메뉴 건너뛰기




Volumn , Issue , 2010, Pages 625-667

G-Protein-Coupled Receptors as Drug Targets

Author keywords

G protein coupled receptors as drug targets; GPCRs as drug targets in inflammation; Obesity and GPCRs drug targets

Indexed keywords


EID: 84884426509     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470538951.ch20     Document Type: Chapter
Times cited : (1)

References (173)
  • 2
    • 33845615783 scopus 로고    scopus 로고
    • Role of PGE2 and EP receptors in the pathogenesis of rheumatoid arthritis and as a novel therapeutic strategy
    • Akaogi J, Nozaki T, Satoh M, Yamada H. Role of PGE2 and EP receptors in the pathogenesis of rheumatoid arthritis and as a novel therapeutic strategy. Endocr Metab Immune Disord Drug Targets 2006; 6 (4): 383-394.
    • (2006) Endocr Metab Immune Disord Drug Targets , vol.6 , Issue.4 , pp. 383-394
    • Akaogi, J.1    Nozaki, T.2    Satoh, M.3    Yamada, H.4
  • 3
    • 34247855761 scopus 로고    scopus 로고
    • Chemokine: receptor structure, interactions, and antagonism
    • Allen SJ, Crown SE, Handel TM. Chemokine: receptor structure, interactions, and antagonism. Annu Rev Immunol 2007; 25: 787-820.
    • (2007) Annu Rev Immunol , vol.25 , pp. 787-820
    • Allen, S.J.1    Crown, S.E.2    Handel, T.M.3
  • 4
    • 0030175987 scopus 로고    scopus 로고
    • N-Formyl-methionyl-leucyl-phenylalanine induces and modulates IL-1 and IL-6 in human PBMC
    • Arbour N, Tremblay P, Oth D. N-Formyl-methionyl-leucyl-phenylalanine induces and modulates IL-1 and IL-6 in human PBMC. Cytokine 1996; 8 (6): 468-475.
    • (1996) Cytokine , vol.8 , Issue.6 , pp. 468-475
    • Arbour, N.1    Tremblay, P.2    Oth, D.3
  • 5
    • 0038304457 scopus 로고    scopus 로고
    • Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
    • Asakawa A, Inui A, Kaga T, Katsuura G, Fujimiya M, Fujino MA, Kasuga M. Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut 2003; 52 (7): 947-952.
    • (2003) Gut , vol.52 , Issue.7 , pp. 947-952
    • Asakawa, A.1    Inui, A.2    Kaga, T.3    Katsuura, G.4    Fujimiya, M.5    Fujino, M.A.6    Kasuga, M.7
  • 6
    • 34248219556 scopus 로고    scopus 로고
    • Cannabinoids for the treatment of inflammation
    • Ashton JC. Cannabinoids for the treatment of inflammation. Curr Opin Investig Drugs 2007; 8 (5): 373-384.
    • (2007) Curr Opin Investig Drugs , vol.8 , Issue.5 , pp. 373-384
    • Ashton, J.C.1
  • 8
    • 33751113286 scopus 로고    scopus 로고
    • Leukotriene receptors in atherosclerosis
    • Back M, Hansson GK. Leukotriene receptors in atherosclerosis. Ann Med 2006; 38 (7): 493-502.
    • (2006) Ann Med , vol.38 , Issue.7 , pp. 493-502
    • Back, M.1    Hansson, G.K.2
  • 9
    • 36148945617 scopus 로고    scopus 로고
    • R4 RGS proteins: regulation of G-protein signaling and beyond
    • Bansal G, Druey KM, Xie Z. R4 RGS proteins: regulation of G-protein signaling and beyond. Pharmacol Ther 2007; 116 (3): 473-495.
    • (2007) Pharmacol Ther , vol.116 , Issue.3 , pp. 473-495
    • Bansal, G.1    Druey, K.M.2    Xie, Z.3
  • 10
    • 34548210999 scopus 로고    scopus 로고
    • Efficacy of the newest COX-2 selective inhibitors in rheumatic disease
    • Baraf HS. Efficacy of the newest COX-2 selective inhibitors in rheumatic disease. Curr Pharm Des 2007; 13 (22): 2228-2236.
    • (2007) Curr Pharm Des , vol.13 , Issue.22 , pp. 2228-2236
    • Baraf, H.S.1
  • 11
    • 33750932721 scopus 로고    scopus 로고
    • Increased expression of mu opioid receptors in animals susceptible to diet-induced obesity
    • Barnes MJ, Holmes G, Primeaux SD, York DA, Bray GA. Increased expression of mu opioid receptors in animals susceptible to diet-induced obesity. Peptides 2006; 27 (12): 3292-3298.
    • (2006) Peptides , vol.27 , Issue.12 , pp. 3292-3298
    • Barnes, M.J.1    Holmes, G.2    Primeaux, S.D.3    York, D.A.4    Bray, G.A.5
  • 13
    • 0034801859 scopus 로고    scopus 로고
    • Opposite regulation of hypothalamic orexin and neuropeptide Y receptors and peptide expressions in obese Zucker rats
    • Beck B, Richy S, Dimitrov T, Stricker-Krongrad A. Opposite regulation of hypothalamic orexin and neuropeptide Y receptors and peptide expressions in obese Zucker rats. Biochem Biophys Res Commun 2001; 286 (3): 518-523.
    • (2001) Biochem Biophys Res Commun , vol.286 , Issue.3 , pp. 518-523
    • Beck, B.1    Richy, S.2    Dimitrov, T.3    Stricker-Krongrad, A.4
  • 15
    • 0033963072 scopus 로고    scopus 로고
    • Dopaminergic agonists normalize elevated hypothalamic neuropeptide Y and corticotropin-releasing hormone, body weight gain, and hyperglycemia in ob/ob mice
    • Bina KG, Cincotta AH. Dopaminergic agonists normalize elevated hypothalamic neuropeptide Y and corticotropin-releasing hormone, body weight gain, and hyperglycemia in ob/ob mice. Neuroendocrinology 2000; 71 (1): 68-78.
    • (2000) Neuroendocrinology , vol.71 , Issue.1 , pp. 68-78
    • Bina, K.G.1    Cincotta, A.H.2
  • 16
    • 34548496308 scopus 로고    scopus 로고
    • Enteric alpha-2 adrenoceptors: pathophysiological implications in functional and inflammatory bowel disorders
    • Blandizzi C. Enteric alpha-2 adrenoceptors: pathophysiological implications in functional and inflammatory bowel disorders. Neurochem Int 2007; 51 (5): 282-288.
    • (2007) Neurochem Int , vol.51 , Issue.5 , pp. 282-288
    • Blandizzi, C.1
  • 17
    • 0030987069 scopus 로고    scopus 로고
    • How receptors talk to trimeric G proteins
    • Bourne HR. How receptors talk to trimeric G proteins. Curr Opin Cell Biol 1997; 9 (2): 134-142.
    • (1997) Curr Opin Cell Biol , vol.9 , Issue.2 , pp. 134-142
    • Bourne, H.R.1
  • 18
  • 19
  • 20
    • 38349099590 scopus 로고    scopus 로고
    • The peripheral cannabinoid receptor knockout mice: an update
    • Buckley NE. The peripheral cannabinoid receptor knockout mice: an update. Br J Pharmacol 2008; 153 (2): 309-318.
