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Volumn 18, Issue 6, 2006, Pages 584-590

Clofarabine and nelarabine: Two new purine nucleoside analogs

Author keywords

Acute leukemias; Arabinosylguanine; Clofarabine; Nelarabine; Purine nucleoside analogs

Indexed keywords

CLOFARABINE; CYCLOPHOSPHAMIDE; DEOXYGUANOSINE TRIPHOSPHATE; DRUG METABOLITE; EVOLTRA; NELARABINE; PURINE NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 33748885763     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cco.0000245326.65152.af     Document Type: Review
Times cited : (44)

References (68)
  • 1
    • 18944392700 scopus 로고    scopus 로고
    • Clofarabine
    • Pui CH, Jeha S, Kilpatrick P. Clofarabine. Nat Rev Drug Discovery 2005; 4:369-370. This is a succinct review of clofarabine at the time of its accelerated approval by the FDA.
    • (2005) Nat Rev Drug Discovery , vol.4 , pp. 369-370
    • Pui, C.H.1    Jeha, S.2    Kilpatrick, P.3
  • 2
    • 0026565544 scopus 로고
    • Synthesis and biologic activity of 2′-fluoro-2-halo derivatives of 9-β-D-arabinofuranosyladenine
    • Montgomery JA, Shortnacy-Fowler AT, Clayton SD, et al. Synthesis and biologic activity of 2′-fluoro-2-halo derivatives of 9-β-D- arabinofuranosyladenine. J Med Chem 1992; 35:397-401.
    • (1992) J Med Chem , vol.35 , pp. 397-401
    • Montgomery, J.A.1    Shortnacy-Fowler, A.T.2    Clayton, S.D.3
  • 3
    • 0025811415 scopus 로고
    • Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5′-trisphosphate
    • Parker WB, Shaddix SC, Chang CH, et al. Effects of 2-chloro-9-(2-deoxy-2- fluoro-β-D-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5′-trisphosphate. Cancer Res 1991; 51:2386-2394.
    • (1991) Cancer Res , vol.51 , pp. 2386-2394
    • Parker, W.B.1    Shaddix, S.C.2    Chang, C.H.3
  • 4
    • 0026533461 scopus 로고
    • Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2′-arabino-fluoro-2′deoxyadenosine
    • Carson DA, Wasson DB, Esparza LM, et al. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2′-arabino-fluoro- 2′deoxyadenosine. Proc Natl Acad Sci U S A 1992; 89:2970-2974.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 2970-2974
    • Carson, D.A.1    Wasson, D.B.2    Esparza, L.M.3
  • 5
    • 0037276433 scopus 로고    scopus 로고
    • Antitumor activity of 2-fluoro-2′-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase
    • Parker WB, Allan PW, Hassan AE, et al. Antitumor activity of 2-fluoro-2′-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase. Cancer Gene Ther 2003; 10:23-29.
    • (2003) Cancer Gene Ther , vol.10 , pp. 23-29
    • Parker, W.B.1    Allan, P.W.2    Hassan, A.E.3
  • 6
    • 0345466497 scopus 로고    scopus 로고
    • Biochemical pharmacology and resistance to 2-chloro-2′- arabinofluoro-2′-deoxyadenosine, a novel analogue of cladribine in human leukemic cells
    • Lotfi K, Mansson E, Spasokoukotskaja T, et al. Biochemical pharmacology and resistance to 2-chloro-2′-arabinofluoro-2′-deoxyadenosine, a novel analogue of cladribine in human leukemic cells. Clin Cancer Res 1999; 5:2438-2444.
    • (1999) Clin Cancer Res , vol.5 , pp. 2438-2444
    • Lotfi, K.1    Mansson, E.2    Spasokoukotskaja, T.3
  • 7
    • 0033063791 scopus 로고    scopus 로고
    • Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2- fluoro-β-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro-β-D- ribofuranosyl)adenine, 2-chloro-9-(2-deoxy-2,2-difluoro-β-D-ribofuranosyl) adenine in CEM cells
    • Parker WB, Shaddix SC, Rose LM, et al. Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)adenine, 2-chloro-9-(2-deoxy-2,2-difluoro-β-D-ribofuranosyl) adenine in CEM cells. Mol Pharmacol 1999; 55:515-520.
