Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function

Journal of Biological Chemistry

Volumn 281, Issue 50, 2006, Pages 38812-38824

  Ellis, James ^a   Pediani, John D ^a   Canals, Meritxell ^a   Milasta, Sandra ^a   Milligan, Graeme ^a,b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENCE RESONANCE; HETERODIMERIZATION; PHENOTYPES; RECEPTOR LOCALIZATION;

AMINO ACIDS; DIMERIZATION; ENERGY TRANSFER; ENZYMES; GENES; MOLECULAR STRUCTURE;

CELLS;

1 [5 (2 FLUOROPHENYL) 2 METHYLTHIAZOL 4 YL]1 [2 (5 PHENYL[1,3,4]OXODIAZOL 2 YLMETHYL)PYRROLIDIN 1 YL]METHANONE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AFFECTING AGENT; CANNABINOID RECEPTOR ANTAGONIST; HETERODIMER; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OREXIN 1 RECEPTOR; OREXIN A; RIMONABANT; SB 674042; UNCLASSIFIED DRUG;

ARTICLE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIMERIZATION; DRUG BINDING; DRUG MECHANISM; ENERGY TRANSFER; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

BASE SEQUENCE; CELL LINE; DIMERIZATION; DNA PRIMERS; HUMANS; LIGANDS; PYRROLIDINES; RECEPTOR, CANNABINOID, CB1; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; THIAZOLES;

EID: 33846030175     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602494200     Document Type: Article

References (59)

