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Volumn 8, Issue 1, 2013, Pages

New insights into the synergism of nucleoside analogs with radiotherapy

Author keywords

ATM; Deoxycytidine kinase; Nucleoside analogs; Radiotherapy

Indexed keywords

ADENYLATE KINASE; CLADRIBINE; CLOFARABINE; CYCLIN DEPENDENT KINASE 1; CYTARABINE; DEOXYCYTIDINE KINASE; FLUDARABINE; GEMCITABINE; NELARABINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEOSIDE ANALOG; NUCLEOSIDE DIPHOSPHATE KINASE; NUCLEOSIDE MONOPHOSPHATE KINASE; PURINE NUCLEOSIDE PHOSPHORYLASE; NUCLEOSIDE;

EID: 84884552734     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-8-223     Document Type: Review
Times cited : (16)

References (128)
  • 1
    • 0014514255 scopus 로고
    • Nucleosides of 2-fluoroadenine
    • 10.1021/jm00303a605, 5788168
    • Montgomery JA, Hewson K. Nucleosides of 2-fluoroadenine. J Med Chem 1969, 12(3):498-504. 10.1021/jm00303a605, 5788168.
    • (1969) J Med Chem , vol.12 , Issue.3 , pp. 498-504
    • Montgomery, J.A.1    Hewson, K.2
  • 2
    • 0023261751 scopus 로고
    • Phosphorolytic cleavage of 2-fluoroadenine from 9-beta-D-arabinofuranosyl-2-fluoroadenine by Escherichia coli. A pathway for 2-fluoro-ATP production
    • 10.1016/0006-2952(87)90207-3, 3307790
    • Huang P, Plunkett W. Phosphorolytic cleavage of 2-fluoroadenine from 9-beta-D-arabinofuranosyl-2-fluoroadenine by Escherichia coli. A pathway for 2-fluoro-ATP production. Biochem Pharmacol 1987, 36(18):2945-2950. 10.1016/0006-2952(87)90207-3, 3307790.
    • (1987) Biochem Pharmacol , vol.36 , Issue.18 , pp. 2945-2950
    • Huang, P.1    Plunkett, W.2
  • 3
    • 0036183496 scopus 로고    scopus 로고
    • Structural analyses reveal two distinct families of nucleoside phosphorylases
    • 1222293, 11743878
    • Pugmire MJ, Ealick SE. Structural analyses reveal two distinct families of nucleoside phosphorylases. Biochem J 2002, 361(Pt 1):1-25. 1222293, 11743878.
    • (2002) Biochem J , vol.361 , Issue.PART 1 , pp. 1-25
    • Pugmire, M.J.1    Ealick, S.E.2
  • 4
    • 0017378726 scopus 로고
    • Biologic activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine, a metabolically stable analog of 9-beta-D-arabinofuranosyladenine
    • 10.1016/0006-2952(77)90275-1, 563233
    • Brockman RW, Schabel FM, Montgomery JA. Biologic activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine, a metabolically stable analog of 9-beta-D-arabinofuranosyladenine. Biochem Pharmacol 1977, 26(22):2193-2196. 10.1016/0006-2952(77)90275-1, 563233.
    • (1977) Biochem Pharmacol , vol.26 , Issue.22 , pp. 2193-2196
    • Brockman, R.W.1    Schabel, F.M.2    Montgomery, J.A.3
  • 5
    • 0022991391 scopus 로고
    • 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate pharmacokinetics in plasma and tumor cells of patients with relapsed leukemia and lymphoma
    • Danhauser L, et al. 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate pharmacokinetics in plasma and tumor cells of patients with relapsed leukemia and lymphoma. Cancer Chemother Pharmacol 1986, 18(2):145-152.
    • (1986) Cancer Chemother Pharmacol , vol.18 , Issue.2 , pp. 145-152
    • Danhauser, L.1
  • 6
    • 0036204648 scopus 로고    scopus 로고
    • Cellular and clinical pharmacology of fludarabine
    • 10.2165/00003088-200241020-00002, 11888330
    • Gandhi V, Plunkett W. Cellular and clinical pharmacology of fludarabine. Clin Pharmacokinet 2002, 41(2):93-103. 10.2165/00003088-200241020-00002, 11888330.
    • (2002) Clin Pharmacokinet , vol.41 , Issue.2 , pp. 93-103
    • Gandhi, V.1    Plunkett, W.2
  • 7
    • 0027085703 scopus 로고
    • Nucleotide specificity of human deoxycytidine kinase
    • Shewach DS, Reynolds KK, Hertel L. Nucleotide specificity of human deoxycytidine kinase. Mol Pharmacol 1992, 42(3):518-524.
    • (1992) Mol Pharmacol , vol.42 , Issue.3 , pp. 518-524
    • Shewach, D.S.1    Reynolds, K.K.2    Hertel, L.3
  • 8
    • 0017157932 scopus 로고
    • Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity
    • Krenitsky TA, et al. Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity. J Biol Chem 1976, 251(13):4055-4061.
    • (1976) J Biol Chem , vol.251 , Issue.13 , pp. 4055-4061
    • Krenitsky, T.A.1
  • 9
    • 0038419639 scopus 로고    scopus 로고
    • Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
    • 10.1038/nsb942, 12808445
    • Sabini E, et al. Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. Nat Struct Biol 2003, 10(7):513-519. 10.1038/nsb942, 12808445.
    • (2003) Nat Struct Biol , vol.10 , Issue.7 , pp. 513-519
    • Sabini, E.1
  • 10
    • 0029162556 scopus 로고
    • Mammalian deoxyribonucleoside kinases
    • 10.1016/0163-7258(95)00015-9, 7494863
    • Arner ES, Eriksson S. Mammalian deoxyribonucleoside kinases. Pharmacol Ther 1995, 67(2):155-186. 10.1016/0163-7258(95)00015-9, 7494863.
    • (1995) Pharmacol Ther , vol.67 , Issue.2 , pp. 155-186
    • Arner, E.S.1    Eriksson, S.2
  • 11
    • 0025077196 scopus 로고
    • A comprehensive phase I and II clinical investigation of fludarabine phosphate
    • Grever M, et al. A comprehensive phase I and II clinical investigation of fludarabine phosphate. Semin Oncol 1990, 17(5 Suppl 8):39-48.
    • (1990) Semin Oncol , vol.17 , Issue.5 SUPPL. 8 , pp. 39-48
    • Grever, M.1
  • 12
    • 84864358937 scopus 로고    scopus 로고
    • Fludarabine combined with radiotherapy in patients with locally advanced NSCLC lung carcinoma: a phase I study
    • 10.1007/s00432-012-1185-3, 3605492, 22402597
    • Nitsche M, et al. Fludarabine combined with radiotherapy in patients with locally advanced NSCLC lung carcinoma: a phase I study. J Cancer Res Clin Oncol 2012, 138(7):1113-1120. 10.1007/s00432-012-1185-3, 3605492, 22402597.
    • (2012) J Cancer Res Clin Oncol , vol.138 , Issue.7 , pp. 1113-1120
    • Nitsche, M.1
  • 13
    • 0032030689 scopus 로고    scopus 로고
    • Differential induction of apoptosis by fludarabine monophosphate in leukemic B and normal T cells in chronic lymphocytic leukemia
    • Consoli U, et al. Differential induction of apoptosis by fludarabine monophosphate in leukemic B and normal T cells in chronic lymphocytic leukemia. Blood 1998, 91(5):1742-1748.