    • (2008) Br J Pharmacol , vol.153 , Issue.2 , pp. 309-318
    • Buckley, N.E.1
  • 21
    • 33646483932 scopus 로고    scopus 로고
    • Protease-activated receptors: how proteases signal to cells to cause inflammation and pain
    • Bunnett NW. Protease-activated receptors: how proteases signal to cells to cause inflammation and pain. Semin Thromb Hemost 2006; 32 (Suppl 1): 39-48.
    • (2006) Semin Thromb Hemost , vol.32 , Issue.SUPPL. 1 , pp. 39-48
    • Bunnett, N.W.1
  • 22
    • 3042806532 scopus 로고    scopus 로고
    • Introduction: P2 receptors
    • Burnstock G. Introduction: P2 receptors. Curr Top Med Chem 2004; 4 (8): 793-803.
    • (2004) Curr Top Med Chem , vol.4 , Issue.8 , pp. 793-803
    • Burnstock, G.1
  • 23
    • 0036553037 scopus 로고    scopus 로고
    • The melanocortin receptors: lessons from knockout models
    • Butler AA, Cone RD. The melanocortin receptors: lessons from knockout models. Neuropeptides 2002; 36 (2-3): 77-84.
    • (2002) Neuropeptides , vol.36 , Issue.2-3 , pp. 77-84
    • Butler, A.A.1    Cone, R.D.2
  • 24
    • 0023195578 scopus 로고
    • Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial hyperresponsiveness
    • Casale TB, Wood D, Richerson HB, Trapp S, Metzger WJ, Zavala D, Hunninghake GW. Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial hyperresponsiveness. J Clin Invest 1987; 79 (4): 1197-1203.
    • (1987) J Clin Invest , vol.79 , Issue.4 , pp. 1197-1203
    • Casale, T.B.1    Wood, D.2    Richerson, H.B.3    Trapp, S.4    Metzger, W.J.5    Zavala, D.6    Hunninghake, G.W.7
  • 25
    • 1542347163 scopus 로고    scopus 로고
    • Targeting melanocortin receptors as a novel strategy to control inflammation
    • Catania A, Gatti S, Colombo G, Lipton JM. Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol Rev 2004; 56 (1): 1-29.
    • (2004) Pharmacol Rev , vol.56 , Issue.1 , pp. 1-29
    • Catania, A.1    Gatti, S.2    Colombo, G.3    Lipton, J.M.4
  • 26
    • 0025092009 scopus 로고
    • Recombinant C5a enhances interleukin 1 and tumor necrosis factor release by lipopolysaccharide-stimulated monocytes and macrophages
    • Cavaillon JM, Fitting C, Haeffner-Cavaillon N. Recombinant C5a enhances interleukin 1 and tumor necrosis factor release by lipopolysaccharide-stimulated monocytes and macrophages. Eur J Immunol 1990; 20 (2): 253-257.
    • (1990) Eur J Immunol , vol.20 , Issue.2 , pp. 253-257
    • Cavaillon, J.M.1    Fitting, C.2    Haeffner-Cavaillon, N.3
  • 27
    • 0242273333 scopus 로고    scopus 로고
    • Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization
    • Charo IF, Peters W. Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization. Microcirculation 2003; 10 (3-4): 259-264.
    • (2003) Microcirculation , vol.10 , Issue.3-4 , pp. 259-264
    • Charo, I.F.1    Peters, W.2
  • 28
    • 33745124738 scopus 로고    scopus 로고
    • Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus
    • Chiba K, Matsuyuki H, Maeda Y, Sugahara K. Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. Cell Mol Immunol 2006; 3 (1): 11-19.
    • (2006) Cell Mol Immunol , vol.3 , Issue.1 , pp. 11-19
    • Chiba, K.1    Matsuyuki, H.2    Maeda, Y.3    Sugahara, K.4
  • 33
    • 0030585368 scopus 로고    scopus 로고
    • Cloning, functional expression and tissue distribution of the human P2Y6 receptor
    • Communi D, Parmentier M, Boeynaems JM. Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun 1996; 222 (2): 303-308.
    • (1996) Biochem Biophys Res Commun , vol.222 , Issue.2 , pp. 303-308
    • Communi, D.1    Parmentier, M.2    Boeynaems, J.M.3
  • 36
    • 0033543739 scopus 로고    scopus 로고
    • Effect of loss of P2Y(2) receptor gene expression on nucleotide regulation of murine epithelial Cl(-) transport
    • Cressman VL, Lazarowski E, Homolya L, Boucher RC, Koller BH, Grubb BR. Effect of loss of P2Y(2) receptor gene expression on nucleotide regulation of murine epithelial Cl(-) transport. J Biol Chem 1999; 274 (37): 26461-26468.
    • (1999) J Biol Chem , vol.274 , Issue.37 , pp. 26461-26468
    • Cressman, V.L.1    Lazarowski, E.2    Homolya, L.3    Boucher, R.C.4    Koller, B.H.5    Grubb, B.R.6
  • 38
    • 0030613761 scopus 로고    scopus 로고
    • Switching of the coupling of the beta2- adrenergic receptor to different G proteins by protein kinase A
    • Daaka Y, Luttrell LM, Lefkowitz RJ. Switching of the coupling of the beta2- adrenergic receptor to different G proteins by protein kinase A. Nature 1997; 390 (6655): 88-91.
    • (1997) Nature , vol.390 , Issue.6655 , pp. 88-91
    • Daaka, Y.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 39
    • 34447258678 scopus 로고    scopus 로고
    • Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity
    • Deupi X, Dolker N, Lopez-Rodriguez ML, Campillo M, Ballesteros JA, Pardo L. Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity. Curr Top Med Chem 2007; 7 (10): 991-998.
    • (2007) Curr Top Med Chem , vol.7 , Issue.10 , pp. 991-998
    • Deupi, X.1    Dolker, N.2    Lopez-Rodriguez, M.L.3    Campillo, M.4    Ballesteros, J.A.5    Pardo, L.6
  • 41
    • 0030153427 scopus 로고    scopus 로고
    • Signaling by the G12 class of G proteins
    • Dhanasekaran N, Dermott JM. Signaling by the G12 class of G proteins. Cell Signal 1996; 8 (4): 235-245.
    • (1996) Cell Signal , vol.8 , Issue.4 , pp. 235-245
    • Dhanasekaran, N.1    Dermott, J.M.2
  • 42
    • 24344487961 scopus 로고    scopus 로고
    • The regulatory mechanisms of export trafficking of G protein-coupled receptors
    • Duvernay MT, Filipeanu CM, Wu G. The regulatory mechanisms of export trafficking of G protein-coupled receptors. Cell Signal 2005; 17 (12): 1457-1465.
    • (2005) Cell Signal , vol.17 , Issue.12 , pp. 1457-1465
    • Duvernay, M.T.1    Filipeanu, C.M.2    Wu, G.3
  • 43
    • 38449122657 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2 promotes allergic sensitization to an inhaled antigen through a TNF-mediated pathway
    • Ebeling C, Lam T, Gordon JR, Hollenberg MD, Vliagoftis H. Proteinase-activated receptor-2 promotes allergic sensitization to an inhaled antigen through a TNF-mediated pathway. J Immunol 2007; 179 (5): 2910-2917.
