Targeting base excision repair suggests a new therapeutic strategy of fludarabine for the treatment of chronic lymphocytic leukemia

Leukemia

Volumn 24, Issue 10, 2010, Pages 1795-1799

  Bulgar, A D ^a   Snell, M ^b   Donze, J R ^b   Kirkland, E B ^b   Li, L ^a   Yang, S ^c   Xu, Y ^a,c   Gerson, S L ^b   Liu, L ^b  

^a CLEVELAND STATE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUDARABINE; METHOXYAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER RESISTANCE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; EXCISION REPAIR; HUMAN; HUMAN CELL; LETTER; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 77957986209     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.166     Document Type: Letter

References (8)

1. Pettitt AR. Mechanism of action of purine analogues in chronic lymphocytic leukemia. Br J Haematol 2003; 121: 692-702.
2. Kamiya K, Huang P, Plunkett W. Inhibition of the 3'-5' exonuclease of human DNA polymerase a? by fludarabine-terminated DNA. J Biol Chem 1996; 271: 19428-19435.
3. Horton JK, Prasad R, Hou E, Wilson SH. Protection against methylation-induced cytotoxicity by DNA polymerase b-dependent long patch base excision repair. J Biol Chem 2000; 275: 2211-2218. (Pubitemid 30060852)
4. Liuzzi M, Talpaert-Borle M. A new approach to study of the base excision repair pathway using methoxyamine. J Biol Chem 1985; 260: 5252-5258.
5. Liu L, Taverna P, Whitacre CM, Chatterjee S, Gerson SL. Pharmacological disruption of base excision repair sensitizes mismatch repair deficient and proficient colon cancer cells to methylating agents. Clin Cancer Res 1999; 5: 2908-2917.
6. Yan L, Bulgar A, Miao YL, Mahajan V, Donze JR, Gerson SL, Liu L. Combined treatment with temozolomide and metho-xyamine: blocking apurinic/pyrimidinic site repair coupled with targeting topoisomerase IIa. Clin Cancer Res 2007; 13: 1532-1539.
7. Rozman C, Montserrat E. Chronic lymphocytic leukemia. N Engl J Med 1995; 333: 1052-1057.
8. Parikh SS, Mol CD, Slupphaug G, Bharati S, Krokan HE, Tainer JA. Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. EMBO J 1998; 17: 5214-5226.