULTURE; CELL PROLIFERATION; RNA; THROUGHPUT;

CLONE CELLS;

ANTIVIRAL 6; ANTIVIRUS AGENT; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA; NUCLEAR FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CD4+ T LYMPHOCYTE; CELL LINE; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA STABILITY; VIRUS ACTIVATION; VIRUS LATENCY;

ANTI-RETROVIRAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, VIRAL; GENOME, VIRAL; HISTONE DEACETYLASE INHIBITORS; HIV-1; HUMANS; LENTIVIRUS; LYMPHOCYTE ACTIVATION; VIRUS INTEGRATION; VIRUS LATENCY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79958739925     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.195537     Document Type: Article

References (44)

1. Chun, T. W., Davey, R. T., Jr., Ostrowski, M., Shawn Justement, J., Engel, D., Mullins, J. I., and Fauci, A. S. (2000) Nat. Med. 6, 757-761
2. Davey, R. T., Jr., Bhat, N., Yoder, C., Chun, T. W., Metcalf, J. A., Dewar, R., Natarajan, V., Lempicki, R. A., Adelsberger, J. W., Miller, K. D., Kovacs, J. A., Polis, M. A., Walker, R. E., Falloon, J., Masur, H., Gee, D., Baseler, M., Dimitrov, D. S., Fauci, A. S., and Lane, H. C. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 15109-15114
3. Chun, T. W., Stuyver, L., Mizell, S. B., Ehler, L. A., Mican, J. A., Baseler, M., Lloyd, A. L., Nowak, M. A., and Fauci, A. S. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 13193-13197
4. Finzi, D., Hermankova, M., Pierson, T., Carruth, L. M., Buck, C., Chaisson, R. E., Quinn, T. C., Chadwick, K., Margolick, J., Brookmeyer, R., Gallant, J., Markowitz, M., Ho, D. D., Richman, D. D., and Siliciano, R. F. (1997) Science 278, 1295-1300
5. Fondere, J. M., Petitjean, G., Huguet, M. F., Salhi, S. L., Baillat, V., Macura-Biegun, A., Becquart, P., Reynes, J., and Vendrell, J. P. (2004) J. Virol. 78, 10536-10542
6. Chun, T. W., Engel, D., Mizell, S. B., Hallahan, C. W., Fischette, M., Park, S., Davey, R. T., Jr., Dybul, M., Kovacs, J. A., Metcalf, J. A., Mican, J. M., Berrey, M. M., Corey, L., Lane, H. C., and Fauci, A. S. (1999) Nat. Med. 5, 651-655
7. Dybul, M., Hidalgo, B., Chun, T. W., Belson, M., Migueles, S. A., Justement, J. S., Herpin, B., Perry, C., Hallahan, C. W., Davey, R. T., Metcalf, J. A., Connors, M., and Fauci, A. S. (2002) J. Infect. Dis. 185, 61-68
8. Prins, J. M., Jurriaans, S., van Praag, R. M., Blaak, H., van Rij, R., Schellekens, P. T., ten Berge, I. J., Yong, S. L., Fox, C. H., Roos, M. T., de Wolf, F., Goudsmit, J., Schuitemaker, H., and Lange, J. M. (1999) AIDS 13, 2405-2410
9. Stellbrink, H. J., van Lunzen, J., Westby, M., O'Sullivan, E., Schneider, C., Adam, A., Weitner, L., Kuhlmann, B., Hoffmann, C., Fenske, S., Aries, P. S., Degen, O., Eggers, C., Petersen, H., Haag, F., Horst, H. A., Dalhoff, K., Möcklinghoff, C., Cammack, N., Tenner-Racz, K., and Racz, P. (2002) AIDS 16, 1479-1487
10. van Praag, R. M., Prins, J. M., Roos, M. T., Schellekens, P. T., Ten Berge, I. J., Yong, S. L., Schuitemaker, H., Eerenberg, A. J., Jurriaans, S., de Wolf, F., Fox, C. H., Goudsmit, J., Miedema, F., and Lange, J. M. (2001) J. Clin. Immunol. 21, 218-226
11. Lehrman, G., Hogue, I. B., Palmer, S., Jennings, C., Spina, C. A., Wiegand, A., Landay, A. L., Coombs, R. W., Richman, D. D., Mellors, J. W., Coffin, J. M., Bosch, R. J., and Margolis, D. M. (2005) Lancet 366, 549-555
12. Siliciano, J. D., Lai, J., Callender, M., Pitt, E., Zhang, H., Margolick, J. B., Gallant, J. E., Cofrancesco, J., Jr., Moore, R. D., Gange, S. J., and Siliciano, R. F. (2007) J. Infect. Dis. 195, 833-836
13. Steel, A., Clark, S., Teo, I., Shaunak, S., Nelson, M., Gazzard, B., and Kelleher, P. (2006) AIDS 20, 1681-1682
14. Archin, N. M., Espeseth, A., Parker, D., Cheema, M., Hazuda, D., and Margolis, D. M. (2009) AIDS Res. Hum. Retroviruses 25, 207-212
