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Volumn 8, Issue 9, 2013, Pages

Effects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in AβPPswe-PS1dE9 Mice

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID PRECURSOR PROTEIN; ASCORBIC ACID; CHOLESTEROL; CHOLINE; CYANOCOBALAMIN; DOCOSAHEXAENOIC ACID; FATTY ACID; FOLIC ACID; ICOSAPENTAENOIC ACID; INTERLEUKIN 1BETA; MESSENGER RNA; PHOSPHOLIPID; PRESENILIN 1; PYRIDOXINE; SELENIUM; URIDINE PHOSPHATE;

EID: 84884569843     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075393     Document Type: Article
Times cited : (39)

References (172)
  • 2
    • 0035950188 scopus 로고    scopus 로고
    • New frontiers in Alzheimer's disease genetics
    • Tanzi RE, Bertram L, (2001) New frontiers in Alzheimer's disease genetics. Neuron 32: 181-184.
    • (2001) Neuron , vol.32 , pp. 181-184
    • Tanzi, R.E.1    Bertram, L.2
  • 4
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • Mattson MP, (2004) Pathways towards and away from Alzheimer's disease. Nature 430: 631-639.
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 5
    • 0036447681 scopus 로고    scopus 로고
    • Vascular basis of Alzheimer's pathogenesis
    • de la Torre JC, (2002) Vascular basis of Alzheimer's pathogenesis. Ann N Y Acad Sci 977: 196-215.
    • (2002) Ann N Y Acad Sci , vol.977 , pp. 196-215
    • de la Torre, J.C.1
  • 6
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola C, (2004) Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 5: 347-360.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 7
    • 33749015483 scopus 로고    scopus 로고
    • Update on hypertension and Alzheimer's disease
    • Skoog I, Gustafson D, (2006) Update on hypertension and Alzheimer's disease. Neurol Res 28: 605-611.
    • (2006) Neurol Res , vol.28 , pp. 605-611
    • Skoog, I.1    Gustafson, D.2
  • 10
    • 34147119059 scopus 로고    scopus 로고
    • Metabolic syndrome and cognitive decline
    • Yaffe K, (2007) Metabolic syndrome and cognitive decline. Curr Alzheimer Res 4: 123-126.
    • (2007) Curr Alzheimer Res , vol.4 , pp. 123-126
    • Yaffe, K.1
  • 11
    • 67749114631 scopus 로고    scopus 로고
    • Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later
    • Solomon A, Kivipelto M, Wolozin B, Zhou J, Whitmer RA, (2009) Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later. Dement Geriatr Cogn Disord 28: 75-80.
    • (2009) Dement Geriatr Cogn Disord , vol.28 , pp. 75-80
    • Solomon, A.1    Kivipelto, M.2    Wolozin, B.3    Zhou, J.4    Whitmer, R.A.5
  • 12
    • 0041921105 scopus 로고    scopus 로고
    • Current treatments for Alzheimer's disease: cholinesterase inhibitors
    • Doody RS, (2003) Current treatments for Alzheimer's disease: cholinesterase inhibitors. J Clin Psychiatry 64Suppl 9: 11-17.
    • (2003) J Clin Psychiatry , vol.64 , pp. 11-17
    • Doody, R.S.1
  • 13
    • 0038115068 scopus 로고    scopus 로고
    • Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease
    • Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, et al. (2003) Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 60: 940-946.
    • (2003) Arch Neurol , vol.60 , pp. 940-946
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3    Tangney, C.C.4    Bennett, D.A.5
  • 14
    • 0030775948 scopus 로고    scopus 로고
    • Dietary fat intake and the risk of incident dementia in the Rotterdam Study
    • Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, et al. (1997) Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol 42: 776-782.
    • (1997) Ann Neurol , vol.42 , pp. 776-782
    • Kalmijn, S.1    Launer, L.J.2    Ott, A.3    Witteman, J.C.4    Hofman, A.5
  • 16
    • 34147100004 scopus 로고    scopus 로고
    • Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study
    • van Gelder BM, Tijhuis M, Kalmijn S, Kromhout D, (2007) Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. Am J Clin Nutr 85: 1142-1147.
    • (2007) Am J Clin Nutr , vol.85 , pp. 1142-1147
    • van Gelder, B.M.1    Tijhuis, M.2    Kalmijn, S.3    Kromhout, D.4
  • 18
  • 19
    • 0035183230 scopus 로고    scopus 로고
    • The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina
    • Lauritzen L, Hansen HS, Jorgensen MH, Michaelsen KF, (2001) The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 40: 1-94.
    • (2001) Prog Lipid Res , vol.40 , pp. 1-94
    • Lauritzen, L.1    Hansen, H.S.2    Jorgensen, M.H.3    Michaelsen, K.F.4
  • 20
    • 1842453667 scopus 로고    scopus 로고
    • Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function
    • Horrocks LA, Farooqui AA, (2004) Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. Prostaglandins Leukot Essent Fatty Acids 70: 361-372.
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 361-372
    • Horrocks, L.A.1    Farooqui, A.A.2
  • 21
    • 0036668195 scopus 로고    scopus 로고
    • Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials
    • Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR, Kok FJ, (2002) Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 20: 1493-1499.
    • (2002) J Hypertens , vol.20 , pp. 1493-1499
    • Geleijnse, J.M.1    Giltay, E.J.2    Grobbee, D.E.3    Donders, A.R.4    Kok, F.J.5
  • 22
    • 0030991110 scopus 로고    scopus 로고
    • n-3 fatty acids and serum lipoproteins: animal studies
    • Harris WS, (1997) n-3 fatty acids and serum lipoproteins: animal studies. Am J Clin Nutr 65: 1611S-1616S.
    • (1997) Am J Clin Nutr , vol.65
    • Harris, W.S.1
  • 23
    • 0037203476 scopus 로고    scopus 로고
    • Randomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease
    • Sacks FM, Katan M, (2002) Randomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease. Am J Med 113Suppl 9B: 13S-24S.
    • (2002) Am J Med , vol.113
    • Sacks, F.M.1    Katan, M.2
  • 24
    • 0037534877 scopus 로고    scopus 로고
    • Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils
    • Leaf A, Kang JX, Xiao YF, Billman GE, (2003) Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation 107: 2646-2652.
    • (2003) Circulation , vol.107 , pp. 2646-2652
    • Leaf, A.1    Kang, J.X.2    Xiao, Y.F.3    Billman, G.E.4
  • 25
    • 0030974010 scopus 로고    scopus 로고
    • n-3 fatty acids and serum lipoproteins: human studies
    • Harris WS, (1997) n-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr 65: 1645S-1654S.
    • (1997) Am J Clin Nutr , vol.65
    • Harris, W.S.1
  • 26
    • 0034006247 scopus 로고    scopus 로고
    • Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia
    • Goodfellow J, Bellamy MF, Ramsey MW, Jones CJ, Lewis MJ, (2000) Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia. J Am Coll Cardiol 35: 265-270.
    • (2000) J Am Coll Cardiol , vol.35 , pp. 265-270
    • Goodfellow, J.1    Bellamy, M.F.2    Ramsey, M.W.3    Jones, C.J.4    Lewis, M.J.5
  • 27
    • 19944432640 scopus 로고    scopus 로고
    • Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: the INTERLIPID study
    • Okuda N, Ueshima H, Okayama A, Saitoh S, Nakagawa H, et al. (2005) Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: the INTERLIPID study. Atherosclerosis 178: 371-379.
    • (2005) Atherosclerosis , vol.178 , pp. 371-379
    • Okuda, N.1    Ueshima, H.2    Okayama, A.3    Saitoh, S.4    Nakagawa, H.5
  • 28
    • 0035160023 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids, inflammation, and immunity
    • Calder PC, (2001) Polyunsaturated fatty acids, inflammation, and immunity. Lipids 36: 1007-1024.