    • (1998) Blood , vol.91 , Issue.5 , pp. 1742-1748
    • Consoli, U.1
  • 14
    • 0029859821 scopus 로고    scopus 로고
    • Fludarabine-mediated inhibition of nucleotide excision repair induces apoptosis in quiescent human lymphocytes
    • Sandoval A, Consoli U, Plunkett W. Fludarabine-mediated inhibition of nucleotide excision repair induces apoptosis in quiescent human lymphocytes. Clin Cancer Res 1996, 2(10):1731-1741.
    • (1996) Clin Cancer Res , vol.2 , Issue.10 , pp. 1731-1741
    • Sandoval, A.1    Consoli, U.2    Plunkett, W.3
  • 15
    • 0025274664 scopus 로고
    • Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine
    • 10.1056/NEJM199004193221605, 1969613
    • Piro LD, et al. Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. N Engl J Med 1990, 322(16):1117-1121. 10.1056/NEJM199004193221605, 1969613.
    • (1990) N Engl J Med , vol.322 , Issue.16 , pp. 1117-1121
    • Piro, L.D.1
  • 16
    • 0027932742 scopus 로고
    • Complete hematologic remissions induced by 2-chlorodeoxyadenosine in children with newly diagnosed acute myeloid leukemia
    • Santana VM, et al. Complete hematologic remissions induced by 2-chlorodeoxyadenosine in children with newly diagnosed acute myeloid leukemia. Blood 1994, 84(4):1237-1242.
    • (1994) Blood , vol.84 , Issue.4 , pp. 1237-1242
    • Santana, V.M.1
  • 17
    • 0029163276 scopus 로고
    • 2-Chlorodeoxyadenosine activity in patients with untreated, indolent non-Hodgkin's lymphoma
    • Saven A, et al. 2-Chlorodeoxyadenosine activity in patients with untreated, indolent non-Hodgkin's lymphoma. Blood 1995, 86(5):1710-1716.
    • (1995) Blood , vol.86 , Issue.5 , pp. 1710-1716
    • Saven, A.1
  • 18
    • 0027481103 scopus 로고
    • 2-Chlorodeoxyadenosine: a new nucleoside agent effective in the treatment of lymphoid malignancies
    • Saven A, Piro LD. 2-Chlorodeoxyadenosine: a new nucleoside agent effective in the treatment of lymphoid malignancies. Leuk Lymphoma 1993, 10(Suppl):43-49.
    • (1993) Leuk Lymphoma , vol.10 , Issue.SUPPL. , pp. 43-49
    • Saven, A.1    Piro, L.D.2
  • 19
    • 0017278672 scopus 로고
    • Enhancement of 9-beta-d-arabinofuranosyladenine cytotoxicity to mouse leukemia L1210 in vitro by 2'-deoxycoformycin
    • Cass CE, Au-Yeung TH. Enhancement of 9-beta-d-arabinofuranosyladenine cytotoxicity to mouse leukemia L1210 in vitro by 2'-deoxycoformycin. Cancer Res 1976, 36(4):1486-1491.
    • (1976) Cancer Res , vol.36 , Issue.4 , pp. 1486-1491
    • Cass, C.E.1    Au-Yeung, T.H.2
  • 20
    • 0004514220 scopus 로고
    • Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines
    • 10.1073/pnas.76.5.2430, 383615, 313056
    • Carson DA, et al. Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines. Proc Natl Acad Sci U S A 1979, 76(5):2430-2433. 10.1073/pnas.76.5.2430, 383615, 313056.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , Issue.5 , pp. 2430-2433
    • Carson, D.A.1
  • 21
    • 0141535442 scopus 로고    scopus 로고
    • Pharmacological basis for cladribine resistance
    • 10.1080/1042819031000099698, 14692522
    • Lotfi K, Juliusson G, Albertioni F. Pharmacological basis for cladribine resistance. Leuk Lymphoma 2003, 44(10):1705-1712. 10.1080/1042819031000099698, 14692522.
    • (2003) Leuk Lymphoma , vol.44 , Issue.10 , pp. 1705-1712
    • Lotfi, K.1    Juliusson, G.2    Albertioni, F.3
  • 22
    • 30044450909 scopus 로고    scopus 로고
    • A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems
    • King KM, et al. A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems. Mol Pharmacol 2006, 69(1):346-353.
    • (2006) Mol Pharmacol , vol.69 , Issue.1 , pp. 346-353
    • King, K.M.1
  • 23
    • 85047685868 scopus 로고    scopus 로고
    • The role of mitochondrial and plasma membrane nucleoside transporters in drug toxicity
    • 10.1517/17425255.3.5.705, 17916056
    • Leung GP, Tse CM. The role of mitochondrial and plasma membrane nucleoside transporters in drug toxicity. Expert Opin Drug Metab Toxicol 2007, 3(5):705-718. 10.1517/17425255.3.5.705, 17916056.
    • (2007) Expert Opin Drug Metab Toxicol , vol.3 , Issue.5 , pp. 705-718
    • Leung, G.P.1    Tse, C.M.2
  • 24
    • 0032188825 scopus 로고    scopus 로고
    • Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
    • Mackey JR, et al. Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res 1998, 58(19):4349-4357.
    • (1998) Cancer Res , vol.58 , Issue.19 , pp. 4349-4357
    • Mackey, J.R.1
  • 25
    • 0027381413 scopus 로고
    • Substrate specificity of mitochondrial 2'-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine
    • Wang L, et al. Substrate specificity of mitochondrial 2'-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine. J Biol Chem 1993, 268(30):22847-22852.
    • (1993) J Biol Chem , vol.268 , Issue.30 , pp. 22847-22852
    • Wang, L.1
  • 26
    • 0032515166 scopus 로고    scopus 로고
    • The intracellular localization of deoxycytidine kinase
    • 10.1074/jbc.273.46.30239, 9804782
    • Hatzis P, et al. The intracellular localization of deoxycytidine kinase. J Biol Chem 1998, 273(46):30239-30243. 10.1074/jbc.273.46.30239, 9804782.
    • (1998) J Biol Chem , vol.273 , Issue.46 , pp. 30239-30243
    • Hatzis, P.1
  • 27
    • 0030704686 scopus 로고    scopus 로고
    • Human deoxycytidine kinase is located in the cell nucleus
    • 10.1073/pnas.94.22.11941, 23663, 9342341
    • Johansson M, Brismar S, Karlsson A. Human deoxycytidine kinase is located in the cell nucleus. Proc Natl Acad Sci U S A 1997, 94(22):11941-11945. 10.1073/pnas.94.22.11941, 23663, 9342341.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.22 , pp. 11941-11945
    • Johansson, M.1    Brismar, S.2    Karlsson, A.3
  • 28
    • 0027525929 scopus 로고
    • Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine
    • Kawasaki H, et al. Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine. Blood 1993, 81(3):597-601.
    • (1993) Blood , vol.81 , Issue.3 , pp. 597-601
    • Kawasaki, H.1
  • 29
    • 0025233649 scopus 로고
    • Incorporation of 2-halogeno-2'-deoxyadenosine 5-triphosphates into DNA during replication by human polymerases alpha and beta
    • Hentosh P, Koob R, Blakley RL. Incorporation of 2-halogeno-2'-deoxyadenosine 5-triphosphates into DNA during replication by human polymerases alpha and beta. J Biol Chem 1990, 265(7):4033-4040.
    • (1990) J Biol Chem , vol.265 , Issue.7 , pp. 4033-4040
    • Hentosh, P.1    Koob, R.2    Blakley, R.L.3
  • 30
    • 0023733094 scopus 로고
    • Interaction of 2-halogenated dATP analogs (F, Cl, and Br) with human DNA polymerases, DNA primase, and ribonucleotide reductase
    • Parker WB, et al. Interaction of 2-halogenated dATP analogs (F, Cl, and Br) with human DNA polymerases, DNA primase, and ribonucleotide reductase. Mol Pharmacol 1988, 34(4):485-491.