    • (1999) Mol Pharmacol , vol.55 , pp. 515-520
    • Parker, W.B.1    Shaddix, S.C.2    Rose, L.M.3
  • 8
    • 0029053894 scopus 로고
    • Metabolism and actions of 2-chloro-9-(2-deoxy-2-fluoro-β-D- arabinofuranosyl)adenine in human lymphoblastoid cells
    • Xie C, Plunkett W. Metabolism and actions of 2-chloro-9-(2-deoxy-2- fluoro-β-D-arabinofuranosyl)adenine in human lymphoblastoid cells. Cancer Res 1995; 55:2847-2852.
    • (1995) Cancer Res , vol.55 , pp. 2847-2852
    • Xie, C.1    Plunkett, W.2
  • 9
    • 33746057854 scopus 로고    scopus 로고
    • Clinical and pharmacokinetic study of clofarabine in chronic lymphocytic leukemia (CLL): Strategy for treatment
    • Gandhi V, Plunkett W, Bonate PL, et al. Clinical and pharmacokinetic study of clofarabine in chronic lymphocytic leukemia (CLL): strategy for treatment. Clin Cancer Res 2006; 12:4011-4017.
    • (2006) Clin Cancer Res , vol.12 , pp. 4011-4017
    • Gandhi, V.1    Plunkett, W.2    Bonate, P.L.3
  • 10
    • 0029927229 scopus 로고    scopus 로고
    • Deoxynucleotide pool deletion and sustained inhibition of ribonucleotide reductase and DNA synthesis after treatment of human lymphoblastoid cells with 2-chloro-(2-deoxy-fluoro-β-D-arabinofuranosyl) adenine
    • Xie KC, Plunkett W. Deoxynucleotide pool deletion and sustained inhibition of ribonucleotide reductase and DNA synthesis after treatment of human lymphoblastoid cells with 2-chloro-(2-deoxy-fluoro-β-D- arabinofuranosyl) adenine. Cancer Res 1996; 56:3030-3037.
    • (1996) Cancer Res , vol.56 , pp. 3030-3037
    • Xie, K.C.1    Plunkett, W.2
  • 11
    • 0035233151 scopus 로고    scopus 로고
    • Purine and pyrimidine nucleoside analogs
    • Giaccone G, Schilsky R, Sondel P, editors. Amsterdam: Elsevier Science BV
    • Plunkett W, Gandhi V. Purine and pyrimidine nucleoside analogs. In: Giaccone G, Schilsky R, Sondel P, editors. Cancer chemotherapy and biological response modifiers, Annual 19. Amsterdam: Elsevier Science BV; 2001. pp. 21-45.
    • (2001) Cancer Chemotherapy and Biological Response Modifiers, Annual 19 , pp. 21-45
    • Plunkett, W.1    Gandhi, V.2
  • 12
    • 0018947647 scopus 로고
    • Effects of deoxyadenosine triphosphate and 9-beta-D-arabinofuranosyl- adenine 5′-triphosphate on human ribonucleotide reductase from Molt-4F cells and the concept of 'self-potentiation'
    • Chang CH, Cheng YC. Effects of deoxyadenosine triphosphate and 9-beta-D-arabinofuranosyl-adenine 5′-triphosphate on human ribonucleotide reductase from Molt-4F cells and the concept of 'self-potentiation'. Cancer Res 1980; 40:3555-3558.
    • (1980) Cancer Res , vol.40 , pp. 3555-3558
    • Chang, C.H.1    Cheng, Y.C.2
  • 13
    • 3943071150 scopus 로고    scopus 로고
    • Cytochrome C-mediated apoptosis
    • Jiang X, Wang X. Cytochrome C-mediated apoptosis. Annu Rev Biochem 2004; 73:87-106.
    • (2004) Annu Rev Biochem , vol.73 , pp. 87-106
    • Jiang, X.1    Wang, X.2
  • 14
    • 0032483010 scopus 로고    scopus 로고
    • Induction of an apoptotic program in cell-free extracts by 2-chloro-2′-deoxyadenosine 5′-triphosphate and cytochrome c
    • Leoni LM, Chao Q, Cottam HB, et al. Induction of an apoptotic program in cell-free extracts by 2-chloro-2′-deoxyadenosine 5′-triphosphate and cytochrome c. Proc Natl Acad Sci U S A 1998; 95:9567-9571.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 9567-9571
    • Leoni, L.M.1    Chao, Q.2    Cottam, H.B.3
  • 15
    • 0034614551 scopus 로고    scopus 로고
    • Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway
    • Genini D, Budihardjo I, Plunkett W, et al. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. J Biol Chem 2000; 275:29-34.