    • (2001) Lipids , vol.36 , pp. 1007-1024
    • Calder, P.C.1
  • 29
    • 0034612313 scopus 로고    scopus 로고
    • Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates
    • Farkas T, Kitajka K, Fodor E, Csengeri I, Lahdes E, et al. (2000) Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates. Proc Natl Acad Sci U S A 97: 6362-6366.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6362-6366
    • Farkas, T.1    Kitajka, K.2    Fodor, E.3    Csengeri, I.4    Lahdes, E.5
  • 30
    • 0037022628 scopus 로고    scopus 로고
    • The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids
    • Kitajka K, Puskas LG, Zvara A, Hackler L Jr, Barcelo-Coblijn G, et al. (2002) The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. Proc Natl Acad Sci U S A 99: 2619-2624.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 2619-2624
    • Kitajka, K.1    Puskas, L.G.2    Zvara, A.3    Hackler Jr., L.4    Barcelo-Coblijn, G.5
  • 31
    • 0141593609 scopus 로고    scopus 로고
    • Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids
    • Barcelo-Coblijn G, Hogyes E, Kitajka K, Puskas LG, Zvara A, et al. (2003) Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids. Proc Natl Acad Sci U S A 100: 11321-11326.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11321-11326
    • Barcelo-Coblijn, G.1    Hogyes, E.2    Kitajka, K.3    Puskas, L.G.4    Zvara, A.5
  • 32
    • 0024788867 scopus 로고
    • The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats
    • Bourre JM, Francois M, Youyou A, Dumont O, Piciotti M, et al. (1989) The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. J Nutr 119: 1880-1892.
    • (1989) J Nutr , vol.119 , pp. 1880-1892
    • Bourre, J.M.1    Francois, M.2    Youyou, A.3    Dumont, O.4    Piciotti, M.5
  • 33
    • 27844525844 scopus 로고    scopus 로고
    • Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects
    • Fontani G, Corradeschi F, Felici A, Alfatti F, Migliorini S, et al. (2005) Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur J Clin Invest 35: 691-699.
    • (2005) Eur J Clin Invest , vol.35 , pp. 691-699
    • Fontani, G.1    Corradeschi, F.2    Felici, A.3    Alfatti, F.4    Migliorini, S.5
  • 34
    • 0032189767 scopus 로고    scopus 로고
    • Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits
    • Joseph JA, Shukitt-Hale B, Denisova NA, Prior RL, Cao G, et al. (1998) Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J Neurosci 18: 8047-8055.
    • (1998) J Neurosci , vol.18 , pp. 8047-8055
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3    Prior, R.L.4    Cao, G.5
  • 36
    • 0032898672 scopus 로고    scopus 로고
    • Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo
    • Yamada K, Tanaka T, Han D, Senzaki K, Kameyama T, et al. (1999) Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. Eur J Neurosci 11: 83-90.
    • (1999) Eur J Neurosci , vol.11 , pp. 83-90
    • Yamada, K.1    Tanaka, T.2    Han, D.3    Senzaki, K.4    Kameyama, T.5
  • 37
    • 0030250825 scopus 로고    scopus 로고
    • Effect of vitamin B complex on neurotransmission and neurite outgrowth
    • Fujii A, Matsumoto H, Yamamoto H, (1996) Effect of vitamin B complex on neurotransmission and neurite outgrowth. Gen Pharmacol 27: 995-1000.
    • (1996) Gen Pharmacol , vol.27 , pp. 995-1000
    • Fujii, A.1    Matsumoto, H.2    Yamamoto, H.3
  • 38
    • 33646096230 scopus 로고    scopus 로고
    • Evidence for growth-promoting effects of omega n - 3 fatty acids alone and in combination with a specific vitamin and mineral complex in rat neuroblastoma cells
    • Shrivastava R, Vincent B, Gobron S, Cucuat N, John GW, (2005) Evidence for growth-promoting effects of omega n- 3 fatty acids alone and in combination with a specific vitamin and mineral complex in rat neuroblastoma cells. Nutr Neurosci 8: 317-321.
    • (2005) Nutr Neurosci , vol.8 , pp. 317-321
    • Shrivastava, R.1    Vincent, B.2    Gobron, S.3    Cucuat, N.4    John, G.W.5
  • 39
    • 47749114025 scopus 로고    scopus 로고
    • The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study
    • Chiu CC, Su KP, Cheng TC, Liu HC, Chang CJ, et al. (2008) The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study. Prog Neuropsychopharmacol Biol Psychiatry 32: 1538-1544.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 1538-1544
    • Chiu, C.C.1    Su, K.P.2    Cheng, T.C.3    Liu, H.C.4    Chang, C.J.5
  • 43
    • 77953809951 scopus 로고    scopus 로고
    • More than the sum of its parts? Nutrition in Alzheimer's disease
    • von Arnim CA, Gola U, Biesalski HK, (2010) More than the sum of its parts? Nutrition in Alzheimer's disease. Nutrition 26: 694-700.
    • (2010) Nutrition , vol.26 , pp. 694-700
    • von Arnim, C.A.1    Gola, U.2    Biesalski, H.K.3
  • 44
    • 43249095375 scopus 로고    scopus 로고
    • Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats
    • Holguin S, Huang Y, Liu J, Wurtman R, (2008) Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats. Behav Brain Res 191: 11-16.
    • (2008) Behav Brain Res , vol.191 , pp. 11-16
    • Holguin, S.1    Huang, Y.2    Liu, J.3    Wurtman, R.4
  • 45
    • 55549148744 scopus 로고    scopus 로고
    • Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils
    • Holguin S, Martinez J, Chow C, Wurtman R, (2008) Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils. Faseb J 22: 3938-3946.
    • (2008) Faseb J , vol.22 , pp. 3938-3946
    • Holguin, S.1    Martinez, J.2    Chow, C.3    Wurtman, R.4
  • 46
    • 1842610448 scopus 로고    scopus 로고
    • Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation
    • Kavanagh T, Lonergan PE, Lynch MA, (2004) Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation. Prostaglandins Leukot Essent Fatty Acids 70: 391-397.
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 391-397
    • Kavanagh, T.1    Lonergan, P.E.2    Lynch, M.A.3
  • 47
    • 84872440907 scopus 로고    scopus 로고
    • A specific multi-nutrient diet reduces Alzheimer-like pathology in young adult AbetaPPswe/PS1dE9 mice
    • Broersen LM, Kuipers AA, Balvers M, van Wijk N, Savelkoul PJ, et al. (2013) A specific multi-nutrient diet reduces Alzheimer-like pathology in young adult AbetaPPswe/PS1dE9 mice. J Alzheimers Dis 33: 177-190.
    • (2013) J Alzheimers Dis , vol.33 , pp. 177-190
    • Broersen, L.M.1    Kuipers, A.A.2    Balvers, M.3    van Wijk, N.4    Savelkoul, P.J.5
  • 48
    • 84855963869 scopus 로고    scopus 로고
    • A specific multi-nutrient formulation enhances M1 muscarinic acetylcholine receptor responses in vitro
    • Savelkoul PJ, Janickova H, Kuipers AA, Hageman RJ, Kamphuis PJ, et al. (2012) A specific multi-nutrient formulation enhances M1 muscarinic acetylcholine receptor responses in vitro. J Neurochem 120: 631-640.
    • (2012) J Neurochem , vol.120 , pp. 631-640
    • Savelkoul, P.J.1    Janickova, H.2    Kuipers, A.A.3    Hageman, R.J.4    Kamphuis, P.J.5
  • 49
    • 51649100533 scopus 로고    scopus 로고
    • Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents
    • Wurtman RJ, (2008) Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents. Metabolism 57Suppl 2: S6-10.
