Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues

FEBS Letters

Volumn 582, Issue 5, 2008, Pages 720-724

  McSorley, Theresa ^a   Ort, Stephan ^a   Hazra, Saugata ^b   Lavie, Arnon ^b   Konrad, Manfred ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Deoxycytidine kinase; Nucleoside analogues; Prodrug phosphorylation; Protein phosphorylation; Subcellular localisation

Indexed keywords

CYTARABINE; DEOXYCYTIDINE; DEOXYCYTIDINE KINASE; GEMCITABINE; GLUTAMINE; GREEN FLUORESCENT PROTEIN; SERINE;

ARTICLE; CATALYSIS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME KINETICS; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ACTIVE TRANSPORT, CELL NUCLEUS; CATALYSIS; CELL LINE; CELL NUCLEUS; DEOXYCYTIDINE; DEOXYCYTIDINE KINASE; HUMANS; INTRACELLULAR SPACE; KINETICS; MOLECULAR MIMICRY; MUTANT PROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; SUBSTRATE SPECIFICITY;

EID: 39649124214     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.01.048     Document Type: Article

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