    • (2000) J Biol Chem , vol.275 , pp. 29-34
    • Genini, D.1    Budihardjo, I.2    Plunkett, W.3
  • 16
    • 0034669944 scopus 로고    scopus 로고
    • Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
    • Genini D, Adachi S, Chao Q, et al. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood 2000; 96:3537-3543.
    • (2000) Blood , vol.96 , pp. 3537-3543
    • Genini, D.1    Adachi, S.2    Chao, Q.3
  • 17
    • 0034057850 scopus 로고    scopus 로고
    • Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D- arabinofuranosyl)adenine, (Cl-F-ara-A)
    • Waud WR, Schmid SM, Harrison SD Jr, et al. Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine, (Cl-F-ara-A). Nucleosides Nucleotides Nucleic Acids 2000; 19:447-460.
    • (2000) Nucleosides Nucleotides Nucleic Acids , vol.19 , pp. 447-460
    • Waud, W.R.1    Schmid, S.M.2    Harrison Jr., S.D.3
  • 18
    • 0036046030 scopus 로고    scopus 로고
    • Mechanisms of the apoptotic activity of Cl-F-araA in a human T-ALL cell line, CCRF-CEM
    • Takahashi T, Shimizu M, Akinaga S. Mechanisms of the apoptotic activity of Cl-F-araA in a human T-ALL cell line, CCRF-CEM. Cancer Chemother Pharmacol 2002; 50:193-201.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 193-201
    • Takahashi, T.1    Shimizu, M.2    Akinaga, S.3
  • 19
    • 0037445122 scopus 로고    scopus 로고
    • Phase I clinical and pharmacology study of clofarabine (chloro-20-fluoro-deoxy-9-beta-D-arabinofuranosyladenine) in patients with solid and hematologic cancers
    • Kantarjian H, Gandhi V, Kozuch P, et al. Phase I clinical and pharmacology study of clofarabine (chloro-20-fluoro-deoxy-9-beta-D- arabinofuranosyladenine) in patients with solid and hematologic cancers. J Clin Oncol 2003;21:1167-1173.
    • (2003) J Clin Oncol , vol.21 , pp. 1167-1173
    • Kantarjian, H.1    Gandhi, V.2    Kozuch, P.3
  • 20
    • 0038804087 scopus 로고    scopus 로고
    • Clofarabine-induced acral erythema during the treatment of patients with myelodysplasia and acute leukemia: Report of two cases
    • Chiao N, Bumgardner A, Duvic M. Clofarabine-induced acral erythema during the treatment of patients with myelodysplasia and acute leukemia: report of two cases. Leuk Lymphoma 2003; 44:1405-1407.
    • (2003) Leuk Lymphoma , vol.44 , pp. 1405-1407
    • Chiao, N.1    Bumgardner, A.2    Duvic, M.3
  • 21
    • 0141482004 scopus 로고    scopus 로고
    • Phase II clinical and pharmacology study of clofarabine in patients with refractory or relapsed acute leukemias
    • Kantarjian H, Gandhi V, Cortes J, et al. Phase II clinical and pharmacology study of clofarabine in patients with refractory or relapsed acute leukemias. Blood 2003; 102:2379-2386.
    • (2003) Blood , vol.102 , pp. 2379-2386
    • Kantarjian, H.1    Gandhi, V.2    Cortes, J.3
  • 22
    • 15044340106 scopus 로고    scopus 로고
    • Biochemical modulation of cytarabine triphosphate by clofarabine
    • Cooper T, Ayres M, Nowak B, et al. Biochemical modulation of cytarabine triphosphate by clofarabine. Cancer Chemother Pharmacol 2005; 55:361-368.
    • (2005) Cancer Chemother Pharmacol , vol.55 , pp. 361-368
    • Cooper, T.1    Ayres, M.2    Nowak, B.3
  • 23
    • 19944433802 scopus 로고    scopus 로고
    • Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias
    • Faderl S, Gandhi V, O'Brien S, et al. Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias. Blood 2005; 105:940-947.
    • (2005) Blood , vol.105 , pp. 940-947
    • Faderl, S.1    Gandhi, V.2    O'Brien, S.3
  • 24
    • 33745586575 scopus 로고    scopus 로고
    • Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older
    • Faderl S, Verstovsek S, Cortes J, et al. Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older. Blood 2006; 108:45-51.