    • (2008) Metabolism , vol.57 , pp. 6-10
    • Wurtman, R.J.1
  • 50
    • 33646592555 scopus 로고    scopus 로고
    • Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally
    • Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L, et al. (2006) Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res 1088: 83-92.
    • (2006) Brain Res , vol.1088 , pp. 83-92
    • Wurtman, R.J.1    Ulus, I.H.2    Cansev, M.3    Watkins, C.J.4    Wang, L.5
  • 52
    • 84856294228 scopus 로고    scopus 로고
    • Efficacy of a medical food on cognition in Alzheimer's disease: results from secondary analyses of a randomized, controlled trial
    • Kamphuis PJ, Verhey FR, Olde Rikkert MG, Twisk JW, Swinkels SH, et al. (2011) Efficacy of a medical food on cognition in Alzheimer's disease: results from secondary analyses of a randomized, controlled trial. J Nutr Health Aging 15: 720-724.
    • (2011) J Nutr Health Aging , vol.15 , pp. 720-724
    • Kamphuis, P.J.1    Verhey, F.R.2    Olde Rikkert, M.G.3    Twisk, J.W.4    Swinkels, S.H.5
  • 53
    • 84863946102 scopus 로고    scopus 로고
    • Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial
    • Scheltens P, Twisk JW, Blesa R, Scarpini E, von Arnim CA, et al. (2012) Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial. J Alzheimers Dis 31: 225-236.
    • (2012) J Alzheimers Dis , vol.31 , pp. 225-236
    • Scheltens, P.1    Twisk, J.W.2    Blesa, R.3    Scarpini, E.4    von Arnim, C.A.5
  • 55
    • 1642555780 scopus 로고    scopus 로고
    • Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase
    • Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, et al. (2004) Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 13: 159-170.
    • (2004) Hum Mol Genet , vol.13 , pp. 159-170
    • Jankowsky, J.L.1    Fadale, D.J.2    Anderson, J.3    Xu, G.M.4    Gonzales, V.5
  • 56
    • 0000749205 scopus 로고
    • The function of cytidine coenzymes in the biosynthesis of phospholipides
    • Kennedy EP, Weiss SB, (1956) The function of cytidine coenzymes in the biosynthesis of phospholipides. J Biol Chem 222: 193-214.
    • (1956) J Biol Chem , vol.222 , pp. 193-214
    • Kennedy, E.P.1    Weiss, S.B.2
  • 57
    • 11444261073 scopus 로고    scopus 로고
    • Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit
    • Streijger F, Oerlemans F, Ellenbroek BA, Jost CR, Wieringa B, et al. (2005) Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit. Behav Brain Res 157: 219-234.
    • (2005) Behav Brain Res , vol.157 , pp. 219-234
    • Streijger, F.1    Oerlemans, F.2    Ellenbroek, B.A.3    Jost, C.R.4    Wieringa, B.5
  • 58
    • 61549097218 scopus 로고    scopus 로고
    • DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice
    • Hooijmans CR, Van der Zee CE, Dederen PJ, Brouwer KM, Reijmer YD, et al. (2009) DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. Neurobiol Dis 33: 482-498.
    • (2009) Neurobiol Dis , vol.33 , pp. 482-498
    • Hooijmans, C.R.1    Van der Zee, C.E.2    Dederen, P.J.3    Brouwer, K.M.4    Reijmer, Y.D.5
  • 59
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R, (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11: 47-60.
    • (1984) J Neurosci Methods , vol.11 , pp. 47-60
    • Morris, R.1
  • 60
    • 0028363247 scopus 로고
    • A behavioural analysis of rats with damage to the medial prefrontal cortex using the Morris water maze: evidence for behavioural flexibility, but not for impaired spatial navigation
    • de Bruin JP, Sanchez-Santed F, Heinsbroek RP, Donker A, Postmes P, (1994) A behavioural analysis of rats with damage to the medial prefrontal cortex using the Morris water maze: evidence for behavioural flexibility, but not for impaired spatial navigation. Brain Res 652: 323-333.
    • (1994) Brain Res , vol.652 , pp. 323-333
    • de Bruin, J.P.1    Sanchez-Santed, F.2    Heinsbroek, R.P.3    Donker, A.4    Postmes, P.5
  • 62
    • 0034099574 scopus 로고    scopus 로고
    • Proton NMR chemical shifts and coupling constants for brain metabolites
    • Govindaraju V, Young K, Maudsley AA, (2000) Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed 13: 129-153.
    • (2000) NMR Biomed , vol.13 , pp. 129-153
    • Govindaraju, V.1    Young, K.2    Maudsley, A.A.3
  • 63
    • 0033153135 scopus 로고    scopus 로고
    • Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons
    • Francis F, Koulakoff A, Boucher D, Chafey P, Schaar B, et al. (1999) Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons. Neuron 23: 247-256.
    • (1999) Neuron , vol.23 , pp. 247-256
    • Francis, F.1    Koulakoff, A.2    Boucher, D.3    Chafey, P.4    Schaar, B.5
  • 64
    • 0033152450 scopus 로고    scopus 로고
    • Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons
    • Gleeson JG, Lin PT, Flanagan LA, Walsh CA, (1999) Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron 23: 257-271.
    • (1999) Neuron , vol.23 , pp. 257-271
    • Gleeson, J.G.1    Lin, P.T.2    Flanagan, L.A.3    Walsh, C.A.4
  • 66
    • 33644781781 scopus 로고    scopus 로고
    • Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin
    • Thelen KM, Rentsch KM, Gutteck U, Heverin M, Olin M, et al. (2006) Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin. J Pharmacol Exp Ther 316: 1146-1152.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 1146-1152
    • Thelen, K.M.1    Rentsch, K.M.2    Gutteck, U.3    Heverin, M.4    Olin, M.5
  • 67
    • 0036314309 scopus 로고    scopus 로고
    • Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain
    • Lutjohann D, Brzezinka A, Barth E, Abramowski D, Staufenbiel M, et al. (2002) Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. J Lipid Res 43: 1078-1085.
    • (2002) J Lipid Res , vol.43 , pp. 1078-1085
    • Lutjohann, D.1    Brzezinka, A.2    Barth, E.3    Abramowski, D.4    Staufenbiel, M.5
  • 68
    • 3042640736 scopus 로고    scopus 로고
    • High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs
    • Lutjohann D, Stroick M, Bertsch T, Kuhl S, Lindenthal B, et al. (2004) High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs. Steroids 69: 431-438.
    • (2004) Steroids , vol.69 , pp. 431-438
    • Lutjohann, D.1    Stroick, M.2    Bertsch, T.3    Kuhl, S.4    Lindenthal, B.5
  • 69
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen TD, Livak KJ, (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101-1108.
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 70
    • 0028299741 scopus 로고
    • Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions
    • Simon P, Dupuis R, Costentin J, (1994) Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions. Behav Brain Res 61: 59-64.
    • (1994) Behav Brain Res , vol.61 , pp. 59-64
    • Simon, P.1    Dupuis, R.2    Costentin, J.3
  • 71
    • 20444435798 scopus 로고    scopus 로고
    • Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease
    • Ackl N, Ising M, Schreiber YA, Atiya M, Sonntag A, et al. (2005) Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease. Neurosci Lett 384: 23-28.
    • (2005) Neurosci Lett , vol.384 , pp. 23-28
    • Ackl, N.1    Ising, M.2    Schreiber, Y.A.3    Atiya, M.4    Sonntag, A.5
  • 73
    • 33751096969 scopus 로고    scopus 로고
    • Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain
    • Bjorkhem I, (2006) Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. J Intern Med 260: 493-508.
    • (2006) J Intern Med , vol.260 , pp. 493-508
    • Bjorkhem, I.1
  • 74
    • 0842303768 scopus 로고    scopus 로고
    • Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
    • Heverin M, Bogdanovic N, Lutjohann D, Bayer T, Pikuleva I, et al. (2004) Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. J Lipid Res 45: 186-193.
