Induction of fetal hemoglobin and ABCB1 gene expression in 9-β-D-arabinofuranosylguanine-resistant MOLT-4 cells

Cancer Chemotherapy and Pharmacology

Volumn 68, Issue 3, 2011, Pages 583-591

  Fyrberg, Anna ^a   Peterson, Curt ^a   Kågedal, Bertil ^a   Lotfi, Kourosh ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

9 D arabinofuranosylguanine; Fetal hemoglobin; Hypomethylation; Microarray; P glycoprotein

Indexed keywords

CLADRIBINE; CLOFARABINE; CYCLOSPORIN A; CYTARABINE; DAUNORUBICIN; DNA; FLUDARABINE; GEMCITABINE; GLYCOPROTEIN P; GUANINE ARABINOSIDE; HEMOGLOBIN C; LANIQUIDAR; MULTIDRUG RESISTANCE PROTEIN 1;

ABCB1 GENE; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CELL STRAIN A549; CELL STRAIN MOLT 4; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS RESISTANCE; DNA METHYLATION; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; FETAL HEMOGLOBIN GAMMA GENE; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LUNG ADENOCARCINOMA; MICROARRAY ANALYSIS; MITOSIS INHIBITION; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; UPREGULATION;

ANTINEOPLASTIC AGENTS; ARABINONUCLEOSIDES; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FETAL HEMOGLOBIN; HUMANS; MICROARRAY ANALYSIS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; TETRAZOLIUM SALTS; THIAZOLES;

EID: 80054694716     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-010-1524-5     Document Type: Article

References (48)