    • (2006) Blood , vol.108 , pp. 45-51
    • Faderl, S.1    Verstovsek, S.2    Cortes, J.3
  • 25
    • 9144222570 scopus 로고    scopus 로고
    • Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia
    • Jeha S, Gandhi V, Chan KW, et al. Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia. Blood 2004; 103:784-789.
    • (2004) Blood , vol.103 , pp. 784-789
    • Jeha, S.1    Gandhi, V.2    Chan, K.W.3
  • 26
    • 33646337195 scopus 로고    scopus 로고
    • Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukaemia
    • Jeha S, Gaynon PS, Razzouk BI, et al. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukaemia. J Clin Oncol 2006; 24:1917-1923. Full phase II investigation in previously treated pediatric patients with ALL. These data were presented to the FDA for approval of the drug.
    • (2006) J Clin Oncol , vol.24 , pp. 1917-1923
    • Jeha, S.1    Gaynon, P.S.2    Razzouk, B.I.3
  • 27
    • 4043182191 scopus 로고    scopus 로고
    • Clofarabine therapy for the treatment of relapsed or refractory pediatric acute leukemias
    • Jeha S, Razzouk B, Gaynon P, et al. Clofarabine therapy for the treatment of relapsed or refractory pediatric acute leukemias. Proc Am Soc Clin Oncol 2004; 22:800S-8504.
    • (2004) Proc Am Soc Clin Oncol , vol.22
    • Jeha, S.1    Razzouk, B.2    Gaynon, P.3
  • 28
    • 6344287274 scopus 로고    scopus 로고
    • Population pharmacokinetics of clofarabine, a second-generation nucleoside analog, in pediatric patients with acute leukemia
    • Bonate PL, Craig A, Gaynon P, et al. Population pharmacokinetics of clofarabine, a second-generation nucleoside analog, in pediatric patients with acute leukemia. J Clin Pharmacol 2004; 44:1309-1322.
    • (2004) J Clin Pharmacol , vol.44 , pp. 1309-1322
    • Bonate, P.L.1    Craig, A.2    Gaynon, P.3
  • 29
    • 0346963139 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias
    • Gandhi V, Kantarjian H, Faderl S, et al. Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias. Clinical Cancer Res 2003; 9:6335-6342.
    • (2003) Clinical Cancer Res , vol.9 , pp. 6335-6342
    • Gandhi, V.1    Kantarjian, H.2    Faderl, S.3
  • 30
    • 0035179950 scopus 로고    scopus 로고
    • DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine
    • Yamauchi T, Nowak B, Keating MJ, et al. DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clin Cancer Res 2001; 7:3580-3589.
    • (2001) Clin Cancer Res , vol.7 , pp. 3580-3589
    • Yamauchi, T.1    Nowak, B.2    Keating, M.J.3
  • 31
    • 33644870568 scopus 로고    scopus 로고
    • Nelarabine
    • Gandhi V, Keating MJ, Bate G, et al. Nelarabine. Nat Rev Drug Discov 2006; 5:17-18. This is a succinct review of nelarabine at the time of its accelerated approval by the FDA.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 17-18
    • Gandhi, V.1    Keating, M.J.2    Bate, G.3
  • 32
    • 84919573117 scopus 로고
    • Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity
    • Giblett ER, Ammann AJ, Wara DW, et al. Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity. Lancet 1975; 1:1010-1013.
    • (1975) Lancet , vol.1 , pp. 1010-1013
    • Giblett, E.R.1    Ammann, A.J.2    Wara, D.W.3
  • 33
    • 0017807276 scopus 로고
    • Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency
    • Cohen A, Gudas LJ, Ammann AJ, et al. Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency. J Clin Invest 1978; 61:1405-1409.
    • (1978) J Clin Invest , vol.61 , pp. 1405-1409
    • Cohen, A.1    Gudas, L.J.2    Ammann, A.J.3
  • 34
    • 0018118318 scopus 로고
    • Purinogenic immunosufficiency diseases: Selective toxicity of deoxyribonucleosides for T cells
    • Mitchell BS, Mejias E, Daddona PE, et al. Purinogenic immunosufficiency diseases: selective toxicity of deoxyribonucleosides for T cells. Proc Nat Acad Sci U S A 1978; 75:5011-5014.