    • (2007) J Immunol , vol.179 , Issue.5 , pp. 2910-2917
    • Ebeling, C.1    Lam, T.2    Gordon, J.R.3    Hollenberg, M.D.4    Vliagoftis, H.5
  • 44
    • 33846030175 scopus 로고    scopus 로고
    • Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and-independent coordinated alterations of receptor localization and function
    • Ellis J, Pediani JD, Canals M, Milasta S, Milligan G. Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and-independent coordinated alterations of receptor localization and function. J Biol Chem 2006; 281 (50): 38812-38824.
    • (2006) J Biol Chem , vol.281 , Issue.50 , pp. 38812-38824
    • Ellis, J.1    Pediani, J.D.2    Canals, M.3    Milasta, S.4    Milligan, G.5
  • 48
    • 0035985601 scopus 로고    scopus 로고
    • Adenosine receptor ligands as potential therapeutics in asthma
    • Fozard JR, McCarthy C. Adenosine receptor ligands as potential therapeutics in asthma. Curr Opin Investig Drugs 2002; 3 (1): 69-77.
    • (2002) Curr Opin Investig Drugs , vol.3 , Issue.1 , pp. 69-77
    • Fozard, J.R.1    McCarthy, C.2
  • 49
    • 0037040392 scopus 로고    scopus 로고
    • Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat
    • Fozard JR, Ellis KM, Villela Dantas MF, Tigani B, Mazzoni L. Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat. Eur J Pharmacol 2002; 438 (3): 183-188.
    • (2002) Eur J Pharmacol , vol.438 , Issue.3 , pp. 183-188
    • Fozard, J.R.1    Ellis, K.M.2    Villela Dantas, M.F.3    Tigani, B.4    Mazzoni, L.5
  • 53
    • 0027449027 scopus 로고
    • Beta 3-adrenoceptors in dog adipose tissue: studies on their involvement in the lipomobilizing effect of catecholamines
    • Galitzky J, Reverte M, Carpene C, Lafontan M, Berlan M. Beta 3-adrenoceptors in dog adipose tissue: studies on their involvement in the lipomobilizing effect of catecholamines. J Pharmacol Exp Ther 1993; 266 (1): 358-366.
    • (1993) J Pharmacol Exp Ther , vol.266 , Issue.1 , pp. 358-366
    • Galitzky, J.1    Reverte, M.2    Carpene, C.3    Lafontan, M.4    Berlan, M.5
  • 55
    • 0030745159 scopus 로고    scopus 로고
    • Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist
    • Ghorbani M, Claus TH, Himms-Hagen J. Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist. Biochem Pharmacol 1997; 54 (1): 121-131.
    • (1997) Biochem Pharmacol , vol.54 , Issue.1 , pp. 121-131
    • Ghorbani, M.1    Claus, T.H.2    Himms-Hagen, J.3
  • 57
    • 47249114523 scopus 로고    scopus 로고
    • Why chemokines are cytokines while their receptors are not cytokine ones?
    • Goncharova LB, Tarakanov AO. Why chemokines are cytokines while their receptors are not cytokine ones? Curr Med Chem 2008; 15 (13): 1297-1304.
    • (2008) Curr Med Chem , vol.15 , Issue.13 , pp. 1297-1304
    • Goncharova, L.B.1    Tarakanov, A.O.2
  • 59
    • 33745218112 scopus 로고    scopus 로고
    • Muscarinic receptor signaling in the pathophysiology of asthma and COPD
    • Gosens R, Zaagsma J, Meurs H, Halayko AJ. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir Res 2006; 7: 73.
    • (2006) Respir Res , vol.7 , pp. 73
    • Gosens, R.1    Zaagsma, J.2    Meurs, H.3    Halayko, A.J.4
  • 60
    • 21044431964 scopus 로고    scopus 로고
    • The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications
    • Gravanis A, Margioris AN. The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications. Curr Med Chem 2005; 12 (13): 1503-1512.
    • (2005) Curr Med Chem , vol.12 , Issue.13 , pp. 1503-1512
    • Gravanis, A.1    Margioris, A.N.2
  • 61
    • 42149193728 scopus 로고    scopus 로고
    • Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP
    • Grbic DM, Degagne E, Langlois C, Dupuis AA, Gendron FP. Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP. J Immunol 2008; 180 (4): 2659-2668.
    • (2008) J Immunol , vol.180 , Issue.4 , pp. 2659-2668
    • Grbic, D.M.1    Degagne, E.2    Langlois, C.3    Dupuis, A.A.4    Gendron, F.P.5
  • 62
    • 17644388462 scopus 로고    scopus 로고
    • Role of C5a in inflammatory responses
    • Guo RF, Ward PA. Role of C5a in inflammatory responses. Annu Rev Immunol 2005; 23: 821-852.
    • (2005) Annu Rev Immunol , vol.23 , pp. 821-852
    • Guo, R.F.1    Ward, P.A.2
  • 63
    • 2542444495 scopus 로고    scopus 로고
    • Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism
    • Halatchev IG, Ellacott KL, Fan W, Cone RD. Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism. Endocrinology 2004; 145 (6): 2585-2590.
    • (2004) Endocrinology , vol.145 , Issue.6 , pp. 2585-2590
    • Halatchev, I.G.1    Ellacott, K.L.2    Fan, W.3    Cone, R.D.4
  • 64
    • 1042266534 scopus 로고    scopus 로고
    • Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat
    • Hansen MJ, Jovanovska V, Morris MJ. Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat. J Neurochem 2004; 88 (4): 909-916.
    • (2004) J Neurochem , vol.88 , Issue.4 , pp. 909-916
    • Hansen, M.J.1    Jovanovska, V.2    Morris, M.J.3
  • 65
    • 38549144692 scopus 로고    scopus 로고
    • Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders
    • Heal DJ, Smith SL, Fisas A, Codony X, Buschmann H. Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. Pharmacol Ther 2008; 117 (2): 207-231.
    • (2008) Pharmacol Ther , vol.117 , Issue.2 , pp. 207-231
    • Heal, D.J.1    Smith, S.L.2    Fisas, A.3    Codony, X.4    Buschmann, H.5
  • 66
    • 0030561086 scopus 로고    scopus 로고
    • Substance P augments interleukin-10 and tumor necrosis factor-alpha release by human cord blood monocytes and macrophages
    • Ho WZ, Kaufman D, Uvaydova M, Douglas SD. Substance P augments interleukin-10 and tumor necrosis factor-alpha release by human cord blood monocytes and macrophages. J Neuroimmunol 1996; 71 (1-2): 73-80.
    • (1996) J Neuroimmunol , vol.71 , Issue.1-2 , pp. 73-80
    • Ho, W.Z.1    Kaufman, D.2    Uvaydova, M.3    Douglas, S.D.4
  • 68
    • 43249119649 scopus 로고    scopus 로고
    • FTY720 (fingolimod) for relapsing multiple sclerosis
    • Horga A, Montalban X. FTY720 (fingolimod) for relapsing multiple sclerosis. Expert Rev Neurother 2008; 8 (5): 699-714.
    • (2008) Expert Rev Neurother , vol.8 , Issue.5 , pp. 699-714
    • Horga, A.1    Montalban, X.2
  • 70
    • 0024477374 scopus 로고
    • Inhibitory histamine H3-receptors on cholinergic nerves in human airways
    • Ichinose M, Barnes PJ. Inhibitory histamine H3-receptors on cholinergic nerves in human airways. Eur J Pharmacol 1989; 163 (2-3): 383-386.