1. J Kurtzberg 2007 The long and winding road of the clinical development of Nelarabine Leuk Lymphoma 48 1 2 17325839 10.1080/10428190601135447 1:CAS:528:DC%2BD2sXitlyhs7g%3D
2. DJ DeAngelo D Yu JL Johnson SE Coutre RM Stone AT Stopeck, et al. 2007 Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: cancer and leukemia Group B study 19801 Blood 109 5136 5142 17344466 10.1182/blood-2006-11- 056754 1:CAS:528:DC%2BD2sXmslOku7k%3D
3. MH Cohen JR Johnson T Massie R Sridhara WD McGuinn Jr. S Abraham, et al. 2006 Approval summary: nelarabine for the treatment of T-cell lymphoblastic leukemia/lymphoma Clin Cancer Res 12 5329 5335 17000665 10.1158/1078-0432.CCR- 06-0606 1:CAS:528:DC%2BD28XpvFShs7k%3D
4. K Lotfi E Mansson C Peterson S Eriksson F Albertioni 2002 Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity Biochem Biophys Res Commun 293 1489 1496 12054684 10.1016/S0006-291X(02)00415-1 1:CAS:528: DC%2BD38Xks1GgsbY%3D
5. C Zhu M Johansson A Karlsson 2000 Incorporation of nucleoside analogs into nuclear or mitochondrial DNA is determined by the intracellular phosphorylation site J Biol Chem 275 26727 26731 10827186 1:CAS:528: DC%2BD3cXmsVWrtLg%3D
6. A Fyrberg F Albertioni K Lotfi 2007 Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes Biochem Biophys Res Commun 357 847 853 17459340 10.1016/j.bbrc.2007.03.176 1:CAS:528:DC%2BD2sXlt1ajsrw%3D
7. J Chandra E Mansson V Gogvadze SH Kaufmann F Albertioni S Orrenius 2002 Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release Blood 99 655 663 11781251 10.1182/blood.V99.2.655 1:CAS:528:DC%2BD38XmslGrtw%3D%3D
8. A Fyrberg S Mirzaee K Lotfi 2006 Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I activity in MOLT-4 cells Nucleosides Nucleotides Nucleic Acids 25 1201 1204 17065091 10.1080/15257770600894386 1:CAS:528:DC%2BD28Xht1WrsrrF
9. RA Irizarry B Hobbs F Collin YD Beazer-Barclay KJ Antonellis U Scherf, et al. 2003 Exploration, normalization, and summaries of high density oligonucleotide array probe level data Biostatistics 4 249 264 12925520 10.1093/biostatistics/4.2.249
10. C Lofgren L Hjortsberg M Blennow K Lotfi C Paul S Eriksson, et al. 2004 Mechanisms of cross-resistance between nucleoside analogues and vincristine or daunorubicin in leukemic cells Biochem Biophys Res Commun 320 825 832 15240122 10.1016/j.bbrc.2004.06.016 1:CAS:528:DC%2BD2cXlsVaqs78%3D
11. SP Perrine R Mankidy MS Boosalis JJ Bieker DV Faller 2009 Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives Eur J Haematol 82 466 476 19220418 10.1111/j.1600-0609. 2009.01234.x 1:CAS:528:DC%2BD1MXmtVyls7k%3D
12. VG Sankaran TF Menne J Xu TE Akie G Lettre B Van Handel, et al. 2008 Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A Science 322 1839 1842 19056937 10.1126/science.1165409 1:CAS:528:DC%2BD1cXhsFSmtrnL
13. LH Lambooy PA Leegwater LP van den Heuvel JP Bokkerink RA De Abreu 1998 Inhibition of DNA methylation in malignant MOLT F4 lymphoblasts by 6-mercaptopurine Clin Chem 44 556 559 9510861 1:CAS:528:DyaK1cXhslSnsr4%3D
14. N Bianchi C Chiarabelli M Borgatti C Mischiati E Fibach R Gambari 2001 Accumulation of gamma-globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine Br J Haematol 113 951 961 11442489 10.1046/j.1365-2141.2001.02843.x 1:CAS:528: DC%2BD3MXlslalsb0%3D
15. A Arora K Seth Y Shukla 2004 Reversal of P-glycoprotein-mediated multidrug resistance by diallyl sulfide in K562 leukemic cells and in mouse liver Carcinogenesis 25 941 949 14729595 10.1093/carcin/bgh060 1:CAS:528:DC%2BD2cXksVahtro%3D
16. T Enver JW Zhang NP Anagnou G Stamatoyannopoulos T Papayannopoulou 1988 Developmental programs of human erythroleukemia cells: globin gene expression and methylation Mol Cell Biol 8 4917 4926 3211133 1:CAS:528:DyaL1cXmt1ertro%3D
17. Kantharidis P, El-Osta A, deSilva M, Wall DM, Hu XF, Slater A et al. (1997) Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance. Clin Cancer Res 3:2025-2032
18. M Nakayama M Wada T Harada J Nagayama H Kusaba K Ohshima, et al. 1998 Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias Blood 92 4296 4307 9834236 1:CAS:528:DyaK1cXnslylsbY%3D
19. Y Saunthararajah CA Hillery D Lavelle R Molokie L Dorn L Bressler, et al. 2003 Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease Blood 102 3865 3870 12907443 10.1182/blood-2003-05-1738 1:CAS:528: DC%2BD3sXpsFamurw%3D
20. M Koshy L Dorn L Bressler R Molokie D Lavelle N Talischy, et al. 2000 2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia Blood 96 2379 2384 11001887 1:CAS:528:DC%2BD3cXntVarur0%3D
21. A Jacquel M Herrant L Legros N Belhacene F Luciano G Pages, et al. 2003 Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage FASEB J 17 2160 2162 14597677 10.1096/fj.03-0322fje 1:CAS:528:DC%2BD3sXovFOhtrY%3D
22. M Huang Y Wang M Collins LM Graves 2004 CPEC induces erythroid differentiation of human myeloid leukemia K562 cells through CTP depletion and p38 MAP kinase Leukemia 18 1857 1863 15385935 10.1038/sj.leu.2403490 1:CAS:528:DC%2BD2cXovVGitb4%3D
23. N Bianchi F Ongaro C Chiarabelli L Gualandi C Mischiati P Bergamini, et al. 2000 Induction of erythroid differentiation of human K562 cells by cisplatin analogs Biochem Pharmacol 60 31 40 10807942 10.1016/S0006-2952(00)00297-5 1:CAS:528:DC%2BD3cXjtVCitrs%3D
24. R Cortesi V Gui R Gambari C Nastruzzi 1999 In vitro effect on human leukemic K562 cells of co-administration of liposome-associated retinoids and cytosine arabinoside (Ara-C) Am J Hematol 62 33 43 10467274 10.1002/(SICI)1096- 8652(199909)62:1<33::AID-AJH6>3.0.CO;2-M 1:CAS:528:DyaK1MXmtlWmu7o%3D
