Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase

Cancer Research

Volumn 62, Issue 11, 2002, Pages 3100-3105

  Rodriguez, Carlos O ^a   Ayres, Mary ^a   Gandhi, Varsha ^a   Mitchell, Beverly S ^b   Eriksson, Staffan ^c  

^a Department of Experimental Therapeutics ^*  (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; DEOXYCYTIDINE KINASE; DEOXYGUANOSINE KINASE; GUANINE ARABINOSIDE; NELARABINE; NUCLEOSIDE TRIPHOSPHATE; PRODRUG; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CELL FREE SYSTEM; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; DRUG ACCUMULATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRION; PHOSPHORYLATION; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ARABINONUCLEOSIDES; CELL LINE; CELL-FREE SYSTEM; CYTOSOL; DEOXYCYTIDINE KINASE; HUMANS; KINETICS; MITOCHONDRIA; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); T-LYMPHOCYTES; TRANSFECTION;

EID: 0036606777     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Metabolism and action of purine nucleoside
2. 2-Amino-6-methoxypurine arabinoside: An agent for T-cell malignancies
3. Compound GW506U78 in refractory hematologic malignancies: Relationship between cellular pharmacokinetics and clinical response
4. 2-Amino-9-β-D-arabinosyl-6-methoxy-9H-guanine (GW 506: Compound 506U) is highly active in patients with T-cell malignancies: Results of a phase I trial in pediatric and adult patients with refractory hematological malignancies
5. Transport and metabolism of 9-β-D-arabinofuranosylguanine in a human T-lymphoblastoid cell line: Nitrobenzyl-thioinosine-sensitive and -insensitive influx
6. Pharmacological and biochemical strategies to increase the accumulation of arabinofuranosylguanine triphosphate in primary human leukemia cells
7. Metabolic basis of arabinonucleoside selectivity for human leukemic T and B lymphoblasts
8. Specific cytotoxicity of ambinosylguanine toward cultured T lymphoblasts
9. Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells
10. Metabolism and selective cytotoxicity of 9-β-D-arabinofuranosylguanine in human lymphoblasts
11. Differential metabolism of 9-β-D-arabinofuranosylguanine in human leukemic cells
12. Inhibitory effects of 9-β-D-arabinofuranosylguanine 5′-triphosphate and 9-β-D-arabinofuranosyladenine 5′-triphosphate on DNA polymerases from murine cells and oncornavirus
13. Cytotoxicity, metabolism, and mechanisms of action of 2′, 2′-difluorodeoxyguanosine in Chinese hamster ovary cells
14. Arabinosylguanine-induced apoptosis of T-lymphoblastic cells: Incorporation into DNA is a necessary step
15. Incorporation of 2-halogeno-2′-deoxyadenosine 5-triphosphates into DNA during replication by human polymerases α and β
16. Correlation of cytotoxicity with incorporation of ara-C into DNA
17. Termination of DNA synthesis by 9-β-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity
18. Fludarabine- and gemcitabine-induced apoptosis: Incorporation of analogs into DNA is a critical event
19. Action of 2′, 2′-difluorodeoxycytidine on DNA synthesis
20. Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity
21. Modulatory activity of 2′, 2′-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides
22. Kinetics of phosphorylation of 5-aza-2′-deoxycytidine by deoxycytidine kinase
23. Substrate specificity of mitochondrial 2′-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine
24. Partial purification and characterization of deoxyguanosine kinase from pig skin
25. Phosphorylation of arabinosyl guanine by a mitochondrial enzyme of bovine liver
26. Resistance to 1-β-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene
27. Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity
28. Viral vector transduction of the human deoxycycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo
29. The intracellular localization of deoxycytidine kinase
30. Mitochondrial and submitochondrial localization of human deoxyguanosine kinase
31. Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues
32. High-performance liquid chromatography method for the determination and quantitation of arabinosylguanine triphosphate and fludarabine triphosphate in human cells
33. Compound 506 has activity in mature lymphoid leukemia
34. Lethality of human myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA
35. Regulation of human placental deoxyguanosine kinase by nucleotides
36. Identification of purine deoxyribonucleoside kinases from human leukemia cells: Substrate activation by purine and pyrimidine deoxyribonucleosides
37. Properties of a highly purified mitochondrial deoxyguanosine kinase
38. Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy
39. Antiviral guanosine analogs as substrates for deoxyguanosine kinase: Implications for chemotherapy
40. Evaluation of the combination of nelarabine and fludarabine in leukemias: Clinical response, pharmacokinetics and pharmacodynamics in leukemia cells
41. Phosphorylation of anticancer nucleoside analogs by human mitochondrial deoxyguanosine kinase
42. Human deoxycytidine kinase is located in the cell nucleus
43. Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine
44. Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol