Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 9-11, 2006, Pages 1177-1180

  Sigmond, J ^a   Haveman, J ^b   Kreder, N Castro ^b   Loves, W J ^a   Van Bree, C ^b   Franken, N A ^b   Peters, G J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Deoxycytidine kinase; Radiation

Indexed keywords

DEOXYCYTIDINE KINASE;

ARTICLE; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVITY; GAMMA IRRADIATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PROCESSING; RADIATION DOSE; RADIOSENSITIZATION;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DEOXYCYTIDINE; DEOXYCYTIDINE KINASE; DNA; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; HUMANS; LUNG NEOPLASMS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RADIATION-SENSITIZING AGENTS; TIME FACTORS;

EID: 33750461300     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770600894394     Document Type: Article

References (10)

1. Pauwels, B.; Korst, A.E.; Lardon, F.; Vermorken, J.B. Combined modality therapy of gemcitabine and radiation. Oncologist 2005, 10, 34-51.
2. Weiss, C.; Grabenbauer, G.G.; Sauer, R.; Distel, L. Significant increase in residual DNA damage as a possible mechanism of radiosensitization by gemcitabine. Strahlenther Onkol. 2003, 179, 93-98.
3. Kroep, J.R.; Loves, W.J.; van Der Wilt, C.L.; Alvarez, E.; Talianidis, I.; Boven, E.; Braakhuis, B.J.; van Groeningen, C.J.; Pinedo, H.M.; Peters, G.J. Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol. Cancer Ther. 2002, 1, 371-376.
4. Csapo, Z.; Keszler, G.; Safrany, G.; Spasokoukotskaja, T.; Talianidis, I.; Staub, M.; Sasvari-Szekely, M. Activation of deoxycytidine kinase by gamma-irradiation and inactivation by hyperosmotic shock in human lymphocytes. Biochem. Pharmacol. 2003, 65, 2031-2039.
5. Castro Kreder, N.; van Bree, C.; Peters, G.J.; Loves, W.J.; Haveman, J. Enhanced levels of deoxycytidine kinase and thymidine kinase 1 and 2 after pulsed low dose rate irradiation as an adaptive response to radiation. Oncol. Rep. 2002, 9, 141-144.
6. Hatzis, P.; Al-Madhoon, A.S.; Jullig, M.; Petrakis, T.G.; Eriksson, S.; Talianidis, I. The intracellular localization of deoxycytidine kinase. J. Biol. Chem. 1998, 273, 30239-30243.
7. Wang, L.M.; Kucera, G.L. Deoxycytidine kinase is phosphorylated in vitro by protein kinase C alpha. Biochim. Biophys. Acta 1994, 1224, 161-167.
8. Spasokoukotskaja, T.; Csapo, Z.; Sasvari-Szekely, M.; Virga, S.; Talianidis, I.; Eriksson, S.; Staub, M. Effect of phosphorylation on deoxycytidine kinase activity. Adv. Exp. Med. Biol. 2000, 486, 281-285.
9. Smal, C.; Cardoen, S.; Bertrand, L.; Delacauw, A.; Ferrant, A.; Van Den Berghe, G.; Van Den Neste, E.; Bontemps, F. Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells. Biochem. Pharmacol. 2004, 68, 95-103.
10. Csapo, Z.; Sasvari-Szekely, M.; Spasokoukotskaja, T.; Talianidis, I.; Eriksson, S.; Staub, M. Activation of deoxycytidine kinase by inhibition of DNA synthesis in human lymphocytes. Biochem. Pharmacol. 2001, 61, 191-197.