    • (2004) J Lipid Res , vol.45 , pp. 186-193
    • Heverin, M.1    Bogdanovic, N.2    Lutjohann, D.3    Bayer, T.4    Pikuleva, I.5
  • 75
    • 23744498856 scopus 로고    scopus 로고
    • Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain
    • Heverin M, Meaney S, Lutjohann D, Diczfalusy U, Wahren J, et al. (2005) Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain. J Lipid Res 46: 1047-1052.
    • (2005) J Lipid Res , vol.46 , pp. 1047-1052
    • Heverin, M.1    Meaney, S.2    Lutjohann, D.3    Diczfalusy, U.4    Wahren, J.5
  • 76
    • 84878050249 scopus 로고    scopus 로고
    • A Longitudinal Study of Cognition, Proton MR Spectroscopy and Synaptic and Neuronal Pathology in Aging Wild-type and AbetaPPswe-PS1dE9 Mice
    • Jansen D, Zerbi V, Janssen CI, Dederen PJ, Mutsaers MP, et al. (2013) A Longitudinal Study of Cognition, Proton MR Spectroscopy and Synaptic and Neuronal Pathology in Aging Wild-type and AbetaPPswe-PS1dE9 Mice. PLoS One 8: e63643.
    • (2013) PLoS One , vol.8
    • Jansen, D.1    Zerbi, V.2    Janssen, C.I.3    Dederen, P.J.4    Mutsaers, M.P.5
  • 77
    • 84858710947 scopus 로고    scopus 로고
    • APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD)
    • Lalonde R, Fukuchi K, Strazielle C, (2012) APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD). Neurosci Biobehav Rev 36: 1357-1375.
    • (2012) Neurosci Biobehav Rev , vol.36 , pp. 1357-1375
    • Lalonde, R.1    Fukuchi, K.2    Strazielle, C.3
  • 78
    • 26244453388 scopus 로고    scopus 로고
    • Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques
    • Lalonde R, Kim HD, Maxwell JA, Fukuchi K, (2005) Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques. Neurosci Lett 390: 87-92.
    • (2005) Neurosci Lett , vol.390 , pp. 87-92
    • Lalonde, R.1    Kim, H.D.2    Maxwell, J.A.3    Fukuchi, K.4
  • 79
    • 4644335036 scopus 로고    scopus 로고
    • Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 mice
    • Lalonde R, Kim HD, Fukuchi K, (2004) Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 mice. Neurosci Lett 369: 156-161.
    • (2004) Neurosci Lett , vol.369 , pp. 156-161
    • Lalonde, R.1    Kim, H.D.2    Fukuchi, K.3
  • 80
    • 0036235633 scopus 로고    scopus 로고
    • Hippocampal A beta 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice
    • Puolivali J, Wang J, Heikkinen T, Heikkila M, Tapiola T, et al. (2002) Hippocampal A beta 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice. Neurobiol Dis 9: 339-347.
    • (2002) Neurobiol Dis , vol.9 , pp. 339-347
    • Puolivali, J.1    Wang, J.2    Heikkinen, T.3    Heikkila, M.4    Tapiola, T.5
  • 81
    • 33846967462 scopus 로고    scopus 로고
    • Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease
    • Pugh PL, Richardson JC, Bate ST, Upton N, Sunter D, (2007) Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease. Behav Brain Res 178: 18-28.
    • (2007) Behav Brain Res , vol.178 , pp. 18-28
    • Pugh, P.L.1    Richardson, J.C.2    Bate, S.T.3    Upton, N.4    Sunter, D.5
  • 82
    • 0041419839 scopus 로고    scopus 로고
    • Diagnosis and treatment of Alzheimer's disease
    • Grossberg GT, (2003) Diagnosis and treatment of Alzheimer's disease. J Clin Psychiatry 64Suppl 9: 3-6.
    • (2003) J Clin Psychiatry , vol.64 , pp. 3-6
    • Grossberg, G.T.1
  • 85
    • 82855172158 scopus 로고    scopus 로고
    • Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood
    • Bhatia HS, Agrawal R, Sharma S, Huo YX, Ying Z, et al. (2011) Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood. PLoS One 6: e28451.
    • (2011) PLoS One , vol.6
    • Bhatia, H.S.1    Agrawal, R.2    Sharma, S.3    Huo, Y.X.4    Ying, Z.5
  • 86
    • 0037458524 scopus 로고    scopus 로고
    • Possible regulatory mechanism of DHA-induced anti-stress reaction in rats
    • Takeuchi T, Iwanaga M, Harada E, (2003) Possible regulatory mechanism of DHA-induced anti-stress reaction in rats. Brain Res 964: 136-143.
    • (2003) Brain Res , vol.964 , pp. 136-143
    • Takeuchi, T.1    Iwanaga, M.2    Harada, E.3
  • 88
    • 0036122486 scopus 로고    scopus 로고
    • Docosahexaenoic acid-rich phospholipid supplementation: effect on behavior, learning ability, and retinal function in control and n-3 polyunsaturated fatty acid deficient old mice
    • Carrie I, Smirnova M, Clement M, De JD, Frances H, et al. (2002) Docosahexaenoic acid-rich phospholipid supplementation: effect on behavior, learning ability, and retinal function in control and n-3 polyunsaturated fatty acid deficient old mice. Nutr Neurosci 5: 43-52.
    • (2002) Nutr Neurosci , vol.5 , pp. 43-52
    • Carrie, I.1    Smirnova, M.2    Clement, M.3    De, J.D.4    Frances, H.5
  • 90
    • 39749095115 scopus 로고    scopus 로고
    • Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms
    • Freund-Levi Y, Basun H, Cederholm T, Faxen-Irving G, Garlind A, et al. (2008) Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms. Int J Geriatr Psychiatry 23: 161-169.
    • (2008) Int J Geriatr Psychiatry , vol.23 , pp. 161-169
    • Freund-Levi, Y.1    Basun, H.2    Cederholm, T.3    Faxen-Irving, G.4    Garlind, A.5
  • 91
    • 79960700818 scopus 로고    scopus 로고
    • A mixed polyunsaturated fatty acid diet normalizes hippocampal neurogenesis and reduces anxiety in serotonin transporter knockout rats
    • Schipper P, Kiliaan AJ, Homberg JR, (2011) A mixed polyunsaturated fatty acid diet normalizes hippocampal neurogenesis and reduces anxiety in serotonin transporter knockout rats. Behav Pharmacol 22: 324-334.
    • (2011) Behav Pharmacol , vol.22 , pp. 324-334
    • Schipper, P.1    Kiliaan, A.J.2    Homberg, J.R.3
  • 92
    • 85027951281 scopus 로고    scopus 로고
    • Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice
    • Jansen D, Zerbi V, Janssen CI, van Rooij D, Zinnhardt B, et al. (2013) Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice. Brain Struct Funct. doi:10.1007/s00429-013-0606-7.
    • (2013) Brain Struct Funct
    • Jansen, D.1    Zerbi, V.2    Janssen, C.I.3    van Rooij, D.4    Zinnhardt, B.5
  • 93
    • 65549133778 scopus 로고    scopus 로고
    • Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies
    • Garthe A, Behr J, Kempermann G, (2009) Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies. PLoS One 4: e5464.
    • (2009) PLoS One , vol.4
    • Garthe, A.1    Behr, J.2    Kempermann, G.3
  • 94
    • 30444454374 scopus 로고    scopus 로고
    • Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury
    • Brody DL, Holtzman DM, (2006) Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury. Exp Neurol 197: 330-340.
    • (2006) Exp Neurol , vol.197 , pp. 330-340
    • Brody, D.L.1    Holtzman, D.M.2
  • 95
    • 64849099564 scopus 로고    scopus 로고
    • Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease
    • O′Leary TP, Brown RE, (2009) Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. Behav Brain Res 201: 120-127.