    • (1989) Eur J Pharmacol , vol.163 , Issue.2-3 , pp. 383-386
    • Ichinose, M.1    Barnes, P.J.2
  • 71
    • 51349114141 scopus 로고    scopus 로고
    • The role of the agouti-related protein in energy balance regulation
    • Ilnytska O, Argyropoulos G. The role of the agouti-related protein in energy balance regulation. Cell Mol Life Sci 2008; 65 (17): 2721-2731.
    • (2008) Cell Mol Life Sci , vol.65 , Issue.17 , pp. 2721-2731
    • Ilnytska, O.1    Argyropoulos, G.2
  • 72
    • 0029165068 scopus 로고
    • Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors
    • Jakubik J, Bacakova L, el-Fakahany EE, Tucek S. Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors. J Pharmacol Exp Ther 1995; 274 (3): 1077-1083.
    • (1995) J Pharmacol Exp Ther , vol.274 , Issue.3 , pp. 1077-1083
    • Jakubik, J.1    Bacakova, L.2    el-Fakahany, E.E.3    Tucek, S.4
  • 73
    • 1842333847 scopus 로고    scopus 로고
    • Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors
    • Jakubik J, Bacakova L, El-Fakahany EE, Tucek S. Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol 1997; 52 (1): 172-179.
    • (1997) Mol Pharmacol , vol.52 , Issue.1 , pp. 172-179
    • Jakubik, J.1    Bacakova, L.2    El-Fakahany, E.E.3    Tucek, S.4
  • 74
    • 0025913012 scopus 로고
    • Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction
    • Jarjour NN, Calhoun WJ, Schwartz LB, Busse WW. Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction. Am Rev Respir Dis 1991; 144 (1): 83-87.
    • (1991) Am Rev Respir Dis , vol.144 , Issue.1 , pp. 83-87
    • Jarjour, N.N.1    Calhoun, W.J.2    Schwartz, L.B.3    Busse, W.W.4
  • 75
    • 34047212268 scopus 로고    scopus 로고
    • The effect of kappa opioid receptor antagonism on energy expenditure in the obese Zucker rat
    • Jarosz PA. The effect of kappa opioid receptor antagonism on energy expenditure in the obese Zucker rat. Biol Res Nurs 2007; 8 (4): 294-299.
    • (2007) Biol Res Nurs , vol.8 , Issue.4 , pp. 294-299
    • Jarosz, P.A.1
  • 76
    • 33846844985 scopus 로고    scopus 로고
    • Generation of gut-homing T cells and their localization to the small intestinal mucosa
    • Johansson-Lindbom B, Agace WW. Generation of gut-homing T cells and their localization to the small intestinal mucosa. Immunol Rev 2007; 215: 226-242.
    • (2007) Immunol Rev , vol.215 , pp. 226-242
    • Johansson-Lindbom, B.1    Agace, W.W.2
  • 77
    • 1842682019 scopus 로고    scopus 로고
    • Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis
    • Jolly PS, Bektas M, Olivera A, Gonzalez-Espinosa C, Proia RL, Rivera J, Milstien S, Spiegel S. Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med 2004; 199 (7): 959-970.
    • (2004) J Exp Med , vol.199 , Issue.7 , pp. 959-970
    • Jolly, P.S.1    Bektas, M.2    Olivera, A.3    Gonzalez-Espinosa, C.4    Proia, R.L.5    Rivera, J.6    Milstien, S.7    Spiegel, S.8
  • 78
    • 35348968460 scopus 로고    scopus 로고
    • Neuropeptide y receptor selective ligands in the treatment of obesity
    • Kamiji MM, Inui A. Neuropeptide y receptor selective ligands in the treatment of obesity. Endocr Rev 2007; 28 (6): 664-684.
    • (2007) Endocr Rev , vol.28 , Issue.6 , pp. 664-684
    • Kamiji, M.M.1    Inui, A.2
  • 79
    • 2342454436 scopus 로고    scopus 로고
    • A role for substance P in arthritis?
    • Keeble JE, Brain SD. A role for substance P in arthritis? Neurosci Lett 2004; 361 (1-3): 176-179.
    • (2004) Neurosci Lett , vol.361 , Issue.1-3 , pp. 176-179
    • Keeble, J.E.1    Brain, S.D.2
  • 80
    • 0038460899 scopus 로고    scopus 로고
    • Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties
    • Kela J, Salmi P, Rimondini-Giorgini R, Heilig M, Wahlestedt C. Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties. Regul Pept 2003; 114 (2-3): 109-114.
    • (2003) Regul Pept , vol.114 , Issue.2-3 , pp. 109-114
    • Kela, J.1    Salmi, P.2    Rimondini-Giorgini, R.3    Heilig, M.4    Wahlestedt, C.5
  • 81
    • 34548791897 scopus 로고    scopus 로고
    • Regulation of immune cells by eicosanoid receptors
    • Kim N, Luster AD. Regulation of immune cells by eicosanoid receptors. Sci World J 2007; 7: 1307-1328.
    • (2007) Sci World J , vol.7 , pp. 1307-1328
    • Kim, N.1    Luster, A.D.2
  • 82
    • 0036185058 scopus 로고    scopus 로고
    • Orexins in the brain- gut axis
    • Kirchgessner AL. Orexins in the brain- gut axis. Endocr Rev 2002; 23 (1): 1-15.
    • (2002) Endocr Rev , vol.23 , Issue.1 , pp. 1-15
    • Kirchgessner, A.L.1
  • 83
    • 0033378162 scopus 로고    scopus 로고
    • Orexin synthesis and response in the gut
    • Kirchgessner AL, Liu M. Orexin synthesis and response in the gut. Neuron 1999; 24 (4): 941-951.
    • (1999) Neuron , vol.24 , Issue.4 , pp. 941-951
    • Kirchgessner, A.L.1    Liu, M.2
  • 84
    • 0029887624 scopus 로고    scopus 로고
    • Induction of inducible nitric-oxide synthase by the heterotrimeric G protein Galpha13
    • Kitamura K, Singer WD, Star RA, Muallem S, Miller RT. Induction of inducible nitric-oxide synthase by the heterotrimeric G protein Galpha13. J Biol Chem 1996; 271 (13): 7412-7415.
    • (1996) J Biol Chem , vol.271 , Issue.13 , pp. 7412-7415
    • Kitamura, K.1    Singer, W.D.2    Star, R.A.3    Muallem, S.4    Miller, R.T.5
  • 86
    • 0036669383 scopus 로고    scopus 로고
    • Function of prostanoid receptors: studies on knockout mice
    • Kobayashi T, Narumiya S. Function of prostanoid receptors: studies on knockout mice. Prostaglandins Other Lipid Mediat 2002; 68-69: 557-573.
    • (2002) Prostaglandins Other Lipid Mediat , vol.68-69 , pp. 557-573
    • Kobayashi, T.1    Narumiya, S.2
  • 87
    • 0028338534 scopus 로고
    • GCRDb: a G-protein-coupled receptor database
    • Kolakowski LF Jr. GCRDb: a G-protein-coupled receptor database. Receptors Channels 1994; 2 (1): 1-7.
    • (1994) Receptors Channels , vol.2 , Issue.1 , pp. 1-7
    • Kolakowski, Jr.L.F.1
  • 88
    • 3042798261 scopus 로고    scopus 로고
    • Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function
    • Kristiansen K. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacol Ther 2004; 103 (1): 21-80.
