The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation

Acta Crystallographica Section D: Biological Crystallography

Volumn 62, Issue 2, 2006, Pages 133-139

  Zhang, Yan ^a   Secrist III, John A ^b   Ealick, Steven E ^a  

^a Cornell University ^*  (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ARABINONUCLEOSIDE; CLOFARABINE; DEOXYCYTIDINE KINASE;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ADENINE NUCLEOTIDES; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ARABINONUCLEOSIDES; BINDING SITES; CATALYSIS; DEOXYCYTIDINE KINASE; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644859099     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444905034293     Document Type: Article

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