메뉴 건너뛰기




Volumn 59, Issue 19, 1999, Pages 4937-4943

Arabinosylguanine-induced apoptosis of T-lymphoblastic cells: Incorporation into DNA is a necessary step

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; GUANINE ARABINOSIDE;

EID: 0345363112     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (48)

References (44)
  • 3
    • 0003317661 scopus 로고    scopus 로고
    • 2-amino-9-β-D-arabinosyl-6-methoxy-9H-guanine (GW 506: Compound 506U) is highly active in patients with T-cell malignancies: Results of a Phase I trial in pediatric and adult patients with refractory hematological malignancies
    • Kurtzberg, J., Keating, M. J., Moore, J. O., Gandhi, V., Blaney, S., Gold, S., Ernst, T., Henslee-Downey, J., Chang, A., Kisor, D., Plunkett, W., and Mitchell, B. 2-amino-9-β-D-arabinosyl-6-methoxy-9H-guanine (GW 506: Compound 506U) is highly active in patients with T-cell malignancies: results of a Phase I trial in pediatric and adult patients with refractory hematological malignancies. Blood, 88: 669a, 1996.
    • (1996) Blood , vol.88
    • Kurtzberg, J.1    Keating, M.J.2    Moore, J.O.3    Gandhi, V.4    Blaney, S.5    Gold, S.6    Ernst, T.7    Henslee-Downey, J.8    Chang, A.9    Kisor, D.10    Plunkett, W.11    Mitchell, B.12
  • 4
    • 0021920019 scopus 로고
    • Metabolism and selective cytotoxicity of 9-β-D-arabinofuranosylguanine in human lymphoblasts
    • Shewach, D. S., Daddona, P. E., Ashcraft, E., and Mitchell, B. S. Metabolism and selective cytotoxicity of 9-β-D-arabinofuranosylguanine in human lymphoblasts. Cancer Res., 45: 1008-1014, 1985.
    • (1985) Cancer Res. , vol.45 , pp. 1008-1014
    • Shewach, D.S.1    Daddona, P.E.2    Ashcraft, E.3    Mitchell, B.S.4
  • 5
    • 1842373912 scopus 로고    scopus 로고
    • Pharmacological and biochemical strategies to increase the accumulation of arabinofuranosylguanine triphosphate in primary human leukemia cells
    • Rodriguez, C. O., Jr., Legha, J. K., Estey, E., Keating, M. J., and Gandhi, V. Pharmacological and biochemical strategies to increase the accumulation of arabinofuranosylguanine triphosphate in primary human leukemia cells. Clin. Cancer Res., 3: 2107-2113, 1997.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 2107-2113
    • Rodriguez C.O., Jr.1    Legha, J.K.2    Estey, E.3    Keating, M.J.4    Gandhi, V.5
  • 6
    • 0026324313 scopus 로고
    • Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
    • Huang, P., Chubb, S., Hertel, L. W., Grindey, G. B., and Plunkett, W. Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res., 51: 6110-6117, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 6110-6117
    • Huang, P.1    Chubb, S.2    Hertel, L.W.3    Grindey, G.B.4    Plunkett, W.5
  • 7
    • 0019131198 scopus 로고
    • Correlation of cytotoxicity with incorporation of ara-C into DNA
    • Kufe, D. W., Major, P. P., Egan, E. M., and Beardsley, G. P. Correlation of cytotoxicity with incorporation of ara-C into DNA. J. Biol. Chem., 255: 8997-900, 1980.
    • (1980) J. Biol. Chem. , vol.255 , pp. 8997-9900
    • Kufe, D.W.1    Major, P.P.2    Egan, E.M.3    Beardsley, G.P.4
  • 8
    • 0025130572 scopus 로고
    • Termination of DNA synthesis by 9-β-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity
    • Huang, P., Chubb, S., and Plunkett, W. Termination of DNA synthesis by 9-β-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity. J. Biol. Chem., 265: 16617-16625, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 16617-16625
    • Huang, P.1    Chubb, S.2    Plunkett, W.3
  • 9
    • 0029060757 scopus 로고
    • Fludarabine- and gemcitibine-induced apoptosis: Incorporation of analogs into DNA is a critical event
    • Huang, P., and Plunkett, W. Fludarabine- and gemcitibine-induced apoptosis: incorporation of analogs into DNA is a critical event. Cancer Chemother. Pharmacol., 36: 181-188, 1995.
