Erratum: Folic Acid Plus α-Tocopherol Mitigates Amyloid-β-Induced Neurotoxicity through Modulation of Mitochondrial Complex Activity (Journal of Alzheimer’s Disease (2010) 24 (61–75) DOI: 10.3233/JAD-2010-101320);Folic acid plus α-tocopherol mitigates amyloid-β-induced neurotoxicity through modulation of mitochondrial complexes activity

Journal of Alzheimer's Disease

Volumn 24, Issue 1, 2011, Pages 61-75

  Figueiredo, Cláudia P ^a   Bicca, Maíra A ^a   Latini, Alexandra ^a   Prediger, Rui Daniel S ^a   Medeiros, Rodrigo ^a   Calixto, Joo B ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Alpha tocopherol; amyloid ; cognition; folic acid; mitochondrial complexes

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN[1-40]; CYTOCHROME C OXIDASE; FOLIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SCOPOLAMINE; SUCCINATE DEHYDROGENASE (UBIQUINONE);

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENERGY METABOLISM; GLIA CELL; HIPPOCAMPUS; LONG TERM CARE; MALE; MENTAL DETERIORATION; MITOCHONDRIAL GENE; MITOCHONDRION; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN METABOLISM; UPREGULATION;

EID: 79955654916     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-229023     Document Type: Erratum

References (78)