    • (1978) Proc Nat Acad Sci U S A , vol.75 , pp. 5011-5014
    • Mitchell, B.S.1    Mejias, E.2    Daddona, P.E.3
  • 35
    • 0018744828 scopus 로고
    • Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function
    • Gelfand EW, Lee JW, Dosch HM. Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function. Proc Nat Acad Sci U S A 1979; 76:1998-2002.
    • (1979) Proc Nat Acad Sci U S A , vol.76 , pp. 1998-2002
    • Gelfand, E.W.1    Lee, J.W.2    Dosch, H.M.3
  • 36
    • 0018931839 scopus 로고
    • The expression of deoxyguanosine toxicity in T lymphocytes at different stages of maturation
    • Cohen A, Lee J, Dosche HM, et al. The expression of deoxyguanosine toxicity in T lymphocytes at different stages of maturation. J Immunol 1980; 125:1578-1582.
    • (1980) J Immunol , vol.125 , pp. 1578-1582
    • Cohen, A.1    Lee, J.2    Dosche, H.M.3
  • 37
    • 0018225470 scopus 로고
    • Deoxyguanosine toxicity in mouse T-lymphoma: Relationship to purine nucleoside phosphorylase-associated immune dysfunction
    • Gudas LJ, Ullman B, Cohen A, et al. Deoxyguanosine toxicity in mouse T-lymphoma: relationship to purine nucleoside phosphorylase-associated immune dysfunction. Cell 1978; 14:531-538.
    • (1978) Cell , vol.14 , pp. 531-538
    • Gudas, L.J.1    Ullman, B.2    Cohen, A.3
  • 38
    • 0002943076 scopus 로고
    • Synthesis of 9-β-D-arabinofuranosylguanine
    • Reist EJ, Goodman L. Synthesis of 9-β-D-arabinofuranosylguanine. Biochemistry 1964; 3:15-18.
    • (1964) Biochemistry , vol.3 , pp. 15-18
    • Reist, E.J.1    Goodman, L.2
  • 39
    • 0016590235 scopus 로고
    • Biological activities of some purine arabinosides
    • Elion GB, Rideout JL, DeMiranda P, et al. Biological activities of some purine arabinosides. Ann N Y Acad Sci 1975; 255:468-480.
    • (1975) Ann N Y Acad Sci , vol.255 , pp. 468-480
    • Elion, G.B.1    Rideout, J.L.2    DeMiranda, P.3
  • 40
    • 0000664303 scopus 로고
    • An enzymatic synthesis of purine-D-arabinonucleosides
    • Krenitsky TA, Koszalka GW, Tuttle JV, et al. An enzymatic synthesis of purine-D-arabinonucleosides. Carbohydr Res 1981; 97:139-146.
    • (1981) Carbohydr Res , vol.97 , pp. 139-146
    • Krenitsky, T.A.1    Koszalka, G.W.2    Tuttle, J.V.3
  • 41
    • 0029127419 scopus 로고
    • 2-Amino-6-methoxypurine arabinoside: An agent for T-cell malignancies
    • Lambe CU, Averett DR, Paff MT, et al. 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies. Cancer Res 1995; 55:3352-3356.
    • (1995) Cancer Res , vol.55 , pp. 3352-3356
    • Lambe, C.U.1    Averett, D.R.2    Paff, M.T.3
  • 42
    • 0033999960 scopus 로고    scopus 로고
    • The pharmacokinetics of nelarabine and 9-β-D-arabinofuranosyl guanine in pediatric and adult patients during a phase I study of nelarabine for the treatment of refractory hematologic malignancies
    • Kisor DF, Plunkett W, Kurtzberg J, et al. The pharmacokinetics of nelarabine and 9-β-D-arabinofuranosyl guanine in pediatric and adult patients during a phase I study of nelarabine for the treatment of refractory hematologic malignancies. J Clin Oncol 2000; 18:995-1003.
    • (2000) J Clin Oncol , vol.18 , pp. 995-1003
    • Kisor, D.F.1    Plunkett, W.2    Kurtzberg, J.3
  • 43
    • 0025317092 scopus 로고
    • Transport and metabolism of 9-β-D-arabinofuranosylguanine in a human T-lymphoblastoid cell line: Notrobenzylthioinosine-sensitive and -insensitive influx
    • Prus KL, Averett DR, Zimmerman TP. Transport and metabolism of 9-β-D-arabinofuranosylguanine in a human T-lymphoblastoid cell line: notrobenzylthioinosine-sensitive and -insensitive influx. Cancer Res 1990; 50:1817-1821.