    • (1995) Cancer Chemother. Pharmacol. , vol.36 , pp. 181-188
    • Huang, P.1    Plunkett, W.2
  • 10
    • 0024439683 scopus 로고
    • Biochemical pharmacology of 2-chlorodeoxyadenosine in malignant human hematopoietic cell lines and therapeutic effects of 2-bromodeoxyadenosine in drug combinations in mice
    • Avery, T. L., Rehg, J. E., Lumm, W. C., Harwood, F. C., Santana, V. M., and Blakley, R. L. Biochemical pharmacology of 2-chlorodeoxyadenosine in malignant human hematopoietic cell lines and therapeutic effects of 2-bromodeoxyadenosine in drug combinations in mice. Cancer Res., 49: 4972-4978, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 4972-4978
    • Avery, T.L.1    Rehg, J.E.2    Lumm, W.C.3    Harwood, F.C.4    Santana, V.M.5    Blakley, R.L.6
  • 11
    • 0020614859 scopus 로고
    • Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells
    • Cohen, A., Lee, J. W., and Gelfand, E. W. Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells. Blood, 61: 660-666, 1983.
    • (1983) Blood , vol.61 , pp. 660-666
    • Cohen, A.1    Lee, J.W.2    Gelfand, E.W.3
  • 12
    • 0018178910 scopus 로고
    • Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine
    • Carson, D. A., Kaye, J., and Seegmiller, J. E. Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine. J. Immunol., 121: 1726-1731, 1978.
    • (1978) J. Immunol. , vol.121 , pp. 1726-1731
    • Carson, D.A.1    Kaye, J.2    Seegmiller, J.E.3
  • 13
    • 0021933378 scopus 로고
    • Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts
    • Verhoef, V., and Fridland, A. Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts Cancer Res., 45: 3646-3650, 1985.
    • (1985) Cancer Res. , vol.45 , pp. 3646-3650
    • Verhoef, V.1    Fridland, A.2
  • 14
    • 0024378948 scopus 로고
    • Differential metabolism of 9-β-D-arabinofuranosylguanine in human leukemic cells
    • Shewach, D. S., and Mitchell, B. S. Differential metabolism of 9-β-D-arabinofuranosylguanine in human leukemic cells. Cancer Res., 49: 6498-6502, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 6498-6502
    • Shewach, D.S.1    Mitchell, B.S.2
  • 15
    • 0026439286 scopus 로고
    • A quantitative assay for fragmented DNA in apoptotic cells
    • Huang, P., and Plunkett, W. A quantitative assay for fragmented DNA in apoptotic cells. Anal. Biochem., 207: 163-167, 1992.
    • (1992) Anal. Biochem. , vol.207 , pp. 163-167
    • Huang, P.1    Plunkett, W.2
  • 16
    • 0027217084 scopus 로고
    • Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation
    • Oberhammer, F., Wilson, J. W., Dive, C., Morris, I. D., Hickman, J. A., Wakeling, A. E., Walker, P. R., and Sikorska, M. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J., 12: 3679-3684, 1993.
    • (1993) EMBO J. , vol.12 , pp. 3679-3684
    • Oberhammer, F.1    Wilson, J.W.2    Dive, C.3    Morris, I.D.4    Hickman, J.A.5    Wakeling, A.E.6    Walker, P.R.7    Sikorska, M.8
  • 17
    • 0026555808 scopus 로고
    • Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis
    • Collins, R. J., Harmon, B. V., Gobe, G. C., and Kerr, J. F. R. Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int. J. Radiat. Biol., 61: 451-453, 1992.
    • (1992) Int. J. Radiat. Biol. , vol.61 , pp. 451-453
    • Collins, R.J.1    Harmon, B.V.2    Gobe, G.C.3    Kerr, J.F.R.4
  • 18
    • 0027276494 scopus 로고
    • The protein kinase inhibitor staurosporine induces morphological changes typical of apoptosis in Molt-4 cells without concomitant DNA fragmentation
    • Falcieri, E., Martelli, A. M., Bareggi, R., Cataldi, A., and Cocco, L. The protein kinase inhibitor staurosporine induces morphological changes typical of apoptosis in Molt-4 cells without concomitant DNA fragmentation. Biochem. Biophys. Res. Commun., 193: 19-25, 1993.