    • (1988) Mol Pharmacol , vol.34 , Issue.4 , pp. 485-491
    • Parker, W.B.1
  • 31
    • 0033869494 scopus 로고    scopus 로고
    • Role of poly(ADP-ribosyl)ation in the killing of chronic lymphocytic leukemia cells by purine analogues
    • Pettitt AR, Sherrington PD, Cawley JC. Role of poly(ADP-ribosyl)ation in the killing of chronic lymphocytic leukemia cells by purine analogues. Cancer Res 2000, 60(15):4187-4193.
    • (2000) Cancer Res , vol.60 , Issue.15 , pp. 4187-4193
    • Pettitt, A.R.1    Sherrington, P.D.2    Cawley, J.C.3
  • 32
    • 0027505303 scopus 로고
    • Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine
    • Robertson LE, et al. Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine. Blood 1993, 81(1):143-150.
    • (1993) Blood , vol.81 , Issue.1 , pp. 143-150
    • Robertson, L.E.1
  • 33
    • 0022003367 scopus 로고
    • Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes
    • 10.1172/JCI111710, 423498, 2579098
    • Seto S, et al. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J Clin Invest 1985, 75(2):377-383. 10.1172/JCI111710, 423498, 2579098.
    • (1985) J Clin Invest , vol.75 , Issue.2 , pp. 377-383
    • Seto, S.1
  • 34
    • 0033028601 scopus 로고    scopus 로고
    • Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms
    • 10.1046/j.1365-2141.1999.01448.x, 10554810
    • Pettitt AR, et al. Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms. Br J Haematol 1999, 105(4):986-988. 10.1046/j.1365-2141.1999.01448.x, 10554810.
    • (1999) Br J Haematol , vol.105 , Issue.4 , pp. 986-988
    • Pettitt, A.R.1
  • 35
    • 0024787036 scopus 로고
    • Mechanisms of inhibition of DNA synthesis by 2-chlorodeoxyadenosine in human lymphoblastic cells
    • Griffig J, Koob R, Blakley RL. Mechanisms of inhibition of DNA synthesis by 2-chlorodeoxyadenosine in human lymphoblastic cells. Cancer Res 1989, 49(24 Pt 1):6923-6928.
    • (1989) Cancer Res , vol.49 , Issue.24 PART 1 , pp. 6923-6928
    • Griffig, J.1    Koob, R.2    Blakley, R.L.3
  • 36
    • 0028875363 scopus 로고
    • The influence of 2-chloro-2'-deoxyadenosine on metabolism of deoxyadenosine in human primary CNS lymphoma
    • 10.1016/0006-2952(95)02018-7, 7503787
    • Fabianowska-Majewska K, et al. The influence of 2-chloro-2'-deoxyadenosine on metabolism of deoxyadenosine in human primary CNS lymphoma. Biochem Pharmacol 1995, 50(9):1379-1383. 10.1016/0006-2952(95)02018-7, 7503787.
    • (1995) Biochem Pharmacol , vol.50 , Issue.9 , pp. 1379-1383
    • Fabianowska-Majewska, K.1
  • 37
    • 0034669944 scopus 로고    scopus 로고
    • Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
    • Genini D, et al. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood 2000, 96(10):3537-3543.
    • (2000) Blood , vol.96 , Issue.10 , pp. 3537-3543
    • Genini, D.1
  • 38
    • 0030935116 scopus 로고    scopus 로고
    • 2-Chloro-2'-deoxyadenosine, an antileukemic drug, has an early effect on cellular mitochondrial function
    • Hentosh P, Tibudan M. 2-Chloro-2'-deoxyadenosine, an antileukemic drug, has an early effect on cellular mitochondrial function. Mol Pharmacol 1997, 51(4):613-619.
    • (1997) Mol Pharmacol , vol.51 , Issue.4 , pp. 613-619
    • Hentosh, P.1    Tibudan, M.2
  • 39
    • 0029825528 scopus 로고    scopus 로고
    • Perspectives on purine analogues
    • Cheson BD. Perspectives on purine analogues. Hematol Cell Ther 1996, 38(Suppl 2):S109-S116.
    • (1996) Hematol Cell Ther , vol.38 , Issue.SUPPL. 2
    • Cheson, B.D.1
  • 40
    • 0028219970 scopus 로고
    • 2-Chlorodeoxyadenosine: a newer purine analog active in the treatment of indolent lymphoid malignancies
    • 10.7326/0003-4819-120-9-199405010-00010, 7908507
    • Saven A, Piro LD. 2-Chlorodeoxyadenosine: a newer purine analog active in the treatment of indolent lymphoid malignancies. Ann Intern Med 1994, 120(9):784-791. 10.7326/0003-4819-120-9-199405010-00010, 7908507.
    • (1994) Ann Intern Med , vol.120 , Issue.9 , pp. 784-791
    • Saven, A.1    Piro, L.D.2
  • 41
    • 33749263031 scopus 로고    scopus 로고
    • Discovery and development of clofarabine: a nucleoside analogue for treating cancer
    • 10.1038/nrd2055, 17016426
    • Bonate PL, et al. Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nat Rev Drug Discov 2006, 5(10):855-863. 10.1038/nrd2055, 17016426.
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.10 , pp. 855-863
    • Bonate, P.L.1
  • 42
    • 0020636463 scopus 로고
    • 2-fluoro-ATP: a toxic metabolite of 9-beta-D-arabinosyl-2-fluoroadenine
    • 10.1016/0006-291X(83)90428-X, 6860342
    • Avramis VI, Plunkett W. 2-fluoro-ATP: a toxic metabolite of 9-beta-D-arabinosyl-2-fluoroadenine. Biochem Biophys Res Commun 1983, 113(1):35-43. 10.1016/0006-291X(83)90428-X, 6860342.
    • (1983) Biochem Biophys Res Commun , vol.113 , Issue.1 , pp. 35-43
    • Avramis, V.I.1    Plunkett, W.2
  • 43
    • 0026565544 scopus 로고
    • Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine
    • 10.1021/jm00080a029, 1732556
    • Montgomery JA, et al. Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine. J Med Chem 1992, 35(2):397-401. 10.1021/jm00080a029, 1732556.
    • (1992) J Med Chem , vol.35 , Issue.2 , pp. 397-401
    • Montgomery, J.A.1
  • 44
    • 0036636579 scopus 로고    scopus 로고
    • Nucleoside analogues and nucleobases in cancer treatment
    • 10.1016/S1470-2045(02)00788-X, 12142171
    • Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues and nucleobases in cancer treatment. Lancet Oncol 2002, 3(7):415-424. 10.1016/S1470-2045(02)00788-X, 12142171.
    • (2002) Lancet Oncol , vol.3 , Issue.7 , pp. 415-424
    • Galmarini, C.M.1    Mackey, J.R.2    Dumontet, C.3
  • 45
    • 33644859099 scopus 로고    scopus 로고
    • The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation
    • Zhang Y, Secrist JA, Ealick SE. The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. Acta Crystallogr D Biol Crystallogr 2006, 62(Pt 2):133-139.
    • (2006) Acta Crystallogr D Biol Crystallogr , vol.62 , Issue.PART 2 , pp. 133-139
    • Zhang, Y.1    Secrist, J.A.2    Ealick, S.E.3
  • 46
    • 70349771790 scopus 로고    scopus 로고
    • Mechanisms of anti-cancer action and pharmacology of clofarabine
    • 10.1016/j.bcp.2009.06.094, 19576186
    • Zhenchuk A, et al. Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol 2009, 78(11):1351-1359. 10.1016/j.bcp.2009.06.094, 19576186.