    • (1990) Cancer Res , vol.50 , pp. 1817-1821
    • Prus, K.L.1    Averett, D.R.2    Zimmerman, T.P.3
  • 44
    • 0024312352 scopus 로고
    • Phosphorylation of arabinosyl guanine by a mitochondrial enzyme of bovine liver
    • Lewis RA, Link L. Phosphorylation of arabinosyl guanine by a mitochondrial enzyme of bovine liver. Biochem Pharmacol 1989; 38:2001-2006.
    • (1989) Biochem Pharmacol , vol.38 , pp. 2001-2006
    • Lewis, R.A.1    Link, L.2
  • 45
    • 0027381413 scopus 로고
    • Substrate specificity of mitochondrial 2′-deoxyguanosine kinase: Efficient phosphorylation of 2-chlorodeoxyadenosine
    • Wang L, Karlsson A, Arnér ESJ, et al. Substrate specificity of mitochondrial 2′-deoxyguanosine kinase: efficient phosphorylation of 2-chlorodeoxyadenosine. J Biol Chem 1993; 268:22847-22852.
    • (1993) J Biol Chem , vol.268 , pp. 22847-22852
    • Wang, L.1    Karlsson, A.2    Arnér, E.S.J.3
  • 46
    • 0017157932 scopus 로고
    • Deoxycytidine kinase from calf thymus: Substrate and inhibitor specificity
    • Krenitsky TA, Tuttle JV, Koszalka GW, et al. Deoxycytidine kinase from calf thymus: substrate and inhibitor specificity. J Biol Chem 1976; 251:4055-4061.
    • (1976) J Biol Chem , vol.251 , pp. 4055-4061
    • Krenitsky, T.A.1    Tuttle, J.V.2    Koszalka, G.W.3
  • 47
    • 0017639365 scopus 로고
    • Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)
    • Carson DA, Kaye J, Seegmiller JE. Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s). Proc Natl Acad Sci U S A 1977; 74:5677-5681.
    • (1977) Proc Natl Acad Sci U S A , vol.74 , pp. 5677-5681
    • Carson, D.A.1    Kaye, J.2    Seegmiller, J.E.3
  • 48
    • 0036606777 scopus 로고    scopus 로고
    • Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase
    • Rodriguez CO Jr, Mitchell BS, Eriksson S, et al. Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. Cancer Res 2002; 62:3100-3105.
    • (2002) Cancer Res , vol.62 , pp. 3100-3105
    • Rodriguez Jr., C.O.1    Mitchell, B.S.2    Eriksson, S.3
  • 49
    • 0020614859 scopus 로고
    • Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells
    • Cohen A, Lee JWW, Gelfand EW. Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells. Blood 1983; 61:660-666.
    • (1983) Blood , vol.61 , pp. 660-666
    • Cohen, A.1    Lee, J.W.W.2    Gelfand, E.W.3
  • 50
    • 0021159928 scopus 로고
    • Specific cytotoxicity of arabinosyl-guanine toward cultured T-lymphoblasts
    • Ullman B, Martin DW. Specific cytotoxicity of arabinosyl-guanine toward cultured T-lymphoblasts. J Clin Invest 1984; 74:951-955.
    • (1984) J Clin Invest , vol.74 , pp. 951-955
    • Ullman, B.1    Martin, D.W.2
  • 51
    • 0021920019 scopus 로고
    • Metabolism and selective cytotoxicity of 9-β-arabinofuranosylguanine in human lymphoblasts
    • Shewach DS, Daddona PE, Ashcraft E, et al. Metabolism and selective cytotoxicity of 9-β-arabinofuranosylguanine in human lymphoblasts. Cancer Res 1985; 45:1008-1014.
    • (1985) Cancer Res , vol.45 , pp. 1008-1014
    • Shewach, D.S.1    Daddona, P.E.2    Ashcraft, E.3
  • 52
    • 0021933378 scopus 로고
    • Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts
    • Verhoef V, Fridland A. Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts. Cancer Res 1985; 45:3646-3650.
    • (1985) Cancer Res , vol.45 , pp. 3646-3650
    • Verhoef, V.1    Fridland, A.2
  • 53
    • 0024378948 scopus 로고
    • Differential metabolism of 9-β-D-arabinofuranosylguanine in human leukemic cells
    • Shewach DS, Mitchell BS. Differential metabolism of 9-β-D- arabinofuranosylguanine in human leukemic cells. Cancer Res 1989; 49:6498-6502.