    • (1993) Biochem. Biophys. Res. Commun. , vol.193 , pp. 19-25
    • Falcieri, E.1    Martelli, A.M.2    Bareggi, R.3    Cataldi, A.4    Cocco, L.5
  • 19
    • 0029150180 scopus 로고
    • High molecular weight DNA fragmentation: A critical event in nucleoside analogue-induced apoptosis in leukemia cells
    • Huang, P., Robertson, L. E., Wright, S., and Plunkett, W. High molecular weight DNA fragmentation: a critical event in nucleoside analogue-induced apoptosis in leukemia cells. Clin. Cancer Res. 1: 1005-1013, 1995.
    • (1995) Clin. Cancer Res. , vol.1 , pp. 1005-1013
    • Huang, P.1    Robertson, L.E.2    Wright, S.3    Plunkett, W.4
  • 20
    • 0030841329 scopus 로고    scopus 로고
    • Biochemical characterization of the protein activity responsible for high molecular weight DNA fragmentation during drug-induced apoptosis
    • Huang, P., Ballal, K., and Plunkett, W. Biochemical characterization of the protein activity responsible for high molecular weight DNA fragmentation during drug-induced apoptosis. Cancer Res., 57: 3407-3414, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 3407-3414
    • Huang, P.1    Ballal, K.2    Plunkett, W.3
  • 21
    • 0025317092 scopus 로고
    • Transport and metabolism of 9-β-D-arabinofuranosylguanine in a human T-lymphoblastoid cell line: Nitrobenzylthioinosine-sensitive and -insensitive influx
    • Prus, K. L., Averett, D. R., and Zimmerman, T. P. Transport and metabolism of 9-β-D-arabinofuranosylguanine in a human T-lymphoblastoid cell line: nitrobenzylthioinosine-sensitive and -insensitive influx. Cancer Res., 50: 1817-1821, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 1817-1821
    • Prus, K.L.1    Averett, D.R.2    Zimmerman, T.P.3
  • 23
    • 0027381413 scopus 로고
    • Substrate specificity of mitochondrial 2′-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine
    • Wang, L., Karlsson, A., Arner, E. S., and Eriksson, S. Substrate specificity of mitochondrial 2′-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine. J. Biol. Chem., 268: 22847-22852, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 22847-22852
    • Wang, L.1    Karlsson, A.2    Arner, E.S.3    Eriksson, S.4
  • 24
    • 0025295958 scopus 로고
    • Modulatory activity of 2′,2′-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides
    • Gandhi, V., and Plunkett, W. Modulatory activity of 2′,2′-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides. Cancer Res., 50: 3675-3680, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 3675-3680
    • Gandhi, V.1    Plunkett, W.2
  • 25
    • 0027085703 scopus 로고
    • Nucleotide specificity of human deoxycytidine kinase
    • Shewach, D. S., Reynolds, K. K., and Hertel, L. Nucleotide specificity of human deoxycytidine kinase. Mol. Pharmacol., 42: 518-524, 1992.
    • (1992) Mol. Pharmacol. , vol.42 , pp. 518-524
    • Shewach, D.S.1    Reynolds, K.K.2    Hertel, L.3
  • 26
    • 0022550428 scopus 로고
    • Regulation of 1-β-D-arabinofuranosylcytosine 5′-triphosphate accumulation in human leukemia cells by deoxycytidine 5′-triphosphate
    • Liliemark, J. O., and Plunkett, W. Regulation of 1-β-D-arabinofuranosylcytosine 5′-triphosphate accumulation in human leukemia cells by deoxycytidine 5′-triphosphate. Cancer Res., 46: 1079-1083, 1986.
    • (1986) Cancer Res. , vol.46 , pp. 1079-1083
    • Liliemark, J.O.1    Plunkett, W.2
  • 27
    • 0018952812 scopus 로고
    • Metabolism and chemotherapeutic activity of 9-β-D-arabinofuranosyl-2-fluoroadenine against murine leukemia L1210 and evidence for its phosphorylation by deoxycytidine kinase
    • Brockman, R. W., Cheng, Y. C., Schabel, F. M. J., and Montgomery, J. A. Metabolism and chemotherapeutic activity of 9-β-D-arabinofuranosyl-2-fluoroadenine against murine leukemia L1210 and evidence for its phosphorylation by deoxycytidine kinase. Cancer Res., 40: 3610-3615, 1980.
