Phosphorylation of deoxycytidine kinase on Ser-74: Impact on kinetic properties and nucleoside analog activation in cancer cells

Biochemical Pharmacology

Volumn 84, Issue 1, 2012, Pages 43-51

  Amsailale, Rachid ^a   Van Den Neste, Eric ^a,b   Arts, Angélique ^a   Starczewska, Eliza ^a   Bontemps, Françoise ^a   Smal, Caroline ^a  

^a DE DUVE INSTITUTE   (Belgium)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

CLL; dCTP; Deoxycytidine kinase; Nucleoside analogs; Ser 74 phosphorylation

Indexed keywords

ADENOSINE TRIPHOSPHATE; APHIDICOLIN; CLADRIBINE; CLOFARABINE; CYTARABINE; DEOXYCYTIDINE KINASE; ETOPOSIDE; FLUDARABINE; GEMCITABINE; GENISTEIN; GLUTAMINE; NUCLEOSIDE ANALOG; PHOSPHATE; PURINE DERIVATIVE; SERINE; TRIPHOSPHATE; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CATALYSIS; CELL ACTIVATION; CELL STRAIN HCT116; CONTROLLED STUDY; CYTOTOXICITY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; FEEDBACK SYSTEM; GENE MUTATION; HUMAN; HUMAN CELL; IN VIVO STUDY; KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; APHIDICOLIN; BIOTRANSFORMATION; CELL LINE, TUMOR; CELL SURVIVAL; CLADRIBINE; DEOXYCYTIDINE; DEOXYCYTIDINE KINASE; ENZYME ACTIVATION; HCT116 CELLS; HT29 CELLS; HUMANS; KINETICS; MUTATION; PHOSPHORYLATION; PURINE NUCLEOSIDES; PYRIMIDINE NUCLEOSIDES; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; VIDARABINE;

EID: 84860694469     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.03.022     Document Type: Article

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