    • (1989) Cancer Res , vol.49 , pp. 6498-6502
    • Shewach, D.S.1    Mitchell, B.S.2
  • 54
    • 1842373912 scopus 로고    scopus 로고
    • Pharmacological and biochemical strategies to increase the accumulation of arabinofuranosylguanine triphosphate in primary human leukemia cells
    • Rodriguez CO Jr, Legha JK, Estey E, et al. Pharmacological and biochemical strategies to increase the accumulation of arabinofuranosylguanine triphosphate in primary human leukemia cells. Clin Cancer Res 1997; 3:2107-2113.
    • (1997) Clin Cancer Res , vol.3 , pp. 2107-2113
    • Rodriguez Jr., C.O.1    Legha, J.K.2    Estey, E.3
  • 55
    • 0345363112 scopus 로고    scopus 로고
    • Arabinosylguanine-induced apoptosis of T-lymphoblastic cells: Incorporation into DNA is a necessary step
    • Rodriguez CO Jr, Gandhi V. Arabinosylguanine-induced apoptosis of T-lymphoblastic cells: incorporation into DNA is a necessary step. Cancer Res 1999; 59:4937-4943.
    • (1999) Cancer Res , vol.59 , pp. 4937-4943
    • Rodriguez Jr., C.O.1    Gandhi, V.2
  • 56
    • 0018635683 scopus 로고
    • Inhibitory effects of 9-β-D-arabinofuranosylguanine 5́-triphosphate and 9-β-D-arabinofuranosyladenine 5′-triphosphate on DNA polymerases from murine cells and oncornavirus
    • Ono K, Ohashi A, Yamamoto A, et al. Inhibitory effects of 9-β-D-arabinofuranosylguanine 5́-triphosphate and 9-β-D-arabinofuranosyladenine 5′-triphosphate on DNA polymerases from murine cells and oncornavirus. Cancer Res 1979; 39:4673-4680.
    • (1979) Cancer Res , vol.39 , pp. 4673-4680
    • Ono, K.1    Ohashi, A.2    Yamamoto, A.3
  • 57
    • 0028926278 scopus 로고
    • Cytotoxicity, metabolism, and mechanisms of action of 2′,2′-difluorodeoxyguanosine in Chinese hamster ovary cells
    • Gandhi V, Mineishi S, Huang P, et al. Cytotoxicity, metabolism, and mechanisms of action of 2′,2′-difluorodeoxyguanosine in Chinese hamster ovary cells. Cancer Res 1995; 55:1517-1524.
    • (1995) Cancer Res , vol.55 , pp. 1517-1524
    • Gandhi, V.1    Mineishi, S.2    Huang, P.3
  • 58
    • 0028874813 scopus 로고
    • Difluorodeoxyguanosine: Cytotoxicity, metabolism, and actions on DNA synthesis in human leukemia cells
    • Gandhi V, Mineishi S, Huang P, et al. Difluorodeoxyguanosine: cytotoxicity, metabolism, and actions on DNA synthesis in human leukemia cells. Semin Oncol 1995; 22:61-67.
    • (1995) Semin Oncol , vol.22 , pp. 61-67
    • Gandhi, V.1    Mineishi, S.2    Huang, P.3
  • 59
    • 0041941097 scopus 로고    scopus 로고
    • Mechanisms for T-cell selective cytotoxicity of arabinosylguanine
    • Rodriguez CO, Stellrecht C, Gandhi V. Mechanisms for T-cell selective cytotoxicity of arabinosylguanine. Blood 2003; 102:1842-1848.
    • (2003) Blood , vol.102 , pp. 1842-1848
    • Rodriguez, C.O.1    Stellrecht, C.2    Gandhi, V.3
  • 60
    • 20644435369 scopus 로고    scopus 로고
    • Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies
    • Kurtzberg J, Ernst TJ, Keating MJ, et al. Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. J Clin Oncol 2005; 23:3396-3403. This is the first phase I investigation of nelarabine in pediatric and adult leukemias and lymphomas. Dose-dependent and lineage-dependent responses are compared in both subgroups of patients.