    • (2004) Pharmacol Ther , vol.103 , Issue.1 , pp. 21-80
    • Kristiansen, K.1
  • 89
    • 34548050674 scopus 로고    scopus 로고
    • Understanding metabolic homeostasis and imbalance: what is the role of the endocannabinoid system?
    • discussion S.
    • Kunos G. Understanding metabolic homeostasis and imbalance: what is the role of the endocannabinoid system? Am J Med 2007; 120 (9 Suppl 1): S18-S24; discussion S.
    • (2007) Am J Med , vol.120 , Issue.9 SUPPL. 1
    • Kunos, G.1
  • 90
    • 0036839229 scopus 로고    scopus 로고
    • Formyl-peptide receptors revisited
    • Le Y, Murphy PM, Wang JM. Formyl-peptide receptors revisited. Trends Immunol 2002; 23 (11): 541-548.
    • (2002) Trends Immunol , vol.23 , Issue.11 , pp. 541-548
    • Le, Y.1    Murphy, P.M.2    Wang, J.M.3
  • 91
    • 0024435368 scopus 로고
    • Medial hypothalamic serotonin: role in circadian patterns of feeding and macronutrient selection
    • Leibowitz SF, Weiss GF, Walsh UA, Viswanath D. Medial hypothalamic serotonin: role in circadian patterns of feeding and macronutrient selection. Brain Res 1989; 503 (1): 132-140.
    • (1989) Brain Res , vol.503 , Issue.1 , pp. 132-140
    • Leibowitz, S.F.1    Weiss, G.F.2    Walsh, U.A.3    Viswanath, D.4
  • 92
    • 0029116310 scopus 로고
    • Endothelins
    • Levin ER. Endothelins. N Engl J Med 1995; 333 (6): 356-363.
    • (1995) N Engl J Med , vol.333 , Issue.6 , pp. 356-363
    • Levin, E.R.1
  • 93
    • 33750502435 scopus 로고    scopus 로고
    • Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers
    • Levoye A, Dam J, Ayoub MA, Guillaume JL, Jockers R. Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers. EMBO Rep 2006; 7 (11): 1094-1098.
    • (2006) EMBO Rep , vol.7 , Issue.11 , pp. 1094-1098
    • Levoye, A.1    Dam, J.2    Ayoub, M.A.3    Guillaume, J.L.4    Jockers, R.5
  • 94
    • 2442449306 scopus 로고    scopus 로고
    • Adenosine, inflammation and asthma - a review
    • Livingston M, Heaney LG, Ennis M. Adenosine, inflammation and asthma - a review. Inflamm Res 2004; 53 (5): 171-178.
    • (2004) Inflamm Res , vol.53 , Issue.5 , pp. 171-178
    • Livingston, M.1    Heaney, L.G.2    Ennis, M.3
  • 95
    • 3543144738 scopus 로고    scopus 로고
    • Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitro
    • Maeda K, Nakata H, Koh Y, Miyakawa T, Ogata H, Takaoka Y, Shibayama S, Sagawa K, Fukushima D, Moravek J, Koyanagi Y, Mitsuya H. Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitro. J Virol 2004; 78 (16): 8654-8662.
    • (2004) J Virol , vol.78 , Issue.16 , pp. 8654-8662
    • Maeda, K.1    Nakata, H.2    Koh, Y.3    Miyakawa, T.4    Ogata, H.5    Takaoka, Y.6    Shibayama, S.7    Sagawa, K.8    Fukushima, D.9    Moravek, J.10    Koyanagi, Y.11    Mitsuya, H.12
  • 96
    • 18744409076 scopus 로고    scopus 로고
    • Adrenergic modulation of dendritic cells function: relevance for the immune homeostasis
    • Maestroni GJ. Adrenergic modulation of dendritic cells function: relevance for the immune homeostasis. Curr Neurovasc Res 2005; 2 (2): 169-173.
    • (2005) Curr Neurovasc Res , vol.2 , Issue.2 , pp. 169-173
    • Maestroni, G.J.1
  • 98
    • 38849100288 scopus 로고    scopus 로고
    • Contribution of bronchial biopsies in the evaluation of pathogenesis and progression of COPD
    • Magno F, Di Stefano A. Contribution of bronchial biopsies in the evaluation of pathogenesis and progression of COPD. Monaldi Arch Chest Dis 2007; 67 (4): 229-233.
    • (2007) Monaldi Arch Chest Dis , vol.67 , Issue.4 , pp. 229-233
    • Magno, F.1    Di Stefano, A.2
  • 99
    • 0037300319 scopus 로고    scopus 로고
    • The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)
    • Mahad DJ, Ransohoff RM. The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Semin Immunol 2003; 15 (1): 23-32.
    • (2003) Semin Immunol , vol.15 , Issue.1 , pp. 23-32
    • Mahad, D.J.1    Ransohoff, R.M.2
  • 101
    • 34548809284 scopus 로고    scopus 로고
    • The role of leukotriene receptor signaling in inflammation and cancer
    • Massoumi R, Sjolander A. The role of leukotriene receptor signaling in inflammation and cancer. Sci World J 2007; 7: 1413-1421.
    • (2007) Sci World J , vol.7 , pp. 1413-1421
    • Massoumi, R.1    Sjolander, A.2
  • 103
    • 4644371318 scopus 로고    scopus 로고
    • Targeting tachykinins for the treatment of obstructive airways disease
    • Mazzone SB. Targeting tachykinins for the treatment of obstructive airways disease. Treat Respir Med 2004; 3 (4): 201-216.
    • (2004) Treat Respir Med , vol.3 , Issue.4 , pp. 201-216
    • Mazzone, S.B.1
  • 105
    • 0030609874 scopus 로고    scopus 로고
    • Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization
    • Menard L, Ferguson SS, Zhang J, Lin FT, Lefkowitz RJ, Caron MG, Barak LS. Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. Mol Pharmacol 1997; 51 (5): 800-808.
    • (1997) Mol Pharmacol , vol.51 , Issue.5 , pp. 800-808
    • Menard, L.1    Ferguson, S.S.2    Zhang, J.3    Lin, F.T.4    Lefkowitz, R.J.5    Caron, M.G.6    Barak, L.S.7
  • 106
    • 0037163104 scopus 로고    scopus 로고
    • Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia
    • Milia AF, Salis MB, Stacca T, Pinna A, Madeddu P, Trevisani M, Geppetti P, Emanueli C. Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia. Circ Res 2002; 91 (4): 346-352.
    • (2002) Circ Res , vol.91 , Issue.4 , pp. 346-352
    • Milia, A.F.1    Salis, M.B.2    Stacca, T.3    Pinna, A.4    Madeddu, P.5    Trevisani, M.6    Geppetti, P.7    Emanueli, C.8
  • 107
    • 0033021674 scopus 로고    scopus 로고
    • Chimaeric G alpha proteins: their potential use in drug discovery
    • Milligan G, Rees S. Chimaeric G alpha proteins: their potential use in drug discovery. Trends Pharmacol Sci 1999; 20 (3): 118-124.
    • (1999) Trends Pharmacol Sci , vol.20 , Issue.3 , pp. 118-124
    • Milligan, G.1    Rees, S.2
  • 108
    • 36448968578 scopus 로고    scopus 로고
    • Allosteric modulation of heterodimeric G-protein-coupled receptors
    • Milligan G, Smith NJ. Allosteric modulation of heterodimeric G-protein-coupled receptors. Trends Pharmacol Sci 2007; 28 (12): 615-620.