    • (2009) Biochem Pharmacol , vol.78 , Issue.11 , pp. 1351-1359
    • Zhenchuk, A.1
  • 47
    • 0345466497 scopus 로고    scopus 로고
    • Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, a novel analogue of cladribine in human leukemic cells
    • Lotfi K, et al. Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, a novel analogue of cladribine in human leukemic cells. Clin Cancer Res 1999, 5(9):2438-2444.
    • (1999) Clin Cancer Res , vol.5 , Issue.9 , pp. 2438-2444
    • Lotfi, K.1
  • 48
    • 0033063791 scopus 로고    scopus 로고
    • Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2- fluoro-beta-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro- beta-D-ribofuranosyl)adenine, and 2-chloro-9-(2-deoxy-2,2-difluoro- beta-D-ribofuranosyl)adenine in CEM cells
    • Parker WB, et al. Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2- fluoro-beta-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro- beta-D-ribofuranosyl)adenine, and 2-chloro-9-(2-deoxy-2,2-difluoro- beta-D-ribofuranosyl)adenine in CEM cells. Mol Pharmacol 1999, 55(3):515-520.
    • (1999) Mol Pharmacol , vol.55 , Issue.3 , pp. 515-520
    • Parker, W.B.1
  • 49
    • 79952210590 scopus 로고    scopus 로고
    • Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity
    • 10.1158/0008-5472.CAN-10-1919, 3531552, 21245102
    • Nagai S, et al. Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity. Cancer Res 2011, 71(5):1781-1791. 10.1158/0008-5472.CAN-10-1919, 3531552, 21245102.
    • (2011) Cancer Res , vol.71 , Issue.5 , pp. 1781-1791
    • Nagai, S.1
  • 50
    • 33646178365 scopus 로고    scopus 로고
    • Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity
    • Smal C, et al. Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity. J Biol Chem 2006, 281(8):4887-4893.
    • (2006) J Biol Chem , vol.281 , Issue.8 , pp. 4887-4893
    • Smal, C.1
  • 51
    • 84868153409 scopus 로고    scopus 로고
    • Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage
    • 10.1093/nar/gks707, 3479177, 22850745
    • Yang C, et al. Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage. Nucleic Acids Res 2012, 40(19):9621-9632. 10.1093/nar/gks707, 3479177, 22850745.
    • (2012) Nucleic Acids Res , vol.40 , Issue.19 , pp. 9621-9632
    • Yang, C.1
  • 52
    • 0025811415 scopus 로고
    • Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate
    • Parker WB, et al. Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res 1991, 51(9):2386-2394.
    • (1991) Cancer Res , vol.51 , Issue.9 , pp. 2386-2394
    • Parker, W.B.1
  • 53
    • 0029053894 scopus 로고
    • Metabolism and actions of 2-chloro-9-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl)-adenine in human lymphoblastoid cells
    • Xie C, Plunkett W. Metabolism and actions of 2-chloro-9-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl)-adenine in human lymphoblastoid cells. Cancer Res 1995, 55(13):2847-2852.
    • (1995) Cancer Res , vol.55 , Issue.13 , pp. 2847-2852
    • Xie, C.1    Plunkett, W.2
  • 54
    • 0034614551 scopus 로고    scopus 로고
    • Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway
    • 10.1074/jbc.275.1.29, 10617581
    • Genini D, et al. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. J Biol Chem 2000, 275(1):29-34. 10.1074/jbc.275.1.29, 10617581.
    • (2000) J Biol Chem , vol.275 , Issue.1 , pp. 29-34
    • Genini, D.1
  • 55
    • 0037445122 scopus 로고    scopus 로고
    • Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers
    • 10.1200/JCO.2003.04.031, 12637486
    • Kantarjian HM, et al. Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers. J Clin Oncol 2003, 21(6):1167-1173. 10.1200/JCO.2003.04.031, 12637486.
    • (2003) J Clin Oncol , vol.21 , Issue.6 , pp. 1167-1173
    • Kantarjian, H.M.1
  • 56
    • 84867031814 scopus 로고    scopus 로고
    • Preclinical combination therapy of clofarabine plus radiation
    • 10.1080/15257770.2012.723770, 23004932
    • Stackhouse MA, et al. Preclinical combination therapy of clofarabine plus radiation. Nucleosides Nucleotides Nucleic Acids 2012, 31(9):692-705. 10.1080/15257770.2012.723770, 23004932.
    • (2012) Nucleosides Nucleotides Nucleic Acids , vol.31 , Issue.9 , pp. 692-705
    • Stackhouse, M.A.1
  • 57
    • 33748885763 scopus 로고    scopus 로고
    • Clofarabine and nelarabine: two new purine nucleoside analogs
    • 10.1097/01.cco.0000245326.65152.af, 16988579
    • Gandhi V, Plunkett W. Clofarabine and nelarabine: two new purine nucleoside analogs. Curr Opin Oncol 2006, 18(6):584-590. 10.1097/01.cco.0000245326.65152.af, 16988579.
    • (2006) Curr Opin Oncol , vol.18 , Issue.6 , pp. 584-590
    • Gandhi, V.1    Plunkett, W.2
  • 58
    • 0029127419 scopus 로고
    • 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies
    • Lambe CU, et al. 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies. Cancer Res 1995, 55(15):3352-3356.
    • (1995) Cancer Res , vol.55 , Issue.15 , pp. 3352-3356
    • Lambe, C.U.1
  • 59
    • 0017807276 scopus 로고
    • Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency
    • 10.1172/JCI109058, 372663, 96138
    • Cohen A, et al. Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency. J Clin Invest 1978, 61(5):1405-1409. 10.1172/JCI109058, 372663, 96138.
    • (1978) J Clin Invest , vol.61 , Issue.5 , pp. 1405-1409
    • Cohen, A.1
  • 60
    • 0018931839 scopus 로고
    • The expression of deoxyguanosine toxicity in T lymphocytes at different stages of maturation
    • Cohen A, et al. The expression of deoxyguanosine toxicity in T lymphocytes at different stages of maturation. J Immunol 1980, 125(4):1578-1582.
    • (1980) J Immunol , vol.125 , Issue.4 , pp. 1578-1582
    • Cohen, A.1
  • 61
    • 0018744828 scopus 로고
    • Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function
    • 10.1073/pnas.76.4.1998, 383521, 313053
    • Gelfand EW, Lee JJ, Dosch HM. Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function. Proc Natl Acad Sci U S A 1979, 76(4):1998-2002. 10.1073/pnas.76.4.1998, 383521, 313053.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , Issue.4 , pp. 1998-2002
    • Gelfand, E.W.1    Lee, J.J.2    Dosch, H.M.3
  • 62
    • 84919573117 scopus 로고
    • Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity
    • Giblett ER, et al. Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity. Lancet 1975, 1(7914):1010-1013.
    • (1975) Lancet , vol.1 , Issue.7914 , pp. 1010-1013
    • Giblett, E.R.1
  • 63
    • 0041941097 scopus 로고    scopus 로고
    • Mechanisms for T-cell selective cytotoxicity of arabinosylguanine
    • 10.1182/blood-2003-01-0317, 12750168
    • Rodriguez CO, Stellrecht CM, Gandhi V. Mechanisms for T-cell selective cytotoxicity of arabinosylguanine. Blood 2003, 102(5):1842-1848. 10.1182/blood-2003-01-0317, 12750168.
    • (2003) Blood , vol.102 , Issue.5 , pp. 1842-1848
    • Rodriguez, C.O.1    Stellrecht, C.M.2    Gandhi, V.3
  • 64
    • 0020614859 scopus 로고
    • Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells
    • Cohen A, Lee JW, Gelfand EW. Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells. Blood 1983, 61(4):660-666.