    • (2005) J Clin Oncol , vol.23 , pp. 3396-3403
    • Kurtzberg, J.1    Ernst, T.J.2    Keating, M.J.3
  • 61
    • 33646184035 scopus 로고    scopus 로고
    • A phase II study of 9-δ-D-arabinosyl-6methoxy-9H-purine (506U78) in patients with relapsed or refractory T-lineage acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL): CALGB study 19801
    • DeAngelo DJ, Yu D, Dodge RK, et al. A phase II study of 9-δ-D-arabinosyl-6methoxy-9H-purine (506U78) in patients with relapsed or refractory T-lineage acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL): CALGB study 19801. Blood 2002; 100:198a.
    • (2002) Blood , vol.100
    • DeAngelo, D.J.1    Yu, D.2    Dodge, R.K.3
  • 62
    • 33646268128 scopus 로고    scopus 로고
    • Results of a phase II study of 506U78 (Nelarabine) in refractory indolent B-cell or peripheral T-cell lymphoma
    • Thompson MA, Pro B, Sarris A, et al. Results of a phase II study of 506U78 (Nelarabine) in refractory indolent B-cell or peripheral T-cell lymphoma. Blood 2005; 106:753a.
    • (2005) Blood , vol.106
    • Thompson, M.A.1    Pro, B.2    Sarris, A.3
  • 63
    • 33746361377 scopus 로고    scopus 로고
    • Phase II study of compound GW506U78 (araG) for patients with indolent B-cell or peripheral T-cell lymphoma previously treated with chemotherapy
    • Goy A, Bleyer A, Hagemeister F. Phase II study of compound GW506U78 (araG) for patients with indolent B-cell or peripheral T-cell lymphoma previously treated with chemotherapy. Blood 2003; 102:639a.
    • (2003) Blood , vol.102
    • Goy, A.1    Bleyer, A.2    Hagemeister, F.3
  • 64
    • 0001462165 scopus 로고    scopus 로고
    • Compound 506 has activity in mature lymphoid leukemia
    • O'Brien S, Thomas D, Kantarjian H, et al. Compound 506 has activity in mature lymphoid leukemia. Blood 1998; 92:490-491a.
    • (1998) Blood , vol.92
    • O'Brien, S.1    Thomas, D.2    Kantarjian, H.3
  • 65
    • 20644464975 scopus 로고    scopus 로고
    • Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: A report from the Children's Oncology Group
    • Berg SL, Blaney SM, DevidasM, et al. Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: a report from the Children's Oncology Group. J Clin Oncol 2005; 23:3376-3382. Full phase II investigation in previously treated pediatric T-cell leukemias. The schedule was daily for 5 days. These data were presented to the FDA for approval of the drug.
    • (2005) J Clin Oncol , vol.23 , pp. 3376-3382
    • Berg, S.L.1    Blaney, S.M.2    Devidas, M.3
  • 66
    • 0031792644 scopus 로고    scopus 로고
    • Compound GW506U78 in refractory hematologic malignancies: Relationship between cellular pharmacokinetics and clinical response
    • Gandhi V, Plunkett W, Rodriguez CO Jr, et al. Compound GW506U78 in refractory hematologic malignancies: relationship between cellular pharmacokinetics and clinical response. J Clin Oncol 1998; 16:3607-3615.
    • (1998) J Clin Oncol , vol.16 , pp. 3607-3615
    • Gandhi, V.1    Plunkett, W.2    Rodriguez Jr., C.O.3
  • 67
    • 0035871440 scopus 로고    scopus 로고
    • Evaluation of the combination of nelarabine and fludarabine in leukemias: Clinical response, pharmacokinetics, and pharmacodynamics in leukemia cells
    • Gandhi V, Plunkett W, Weller S, et al. Evaluation of the combination of nelarabine and fludarabine in leukemias: clinical response, pharmacokinetics, and pharmacodynamics in leukemia cells. J Clin Oncol 2001; 19:2142-2152.
    • (2001) J Clin Oncol , vol.19 , pp. 2142-2152
    • Gandhi, V.1    Plunkett, W.2    Weller, S.3
  • 68
    • 0024421965 scopus 로고
    • Interaction of arabinosyl nucleotides in K562 human leukemia cells
    • Gandhi V, Plunkett W. Interaction of arabinosyl nucleotides in K562 human leukemia cells. Biochem Pharmacol 1989; 38:3551-3558.
    • (1989) Biochem Pharmacol , vol.38 , pp. 3551-3558
    • Gandhi, V.1    Plunkett, W.2


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