    • (2009) Behav Brain Res , vol.201 , pp. 120-127
    • OLeary, T.P.1    Brown, R.E.2
  • 96
    • 17644412057 scopus 로고    scopus 로고
    • Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease
    • Lovasic L, Bauschke H, Janus C, (2005) Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease. Genes Brain Behav 4: 197-208.
    • (2005) Genes Brain Behav , vol.4 , pp. 197-208
    • Lovasic, L.1    Bauschke, H.2    Janus, C.3
  • 97
    • 2542622162 scopus 로고    scopus 로고
    • Search strategies used by APP transgenic mice during navigation in the Morris water maze
    • Janus C, (2004) Search strategies used by APP transgenic mice during navigation in the Morris water maze. Learn Mem 11: 337-346.
    • (2004) Learn Mem , vol.11 , pp. 337-346
    • Janus, C.1
  • 98
    • 37349128902 scopus 로고    scopus 로고
    • Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic mice
    • Taniuchi N, Niidome T, Goto Y, Akaike A, Kihara T, et al. (2007) Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic mice. Neuroreport 18: 1801-1805.
    • (2007) Neuroreport , vol.18 , pp. 1801-1805
    • Taniuchi, N.1    Niidome, T.2    Goto, Y.3    Akaike, A.4    Kihara, T.5
  • 99
    • 54049102941 scopus 로고    scopus 로고
    • Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice
    • Niidome T, Taniuchi N, Akaike A, Kihara T, Sugimoto H, (2008) Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice. Neuroreport 19: 1361-1364.
    • (2008) Neuroreport , vol.19 , pp. 1361-1364
    • Niidome, T.1    Taniuchi, N.2    Akaike, A.3    Kihara, T.4    Sugimoto, H.5
  • 100
    • 84859429769 scopus 로고    scopus 로고
    • The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease
    • Hamilton A, Holscher C, (2012) The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease. Brain Res 1449: 83-93.
    • (2012) Brain Res , vol.1449 , pp. 83-93
    • Hamilton, A.1    Holscher, C.2
  • 102
    • 77952543738 scopus 로고    scopus 로고
    • Neurogenesis and Alzheimer's disease: at the crossroads
    • Lazarov O, Marr RA, (2010) Neurogenesis and Alzheimer's disease: at the crossroads. Exp Neurol 223: 267-281.
    • (2010) Exp Neurol , vol.223 , pp. 267-281
    • Lazarov, O.1    Marr, R.A.2
  • 103
    • 0034700480 scopus 로고    scopus 로고
    • A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease
    • Chen G, Chen KS, Knox J, Inglis J, Bernard A, et al. (2000) A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature 408: 975-979.
    • (2000) Nature , vol.408 , pp. 975-979
    • Chen, G.1    Chen, K.S.2    Knox, J.3    Inglis, J.4    Bernard, A.5
  • 104
    • 0028848661 scopus 로고
    • Cognitive test performance in detecting, staging, and tracking Alzheimer's disease
    • Locascio JJ, Growdon JH, Corkin S, (1995) Cognitive test performance in detecting, staging, and tracking Alzheimer's disease. Arch Neurol 52: 1087-1099.
    • (1995) Arch Neurol , vol.52 , pp. 1087-1099
    • Locascio, J.J.1    Growdon, J.H.2    Corkin, S.3
  • 106
    • 0026023082 scopus 로고
    • Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures
    • Welsh K, Butters N, Hughes J, Mohs R, Heyman A, (1991) Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures. Arch Neurol 48: 278-281.
    • (1991) Arch Neurol , vol.48 , pp. 278-281
    • Welsh, K.1    Butters, N.2    Hughes, J.3    Mohs, R.4    Heyman, A.5
  • 107
    • 33846461062 scopus 로고    scopus 로고
    • Morris water maze: procedures for assessing spatial and related forms of learning and memory
    • Vorhees CV, Williams MT, (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1: 848-858.
    • (2006) Nat Protoc , vol.1 , pp. 848-858
    • Vorhees, C.V.1    Williams, M.T.2
  • 108
    • 32644474211 scopus 로고    scopus 로고
    • Effect of Morris water maze diameter on visual-spatial learning in different mouse strains
    • Van Dam D, Lenders G, De Deyn PP, (2006) Effect of Morris water maze diameter on visual-spatial learning in different mouse strains. Neurobiol Learn Mem 85: 164-172.
    • (2006) Neurobiol Learn Mem , vol.85 , pp. 164-172
    • Van Dam, D.1    Lenders, G.2    De Deyn, P.P.3
  • 109
    • 9144266990 scopus 로고    scopus 로고
    • Improvement of spatial cognition with dietary docosahexaenoic acid is associated with an increase in Fos expression in rat CA1 hippocampus
    • Tanabe Y, Hashimoto M, Sugioka K, Maruyama M, Fujii Y, et al. (2004) Improvement of spatial cognition with dietary docosahexaenoic acid is associated with an increase in Fos expression in rat CA1 hippocampus. Clin Exp Pharmacol Physiol 31: 700-703.
    • (2004) Clin Exp Pharmacol Physiol , vol.31 , pp. 700-703
    • Tanabe, Y.1    Hashimoto, M.2    Sugioka, K.3    Maruyama, M.4    Fujii, Y.5
  • 110
    • 2542505265 scopus 로고    scopus 로고
    • Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration
    • Song C, Horrobin D, (2004) Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration. J Lipid Res 45: 1112-1121.
    • (2004) J Lipid Res , vol.45 , pp. 1112-1121
    • Song, C.1    Horrobin, D.2
  • 111
    • 0037739814 scopus 로고    scopus 로고
    • Combined uridine and choline administration improves cognitive deficits in spontaneously hypertensive rats
    • De Bruin NM, Kiliaan AJ, De Wilde MC, Broersen LM, (2003) Combined uridine and choline administration improves cognitive deficits in spontaneously hypertensive rats. Neurobiol Learn Mem 80: 63-79.
    • (2003) Neurobiol Learn Mem , vol.80 , pp. 63-79
    • De Bruin, N.M.1    Kiliaan, A.J.2    De Wilde, M.C.3    Broersen, L.M.4
  • 112
    • 0038012555 scopus 로고    scopus 로고
    • Dietary cytidine (5′)-diphosphocholine supplementation protects against development of memory deficits in aging rats
    • Teather LA, Wurtman RJ, (2003) Dietary cytidine (5′)-diphosphocholine supplementation protects against development of memory deficits in aging rats. Prog Neuropsychopharmacol Biol Psychiatry 27: 711-717.
    • (2003) Prog Neuropsychopharmacol Biol Psychiatry , vol.27 , pp. 711-717
    • Teather, L.A.1    Wurtman, R.J.2
  • 113
    • 3342903288 scopus 로고    scopus 로고
    • Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury
    • Conte V, Uryu K, Fujimoto S, Yao Y, Rokach J, et al. (2004) Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury. J Neurochem 90: 758-764.
    • (2004) J Neurochem , vol.90 , pp. 758-764
    • Conte, V.1    Uryu, K.2    Fujimoto, S.3    Yao, Y.4    Rokach, J.5
  • 114
    • 58149267462 scopus 로고    scopus 로고
    • Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
    • Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, et al. (2008) Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci 28: 11500-11510.
    • (2008) J Neurosci , vol.28 , pp. 11500-11510
    • Green, K.N.1    Steffan, J.S.2    Martinez-Coria, H.3    Sun, X.4    Schreiber, S.S.5
  • 115
    • 79955654916 scopus 로고    scopus 로고
    • Folic acid plus alpha-tocopherol mitigates amyloid-beta-induced neurotoxicity through modulation of mitochondrial complexes activity
    • Figueiredo CP, Bicca MA, Latini A, Prediger RD, Medeiros R, et al. (2011) Folic acid plus alpha-tocopherol mitigates amyloid-beta-induced neurotoxicity through modulation of mitochondrial complexes activity. J Alzheimers Dis 24: 61-75.