    • (2007) Trends Pharmacol Sci , vol.28 , Issue.12 , pp. 615-620
    • Milligan, G.1    Smith, N.J.2
  • 111
    • 33646826840 scopus 로고    scopus 로고
    • Adenosine signaling in asthma and chronic obstructive pulmonary disease
    • Mohsenin A, Blackburn MR. Adenosine signaling in asthma and chronic obstructive pulmonary disease. Curr Opin Pulm Med 2006; 12 (1): 54-59.
    • (2006) Curr Opin Pulm Med , vol.12 , Issue.1 , pp. 54-59
    • Mohsenin, A.1    Blackburn, M.R.2
  • 113
    • 0029035579 scopus 로고
    • Substance P and alveolar macrophages: effects on oxidative metabolism and eicosanoid production
    • Murris-Espin M, Pinelli E, Pipy B, Leophonte P, Didier A. Substance P and alveolar macrophages: effects on oxidative metabolism and eicosanoid production. Allergy 1995; 50 (4): 334-339.
    • (1995) Allergy , vol.50 , Issue.4 , pp. 334-339
    • Murris-Espin, M.1    Pinelli, E.2    Pipy, B.3    Leophonte, P.4    Didier, A.5
  • 114
    • 0029887455 scopus 로고    scopus 로고
    • Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist
    • Nagase I, Yoshida T, Kumamoto K, Umekawa T, Sakane N, Nikami H, Kawada T, Saito M. Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist. J Clin Invest 1996; 97 (12): 2898-2904.
    • (1996) J Clin Invest , vol.97 , Issue.12 , pp. 2898-2904
    • Nagase, I.1    Yoshida, T.2    Kumamoto, K.3    Umekawa, T.4    Sakane, N.5    Nikami, H.6    Kawada, T.7    Saito, M.8
  • 115
    • 39049160165 scopus 로고    scopus 로고
    • Recent developments on endothelin antagonists as immunomodulatory drugs - from infection to transplantation medicine
    • Nett PC, Teixeira MM, Candinas D, Barton M. Recent developments on endothelin antagonists as immunomodulatory drugs - from infection to transplantation medicine. Recent Patents Cardiovasc Drug Discovery 2006; 1 (3): 265-276.
    • (2006) Recent Patents Cardiovasc Drug Discovery , vol.1 , Issue.3 , pp. 265-276
    • Nett, P.C.1    Teixeira, M.M.2    Candinas, D.3    Barton, M.4
  • 116
    • 0037205055 scopus 로고    scopus 로고
    • G protein pathways
    • Neves SR, Ram PT, Iyengar R. G protein pathways. Science 2002; 296 (5573): 1636-1639.
    • (2002) Science , vol.296 , Issue.5573 , pp. 1636-1639
    • Neves, S.R.1    Ram, P.T.2    Iyengar, R.3
  • 118
    • 0036788971 scopus 로고    scopus 로고
    • Molecular physiology of P2X receptors
    • North RA. Molecular physiology of P2X receptors. Physiol Rev 2002; 82 (4): 1013-1067.
    • (2002) Physiol Rev , vol.82 , Issue.4 , pp. 1013-1067
    • North, R.A.1
  • 119
    • 0027459960 scopus 로고
    • Effect of an inhaled histamine H3-receptor agonist on airway responses to sodium metabisulphite in asthma
    • O'Connor BJ, Lecomte JM, Barnes PJ. Effect of an inhaled histamine H3-receptor agonist on airway responses to sodium metabisulphite in asthma. Br J Clin Pharmacol 1993; 35 (1): 55-57.
    • (1993) Br J Clin Pharmacol , vol.35 , Issue.1 , pp. 55-57
    • O'Connor, B.J.1    Lecomte, J.M.2    Barnes, P.J.3
  • 120
    • 38949205852 scopus 로고    scopus 로고
    • Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment
    • O'Hayre M, Salanga CL, Handel TM, Allen SJ. Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment. Biochem J 2008; 409 (3): 635-649.
    • (2008) Biochem J , vol.409 , Issue.3 , pp. 635-649
    • O'Hayre, M.1    Salanga, C.L.2    Handel, T.M.3    Allen, S.J.4
  • 121
    • 0035924320 scopus 로고    scopus 로고
    • Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage
    • Ohta A, Sitkovsky M. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 2001; 414 (6866): 916-920.
    • (2001) Nature , vol.414 , Issue.6866 , pp. 916-920
    • Ohta, A.1    Sitkovsky, M.2
  • 125
    • 0032842757 scopus 로고    scopus 로고
    • Cellular responses to FMLP challenging: a mini-review
    • Panaro MA, Mitolo V. Cellular responses to FMLP challenging: a mini-review. Immunopharmacol Immunotoxicol 1999; 21 (3): 397-419.
    • (1999) Immunopharmacol Immunotoxicol , vol.21 , Issue.3 , pp. 397-419
    • Panaro, M.A.1    Mitolo, V.2
  • 126
    • 33644883892 scopus 로고    scopus 로고
    • Asthma, allergy and chemokines
    • Pease JE. Asthma, allergy and chemokines. Curr Drug Targets 2006; 7 (1): 3-12.
    • (2006) Curr Drug Targets , vol.7 , Issue.1 , pp. 3-12
    • Pease, J.E.1
  • 127
    • 22744448476 scopus 로고    scopus 로고
    • CCR1 antagonists in clinical development
    • Pease JE, Horuk R. CCR1 antagonists in clinical development. Expert Opin Investig Drugs 2005; 14 (7): 785-796.
    • (2005) Expert Opin Investig Drugs , vol.14 , Issue.7 , pp. 785-796
    • Pease, J.E.1    Horuk, R.2
  • 128
    • 0141629679 scopus 로고    scopus 로고
    • Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases
    • Penela P, Ribas C, Mayor F Jr. Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal 2003; 15 (11): 973-981.
    • (2003) Cell Signal , vol.15 , Issue.11 , pp. 973-981
    • Penela, P.1    Ribas, C.2    Mayor, Jr.F.3
  • 129
    • 40349108550 scopus 로고    scopus 로고
    • The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses
    • Pettipher R. The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses. Br J Pharmacol 2008; 153 (Suppl 1): S191-S199.
    • (2008) Br J Pharmacol , vol.153 , Issue.SUPPL. 1
    • Pettipher, R.1
  • 130
    • 13444269196 scopus 로고    scopus 로고
    • Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells
    • Pfleger KD, Eidne KA. Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells. Biochem J 2005; 385 (Pt 3): 625-637.
    • (2005) Biochem J , vol.385 , Issue.PART 3 , pp. 625-637
    • Pfleger, K.D.1    Eidne, K.A.2
  • 132
    • 33947375174 scopus 로고    scopus 로고
    • Physiological roles of G protein-coupled receptor kinases and arrestins
    • Premont RT, Gainetdinov RR. Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol 2007; 69: 511-534.
    • (2007) Annu Rev Physiol , vol.69 , pp. 511-534
    • Premont, R.T.1    Gainetdinov, R.R.2
  • 134
    • 24044546528 scopus 로고    scopus 로고
    • The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis
    • Quinones MP, Estrada CA, Kalkonde Y, Ahuja SK, Kuziel WA, Mack M, Ahuja SS. The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis. J Mol Med 2005; 83 (9): 672-681.