    • (1983) Blood , vol.61 , Issue.4 , pp. 660-666
    • Cohen, A.1    Lee, J.W.2    Gelfand, E.W.3
  • 65
    • 0025317092 scopus 로고
    • Transport and metabolism of 9-beta-D-arabinofuranosylguanine in a human T-lymphoblastoid cell line: nitrobenzylthioinosine-sensitive and -insensitive influx
    • Prus KL, Averett DR, Zimmerman TP. Transport and metabolism of 9-beta-D-arabinofuranosylguanine in a human T-lymphoblastoid cell line: nitrobenzylthioinosine-sensitive and -insensitive influx. Cancer Res 1990, 50(6):1817-1821.
    • (1990) Cancer Res , vol.50 , Issue.6 , pp. 1817-1821
    • Prus, K.L.1    Averett, D.R.2    Zimmerman, T.P.3
  • 66
    • 0036606777 scopus 로고    scopus 로고
    • Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase
    • Rodriguez CO, et al. Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. Cancer Res 2002, 62(11):3100-3105.
    • (2002) Cancer Res , vol.62 , Issue.11 , pp. 3100-3105
    • Rodriguez, C.O.1
  • 67
    • 80054694716 scopus 로고    scopus 로고
    • Induction of fetal hemoglobin and ABCB1 gene expression in 9-beta-D-arabinofuranosylguanine-resistant MOLT-4 cells
    • 10.1007/s00280-010-1524-5, 21110023
    • Fyrberg A, et al. Induction of fetal hemoglobin and ABCB1 gene expression in 9-beta-D-arabinofuranosylguanine-resistant MOLT-4 cells. Cancer Chemother Pharmacol 2011, 68(3):583-591. 10.1007/s00280-010-1524-5, 21110023.
    • (2011) Cancer Chemother Pharmacol , vol.68 , Issue.3 , pp. 583-591
    • Fyrberg, A.1
  • 68
    • 0345363112 scopus 로고    scopus 로고
    • Arabinosylguanine-induced apoptosis of T-lymphoblastic cells: incorporation into DNA is a necessary step
    • Rodriguez CO, Gandh V. Arabinosylguanine-induced apoptosis of T-lymphoblastic cells: incorporation into DNA is a necessary step. Cancer Res 1999, 59(19):4937-4943.
    • (1999) Cancer Res , vol.59 , Issue.19 , pp. 4937-4943
    • Rodriguez, C.O.1    Gandh, V.2
  • 69
    • 0035976921 scopus 로고    scopus 로고
    • Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs
    • 10.1074/jbc.M107169200, 11584005
    • Sundaram M, et al. Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs. J Biol Chem 2001, 276(48):45270-45275. 10.1074/jbc.M107169200, 11584005.
    • (2001) J Biol Chem , vol.276 , Issue.48 , pp. 45270-45275
    • Sundaram, M.1
  • 70
    • 0021025261 scopus 로고
    • Alteration of the pharmacokinetics of high-dose ara-C by its metabolite, high ara-U in patients with acute leukemia
    • Capizzi RL, et al. Alteration of the pharmacokinetics of high-dose ara-C by its metabolite, high ara-U in patients with acute leukemia. J Clin Oncol 1983, 1(12):763-771.
    • (1983) J Clin Oncol , vol.1 , Issue.12 , pp. 763-771
    • Capizzi, R.L.1
  • 71
    • 0019808979 scopus 로고
    • Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases
    • Verhoef V, Sarup J, Fridland A. Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases. Cancer Res 1981, 41(11 Pt 1):4478-4483.
    • (1981) Cancer Res , vol.41 , Issue.11 PART 1 , pp. 4478-4483
    • Verhoef, V.1    Sarup, J.2    Fridland, A.3
  • 72
    • 80052449326 scopus 로고    scopus 로고
    • Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases
    • 10.1111/j.1742-4658.2011.08235.x, 3168698, 21740521
    • Chen ZS, Tiwari AK. Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases. FEBS J 2011, 278(18):3226-3245. 10.1111/j.1742-4658.2011.08235.x, 3168698, 21740521.
    • (2011) FEBS J , vol.278 , Issue.18 , pp. 3226-3245
    • Chen, Z.S.1    Tiwari, A.K.2
  • 73
    • 0021719254 scopus 로고
    • Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D- arabinofuranosylcytosine
    • Bhalla K, Nayak R, Grant S. Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D- arabinofuranosylcytosine. Cancer Res 1984, 44(11):5029-5037.
    • (1984) Cancer Res , vol.44 , Issue.11 , pp. 5029-5037
    • Bhalla, K.1    Nayak, R.2    Grant, S.3
  • 74
    • 0026637308 scopus 로고
    • Resistance to 1-beta-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene
    • Owens JK, et al. Resistance to 1-beta-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene. Cancer Res 1992, 52(9):2389-2393.
    • (1992) Cancer Res , vol.52 , Issue.9 , pp. 2389-2393
    • Owens, J.K.1
  • 75
    • 0028910558 scopus 로고
    • Inhibition of bcl-2 with antisense oligonucleotides induces apoptosis and increases the sensitivity of AML blasts to Ara-C
    • Keith FJ, et al. Inhibition of bcl-2 with antisense oligonucleotides induces apoptosis and increases the sensitivity of AML blasts to Ara-C. Leukemia 1995, 9(1):131-138.
    • (1995) Leukemia , vol.9 , Issue.1 , pp. 131-138
    • Keith, F.J.1
  • 76
    • 0035871907 scopus 로고    scopus 로고
    • Involvement of oxygen radicals in cytarabine-induced apoptosis in human polymorphonuclear cells
    • 10.1016/S0006-2952(01)00548-2, 11286995
    • Iacobini M, et al. Involvement of oxygen radicals in cytarabine-induced apoptosis in human polymorphonuclear cells. Biochem Pharmacol 2001, 61(8):1033-1040. 10.1016/S0006-2952(01)00548-2, 11286995.
    • (2001) Biochem Pharmacol , vol.61 , Issue.8 , pp. 1033-1040
    • Iacobini, M.1
  • 77
    • 0035260635 scopus 로고    scopus 로고
    • Gemcitabine as single-agent therapy in the management of advanced breast cancer
    • Seidman AD. Gemcitabine as single-agent therapy in the management of advanced breast cancer. Oncology (Williston Park) 2001, 15(2 Suppl 3):11-14.
    • (2001) Oncology (Williston Park) , vol.15 , Issue.2 SUPPL. 3 , pp. 11-14
    • Seidman, A.D.1
  • 78
    • 0028799915 scopus 로고
    • Advanced breast cancer: a phase II trial with gemcitabine
    • Carmichael J, et al. Advanced breast cancer: a phase II trial with gemcitabine. J Clin Oncol 1995, 13(11):2731-2736.
    • (1995) J Clin Oncol , vol.13 , Issue.11 , pp. 2731-2736
    • Carmichael, J.1
  • 79
    • 0028039840 scopus 로고
    • Weekly gemcitabine in advanced bladder cancer: a preliminary report from a phase I study
    • Pollera CF, et al. Weekly gemcitabine in advanced bladder cancer: a preliminary report from a phase I study. Ann Oncol 1994, 5(2):182-184.
    • (1994) Ann Oncol , vol.5 , Issue.2 , pp. 182-184
    • Pollera, C.F.1
  • 80
    • 0028020890 scopus 로고
    • Phase II study of gemcitabine (2',2'-difluorodeoxycytidine) in previously treated ovarian cancer patients
    • 10.1093/jnci/86.20.1530, 7932808
    • Lund B, et al. Phase II study of gemcitabine (2',2'-difluorodeoxycytidine) in previously treated ovarian cancer patients. J Natl Cancer Inst 1994, 86(20):1530-1533. 10.1093/jnci/86.20.1530, 7932808.