    • (1980) Cancer Res. , vol.40 , pp. 3610-3615
    • Brockman, R.W.1    Cheng, Y.C.2    Schabel, F.M.J.3    Montgomery, J.A.4
  • 28
    • 0018621940 scopus 로고
    • Partial purification and characterization of deoxyguanosine kinase from pig skin
    • Green, F. J., and Lewis, R. A. Partial purification and characterization of deoxyguanosine kinase from pig skin. Biochem J., 183: 547-553, 1979.
    • (1979) Biochem J. , vol.183 , pp. 547-553
    • Green, F.J.1    Lewis, R.A.2
  • 29
    • 0024312352 scopus 로고
    • Phosphorylation of arabinosyl guanine by a mitochondrial enzyme of bovine liver
    • Lewis, R. A., and Link, L. Phosphorylation of arabinosyl guanine by a mitochondrial enzyme of bovine liver. Biochem. Pharmacol., 38: 2001-2006, 1989.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 2001-2006
    • Lewis, R.A.1    Link, L.2
  • 30
    • 0023951483 scopus 로고
    • Regulation of human thymidine kinase during the cell cycle
    • Sherley, J. L., and Kelly, T. J. Regulation of human thymidine kinase during the cell cycle. J. Biol. Chem., 263: 8350-8358, 1988.
    • (1988) J. Biol. Chem. , vol.263 , pp. 8350-8358
    • Sherley, J.L.1    Kelly, T.J.2
  • 31
    • 0023792806 scopus 로고
    • Deoxycytidine kinase is constitutively expressed in human lymphocytes: Consequences for compartmentation effects, unscheduled DNA synthesis, and viral replication in resting cells
    • Arner, E. S., Flygar, M., Bohman, C., Wallstrom, B., and Eriksson, S. Deoxycytidine kinase is constitutively expressed in human lymphocytes: consequences for compartmentation effects, unscheduled DNA synthesis, and viral replication in resting cells. Exp. Cell Res., 178: 335-342, 1988.
    • (1988) Exp. Cell Res. , vol.178 , pp. 335-342
    • Arner, E.S.1    Flygar, M.2    Bohman, C.3    Wallstrom, B.4    Eriksson, S.5
  • 32
    • 0026440506 scopus 로고
    • Cell cycle-specific metabolism of arabinosyl nucleosides in K562 human leukemia cells
    • Gandhi, V., and Plunkett, W. Cell cycle-specific metabolism of arabinosyl nucleosides in K562 human leukemia cells. Cancer Chemother. Pharmacol., 31: 11-17, 1992.
    • (1992) Cancer Chemother. Pharmacol. , vol.31 , pp. 11-17
    • Gandhi, V.1    Plunkett, W.2
  • 34
    • 0027377063 scopus 로고
    • Regulation of thymidine kinase and thymidylate synthase in intact human lymphoblast CCRF-CEM cells
    • Xu, Y. Z., and Plunkett, W. Regulation of thymidine kinase and thymidylate synthase in intact human lymphoblast CCRF-CEM cells. J. Biol. Chem., 268: 22363-22368, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 22363-22368
    • Xu, Y.Z.1    Plunkett, W.2
  • 35
    • 0025777811 scopus 로고
    • Action of 9-β-D-arabinofuranosyl-2-fluoroadenine on RNA metabolism
    • Huang, P., and Plunkett, W. Action of 9-β-D-arabinofuranosyl-2-fluoroadenine on RNA metabolism. Mol. Pharmacol., 39: 449-455, 1991.