1. Querfurth HW, LaFerla FM (2010) Alzheimer's disease. N Engl J Med 362, 329-344.
2. Medeiros R, Baglietto-Vargas D, Laferla FM (2010) The role of tau in Alzheimer's disease and related disorders. CNSNeu-rosci Ther. In press.
3. Westermann B (2009) Nitric oxide links mitochondrial fission to Alzheimer's disease. Sci Signal 2, pe29.
4. Parker WD Jr., Parks J, Filley CM, Kleinschmidt-DeMasters BK (1994) Electron transport chain defects in Alzheimer's disease brain. Neurology 44, 1090-1096. (Pubitemid 24188184)
5. Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen RB, Perry G, Smith MA (2001) Mitochondrial abnor-malities in Alzheimer's disease. JNeurosci 21, 3017-3023.
6. Crouch PJ, Blake R, Duce JA, Ciccotosto GD, Li QX, Barnham KJ, Curtain CC, Cherny RA, Cappai R, Dyrks T, Masters CL, Trounce IA (2005) Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42. J Neurosci 25, 672-679.
7. He Y, Leung KW, Zhang YH, Duan S, Zhong XF, Jiang RZ, Peng Z, Tombran-Tink J, Ge J (2008) Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants. Invest Ophthalmol Vis Sci 49, 1447-1458.
8. Cardoso SM, Santos S, Swerdlow RH, Oliveira CR (2001) Functional mitochondria are required for amyloid beta-mediated neurotoxicity. FASEB J 15, 1439-1441.
9. Conte V, Uryu K, Fujimoto S, Yao Y, Rokach J, Longhi L, Trojanowski JQ, Lee VM, McIntosh TK, Pratico D (2004) Vitamin E reduces amyloidosis and improves cognitive func-tion in Tg 2576 mice following repetitive concussive brain injury. J Neurochem 90, 758-764. (Pubitemid 38989408)
10. Aisen PS, Schneider LS, Sano M, Diaz-Arrastia R, van Dyck CH, Weiner MF, Bottiglieri T, Jin S, Stokes KT, Thomas RG, Thal LJ (2008) High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA 300, 1774-1783.
11. Durga J, van Boxtel MP, Schouten EG, Kok FJ, Jolles J, Katan MB, Verhoef P (2007) Effect of 3-year folic acid supple-mentation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 369, 208-216. (Pubitemid 46107683)
12. Mattson MP, Shea TB (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative dis-orders. Trends Neurosci 26, 137-146. (Pubitemid 36183675)
13. Sinha M, Saha A, Basu S, Pal K, Chakrabarti S (2010) Aging and antioxidants modulate rat brain levels of homocysteine and dehydroepiandrosterone sulphate (DHEA-S): implica-tions in the pathogenesis of Alzheimer's disease. Neurosci Lett483, 123-126.
14. Zhuo JM, Portugal GS, Kruger WD, Wang H, Gould TJ, Pratico D (2010) Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease. Curr Alzheimer Res 7, 140-149.
15. Jara-Prado A, Ortega-Vazquez A, Martinez-Ruano L, Rios C, Santamaria A (2003) Homocysteine-induced brain lipid per-oxidation: effects of NMDA receptor blockade, antioxidant treatment, and nitric oxide synthase inhibition. Neurotox Res 5, 237-243.
16. Tjiattas L, Ortiz DO, Dhivant S, Mitton K, Rogers E, Shea TB (2004) Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation. Aging Cell 3, 71-76. (Pubitemid 40246667)
17. McAnulty SR, McAnulty LS, Nieman DC, Morrow JD, Shooter LA, Holmes S, Heward C, Henson DA (2005) Effect of alpha-tocopherol supplementation on plasma homocys-teine and oxidative stress in highly trained athletes before and after exhaustive exercise. J Nutr Biochem 16, 530-537. (Pubitemid 41188033)
18. Fuchs D, Jaeger M, Widner B, Wirleitner B, Artner-Dworzak E, Leblhuber F (2001) Is hyperhomocysteinemia due to the oxidative depletion offolate rather than to insufficient dietary intake? Clin Chem Lab Med 39, 691-694. (Pubitemid 32894411)
19. Medeiros R, Figueiredo CP, Pandolfo P, Duarte FS, Prediger RD, Passos GF, Calixto JB (2010) The role of TNF-alpha sig-naling pathway on COX-2 upregulation and cognitive decline induced by beta-amyloid peptide. Behav Brain Res 209, 165-173.
20. Passos GF, Figueiredo CP, Prediger RD, Pandolfo P, Duarte FS, Medeiros R, Calixto JB (2009) Role of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 sig-naling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptide. Am JPathol 175, 1586-1597.
21. Passos GF, Figueiredo CP, Prediger RD, Silva KA, Siqueira JM, Duarte FS, Leal PC, Medeiros R, Calixto JB (2010) Involvement of phosphoinositide 3-kinase gamma in the neuro-inflammatory response and cognitive impairments induced by beta-amyloid 1-40 peptide in mice. Brain Behav Immun 24, 493-501.
22. Medeiros R, Prediger RD, Passos GF, Pandolfo P, Duarte FS, Franco JL, Dafre AL, Di Giunta G, Figueiredo CP, Takahashi RN, Campos MM, Calixto JB (2007) Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein. JNeurosci 27, 5394-5404. (Pubitemid 46790177)
23. Prediger RD, Franco JL, Pandolfo P, Medeiros R, Duarte FS, Di Giunta G, Figueiredo CP, Farina M, Calixto JB, Takahashi RN, Dafre AL (2007) Differential susceptibility following beta-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cogni-tive deficits and the glutathione system response. Behav Brain Res 177, 205-213. (Pubitemid 46149914)