    • (2005) J Mol Med , vol.83 , Issue.9 , pp. 672-681
    • Quinones, M.P.1    Estrada, C.A.2    Kalkonde, Y.3    Ahuja, S.K.4    Kuziel, W.A.5    Mack, M.6    Ahuja, S.S.7
  • 135
    • 43449130045 scopus 로고    scopus 로고
    • The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB(2) receptor
    • Raborn ES, Marciano-Cabral F, Buckley NE, Martin BR, Cabral GA. The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB(2) receptor. J Neuroimmune Pharmacol 2008; 3 (2): 117-129.
    • (2008) J Neuroimmune Pharmacol , vol.3 , Issue.2 , pp. 117-129
    • Raborn, E.S.1    Marciano-Cabral, F.2    Buckley, N.E.3    Martin, B.R.4    Cabral, G.A.5
  • 136
    • 34250743762 scopus 로고    scopus 로고
    • Allosteric approaches to the targeting of G-protein-coupled receptors for novel drug discovery: a critical assessment
    • Raddatz R, Schaffhauser H, Marino MJ. Allosteric approaches to the targeting of G-protein-coupled receptors for novel drug discovery: a critical assessment. Biochem Pharmacol 2007; 74 (3): 383-391.
    • (2007) Biochem Pharmacol , vol.74 , Issue.3 , pp. 383-391
    • Raddatz, R.1    Schaffhauser, H.2    Marino, M.J.3
  • 137
    • 49449095849 scopus 로고    scopus 로고
    • Complement: an efficient sword of innate immunity
    • Rambach G, Wurzner R, Speth C. Complement: an efficient sword of innate immunity. Contrib Microbiol 2008; 15: 78-100.
    • (2008) Contrib Microbiol , vol.15 , pp. 78-100
    • Rambach, G.1    Wurzner, R.2    Speth, C.3
  • 139
    • 33748702691 scopus 로고    scopus 로고
    • Beneficial effect of tachykinin NK1 receptor antagonism in the development of hapten-induced colitis in mice
    • Rijnierse A, van Zijl KM, Koster AS, Nijkamp FP, Kraneveld AD. Beneficial effect of tachykinin NK1 receptor antagonism in the development of hapten-induced colitis in mice. Eur J Pharmacol 2006; 548 (1-3): 150-157.
    • (2006) Eur J Pharmacol , vol.548 , Issue.1-3 , pp. 150-157
    • Rijnierse, A.1    van Zijl, K.M.2    Koster, A.S.3    Nijkamp, F.P.4    Kraneveld, A.D.5
  • 140
    • 0031023301 scopus 로고    scopus 로고
    • Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight
    • Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA, Bloom SR. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 1997; 138 (1): 351-355.
    • (1997) Endocrinology , vol.138 , Issue.1 , pp. 351-355
    • Rossi, M.1    Choi, S.J.2    O'Shea, D.3    Miyoshi, T.4    Ghatei, M.A.5    Bloom, S.R.6
  • 141
    • 0032540196 scopus 로고    scopus 로고
    • Adenosine receptor activation and nociception
    • Sawynok J. Adenosine receptor activation and nociception. Eur J Pharmacol 1998; 347 (1): 1-11.
    • (1998) Eur J Pharmacol , vol.347 , Issue.1 , pp. 1-11
    • Sawynok, J.1
  • 143
    • 0038354974 scopus 로고    scopus 로고
    • Bradykinin receptor antagonists: therapeutic implications
    • Sharma JN, Al-Dhalmawi GS. Bradykinin receptor antagonists: therapeutic implications. IDrugs 2003; 6 (6): 581-586.
    • (2003) IDrugs , vol.6 , Issue.6 , pp. 581-586
    • Sharma, J.N.1    Al-Dhalmawi, G.S.2
  • 145
    • 0032542294 scopus 로고    scopus 로고
    • Mice lacking melanin-concentrating hormone are hypophagic and lean
    • Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 1998; 396 (6712): 670-674.
    • (1998) Nature , vol.396 , Issue.6712 , pp. 670-674
    • Shimada, M.1    Tritos, N.A.2    Lowell, B.B.3    Flier, J.S.4    Maratos-Flier, E.5
  • 147
    • 0036486775 scopus 로고    scopus 로고
    • FMLP-induced i n vitro nitric oxide production and its regulation in murine peritoneal macrophages
    • Sodhi A, Biswas SK. fMLP-induced i n vitro nitric oxide production and its regulation in murine peritoneal macrophages. J Leukoc Biol 2002; 71 (2): 262-270.
    • (2002) J Leukoc Biol , vol.71 , Issue.2 , pp. 262-270
    • Sodhi, A.1    Biswas, S.K.2
  • 148
    • 0031730280 scopus 로고    scopus 로고
    • Expression of the P2Y6 purinergic receptor in human T cells infiltrating inflammatory bowel disease
    • Somers GR, Hammet FM, Trute L, Southey MC, Venter DJ. Expression of the P2Y6 purinergic receptor in human T cells infiltrating inflammatory bowel disease. Lab Invest 1998; 78 (11): 1375-1383.
    • (1998) Lab Invest , vol.78 , Issue.11 , pp. 1375-1383
    • Somers, G.R.1    Hammet, F.M.2    Trute, L.3    Southey, M.C.4    Venter, D.J.5
  • 149
    • 0344081893 scopus 로고    scopus 로고
    • Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes
    • Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM. Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. Crit Rev Clin Lab Sci 2003; 40 (6): 643-672.
    • (2003) Crit Rev Clin Lab Sci , vol.40 , Issue.6 , pp. 643-672
    • Stafforini, D.M.1    McIntyre, T.M.2    Zimmerman, G.A.3    Prescott, S.M.4
  • 150
    • 25144441651 scopus 로고    scopus 로고
    • The Agouti-related protein and its role in energy homeostasis
    • Stutz AM, Morrison CD, Argyropoulos G. The Agouti-related protein and its role in energy homeostasis. Peptides 2005; 26 (10): 1771-1781.
    • (2005) Peptides , vol.26 , Issue.10 , pp. 1771-1781
    • Stutz, A.M.1    Morrison, C.D.2    Argyropoulos, G.3
  • 153
    • 36148944785 scopus 로고    scopus 로고
    • When a G protein-coupled receptor does not couple to a G protein
    • Sun Y, McGarrigle D, Huang XY. When a G protein-coupled receptor does not couple to a G protein. Mol Biosyst 2007a; 3 (12): 849-854.
    • (2007) Mol Biosyst , vol.3 , Issue.12 , pp. 849-854
    • Sun, Y.1    McGarrigle, D.2    Huang, X.Y.3
  • 154
    • 33846245114 scopus 로고    scopus 로고
    • Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
    • Sun Y, Huang J, Xiang Y, Bastepe M, Juppner H, Kobilka BK, Zhang JJ, Huang XY. Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J 2007b; 26 (1): 53-64.
    • (2007) EMBO J , vol.26 , Issue.1 , pp. 53-64
    • Sun, Y.1    Huang, J.2    Xiang, Y.3    Bastepe, M.4    Juppner, H.5    Kobilka, B.K.6    Zhang, J.J.7    Huang, X.Y.8
  • 156
    • 37749048627 scopus 로고    scopus 로고
    • The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines
    • Thurmond RL, Gelfand EW, Dunford PJ. The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat Rev Drug Discovery 2008; 7 (1): 41-53.