    • (2011) J Alzheimers Dis , vol.24 , pp. 61-75
    • Figueiredo, C.P.1    Bicca, M.A.2    Latini, A.3    Prediger, R.D.4    Medeiros, R.5
  • 116
    • 33747180133 scopus 로고    scopus 로고
    • Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice
    • Oksman M, Iivonen H, Hogyes E, Amtul Z, Penke B, et al. (2006) Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. Neurobiol Dis 23: 563-572.
    • (2006) Neurobiol Dis , vol.23 , pp. 563-572
    • Oksman, M.1    Iivonen, H.2    Hogyes, E.3    Amtul, Z.4    Penke, B.5
  • 117
    • 35348824359 scopus 로고    scopus 로고
    • A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer's transgenic mice
    • Arendash GW, Jensen MT, Salem N Jr, Hussein N, Cracchiolo J, et al. (2007) A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer's transgenic mice. Neuroscience 149: 286-302.
    • (2007) Neuroscience , vol.149 , pp. 286-302
    • Arendash, G.W.1    Jensen, M.T.2    Salem Jr., N.3    Hussein, N.4    Cracchiolo, J.5
  • 119
    • 49049099040 scopus 로고    scopus 로고
    • Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial
    • van de Rest O, Geleijnse JM, Kok FJ, van Staveren WA, Dullemeijer C, et al. (2008) Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial. Neurology 71: 430-438.
    • (2008) Neurology , vol.71 , pp. 430-438
    • van de Rest, O.1    Geleijnse, J.M.2    Kok, F.J.3    van Staveren, W.A.4    Dullemeijer, C.5
  • 120
    • 38049182755 scopus 로고    scopus 로고
    • No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial
    • Rogers PJ, Appleton KM, Kessler D, Peters TJ, Gunnell D, et al. (2008) No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial. Br J Nutr 99: 421-431.
    • (2008) Br J Nutr , vol.99 , pp. 421-431
    • Rogers, P.J.1    Appleton, K.M.2    Kessler, D.3    Peters, T.J.4    Gunnell, D.5
  • 121
    • 77953066352 scopus 로고    scopus 로고
    • Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial
    • Dangour AD, Allen E, Elbourne D, Fasey N, Fletcher AE, et al. (2010) Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial. Am J Clin Nutr 91: 1725-1732.
    • (2010) Am J Clin Nutr , vol.91 , pp. 1725-1732
    • Dangour, A.D.1    Allen, E.2    Elbourne, D.3    Fasey, N.4    Fletcher, A.E.5
  • 122
    • 33748534825 scopus 로고    scopus 로고
    • Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
    • Kotani S, Sakaguchi E, Warashina S, Matsukawa N, Ishikura Y, et al. (2006) Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neurosci Res 56: 159-164.
    • (2006) Neurosci Res , vol.56 , pp. 159-164
    • Kotani, S.1    Sakaguchi, E.2    Warashina, S.3    Matsukawa, N.4    Ishikura, Y.5
  • 123
    • 33749633921 scopus 로고    scopus 로고
    • Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial
    • Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, Basun H, Faxen-Irving G, et al. (2006) Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch Neurol 63: 1402-1408.
    • (2006) Arch Neurol , vol.63 , pp. 1402-1408
    • Freund-Levi, Y.1    Eriksdotter-Jonhagen, M.2    Cederholm, T.3    Basun, H.4    Faxen-Irving, G.5
  • 124
    • 84883199083 scopus 로고    scopus 로고
    • Improved Spatial Learning Strategy and Memory in Aged Alzheimer AbetaPPswe/PS1dE9 Mice on a Multi-Nutrient Diet
    • Wiesmann M, Jansen D, Zerbi V, Broersen LM, Garthe A, et al. (2013) Improved Spatial Learning Strategy and Memory in Aged Alzheimer AbetaPPswe/PS1dE9 Mice on a Multi-Nutrient Diet. J Alzheimers Dis. doi:10.3223/JAD-130179.
    • (2013) J Alzheimers Dis
    • Wiesmann, M.1    Jansen, D.2    Zerbi, V.3    Broersen, L.M.4    Garthe, A.5
  • 125
    • 0031454126 scopus 로고    scopus 로고
    • Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study
    • Schuff N, Amend D, Ezekiel F, Steinman SK, Tanabe J, et al. (1997) Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study. Neurology 49: 1513-1521.
    • (1997) Neurology , vol.49 , pp. 1513-1521
    • Schuff, N.1    Amend, D.2    Ezekiel, F.3    Steinman, S.K.4    Tanabe, J.5
  • 127
    • 43549126232 scopus 로고    scopus 로고
    • 1H magnetic resonance spectroscopy in dementia
    • Kantarci K, (2007) 1H magnetic resonance spectroscopy in dementia. Br J Radiol 80 Spec No 2: S146-152.
    • (2007) Br J Radiol 80 Spec No , vol.2
    • Kantarci, K.1
  • 128
    • 84862828401 scopus 로고    scopus 로고
    • Hippocampal metabolites and memory performances in patients with amnestic mild cognitive impairment and Alzheimer's disease
    • Watanabe T, Shiino A, Akiguchi I, (2012) Hippocampal metabolites and memory performances in patients with amnestic mild cognitive impairment and Alzheimer's disease. Neurobiol Learn Mem 97: 289-293.
    • (2012) Neurobiol Learn Mem , vol.97 , pp. 289-293
    • Watanabe, T.1    Shiino, A.2    Akiguchi, I.3
  • 129
    • 2442582930 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile
    • Dedeoglu A, Choi JK, Cormier K, Kowall NW, Jenkins BG, (2004) Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile. Brain Res 1012: 60-65.
    • (2004) Brain Res , vol.1012 , pp. 60-65
    • Dedeoglu, A.1    Choi, J.K.2    Cormier, K.3    Kowall, N.W.4    Jenkins, B.G.5
  • 130
    • 23844505632 scopus 로고    scopus 로고
    • Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy
    • Marjanska M, Curran GL, Wengenack TM, Henry PG, Bliss RL, et al. (2005) Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy. Proc Natl Acad Sci U S A 102: 11906-11910.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 11906-11910
    • Marjanska, M.1    Curran, G.L.2    Wengenack, T.M.3    Henry, P.G.4    Bliss, R.L.5
  • 131
    • 47049101371 scopus 로고    scopus 로고
    • Age related changes in brain metabolites observed by 1H MRS in APP/PS1 mice
    • Oberg J, Spenger C, Wang FH, Andersson A, Westman E, et al. (2008) Age related changes in brain metabolites observed by 1H MRS in APP/PS1 mice. Neurobiol Aging 29: 1423-1433.
    • (2008) Neurobiol Aging , vol.29 , pp. 1423-1433
    • Oberg, J.1    Spenger, C.2    Wang, F.H.3    Andersson, A.4    Westman, E.5
  • 132
    • 84866865925 scopus 로고    scopus 로고
    • Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease
    • Mlynarik V, Cacquevel M, Sun-Reimer L, Janssens S, Cudalbu C, et al. (2012) Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease. J Alzheimers Dis 31Suppl 3: S87-99.
    • (2012) J Alzheimers Dis , vol.31
    • Mlynarik, V.1    Cacquevel, M.2    Sun-Reimer, L.3    Janssens, S.4    Cudalbu, C.5
  • 133
    • 78149309514 scopus 로고    scopus 로고
    • Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons
    • Xu W, Zhan Y, Huang W, Wang X, Zhang S, et al. (2010) Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons. J Neurosci Res 88: 3155-3160.