    • (1994) J Natl Cancer Inst , vol.86 , Issue.20 , pp. 1530-1533
    • Lund, B.1
  • 81
    • 0028033227 scopus 로고
    • Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: a phase II study
    • Anderson H, et al. Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: a phase II study. J Clin Oncol 1994, 12(9):1821-1826.
    • (1994) J Clin Oncol , vol.12 , Issue.9 , pp. 1821-1826
    • Anderson, H.1
  • 82
    • 0027993707 scopus 로고
    • Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: a phase II study
    • Abratt RP, et al. Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: a phase II study. J Clin Oncol 1994, 12(8):1535-1540.
    • (1994) J Clin Oncol , vol.12 , Issue.8 , pp. 1535-1540
    • Abratt, R.P.1
  • 83
    • 0028292341 scopus 로고
    • Phase II trial of gemcitabine (2,2'-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas
    • 10.1007/BF00873232, 7960602
    • Casper ES, et al. Phase II trial of gemcitabine (2,2'-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas. Invest New Drugs 1994, 12(1):29-34. 10.1007/BF00873232, 7960602.
    • (1994) Invest New Drugs , vol.12 , Issue.1 , pp. 29-34
    • Casper, E.S.1
  • 84
    • 0029943675 scopus 로고    scopus 로고
    • Activity of gemcitabine in patients with advanced pancreatic carcinoma
    • Moore M. Activity of gemcitabine in patients with advanced pancreatic carcinoma. A review. Cancer 1996, 78(3 Suppl):633-638.
    • (1996) A review. Cancer , vol.78 , Issue.3 SUPPL. , pp. 633-638
    • Moore, M.1
  • 85
    • 0034327360 scopus 로고    scopus 로고
    • Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivity
    • Rauchwerger DR, et al. Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivity. Cancer Res 2000, 60(21):6075-6079.
    • (2000) Cancer Res , vol.60 , Issue.21 , pp. 6075-6079
    • Rauchwerger, D.R.1
  • 86
    • 0345688175 scopus 로고    scopus 로고
    • Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy
    • 10.1038/sj.onc.1206952, 14576856
    • Damaraju VL, et al. Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene 2003, 22(47):7524-7536. 10.1038/sj.onc.1206952, 14576856.
    • (2003) Oncogene , vol.22 , Issue.47 , pp. 7524-7536
    • Damaraju, V.L.1
  • 87
    • 0023783698 scopus 로고
    • Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine
    • Heinemann V, et al. Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine. Cancer Res 1988, 48(14):4024-4031.
    • (1988) Cancer Res , vol.48 , Issue.14 , pp. 4024-4031
    • Heinemann, V.1
  • 88
    • 0034994444 scopus 로고    scopus 로고
    • Nucleoside analogues: mechanisms of drug resistance and reversal strategies
    • 10.1038/sj.leu.2402114, 11417472
    • Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 2001, 15(6):875-890. 10.1038/sj.leu.2402114, 11417472.
    • (2001) Leukemia , vol.15 , Issue.6 , pp. 875-890
    • Galmarini, C.M.1    Mackey, J.R.2    Dumontet, C.3
  • 89
    • 0028799108 scopus 로고
    • Gemcitabine: metabolism, mechanisms of action, and self-potentiation
    • Plunkett W, et al. Gemcitabine: metabolism, mechanisms of action, and self-potentiation. Semin Oncol 1995, 22(4 Suppl 11):3-10.
    • (1995) Semin Oncol , vol.22 , Issue.4 SUPPL. 11 , pp. 3-10
    • Plunkett, W.1
  • 90
    • 0026324313 scopus 로고
    • Action of 2',2'-difluorodeoxycytidine on DNA synthesis
    • Huang P, et al. Action of 2',2'-difluorodeoxycytidine on DNA synthesis. Cancer Res 1991, 51(22):6110-6117.
    • (1991) Cancer Res , vol.51 , Issue.22 , pp. 6110-6117
    • Huang, P.1
  • 91
    • 0028783440 scopus 로고
    • Induction of apoptosis by gemcitabine
    • Huang P, Plunkett W. Induction of apoptosis by gemcitabine. Semin Oncol 1995, 22(4 Suppl 11):19-25.
    • (1995) Semin Oncol , vol.22 , Issue.4 SUPPL. 11 , pp. 19-25
    • Huang, P.1    Plunkett, W.2
  • 92
    • 0025049372 scopus 로고
    • Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine
    • Heinemann V, et al. Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine. Mol Pharmacol 1990, 38(4):567-572.
    • (1990) Mol Pharmacol , vol.38 , Issue.4 , pp. 567-572
    • Heinemann, V.1
  • 93
    • 10044263366 scopus 로고    scopus 로고
    • Caspase-3 drives apoptosis in pancreatic cancer cells after treatment with gemcitabine
    • 10.1016/j.gassur.2004.09.054, 15585396
    • Chandler NM, Canete JJ, Callery MP. Caspase-3 drives apoptosis in pancreatic cancer cells after treatment with gemcitabine. J Gastrointest Surg 2004, 8(8):1072-1078. 10.1016/j.gassur.2004.09.054, 15585396.
    • (2004) J Gastrointest Surg , vol.8 , Issue.8 , pp. 1072-1078
    • Chandler, N.M.1    Canete, J.J.2    Callery, M.P.3
  • 94
    • 1542263998 scopus 로고    scopus 로고
    • Caspase activation is required for gemcitabine activity in multiple myeloma cell lines
    • Nabhan C, et al. Caspase activation is required for gemcitabine activity in multiple myeloma cell lines. Mol Cancer Ther 2002, 1(13):1221-1227.
    • (2002) Mol Cancer Ther , vol.1 , Issue.13 , pp. 1221-1227
    • Nabhan, C.1
  • 95
    • 4544384318 scopus 로고    scopus 로고
    • Radiation oncology: a century of achievements
    • Bernier J, Hall EJ, Giaccia A. Radiation oncology: a century of achievements. Nat Rev Cancer 2004, 4(9):737-747.
    • (2004) Nat Rev Cancer , vol.4 , Issue.9 , pp. 737-747
    • Bernier, J.1    Hall, E.J.2    Giaccia, A.3
  • 96
    • 37049017587 scopus 로고    scopus 로고
    • Clofarabine acts as radiosensitizer in vitro and in vivo by interfering with DNA damage response
    • 10.1016/j.ijrobp.2007.09.012, 18037589
    • Cariveau MJ, et al. Clofarabine acts as radiosensitizer in vitro and in vivo by interfering with DNA damage response. Int J Radiat Oncol Biol Phys 2008, 70(1):213-220. 10.1016/j.ijrobp.2007.09.012, 18037589.
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , Issue.1 , pp. 213-220
    • Cariveau, M.J.1
  • 97
    • 0036023450 scopus 로고    scopus 로고
    • Role of deoxycytidine kinase (dCK) activity in gemcitabine's radioenhancement in mice and human cell lines in vitro
    • 10.1016/S0167-8140(02)00106-8, 12142097
    • Gregoire V, et al. Role of deoxycytidine kinase (dCK) activity in gemcitabine's radioenhancement in mice and human cell lines in vitro. Radiother Oncol 2002, 63(3):329-338. 10.1016/S0167-8140(02)00106-8, 12142097.