    • (2008) Nat Rev Drug Discovery , vol.7 , Issue.1 , pp. 41-53
    • Thurmond, R.L.1    Gelfand, E.W.2    Dunford, P.J.3
  • 157
    • 34548688420 scopus 로고    scopus 로고
    • Interleukin 13 and the beta-adrenergic blockade theory of asthma revisited 40 years later
    • Townley RG. Interleukin 13 and the beta-adrenergic blockade theory of asthma revisited 40 years later. Ann Allergy Asthma Immunol 2007; 99 (3): 215-224.
    • (2007) Ann Allergy Asthma Immunol , vol.99 , Issue.3 , pp. 215-224
    • Townley, R.G.1
  • 158
    • 36849075379 scopus 로고    scopus 로고
    • Targeting of Th1-associated chemokine receptors CXCR3 and CCR5 as therapeutic strategy for inflammatory diseases
    • Turner JE, Steinmetz OM, Stahl RA, Panzer U. Targeting of Th1-associated chemokine receptors CXCR3 and CCR5 as therapeutic strategy for inflammatory diseases. Mini Rev Med Chem 2007; 7 (11): 1089-1096.
    • (2007) Mini Rev Med Chem , vol.7 , Issue.11 , pp. 1089-1096
    • Turner, J.E.1    Steinmetz, O.M.2    Stahl, R.A.3    Panzer, U.4
  • 159
    • 41149111580 scopus 로고    scopus 로고
    • Chemokines and their receptors: drug targets in immunity and inflammation
    • Viola A, Luster AD. Chemokines and their receptors: drug targets in immunity and inflammation. Annu Rev Pharmacol Toxicol 2008; 48: 171-197.
    • (2008) Annu Rev Pharmacol Toxicol , vol.48 , pp. 171-197
    • Viola, A.1    Luster, A.D.2
  • 160
    • 33747170186 scopus 로고    scopus 로고
    • The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology
    • von Wenckstern H, Zimmermann K, Kleuser B. The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology. Arch Immunol Ther Exp (Warsz) 2006; 54 (4): 239-251.
    • (2006) Arch Immunol Ther Exp (Warsz) , vol.54 , Issue.4 , pp. 239-251
    • von Wenckstern, H.1    Zimmermann, K.2    Kleuser, B.3
  • 161
    • 26444606350 scopus 로고    scopus 로고
    • Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration
    • Wang W, Graeler MH, Goetzl EJ. Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration. FASEB J 2005; 19 (12): 1731-1733.
    • (2005) FASEB J , vol.19 , Issue.12 , pp. 1731-1733
    • Wang, W.1    Graeler, M.H.2    Goetzl, E.J.3
  • 162
    • 0035854734 scopus 로고    scopus 로고
    • P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide
    • Warny M, Aboudola S, Robson SC, Sevigny J, Communi D, Soltoff SP, Kelly CP. P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide. J Biol Chem 2001; 276 (28): 26051-26056.
    • (2001) J Biol Chem , vol.276 , Issue.28 , pp. 26051-26056
    • Warny, M.1    Aboudola, S.2    Robson, S.C.3    Sevigny, J.4    Communi, D.5    Soltoff, S.P.6    Kelly, C.P.7
  • 163
    • 0032799753 scopus 로고    scopus 로고
    • Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role
    • Wheatley M, Hawtin SR. Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role. Hum Reprod Update 1999; 5 (4): 356-364.
    • (1999) Hum Reprod Update , vol.5 , Issue.4 , pp. 356-364
    • Wheatley, M.1    Hawtin, S.R.2
  • 164
    • 0035874638 scopus 로고    scopus 로고
    • The P2Y11 receptor mediates the ATP-induced maturation of human monocyte-derived dendritic cells
    • Wilkin F, Duhant X, Bruyns C, Suarez-Huerta N, Boeynaems JM, Robaye B. The P2Y11 receptor mediates the ATP-induced maturation of human monocyte-derived dendritic cells. J Immunol 2001; 166 (12): 7172-7177.
    • (2001) J Immunol , vol.166 , Issue.12 , pp. 7172-7177
    • Wilkin, F.1    Duhant, X.2    Bruyns, C.3    Suarez-Huerta, N.4    Boeynaems, J.M.5    Robaye, B.6
  • 166
    • 38349119136 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation
    • Wright KL, Duncan M, Sharkey KA. Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation. Br J Pharmacol 2008; 153 (2): 263-270.
    • (2008) Br J Pharmacol , vol.153 , Issue.2 , pp. 263-270
    • Wright, K.L.1    Duncan, M.2    Sharkey, K.A.3
  • 167
    • 33846376810 scopus 로고    scopus 로고
    • How regulators of G protein signaling achieve selective regulation
    • Xie GX, Palmer PP. How regulators of G protein signaling achieve selective regulation. J Mol Biol 2007; 366 (2): 349-365.
    • (2007) J Mol Biol , vol.366 , Issue.2 , pp. 349-365
    • Xie, G.X.1    Palmer, P.P.2
  • 168
    • 0036817344 scopus 로고    scopus 로고
    • Opioid peptides and the control of human ingestive behaviour
    • Yeomans MR, Gray RW. Opioid peptides and the control of human ingestive behaviour. Neurosci Biobehav Rev 2002; 26 (6): 713-728.
    • (2002) Neurosci Biobehav Rev , vol.26 , Issue.6 , pp. 713-728
    • Yeomans, M.R.1    Gray, R.W.2
  • 169
    • 0027362079 scopus 로고
    • Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity
    • Zarjevski N, Cusin I, Vettor R, Rohner-Jeanrenaud F, Jeanrenaud B. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 1993; 133 (4): 1753-1758.
    • (1993) Endocrinology , vol.133 , Issue.4 , pp. 1753-1758
    • Zarjevski, N.1    Cusin, I.2    Vettor, R.3    Rohner-Jeanrenaud, F.4    Jeanrenaud, B.5
  • 171
    • 34548170471 scopus 로고    scopus 로고
    • FTY720: a most promising immunosuppressant modulating immune cell functions
    • Zhang Z, Schluesener HJ. FTY720: a most promising immunosuppressant modulating immune cell functions. Mini Rev Med Chem 2007; 7 (8): 845-850.
    • (2007) Mini Rev Med Chem , vol.7 , Issue.8 , pp. 845-850
    • Zhang, Z.1    Schluesener, H.J.2
  • 172
    • 0034566907 scopus 로고    scopus 로고
    • Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes
    • Zheng Y, Voice JK, Kong Y, Goetzl EJ. Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes. FASEB J 2000; 14 (15): 2387-2389.
    • (2000) FASEB J , vol.14 , Issue.15 , pp. 2387-2389
    • Zheng, Y.1    Voice, J.K.2    Kong, Y.3    Goetzl, E.J.4
  • 173
    • 0035865386 scopus 로고    scopus 로고
    • Lysophosphatidic acid receptor-selective effects on Jurkat T cell migration through a Matrigel model basement membrane
    • Zheng Y, Kong Y, Goetzl EJ. Lysophosphatidic acid receptor-selective effects on Jurkat T cell migration through a Matrigel model basement membrane. J Immunol 2001; 166 (4): 2317-2322.
    • (2001) J Immunol , vol.166 , Issue.4 , pp. 2317-2322
    • Zheng, Y.1    Kong, Y.2    Goetzl, E.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.