    • (2010) J Neurosci Res , vol.88 , pp. 3155-3160
    • Xu, W.1    Zhan, Y.2    Huang, W.3    Wang, X.4    Zhang, S.5
  • 135
    • 0036386840 scopus 로고    scopus 로고
    • In-vivo proton MR-spectroscopy of the human brain: assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration
    • Block W, Traber F, Flacke S, Jessen F, Pohl C, et al. (2002) In-vivo proton MR-spectroscopy of the human brain: assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration. Amino Acids 23: 317-323.
    • (2002) Amino Acids , vol.23 , pp. 317-323
    • Block, W.1    Traber, F.2    Flacke, S.3    Jessen, F.4    Pohl, C.5
  • 136
    • 0038632317 scopus 로고    scopus 로고
    • In vivo NMR studies of neurodegenerative diseases in transgenic and rodent models
    • Choi IY, Lee SP, Guilfoyle DN, Helpern JA, (2003) In vivo NMR studies of neurodegenerative diseases in transgenic and rodent models. Neurochem Res 28: 987-1001.
    • (2003) Neurochem Res , vol.28 , pp. 987-1001
    • Choi, I.Y.1    Lee, S.P.2    Guilfoyle, D.N.3    Helpern, J.A.4
  • 137
    • 11844258289 scopus 로고    scopus 로고
    • Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span
    • von Kienlin M, Kunnecke B, Metzger F, Steiner G, Richards JG, et al. (2005) Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span. Neurobiol Dis 18: 32-39.
    • (2005) Neurobiol Dis , vol.18 , pp. 32-39
    • von Kienlin, M.1    Kunnecke, B.2    Metzger, F.3    Steiner, G.4    Richards, J.G.5
  • 138
    • 84864565343 scopus 로고    scopus 로고
    • Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice
    • Chen SQ, Cai Q, Shen YY, Wang PJ, Teng GJ, et al. (2012) Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice. Behav Brain Res 235: 1-6.
    • (2012) Behav Brain Res , vol.235 , pp. 1-6
    • Chen, S.Q.1    Cai, Q.2    Shen, Y.Y.3    Wang, P.J.4    Teng, G.J.5
  • 139
    • 77951642086 scopus 로고    scopus 로고
    • Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice
    • Chen SQ, Wang PJ, Ten GJ, Zhan W, Li MH, et al. (2009) Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice. Dement Geriatr Cogn Disord 28: 558-566.
    • (2009) Dement Geriatr Cogn Disord , vol.28 , pp. 558-566
    • Chen, S.Q.1    Wang, P.J.2    Ten, G.J.3    Zhan, W.4    Li, M.H.5
  • 140
    • 0032966732 scopus 로고    scopus 로고
    • In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging
    • Pfefferbaum A, Adalsteinsson E, Spielman D, Sullivan EV, Lim KO, (1999) In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging. Magn Reson Med 41: 276-284.
    • (1999) Magn Reson Med , vol.41 , pp. 276-284
    • Pfefferbaum, A.1    Adalsteinsson, E.2    Spielman, D.3    Sullivan, E.V.4    Lim, K.O.5
  • 142
    • 0035964302 scopus 로고    scopus 로고
    • Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study
    • Huang W, Alexander GE, Chang L, Shetty HU, Krasuski JS, et al. (2001) Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study. Neurology 57: 626-632.
    • (2001) Neurology , vol.57 , pp. 626-632
    • Huang, W.1    Alexander, G.E.2    Chang, L.3    Shetty, H.U.4    Krasuski, J.S.5
  • 143
    • 0032587972 scopus 로고    scopus 로고
    • A 1H MRS study of probable Alzheimer's disease and normal aging: implications for longitudinal monitoring of dementia progression
    • Rose SE, de Zubicaray GI, Wang D, Galloway GJ, Chalk JB, et al. (1999) A 1H MRS study of probable Alzheimer's disease and normal aging: implications for longitudinal monitoring of dementia progression. Magn Reson Imaging 17: 291-299.
    • (1999) Magn Reson Imaging , vol.17 , pp. 291-299
    • Rose, S.E.1    de Zubicaray, G.I.2    Wang, D.3    Galloway, G.J.4    Chalk, J.B.5
  • 144
    • 0028290204 scopus 로고
    • Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging
    • Meyerhoff DJ, MacKay S, Constans JM, Norman D, Van Dyke C, et al. (1994) Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging. Ann Neurol 36: 40-47.
    • (1994) Ann Neurol , vol.36 , pp. 40-47
    • Meyerhoff, D.J.1    MacKay, S.2    Constans, J.M.3    Norman, D.4    Van Dyke, C.5
  • 145
    • 0027158502 scopus 로고
    • Regional specificity of membrane instability in Alzheimer's disease brain
    • Ginsberg L, Atack JR, Rapoport SI, Gershfeld NL, (1993) Regional specificity of membrane instability in Alzheimer's disease brain. Brain Res 615: 355-357.
    • (1993) Brain Res , vol.615 , pp. 355-357
    • Ginsberg, L.1    Atack, J.R.2    Rapoport, S.I.3    Gershfeld, N.L.4
  • 146
    • 0030059064 scopus 로고    scopus 로고
    • Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging
    • MacKay S, Meyerhoff DJ, Constans JM, Norman D, Fein G, et al. (1996) Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging. Arch Neurol 53: 167-174.
    • (1996) Arch Neurol , vol.53 , pp. 167-174
    • MacKay, S.1    Meyerhoff, D.J.2    Constans, J.M.3    Norman, D.4    Fein, G.5
  • 147
    • 0021956721 scopus 로고
    • "Autocannibalism" of choline-containing membrane phospholipids in the pathogenesis of Alzheimer's disease-A hypothesis
    • Wurtman RJ, Blusztajn JK, Maire JC, (1985) "Autocannibalism" of choline-containing membrane phospholipids in the pathogenesis of Alzheimer's disease-A hypothesis. Neurochem Int 7: 369-372.
    • (1985) Neurochem Int , vol.7 , pp. 369-372
    • Wurtman, R.J.1    Blusztajn, J.K.2    Maire, J.C.3
  • 148
    • 77953505738 scopus 로고    scopus 로고
    • Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice
    • Demars M, Hu YS, Gadadhar A, Lazarov O, (2010) Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. J Neurosci Res 88: 2103-2117.
    • (2010) J Neurosci Res , vol.88 , pp. 2103-2117
    • Demars, M.1    Hu, Y.S.2    Gadadhar, A.3    Lazarov, O.4
  • 149
    • 33748790666 scopus 로고    scopus 로고
    • Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus
    • Boekhoorn K, Joels M, Lucassen PJ, (2006) Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiol Dis 24: 1-14.
    • (2006) Neurobiol Dis , vol.24 , pp. 1-14
    • Boekhoorn, K.1    Joels, M.2    Lucassen, P.J.3
  • 151
    • 77953626742 scopus 로고    scopus 로고
    • Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats
    • Dyall SC, Michael GJ, Michael-Titus AT, (2010) Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J Neurosci Res 88: 2091-2102.
    • (2010) J Neurosci Res , vol.88 , pp. 2091-2102
    • Dyall, S.C.1    Michael, G.J.2    Michael-Titus, A.T.3
  • 152
    • 33646138943 scopus 로고    scopus 로고
    • Docosahexaenoic acid promotes neurogenesis in vitro and in vivo
    • Kawakita E, Hashimoto M, Shido O, (2006) Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience 139: 991-997.
    • (2006) Neuroscience , vol.139 , pp. 991-997
    • Kawakita, E.1    Hashimoto, M.2    Shido, O.3
  • 153
    • 84863370885 scopus 로고    scopus 로고
    • Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia
    • Zhang X, Huang G, Liu H, Chang H, Wilson JX, (2012) Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia. Nutr Neurosci 15: 55-61.