    • (1991) Mol. Pharmacol. , vol.39 , pp. 449-455
    • Huang, P.1    Plunkett, W.2
  • 36
    • 0025811415 scopus 로고
    • Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5′-triphosphate
    • Parker, W. B., Shaddix, S. C., Chang, C. H., White, E. L., Rose, L. M., Brockman, R. W., Shortnacy, A. T., Montgomery, J. A., Secrist, J. A., and Bennett, L. L. J. Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5′-triphosphate. Cancer Res., 51: 2386-2394, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 2386-2394
    • Parker, W.B.1    Shaddix, S.C.2    Chang, C.H.3    White, E.L.4    Rose, L.M.5    Brockman, R.W.6    Shortnacy, A.T.7    Montgomery, J.A.8    Secrist, J.A.9    Bennett, L.L.J.10
  • 37
    • 0029989449 scopus 로고    scopus 로고
    • Influence of fludarabine on pharmacokinetics and pharmacodynamics of cytarabine: Implications for a continuous infusion schedule
    • Seymour, J. F., Huang, P., Plunkett, W., and Gandhi, V. Influence of fludarabine on pharmacokinetics and pharmacodynamics of cytarabine: implications for a continuous infusion schedule. Clin. Cancer Res., 2: 653-658, 1996.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 653-658
    • Seymour, J.F.1    Huang, P.2    Plunkett, W.3    Gandhi, V.4
  • 38
    • 0026638006 scopus 로고
    • 1-β-D-arabinofuranosylcytosine-diphosphatecholine is formed by the reversal of cholinephosphotransferase and not via cytidylyltransferase
    • Kucera, G. L., and Capizzi, R. L. 1-β-D-arabinofuranosylcytosine-diphosphatecholine is formed by the reversal of cholinephosphotransferase and not via cytidylyltransferase. Cancer Res., 52: 3886-3891, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 3886-3891
    • Kucera, G.L.1    Capizzi, R.L.2
  • 39
    • 0018635683 scopus 로고
    • Inhibitory effects of 9-β-D-arabinofuranosylguanine 5′-triphosphate and 9-β-D-arabinofuranosyladenine 5′-triphosphate on DNA polymerases from murine cells and oncornavirus
    • Ono, K., Ohashi, A., Yamamoto, A., Matsukage, A., Takahasi, T., Saneyoshi, M., and Ueda, T. Inhibitory effects of 9-β-D-arabinofuranosylguanine 5′-triphosphate and 9-β-D-arabinofuranosyladenine 5′-triphosphate on DNA polymerases from murine cells and oncornavirus. Cancer Res., 39: 4673-4680, 1979.
    • (1979) Cancer Res. , vol.39 , pp. 4673-4680
    • Ono, K.1    Ohashi, A.2    Yamamoto, A.3    Matsukage, A.4    Takahasi, T.5    Saneyoshi, M.6    Ueda, T.7
  • 40
  • 41
    • 0021282176 scopus 로고
    • Relationships among Ara-CTP pools, formation of (Ara-C)DNA, and cytotoxicity of human leukemic cells
    • Kufe, D., Spriggs, D., Egan, E. M., and Munroe, D. Relationships among Ara-CTP pools, formation of (Ara-C)DNA, and cytotoxicity of human leukemic cells. Blood, 64: 54-58, 1984.
    • (1984) Blood , vol.64 , pp. 54-58
    • Kufe, D.1    Spriggs, D.2    Egan, E.M.3    Munroe, D.4
  • 42
    • 0023608923 scopus 로고
    • Detection of 1-β-D-arabinofuranosylcytosine incorporation into DNA in vivo
    • Spriggs, D., Robbins, G., Ohno, Y., and Kufe, D. Detection of 1-β-D-arabinofuranosylcytosine incorporation into DNA in vivo. Cancer Res., 47: 6532-6536, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 6532-6536
    • Spriggs, D.1    Robbins, G.2    Ohno, Y.3    Kufe, D.4
  • 43
    • 0344580854 scopus 로고    scopus 로고
    • Differential cellular accumulation of arabinofuranosylguanine triphosphate and its incorporation into DNA in acute leukemia cell lines: Relationship with cytotoxicity
    • Rodriguez, C. O., Jr., and Gandhi, G. Differential cellular accumulation of arabinofuranosylguanine triphosphate and its incorporation into DNA in acute leukemia cell lines: relationship with cytotoxicity. Proc. Am. Assoc. Cancer Res., 40: 517, 1999.
    • (1999) Proc. Am. Assoc. Cancer Res. , vol.40 , pp. 517
    • Rodriguez C.O., Jr.1    Gandhi, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.