15. Contreras, X., Schweneker, M., Chen, C. S., McCune, J. M., Deeks, S. G., Martin, J., and Peterlin, B. M. (2009) J. Biol. Chem. 284, 6782-6789
16. Edelstein, L. C., Micheva-Viteva, S., Phelan, B. D., and Dougherty, J. P. (2009) AIDS Res. Hum. Retroviruses 25, 883-887
17. Krishnan, V., and Zeichner, S. L. (2004) J. Virol. 78, 9458-9473
18. Brooks, D. G., Arlen, P. A., Gao, L., Kitchen, C. M., and Zack, J. A. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 12955-12960
19. Korin, Y. D., Brooks, D. G., Brown, S., Korotzer, A., and Zack, J. A. (2002) J. Virol. 76, 8118-8123
20. Rullas, J., Bermejo, M., García-Pérez, J., Beltán, M., González, N., Hezareh, M., Brown, S. J., and Alcamí, J. (2004) Antivir. Ther. 9, 545-554
21. Williams, S. A., Chen, L. F., Kwon, H., Fenard, D., Bisgrove, D., Verdin, E., and Greene, W. C. (2004) J. Biol. Chem. 279, 42008-42017
22. Greten, F. R., and Karin, M. (2004) Cancer Lett. 206, 193-199
23. Karin, M. (2006) Nature 441, 431-436
24. Pikarsky, E., Porat, R. M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., Gutkovich-Pyest, E., Urieli-Shoval, S., Galun, E., and Ben-Neriah, Y. (2004) Nature 431, 461-466
25. Kucharczak, J., Simmons, M. J., Fan, Y., and Gélinas, C. (2003) Oncogene 22, 8961-8982
26. Yang, H. C., Xing, S., Shan, L., O'Connell, K., Dinoso, J., Shen, A., Zhou, Y., Shrum, C. K., Han, Y., Liu, J. O., Zhang, H., Margolick, J. B., and Siliciano, R. F. (2009) J. Clin. Invest. 119, 3473-3486
27. Micheva-Viteva, S., Pacchia, A. L., Ron, Y., Peltz, S. W., and Dougherty, J. P. (2005) Antimicrob. Agents Chemother. 49, 5185-5188
28. Ahlberg, C. (1999) Drug Discov. Today 4, 370-376
29. Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., and Trono, D. (1996) Science 272, 263-267
30. Zhang, J. H., Chung, T. D., and Oldenburg, K. R. (1999) J. Biomol. Screen. 4, 67-73
31. Duh, E. J., Maury, W. J., Folks, T. M., Fauci, A. S., and Rabson, A. B. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 5974-5978
32. Agosto, L. M., Yu, J. J., Dai, J., Kaletsky, R., Monie, D., and O'Doherty, U. (2007) Virology 368, 60-72
33. Agosto, L. M., Yu, J. J., Liszewski, M. K., Baytop, C., Korokhov, N., Humeau, L. M., and O'Doherty, U. (2009) J. Virol. 83, 8153-8162
34. Swiggard, W. J., Baytop, C., Yu, J. J., Dai, J., Li, C., Schretzenmair, R., Theodosopoulos, T., and O'Doherty, U. (2005) J. Virol. 79, 14179-14188
35. Yu, D., Wang, W., Yoder, A., Spear, M., Wu, Y., and Farzan, M. (2009) PLoS Pathog. 5, e1000633-e1000633
36. Hermankova, M., Siliciano, J. D., Zhou, Y., Monie, D., Chadwick, K., Margolick, J. B., Quinn, T. C., and Siliciano, R. F. (2003) J. Virol. 77, 7383-7392
37. Williams, S. A., Kwon, H., Chen, L. F., and Greene, W. C. (2007) J. Virol. 81, 6043-6056
38. Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Lo Coco, F., Nervi, C., Pelicci, P. G., and Heinzel, T. (2001) EMBO J. 20, 6969-6978
39. Noguchi, H., Matsushita, M., Okitsu, T., Moriwaki, A., Tomizawa, K., Kang, S., Li, S. T., Kobayashi, N., Matsumoto, S., Tanaka, K., Tanaka, N., and Matsui, H. (2004) Nat. Med. 10, 305-309
40. Jain, J., McCaffrey, P. G., Miner, Z., Kerppola, T. K., Lambert, J. N., Verdine, G. L., Curran, T., and Rao, A. (1993) Nature 365, 352-355
41. Archin, N. M., Cheema, M., Parker, D., Wiegand, A., Bosch, R. J., Coffin, J. M., Eron, J., Cohen, M., and Margolis, D. M. (2010) PLoS ONE 5, e9390
42. Archin, N. M., Eron, J. J., Palmer, S., Hartmann-Duff, A., Martinson, J. A., Wiegand, A., Bandarenko, N., Schmitz, J. L., Bosch, R. J., Landay, A. L., Coffin, J. M., and Margolis, D. M. (2008) AIDS 22, 1131-1135
43. Ylisastigui, L., Archin, N. M., Lehrman, G., Bosch, R. J., and Margolis, D. M. (2004) AIDS 18, 1101-1108
44. Bosque, A., and Planelles, V. (2009) Blood 113, 58-65