Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

Blood

Volumn 96, Issue 10, 2000, Pages 3537-3543

  Genini, D ^a   Adachi, S ^a   Chao, Q ^a   Rose, D W ^a   Carrera, C J ^a   Cottam, H B ^a   Carson, D A ^a   Leoni, L M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; CLADRIBINE; CYTOCHROME C; DEOXYADENOSINE DERIVATIVE; FLUDARABINE;

APOPTOSIS; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DNA DAMAGE; DNA SYNTHESIS; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; LYMPHOPROLIFERATIVE DISEASE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN SECRETION;

EID: 0034669944     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.10.3537     Document Type: Article

References (36)

1. 2-Chlorodeoxyadenosine: Hairy cell leukemia takes a surprising turn
2. Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes
3. Biochemical correlates of the differential sensitivity of subtypes of human leukemia to deoxyadenosine and deoxycoformycin
4. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine
5. Caspases: Intracellular signaling by proteolysis
6. Mitochondrial control of apoptosis
7. Cytochrome c and dATP-dependent formation of Apaf-1/ caspase-9 complex initiates an apoptotic protease cascade
8. Implication of mitochondria in apoptosis
9. Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions
10. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
11. An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
12. Molecular characterization of mitochondrial apoptosis-inducing factor
13. A matter of life and cell death
14. Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice
15. Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c
16. Events in apoptosis: Acidification is downstream of protease activation and BCL-2 protection
17. Synthesis of 2'-deoxytubercidin, 2'-deoxyadenosine, and related 2'-deoxynucleosides via a novel direct stereospecific sodium salt glycosylation procedure
18. 7-Deazapurine containing DNA: Efficiency of NdTP incorporation during PCR-amplification and protection from endonuclease hydrolysis
19. Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation
20. Lack of release of cytochrome C from mitochondria into cytosol early in the course of Fas-mediated apoptosis of Jurkat cells
21. Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine
22. Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA
23. Mitochondria and apoptosis
24. Adaptation of the TdT assay for semi-quantitative flow cytometric detection of DNA strand breaks
25. High molecular weight DNA fragmentation: A critical event in nucleoside analogue-induced apoptosis in leukemia cells
26. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
27. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
28. Properties of H(+)-ATPase from rat liver lysosomes as reveated by reconstitution into proteoliposomes
29. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway
30. Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition
31. Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore: Implication for regulation of permeability transition by the kinases
32. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
33. dATP causes specific release of cytochrome C from mitochondria
34. Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs
35. Enhanced cytotoxicity of nucleoside analogs by overexpression of mitochondrial deoxyguanosine kinase in cancer cell lines
36. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2