25. JI Park HS Choi JS Jeong JY Han IH Kim 2001 Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells Cell Growth Differ 12 481 486 11571231 1:CAS:528:DC%2BD3MXntlSju74%3D
26. O Witt S Monkemeyer G Ronndahl B Erdlenbruch D Reinhardt K Kanbach, et al. 2003 Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin Blood 101 2001 2007 12393499 10.1182/blood-2002-08-2617 1:CAS:528:DC%2BD3sXhslCrtbo%3D
27. O Witt K Sand A Pekrun 2000 Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways Blood 95 2391 2396 10733512 1:CAS:528:DC%2BD3cXitFeitL0%3D
28. S Charache G Dover K Smith CC Talbot Jr. M Moyer S Boyer 1983 Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex Proc Natl Acad Sci U S A 80 4842 4846 6192443 10.1073/pnas.80.15.4842 1:CAS:528:DyaL3sXltlensLo%3D
29. CH Lowrey AW Nienhuis 1993 Brief report: treatment with azacitidine of patients with end-stage beta-thalassemia N Engl J Med 329 845 848 7689171 10.1056/NEJM199309163291205 1:STN:280:DyaK3szmtFSltQ%3D%3D
30. TJ Ley J DeSimone CT Noguchi PH Turner AN Schechter P Heller, et al. 1983 5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia Blood 62 370 380 6191799 1:CAS:528:DyaL3sXltlensbo%3D
31. J DeSimone P Heller L Hall D Zwiers 1982 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons Proc Natl Acad Sci U S A 79 4428 4431 6181507 10.1073/pnas.79.14.4428 1:CAS:528:DyaL38XkvVGjtr4%3D
32. Miccio A, Blobel GA. The role of the GATA-1/FOG-1/NuRD pathway in the expression of human {beta}-like globin genes. Mol Cell Biol
33. K Lotfi K Karlsson A Fyrberg G Juliusson V Jonsson C Peterson, et al. 2006 The pattern of deoxycytidine- and deoxyguanosine kinase activity in relation to messenger RNA expression in blood cells from untreated patients with B-cell chronic lymphocytic leukemia Biochem Pharmacol 71 882 890 16436271 10.1016/j.bcp.2005.12.007 1:CAS:528:DC%2BD28XhtlKmtb8%3D
34. H Green K Lotfi AL Zackrisson C Peterson 2003 Spontaneous reversal of p-glycoprotein expression in multidrug resistant cell lines Pharmacol Toxicol 93 297 304 14675464 10.1111/j.1600-0773.2003.pto930608.x 1:CAS:528: DC%2BD2cXhsFSquw%3D%3D
35. T Litman TE Druley WD Stein SE Bates 2001 From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance Cell Mol Life Sci 58 931 959 11497241 10.1007/PL00000912 1:CAS:528:DC%2BD3MXlvFSms74%3D
36. M Prenkert B Uggla E Tina U Tidefelt H Strid 2009 Rapid induction of P-glycoprotein mRNA and protein expression by cytarabine in HL-60 cells Anticancer Res 29 4071 4076 19846953 1:CAS:528:DC%2BD1MXhsVOlt7bF
37. E Mansson A Paul C Lofgren K Ullberg C Paul S Eriksson, et al. 2001 Cross-resistance to cytosine arabinoside in a multidrug-resistant human promyelocytic cell line selected for resistance to doxorubicin: implications for combination chemotherapy Br J Haematol 114 557 565 11552980 10.1046/j.1365-2141.2001.02979.x 1:CAS:528:DC%2BD3MXntlansLk%3D
38. S Kharbanda R Datta D Kufe 1991 Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism Biochemistry 30 7947 7952 1907849 10.1021/bi00246a011 1:CAS:528:DyaK3MXkvVCqsbk%3D
39. S Kharbanda Y Emoto H Kisaki A Saleem D Kufe 1994 1-beta-D- arabinofuranosylcytosine activates serine/threonine protein kinases and c-jun gene expression in phorbol ester-resistant myeloid leukemia cells Mol Pharmacol 46 67 72 8058058 1:CAS:528:DyaK2cXlsVymsL8%3D
40. T Ikuta T Papayannopoulou G Stamatoyannopoulos YW Kan 1996 Globin gene switching. In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program J Biol Chem 271 14082 14091 8662960 10.1074/jbc.271.24.14082 1:CAS:528: DyaK28Xjs1Oitrw%3D
41. Guo X, Ma N, Wang J, Song J, Bu X, Cheng Y et al (2008) Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells. BMC Cancer 8:375
42. D Lavelle J DeSimone M Hankewych T Kousnetzova YH Chen 2003 Decitabine induces cell cycle arrest at the G1 phase via p21(WAF1) and the G2/M phase via the p38 MAP kinase pathway Leuk Res 27 999 1007 12859993 10.1016/S0145-2126(03) 00068-7 1:CAS:528:DC%2BD3sXltF2jsb0%3D
43. Beukeveld GJ, In 't Veld G, Havinga R, Groen AK, Wolthers BG, Kuipers F (1996) Relationship between biliary lipid and protoporphyrin secretion; potential role of mdr2 P-glycoprotein in hepatobiliary organic anion transport. J Hepatol 24:343-352
44. E Hanko S Tommarello JF Watchko TW Hansen 2003 Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain Pediatr Res 54 441 445 12904601 10.1203/01.PDR.0000085169.87948.B6 1:CAS:528:DC%2BD3sXntlejs7k%3D
45. PC Krishnamurthy G Du Y Fukuda D Sun J Sampath KE Mercer, et al. 2006 Identification of a mammalian mitochondrial porphyrin transporter Nature 443 586 589 17006453 10.1038/nature05092 1:CAS:528:DC%2BD28XhtVCiu7zM
46. A Tamura M Watanabe H Saito H Nakagawa T Kamachi I Okura, et al. 2006 Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport Mol Pharmacol 70 287 296 16608919 1:CAS:528: DC%2BD28XmsFymsr8%3D
47. E Yague AL Armesilla G Harrison J Elliott A Sardini CF Higgins, et al. 2003 P-glycoprotein (MDR1) expression in leukemic cells is regulated at two distinct steps, mRNA stabilization and translational initiation J Biol Chem 278 10344 10352 12525496 10.1074/jbc.M211093200
48. J Lotem L Sachs 1974 Different blocks in the differentiation of myeloid leukemic cells Proc Natl Acad Sci U S A 71 3507 3511 4530318 10.1073/pnas.71.9.3507 1:STN:280:DyaE2M%2Fks1yguw%3D%3D