    • (2002) Radiother Oncol , vol.63 , Issue.3 , pp. 329-338
    • Gregoire, V.1
  • 98
    • 84883849518 scopus 로고
    • Combined Radiation and Chemotherapy
    • 10.1001/jama.1963.03710120039008, 14061412
    • Latourette HB, Lawton RL. Combined Radiation and Chemotherapy. JAMA 1963, 186:1057-1060. 10.1001/jama.1963.03710120039008, 14061412.
    • (1963) JAMA , vol.186 , pp. 1057-1060
    • Latourette, H.B.1    Lawton, R.L.2
  • 99
    • 0028240063 scopus 로고
    • Metabolism of 2',2'-difluoro-2'-deoxycytidine and radiation sensitization of human colon carcinoma cells
    • Shewach DS, et al. Metabolism of 2',2'-difluoro-2'-deoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Res 1994, 54(12):3218-3223.
    • (1994) Cancer Res , vol.54 , Issue.12 , pp. 3218-3223
    • Shewach, D.S.1
  • 100
    • 34748903527 scopus 로고    scopus 로고
    • Antimetabolite radiosensitizers
    • 10.1200/JCO.2007.11.5287, 17827452
    • Shewach DS, Lawrence TS. Antimetabolite radiosensitizers. J Clin Oncol 2007, 25(26):4043-4050. 10.1200/JCO.2007.11.5287, 17827452.
    • (2007) J Clin Oncol , vol.25 , Issue.26 , pp. 4043-4050
    • Shewach, D.S.1    Lawrence, T.S.2
  • 101
    • 54949098894 scopus 로고    scopus 로고
    • Nucleoside analogs: molecular mechanisms signaling cell death
    • 10.1038/onc.2008.316, 18955977
    • Ewald B, Sampath D, Plunkett W. Nucleoside analogs: molecular mechanisms signaling cell death. Oncogene 2008, 27(50):6522-6537. 10.1038/onc.2008.316, 18955977.
    • (2008) Oncogene , vol.27 , Issue.50 , pp. 6522-6537
    • Ewald, B.1    Sampath, D.2    Plunkett, W.3
  • 102
    • 0041881891 scopus 로고    scopus 로고
    • Selective targeting of homologous DNA recombination repair by gemcitabine
    • 10.1016/S0360-3016(03)00503-0, 12957269
    • Wachters FM, et al. Selective targeting of homologous DNA recombination repair by gemcitabine. Int J Radiat Oncol Biol Phys 2003, 57(2):553-562. 10.1016/S0360-3016(03)00503-0, 12957269.
    • (2003) Int J Radiat Oncol Biol Phys , vol.57 , Issue.2 , pp. 553-562
    • Wachters, F.M.1
  • 103
    • 0035866412 scopus 로고    scopus 로고
    • End-joining deficiency and radiosensitization induced by gemcitabine
    • van Putten JWG, et al. End-joining deficiency and radiosensitization induced by gemcitabine. Cancer Res 2001, 61(4):1585-1591.
    • (2001) Cancer Res , vol.61 , Issue.4 , pp. 1585-1591
    • van Putten, J.W.G.1
  • 104
    • 0031804603 scopus 로고    scopus 로고
    • Radiosensitizing potential of gemcitabine (2',2'-difluoro-2'-deoxycytidine) within the cell cycle in vitro
    • 10.1016/S0360-3016(98)00105-9, 9652852
    • Latz D, et al. Radiosensitizing potential of gemcitabine (2',2'-difluoro-2'-deoxycytidine) within the cell cycle in vitro. Int J Radiat Oncol Biol Phys 1998, 41(4):875-882. 10.1016/S0360-3016(98)00105-9, 9652852.
    • (1998) Int J Radiat Oncol Biol Phys , vol.41 , Issue.4 , pp. 875-882
    • Latz, D.1
  • 105
    • 0030922494 scopus 로고    scopus 로고
    • Delayed radiosensitization of human colon carcinoma cells after a brief exposure to 2',2'-difluoro-2'-deoxycytidine (Gemcitabine)
    • Lawrence TS, et al. Delayed radiosensitization of human colon carcinoma cells after a brief exposure to 2',2'-difluoro-2'-deoxycytidine (Gemcitabine). Clin Cancer Res 1997, 3(5):777-782.
    • (1997) Clin Cancer Res , vol.3 , Issue.5 , pp. 777-782
    • Lawrence, T.S.1
  • 106
    • 7144264394 scopus 로고    scopus 로고
    • Radiosensitization of mouse sarcoma cells by fludarabine (F-ara-A) or gemcitabine (dFdC), two nucleoside analogues, is not mediated by an increased induction or a repair inhibition of DNA double-strand breaks as measured by pulsed-field gel electrophoresis
    • 10.1080/095530098142059, 9652808
    • Gregoire V, et al. Radiosensitization of mouse sarcoma cells by fludarabine (F-ara-A) or gemcitabine (dFdC), two nucleoside analogues, is not mediated by an increased induction or a repair inhibition of DNA double-strand breaks as measured by pulsed-field gel electrophoresis. Int J Radiat Biol 1998, 73(5):511-520. 10.1080/095530098142059, 9652808.
    • (1998) Int J Radiat Biol , vol.73 , Issue.5 , pp. 511-520
    • Gregoire, V.1
  • 107
    • 78650334762 scopus 로고    scopus 로고
    • Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase
    • 10.4161/cc.9.24.14155, 21131780
    • Taricani L, et al. Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase. Cell Cycle 2010, 9(24):4876-4883. 10.4161/cc.9.24.14155, 21131780.
    • (2010) Cell Cycle , vol.9 , Issue.24 , pp. 4876-4883
    • Taricani, L.1
  • 108
    • 0035179950 scopus 로고    scopus 로고
    • DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine
    • Yamauchi T, et al. DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clin Cancer Res 2001, 7(11):3580-3589.
    • (2001) Clin Cancer Res , vol.7 , Issue.11 , pp. 3580-3589
    • Yamauchi, T.1
  • 109
    • 77957986209 scopus 로고    scopus 로고
    • Targeting base excision repair suggests a new therapeutic strategy of fludarabine for the treatment of chronic lymphocytic leukemia
    • 10.1038/leu.2010.166, 20811400
    • Bulgar AD, et al. Targeting base excision repair suggests a new therapeutic strategy of fludarabine for the treatment of chronic lymphocytic leukemia. Leukemia 2010, 24(10):1795-1799. 10.1038/leu.2010.166, 20811400.
    • (2010) Leukemia , vol.24 , Issue.10 , pp. 1795-1799
    • Bulgar, A.D.1
  • 110
    • 0038730444 scopus 로고    scopus 로고
    • Activation of deoxycytidine kinase by gamma-irradiation and inactivation by hyperosmotic shock in human lymphocytes
    • 10.1016/S0006-2952(03)00182-5, 12787883
    • Csapo Z, et al. Activation of deoxycytidine kinase by gamma-irradiation and inactivation by hyperosmotic shock in human lymphocytes. Biochem Pharmacol 2003, 65(12):2031-2039. 10.1016/S0006-2952(03)00182-5, 12787883.
    • (2003) Biochem Pharmacol , vol.65 , Issue.12 , pp. 2031-2039
    • Csapo, Z.1
  • 111
    • 33746324243 scopus 로고    scopus 로고
    • The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines
    • 10.1186/1471-2407-6-142, 1513392, 16734894
    • Pauwels B, et al. The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines. BMC Cancer 2006, 6:142. 10.1186/1471-2407-6-142, 1513392, 16734894.
    • (2006) BMC Cancer , vol.6 , pp. 142
    • Pauwels, B.1
  • 112
    • 33750461300 scopus 로고    scopus 로고
    • Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation
    • Sigmond J, et al. Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation. Nucleosides Nucleotides Nucleic Acids 2006, 25(9-11):1177-1180.
