Role of poly(ADP-ribosyl)ation in the killing of chronic lymphocytic leukemia cells by purine analogues

Cancer Research

Volumn 60, Issue 15, 2000, Pages 4187-4193

  Pettitt, A R ^a   Sherrington, P D ^a   Cawley, J C ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOBENZAMIDE; CLADRIBINE; CLENBUTEROL; DNA FRAGMENT; FLUDARABINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLSERINE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PURINE DERIVATIVE;

ARTICLE; CELL KILLING; CELL STRUCTURE; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA MODIFICATION; ENZYME ACTIVITY; HUMAN; MEMBRANE DAMAGE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; PHOSPHORYLATION; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BENZAMIDES; CELL DEATH; CELL MEMBRANE; CELL SIZE; CLADRIBINE; DNA FRAGMENTATION; DRUG INTERACTIONS; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; POLY(ADP-RIBOSE) POLYMERASES; TUMOR SUPPRESSOR PROTEIN P53; VIDARABINE;

EID: 0033869494     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Chronic lymphocytic leukemia
2. Purine nucleoside analogues: Emerging roles in indolent lymphoproliferative disorders
3. Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-β-D-arabinosyl-2-fluoroadenine
4. The induction of p53 and WAF1/CIP1 in chronic lymphocytic leukemia cells treated with 2-chlorodeoxyadenosine
5. p53, MDM-2, BAX, and BCL-2, and drug resistance in chronic lymphocytic leukemia
6. Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: Relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance
7. Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms
8. The effect of p53 dysfunction on purine analogue cytotoxicity in chronic lymphocytic leukaemia
9. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes
10. Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers
11. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
12. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
13. Poly(ADP-ribose) polymerase: A molecular nick-sensor
14. ADP-ribosylation of proteins: Enzymology and biological significance
15. Programmed cell death and adenine nucleotide metabolism in human lymphocytes
16. Intracellular ATP levels determine cell death fate by apoptosis or necrosis
17. Intracellular adenosine triphosphate concentration: A switch in the decision between apoptosis and necrosis
18. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
19. Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo
20. Role of shape change in growth control
21. Cladribine: A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies
22. Fludarabine: A review of its pharmacological properties and therapeutic potential in malignancy
23. Caspases influence the mode but not the extent of cell death induced by purine analogues in chronic lymphocytic leukaemia
24. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl) transferase
25. The study of apoptotic cells by flow cytometry
26. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
27. Mitochondrial control of apoptosis
28. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
29. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
30. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
31. p53 Mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
32. p53 Gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias
33. Possible involvement of poly(ADP-ribosyl) polymerase in triggering stress-induced apoptosis
34. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity
35. + depletion
36. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic β-cell destruction and diabetes development induced by streptozocin
37. PARP is important for genomic stability but dispensable in apoptosis
38. Enhanced cytotoxicity and inhibition of DNA damage repair in irradiated murine L5178 lymphoblasts and human chronic lymphocytic leukemia cells treated with 2'-deoxycoformycin and deoxyadenosine in vitro