24. Prediger RD, Medeiros R, Pandolfo P, Duarte FS, Passos GF, Pesquero JB, Campos MM, Calixto JB, Takahashi RN (2008) Genetic deletion or antagonism of kinin B(1) and B(2) receptors improves cognitive deficits in a mouse model of Alzheimer's disease. Neuroscience 151, 631-643.
25. Morris RG, Garrud P, Rawlins JN, O'Keefe J (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297, 681-683. (Pubitemid 12096189)
26. Figueiredo CP, Franz-Vasconcelos HC, Giunta G, Mazzuco TL, Caon T, Fernandes AL, Simoes CM, Antunes VL, Niel C, Barardi CR (2007) Detection of Torque teno virus in Epstein-Barr virus positive and negative lymph nodes of patients with Hodgkin lymphoma. Leuk Lymphoma 48, 731-735. (Pubitemid 46605545)
27. Latini A, Rodriguez M, Borba Rosa R, Scussiato K, Leipnitz G, Reis de Assis D, da Costa Ferreira G, Funchal C, Jacques-Silva MC, Buzin L, Giugliani R, Cassina A, Radi R, Wajner M (2005) 3-Hydroxyglutaric acid moderately impairs energy metabolism in brain of young rats. Neuroscience 135, 111-120. (Pubitemid 41219742)
28. Ebert U, Kirch W (1998) Scopolamine model of dementia: electroencephalogram findings and cognitive performance. Eur J Clin Invest 28, 944-949. (Pubitemid 28521587)
29. Yamada K, Nabeshima T (2000) Animal models of Alzheimer's disease and evaluation of anti-dementia drugs. Pharmacol Ther 88, 93-113. (Pubitemid 32057133)
30. Hartmann T, Bieger SC, Bruhl B, Tienari PJ, Ida N, Allsop D, Roberts GW, Masters CL, Dotti CG, Unsicker K, Beyreuther K (1997) Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med 3, 1016-1020. (Pubitemid 27391957)
31. Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ (2002) Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans 30, 552-557. (Pubitemid 35001597)
32. Mattson MP (2004) Pathways towards and away from Alzheimer's disease. Nature 430, 631-639. (Pubitemid 39061671)
33. Figueiredo CP, Pamplona FA, Mazzuco TL, Aguiar AS Jr, Walz R, Prediger RD (2010) Role of the glucose-dependent insulinotropic polypeptide and its receptor in the central ner-vous system: therapeutic potential in neurological diseases. Behav Pharmacol 21, 394-408.
34. Takeda S, Sato N, Niisato K, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Kano M, Morishita R (2009) Validation of Abeta1-40 administration into mouse cere-broventricles as an animal model for Alzheimer disease. Brain Res 1280, 137-147.
35. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274, 99-102. (Pubitemid 26332733)
36. Pratico D, Delanty N (2000) Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. Am J Med 109, 577-585.
37. Resende R, Moreira PI, Proenca T, Deshpande A, Busciglio J, Pereira C, Oliveira CR (2008) Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radic Biol Med 44, 2051-2057.
38. Law A, Gauthier S, Quirion R (2001) Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type. Brain Res Brain Res Rev 35, 73-96. (Pubitemid 32201877)
39. Brown GC, Cooper CE (1994) Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 356, 295-298. (Pubitemid 24376992)
40. Bolanos JP, Heales SJ, Land JM, Clark JB (1995) Effect of per-oxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture. JNeurochem64, 1965-1972.
41. Casley CS, Canevari L, Land JM, Clark JB, Sharpe MA (2002) Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem 80, 91-100. (Pubitemid 34614581)
42. Brewer GJ (2010) Why vitamin E therapy fails for treatment of Alzheimer's disease. J Alzheimers Dis 19, 27-30.
43. Yokota T, Igarashi K, Uchihara T, Jishage K, Tomita H, Inaba A, Li Y, Arita M, Suzuki H, Mizusawa H, Arai H (2001) Delayed-onset ataxiain micelacking alpha-tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress. Proc Natl Acad Sci US A98, 15185-15190. (Pubitemid 34013990)
44. Traber MG, Burton GW, Hamilton RL (2004) Vitamin E traf-ficking. Ann NY Acad Sci 1031, 1-12.
45. d'Ischia M, Novellino L (1996) Nitric oxide-induced oxida-tion of alpha-tocopherol. Bioorg Med Chem 4, 1747-1753.
46. Chow CK, Hong CB (2002) Dietary vitamin E and selenium and toxicity of nitrite and nitrate. Toxicology 180, 195-207. (Pubitemid 35254074)
47. Sen CK, Khanna S, Roy S, Packer L (2000) Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. J Biol Chem 275, 13049-13055. (Pubitemid 30241466)
48. Khanna S, Parinandi NL, Kotha SR, Roy S, Rink C, Bibus D, Sen CK (2010) Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection. J Neurochem 112, 1249-1260.
49. Khanna S, Roy S, Slivka A, Craft TK, Chaki S, Rink C, Notestine MA, DeVries AC, Parinandi NL, Sen CK (2005) Neuroprotective properties of the natural vitamin E alpha-tocotrienol. Stroke 36, 2258-2264. (Pubitemid 41429256)
50. Khanna S, Roy S, Parinandi NL, Maurer M, Sen CK (2006) Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. J Neurochem 98, 1474-1486. (Pubitemid 44200439)
51. Lloret A, Badia MC, Mora NJ, Pallardo FV, Alonso MD, Vina J (2009) Vitamin E paradox in Alzheimer's disease: it does not prevent loss of cognition and may even be detrimental. J Alzheimers Dis 17, 143-149.
52. Cockroft DL (1991) Vitamin deficiencies and neural-tube defects: human and animal studies. Hum Reprod 6, 148-157.
53. Brewer GJ, Torricelli JR, Lindsey AL, Kunz EZ, Neuman A, Fisher DR, Joseph JA (2010) Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem 21, 991-998.
54. Milgram NW, Head E, Zicker SC, Ikeda-Douglas CJ, Murphey H, Muggenburg B, Siwak C, Tapp D, Cotman CW (2005) Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Neurobiol Aging 26, 77-90. (Pubitemid 39600593)
55. Joseph JA, Denisova NA, Arendash G, Gordon M, Diamond D, Shukitt-Hale B, Morgan D (2003) Blueberry supplemen-tation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci 6, 153-162. (Pubitemid 36656693)
56. Macreadie I, Lotfi-Miri M, Mohotti S, Shapira D, Bennett L, Varghese J (2008) Validation of folate in a convenient yeast assay suited for identification of inhibitors of Alzheimer's amyloid-beta aggregation. J Alzheimers Dis 15, 391-396.
57. Luchsinger JA, Mayeux R (2004) Dietary factors and Alzheimer's disease. Lancet Neurol 3, 579-587. (Pubitemid 39221925)
58. Boche D, Nicoll JA (2008) The role of the immune system in clearance of Abeta from the brain. Brain Pathol 18, 267-278. (Pubitemid 351430403)
59. Emerit J, Edeas M, Bricaire F (2004) Neurodegenerative diseases and oxidative stress. Biomed Pharmacother 58, 39-46. (Pubitemid 38117047)
60. Muchowski PJ (2002) Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones? Neuron 35, 9-12. (Pubitemid 34804316)
61. Gu Z, Nakamura T, Lipton SA (2010) Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Mol Neurobiol 41, 55-72.
62. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci US A 88, 6368-6371. (Pubitemid 21914947)
63. Christopherson KS, Bredt DS (1997) Nitric oxide in excitable tissues: physiological roles and disease. J Clin Invest 100, 2424-2429. (Pubitemid 27514880)
64. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265, 1883-1885. (Pubitemid 24324247)
65. Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S, Ross ME (2001) Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc Natl Acad Sci USA 98, 1294-1299. (Pubitemid 32121226)
66. Przedborski S, Jackson-Lewis V, Yokoyama R, Shibata T, Dawson VL, Dawson TM (1996) Role of neuronal nitric oxide in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc Natl Acad Sci USA 93, 4565-4571.
67. Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, Matthews RT, Beal MF (1996) Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med 2, 1017-1021. (Pubitemid 26306841)
68. Li Z, Okamoto K, Hayashi Y, Sheng M (2004) The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 119, 873-887. (Pubitemid 40017692)
69. Yin KJ, Hsu CY, Hu XY, Chen H, Chen SW, Xu J, Lee JM (2006) Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death. JNeurosci 26, 2290-2299. (Pubitemid 44699038)
70. Dinamarca MC, Sagal JP, Quintanilla RA, Godoy JA, Arrazola MS, Inestrosa NC (2010) Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenera-tive changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's disease. Mol Neurodegener 5, 4.
71. Jimenez S, Baglietto-Vargas D, Caballero C, Moreno-Gonzalez I, Torres M, Sanchez-Varo R, Ruano D, Vizuete M, Gutierrez A, Vitorica J (2008) Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. J Neurosci 28, 11650-11661.
72. Reddy PH, McWeeney S, Park BS, Manczak M, Gutala RV, Partovi D, Jung Y, Yau V, Searles R, Mori M, Quinn J (2004) Gene expression profiles of transcripts in amyloid precur-sor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum Mol Genet 15, 1225-1240. (Pubitemid 38877876)
73. Reddy DS (2009) The role of neurosteroids in the pathophys-iology and treatment of catamenial epilepsy. Epilepsy Res 85, 1-30.
74. Rimbach G, Minihane AM, Majewicz J, Fischer A, Pallauf J, Virgli F, Weinberg PD (2002) Regulation of cell signalling by vitaminE. Proc Nutr Soc 61, 415-425.
75. Burk RF, Hill KE, Nakayama A, Mostert V, Levander XA, Motley AK, Johnson DA, Johnson JA, Freeman ML, Austin LM (2008) Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not. Free Radic Biol Med 44, 1617-1623.
76. Choi SW, Mason JB (2000) Folate and carcinogenesis: an integrated scheme. J Nutr 130, 129-132. (Pubitemid 30073783)
77. Ho PI, Collins SC, Dhitavat S, Ortiz D, Ashline D, Rogers E, Shea TB (2001) Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress. J Neurochem 78, 249-253. (Pubitemid 32664406)
78. Kruman II, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, Evans M, Mattson MP (2002) Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amy-loid toxicity in experimental models of Alzheimer's disease. JNeurosci22, 1752-1762. (Pubitemid 35386293)