    • (2012) Nutr Neurosci , vol.15 , pp. 55-61
    • Zhang, X.1    Huang, G.2    Liu, H.3    Chang, H.4    Wilson, J.X.5
  • 154
    • 38049045075 scopus 로고    scopus 로고
    • Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease-but how and why?
    • Das UN, (2008) Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease-but how and why? Prostaglandins Leukot Essent Fatty Acids 78: 11-19.
    • (2008) Prostaglandins Leukot Essent Fatty Acids , vol.78 , pp. 11-19
    • Das, U.N.1
  • 156
    • 55849140531 scopus 로고    scopus 로고
    • Retinoic acid restores adult hippocampal neurogenesis and reverses spatial memory deficit in vitamin A deprived rats
    • Bonnet E, Touyarot K, Alfos S, Pallet V, Higueret P, et al. (2008) Retinoic acid restores adult hippocampal neurogenesis and reverses spatial memory deficit in vitamin A deprived rats. PLoS One 3: e3487.
    • (2008) PLoS One , vol.3
    • Bonnet, E.1    Touyarot, K.2    Alfos, S.3    Pallet, V.4    Higueret, P.5
  • 157
    • 0025917616 scopus 로고
    • Induction of interleukin-1 beta mRNA in adult rat brain
    • Higgins GA, Olschowka JA, (1991) Induction of interleukin-1 beta mRNA in adult rat brain. Brain Res Mol Brain Res 9: 143-148.
    • (1991) Brain Res Mol Brain Res , vol.9 , pp. 143-148
    • Higgins, G.A.1    Olschowka, J.A.2
  • 158
    • 0032805573 scopus 로고    scopus 로고
    • Immunohistochemical localization of interleukin-1beta, interleukin-1 receptor antagonist and interleukin-1beta converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid
    • Eriksson C, Van Dam AM, Lucassen PJ, Bol JG, Winblad B, et al. (1999) Immunohistochemical localization of interleukin-1beta, interleukin-1 receptor antagonist and interleukin-1beta converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid. Neuroscience 93: 915-930.
    • (1999) Neuroscience , vol.93 , pp. 915-930
    • Eriksson, C.1    Van Dam, A.M.2    Lucassen, P.J.3    Bol, J.G.4    Winblad, B.5
  • 159
    • 0036353262 scopus 로고    scopus 로고
    • Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells
    • Vela JM, Molina-Holgado E, Arevalo-Martin A, Almazan G, Guaza C, (2002) Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells. Mol Cell Neurosci 20: 489-502.
    • (2002) Mol Cell Neurosci , vol.20 , pp. 489-502
    • Vela, J.M.1    Molina-Holgado, E.2    Arevalo-Martin, A.3    Almazan, G.4    Guaza, C.5
  • 160
    • 11444256801 scopus 로고    scopus 로고
    • Glia and their cytokines in progression of neurodegeneration
    • Mrak RE, Griffin WS, (2005) Glia and their cytokines in progression of neurodegeneration. Neurobiol Aging 26: 349-354.
    • (2005) Neurobiol Aging , vol.26 , pp. 349-354
    • Mrak, R.E.1    Griffin, W.S.2
  • 161
    • 34249899174 scopus 로고    scopus 로고
    • Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
    • Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE, et al. (2007) Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 117: 1595-1604.
    • (2007) J Clin Invest , vol.117 , pp. 1595-1604
    • Shaftel, S.S.1    Kyrkanides, S.2    Olschowka, J.A.3    Miller, J.N.4    Johnson, R.E.5
  • 162
    • 84860751910 scopus 로고    scopus 로고
    • Chronic IL-1beta-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration
    • Matousek SB, Ghosh S, Shaftel SS, Kyrkanides S, Olschowka JA, et al. (2012) Chronic IL-1beta-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration. J Neuroimmune Pharmacol 7: 156-164.
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 156-164
    • Matousek, S.B.1    Ghosh, S.2    Shaftel, S.S.3    Kyrkanides, S.4    Olschowka, J.A.5
  • 163
    • 42649084052 scopus 로고    scopus 로고
    • The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective
    • Shaftel SS, Griffin WS, O'Banion MK, (2008) The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J Neuroinflammation 5: 7.
    • (2008) J Neuroinflammation , vol.5 , pp. 7
    • Shaftel, S.S.1    Griffin, W.S.2    O'Banion, M.K.3
  • 164
    • 25844482682 scopus 로고    scopus 로고
    • Differential effects of interleukin-1beta on neurotoxicity, cytokine induction and glial reaction in specific brain regions
    • Depino A, Ferrari C, Pott Godoy MC, Tarelli R, Pitossi FJ, (2005) Differential effects of interleukin-1beta on neurotoxicity, cytokine induction and glial reaction in specific brain regions. J Neuroimmunol 168: 96-110.
    • (2005) J Neuroimmunol , vol.168 , pp. 96-110
    • Depino, A.1    Ferrari, C.2    Pott Godoy, M.C.3    Tarelli, R.4    Pitossi, F.J.5
  • 165
    • 4744352557 scopus 로고    scopus 로고
    • Interleukin-1: a master regulator of neuroinflammation
    • Basu A, Krady JK, Levison SW, (2004) Interleukin-1: a master regulator of neuroinflammation. J Neurosci Res 78: 151-156.
    • (2004) J Neurosci Res , vol.78 , pp. 151-156
    • Basu, A.1    Krady, J.K.2    Levison, S.W.3
  • 166
    • 0037025054 scopus 로고    scopus 로고
    • Intracerebroventricular but not intravenous interleukin-1beta induces widespread vascular-mediated leukocyte infiltration and immune signal mRNA expression followed by brain-wide glial activation
    • Proescholdt MG, Chakravarty S, Foster JA, Foti SB, Briley EM, et al. (2002) Intracerebroventricular but not intravenous interleukin-1beta induces widespread vascular-mediated leukocyte infiltration and immune signal mRNA expression followed by brain-wide glial activation. Neuroscience 112: 731-749.
    • (2002) Neuroscience , vol.112 , pp. 731-749
    • Proescholdt, M.G.1    Chakravarty, S.2    Foster, J.A.3    Foti, S.B.4    Briley, E.M.5
  • 167
    • 34548434392 scopus 로고    scopus 로고
    • Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration
    • Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, et al. (2007) Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J Neurosci 27: 9301-9309.
    • (2007) J Neurosci , vol.27 , pp. 9301-9309
    • Shaftel, S.S.1    Carlson, T.J.2    Olschowka, J.A.3    Kyrkanides, S.4    Matousek, S.B.5
  • 168
    • 42449118315 scopus 로고    scopus 로고
    • Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats
    • Song C, Manku MS, Horrobin DF, (2008) Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. J Nutr 138: 954-963.
    • (2008) J Nutr , vol.138 , pp. 954-963
    • Song, C.1    Manku, M.S.2    Horrobin, D.F.3
  • 169
    • 0034765960 scopus 로고    scopus 로고
    • Interleukin-1 beta, but not IL-1 alpha, mediates nerve growth factor secretion from rat astrocytes via type I IL-1 receptor
    • Juric DM, Carman-Krzan M, (2001) Interleukin-1 beta, but not IL-1 alpha, mediates nerve growth factor secretion from rat astrocytes via type I IL-1 receptor. Int J Dev Neurosci 19: 675-683.
    • (2001) Int J Dev Neurosci , vol.19 , pp. 675-683
    • Juric, D.M.1    Carman-Krzan, M.2
  • 170
    • 0029047891 scopus 로고
    • Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor
    • Strijbos PJ, Rothwell NJ, (1995) Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor. J Neurosci 15: 3468-3474.
    • (1995) J Neurosci , vol.15 , pp. 3468-3474
    • Strijbos, P.J.1    Rothwell, N.J.2
  • 172
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
    • Reeves PG, Nielsen FH, Fahey GC Jr, (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123: 1939-1951.
    • (1993) J Nutr , vol.123 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey Jr., G.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.