    • (2006) Nucleosides Nucleotides Nucleic Acids , vol.25 , Issue.9-11 , pp. 1177-1180
    • Sigmond, J.1
  • 113
    • 2942627604 scopus 로고    scopus 로고
    • Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells
    • 10.1016/j.bcp.2004.02.031, 15183121
    • Smal C, et al. Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells. Biochem Pharmacol 2004, 68(1):95-103. 10.1016/j.bcp.2004.02.031, 15183121.
    • (2004) Biochem Pharmacol , vol.68 , Issue.1 , pp. 95-103
    • Smal, C.1
  • 114
    • 34249899423 scopus 로고    scopus 로고
    • Positive regulation of deoxycytidine kinase activity by phosphorylation of Ser-74 in B-cell chronic lymphocytic leukaemia lymphocytes
    • 10.1016/j.canlet.2007.01.013, 17350163
    • Smal C, et al. Positive regulation of deoxycytidine kinase activity by phosphorylation of Ser-74 in B-cell chronic lymphocytic leukaemia lymphocytes. Cancer Lett 2007, 253(1):68-73. 10.1016/j.canlet.2007.01.013, 17350163.
    • (2007) Cancer Lett , vol.253 , Issue.1 , pp. 68-73
    • Smal, C.1
  • 115
    • 77956185475 scopus 로고    scopus 로고
    • Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity
    • 10.1016/j.abb.2010.07.009, 20637175
    • Smal C, et al. Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity. Arch Biochem Biophys 2010, 502(1):44-52. 10.1016/j.abb.2010.07.009, 20637175.
    • (2010) Arch Biochem Biophys , vol.502 , Issue.1 , pp. 44-52
    • Smal, C.1
  • 116
    • 0242300176 scopus 로고    scopus 로고
    • Targets of the cyclin-dependent kinase Cdk1
    • 10.1038/nature02062, 14574415
    • Ubersax JA, et al. Targets of the cyclin-dependent kinase Cdk1. Nature 2003, 425(6960):859-864. 10.1038/nature02062, 14574415.
    • (2003) Nature , vol.425 , Issue.6960 , pp. 859-864
    • Ubersax, J.A.1
  • 117
    • 84860694469 scopus 로고    scopus 로고
    • Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells
    • 10.1016/j.bcp.2012.03.022, 22490700
    • Amsailale R, et al. Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells. Biochem Pharmacol 2012, 84(1):43-51. 10.1016/j.bcp.2012.03.022, 22490700.
    • (2012) Biochem Pharmacol , vol.84 , Issue.1 , pp. 43-51
    • Amsailale, R.1
  • 118
    • 39649124214 scopus 로고    scopus 로고
    • Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues
    • 10.1016/j.febslet.2008.01.048, 2636680, 18258203
    • McSorley T, et al. Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues. FEBS Lett 2008, 582(5):720-724. 10.1016/j.febslet.2008.01.048, 2636680, 18258203.
    • (2008) FEBS Lett , vol.582 , Issue.5 , pp. 720-724
    • McSorley, T.1
  • 119
    • 36348945304 scopus 로고    scopus 로고
    • Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants
    • 10.1124/jpet.107.128595, 17855478
    • Lamba JK, et al. Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants. J Pharmacol Exp Ther 2007, 323(3):935-945. 10.1124/jpet.107.128595, 17855478.
    • (2007) J Pharmacol Exp Ther , vol.323 , Issue.3 , pp. 935-945
    • Lamba, J.K.1
  • 120
    • 50049105739 scopus 로고    scopus 로고
    • Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics
    • 10.1124/dmd.108.020925, 3066084, 18556440
    • Kocabas NA, et al. Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics. Drug Metab Dispos 2008, 36(9):1951-1959. 10.1124/dmd.108.020925, 3066084, 18556440.
    • (2008) Drug Metab Dispos , vol.36 , Issue.9 , pp. 1951-1959
    • Kocabas, N.A.1
  • 121
    • 70450189297 scopus 로고    scopus 로고
    • Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers
    • 10.1371/journal.pone.0007765, 2770319, 19898621
    • Li L, et al. Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers. PLoS One 2009, 4(11):e7765. 10.1371/journal.pone.0007765, 2770319, 19898621.
    • (2009) PLoS One , vol.4 , Issue.11
    • Li, L.1
  • 122
    • 84865465698 scopus 로고    scopus 로고
    • Lack of association of genetic variations of deoxycytidine kinase with toxicity or survival of non-small-cell lung cancer patients treated with gemcitabine plus cisplatin
    • 10.3727/096504012X13425470196137, 23035362
    • Ryu JS, et al. Lack of association of genetic variations of deoxycytidine kinase with toxicity or survival of non-small-cell lung cancer patients treated with gemcitabine plus cisplatin. Oncol Res 2012, 20(1):25-30. 10.3727/096504012X13425470196137, 23035362.
    • (2012) Oncol Res , vol.20 , Issue.1 , pp. 25-30
    • Ryu, J.S.1
  • 123
    • 84862608491 scopus 로고    scopus 로고
    • Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells
    • 10.1007/s11095-012-0728-2, 22419259
    • Ohmine K, et al. Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells. Pharm Res 2012, 29(7):2006-2016. 10.1007/s11095-012-0728-2, 22419259.
    • (2012) Pharm Res , vol.29 , Issue.7 , pp. 2006-2016
    • Ohmine, K.1
  • 124
    • 84860332244 scopus 로고    scopus 로고
    • DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells
    • 10.1016/j.bbrc.2012.03.122, 22490663
    • Saiki Y, et al. DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells. Biochem Biophys Res Commun 2012, 421(1):98-104. 10.1016/j.bbrc.2012.03.122, 22490663.
    • (2012) Biochem Biophys Res Commun , vol.421 , Issue.1 , pp. 98-104
    • Saiki, Y.1
  • 125
    • 84866150105 scopus 로고    scopus 로고
    • Retrovolution: HIV-driven evolution of cellular genes and improvement of anticancer drug activation
    • 10.1371/journal.pgen.1002904, 3426553, 22927829
    • Rossolillo P, et al. Retrovolution: HIV-driven evolution of cellular genes and improvement of anticancer drug activation. PLoS Genet 2012, 8(8):e1002904. 10.1371/journal.pgen.1002904, 3426553, 22927829.
    • (2012) PLoS Genet , vol.8 , Issue.8
    • Rossolillo, P.1
  • 126
    • 79953673896 scopus 로고    scopus 로고
    • Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release
    • 10.1021/bi2001032, 3071448, 21351740
    • Hazra S, et al. Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release. Biochemistry 2011, 50(14):2870-2880. 10.1021/bi2001032, 3071448, 21351740.
    • (2011) Biochemistry , vol.50 , Issue.14 , pp. 2870-2880
    • Hazra, S.1
  • 127
    • 84862829497 scopus 로고    scopus 로고
    • Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase
    • 10.1038/mt.2011.298, 3345984, 22273576
    • Neschadim A, et al. Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase. Mol Ther 2012, 20(5):1002-1013. 10.1038/mt.2011.298, 3345984, 22273576.
    • (2012) Mol Ther , vol.20 , Issue.5 , pp. 1002-1013
    • Neschadim, A.1
  • 128
    • 64349104090 scopus 로고    scopus 로고
    • Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase
    • 10.1021/bi802062w, 2701478, 19159229
    • Hazra S, et al. Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. Biochemistry 2009, 48(6):1256-1263. 10.1021/bi802062w, 2701478, 19159229.
    • (2009) Biochemistry , vol.48 , Issue.6 , pp. 1256-1263
    • Hazra, S.1


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