1. Angers, S., Salahpour, A., and Bouvier, M. (2002) Annu. Rev. Pharmacol. Toxicol. 42, 409-435
2. Milligan, G., Ramsay, D., Pascal, G., and Carrillo, J. J. (2003) Life Sci. 74, 181-188
3. Breitwieser, G. E. (2004) Circ. Res. 94, 17-27
4. Milligan, G. (2004) Mol. Pharmacol. 66, 1-7
5. Meyer, B. H., Segura, J.-M., Martinez, K. L., Hovius, R., George, N., Johnsson, K., and Vogel, H. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 2138-2143
6. Park, P. S., Sum., C. S., Pawagi, A. B., and Wells, J. W. (2002) Biochemistry 30, 5588-5604
7. Armstrong, D., and Strange, P. G. (2001) J. Biol. Chem. 276, 22621-22629
8. Strange, P. G. (2005) J. Mol. Neurosci. 26, 155-160
9. Franco, R., Casado, V., Mallol, J., Ferre, S., Fuxe, K., Cortes, A., Ciruela, F., Lluis, C., and Canela, E. I. (2005) Trends Biochem. Sci. 30, 360-366
10. Vassilatis, D. K., Hohmann, J. G., Zeng, H., Li, F., Ranchalis, J. E., Mortrud, M. T., Brown, A., Wright, A. C., Bergmann, J. E., and Gaitanaris, G. A. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 4903-4908
11. Hakak, Y., Shrestha, D., Goegel, M. C., Behan, D. P., and Chalmers, D. T. (2003) FEBS Lett. 550, 11-17
12. AbdAlla, S., Lother, H., Abdel-tawab, A. M., and Quitterer, U. (2001) J. Biol. Chem. 276, 39721-39726
13. Kostenis, E., Milligan, G., Christopoulos, A., Sanchez-Ferrer, C. F., Heringer-Walther, S., Sexton, P. M., Gembardt, F., Kellett, E., Martini, L., Vanderheyden, P., Schultheiss, H. P., and Walther, T. (2005) Circulation 111, 1806-1813
14. Fuxe, K., Ferre, S., Canals, M., Torvinen, M., Terasmaa, A., Marcellino, D., Goldberg, S. R., Staines, W., Jacobsen, K. X., Lluis, C., Woods, A. S., Agnati, L. F., and Franco, R. (2005) J. Mol. Neurosci. 26, 209-220
15. Ciruela, F., Casadó, V., Ferré, S., Rodrigues, R. J., Luján, R., Burgueño, J., Canals, M., Borycz, J., Rebola, N., Goldberg, S. R., Mallol, J., Cortes, A., Canela, E. I., López- Giménez, J. F., Milligan, G., Lluis, C., Rodrigo, A., Cunha, R. A., Ferre, S., and Franco, F. (2006) J. Neurosci. 26, 2080-2087
16. Waldhoer, M., Fong, J., Jones, R. M., Luzner, M. M., Sharma, S. K., Kostenis, E., Portoghese, P. S., and Whistler, J. L. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 9050-9055
17. Milligan, G. (2006) Drug Discov. Today 11, 541-549
18. Mackie, K. (2006) Annu. Rev. Pharmacol. Toxicol. 6, 101-122
19. Mackie, K. (2005) Handb. Exp. Pharmacol. 168, 299-325
20. Le Foll, B., and Golberg, S. R. (2005) J. Pharmacol. Exp. Ther. 312, 875-883
21. De Vries, T. J., and Schoffelmeer, A. N. (2005) Trends Pharmacol. Sci. 26, 420-426
22. Fernandez, J. R., and Allison, D. B. (2004) Curr. Opin. Investig. Drugs 5, 430-435
23. Lange, J. H., and Kruse, C. G. (2004) Curr. Opin. Drug Discovery Dev. 7, 498-506
24. Boyd, S. T., and Fremming, B. A. (2005) Ann. Pharmacother. 39, 684-690
25. Black, S. C. (2004) Curr. Opin. Investig. Drugs 5, 389-394
26. Kirkham, T. C., and Williams, C. M. (2004) Treat. Endocrinol. 3, 345-360
27. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G., Wilson, S., Arch, J. R., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W. S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J., and Yanagisawa, M. (1998) Cell 92, 573-585
28. Smart, D., Haynes, A. C., Williams, G., and Arch, J. R. (2002) Eur. J. Pharmacol. 440, 199-212
29. Mieda, M., and Yanagisawa, M. (2002) Curr. Opin. Neurobiol. 12, 339-345
30. Backberg, M., Hervieu, G., Wilson, S., and Meister, B. (2002) Eur. J. Neurosci. 15, 315-328
31. Hervieu, G. J., Cluderay, J. E., Harrison, D. C., Roberts, J. C., and Leslie, R. A. (2001) Neuroscience 103, 777-797
32. Taheri, S., Zeitzer, J. M., and Mignot, E. (2002) Annu. Rev. Neurosci. 25, 283-313
33. Baumann, C. R., and Bassetti, C. L. (2005) Lancet Neurol. 4, 673-682
34. Mieda, M., Willie, J. T., Hara, J., Sinton, C. M., Sakurai, T., and Yanagisawa, M. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 4649-4654
35. Hilairet, S., Bouaboula, M., Carriere, D., Le Fur, G., and Casellas, P. (2003) J. Biol. Chem. 278, 23731-23737
36. Langmead, C. J., Jerman, J. C., Brough, S. J., Scott, C., Porter, R. A., and Herdon, H. J. (2004) Br. J. Pharmacol. 141, 340-346
37. Milasta, S., Evans, N., Ormiston, L., Wilson, S., Lefkowitz, R. J., and Milligan, G. (2005) Biochem. J. 387, 573-584
38. Milasta, S., Pediani, J., Appelebe, S., Trim, S., Wyatt, M., Cox, P., Fidock, M., and Milligan, G. (2006) Mol. Pharmacol. 69, 479-491
39. Canals, M., Jenkins, L., Kellett, E., and Milligan, G. (2006) J. Biol. Chem. 281, 16757-16767
40. Carrillo, J. J., López-Gimenez, J. F., and Milligan, G. (2004) Mol. Pharmacol. 66, 1123-1137
41. Wilson, S., Wilkinson, G., and Milligan, G. (2005) J. Biol. Chem. 280, 28663-28674
42. Bulenger, S., Marullo, S., and Bouvier, M. (2005) Trends Pharmacol. Sci. 26, 131-137
43. Lee, S. P., So, C. H., Rashid, A. J., Varghese, G., Cheng, R., Lanca, A. J., O'Dowd, B. F., and George, S. R. (2004) J. Biol. Chem. 279, 35671-35678
44. El-Asmar, L., Springael, J. Y., Ballet, S., Andrieu, E. U., Vassart, G., Parmentier, M. (2005) Mol. Pharmacol. 67, 460-469
45. Jordan, B. A., Trapaidze, N., Gomes, I., Nivarthi, R., and Devi, L. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 343-348
46. So, C. H., Varghese, G., Curley, K. J., Kong, M. M., Alijaniaram, M., Ji, X., Nguyen, T., O'Dowd, B. F., and George, S. R. (2005) Mol. Pharmacol. 68, 568-578
47. Pin, J. P., Kniazeff, J., Binet, V., Liu, J., Maurel, D., Galvez, T., Duthey, B., Havlickova, M., Blahos, J., Prezeau, L., and Rondard, P. (2004) Biochem. Pharmacol. 68, 1565-1572
48. Zhao, G. Q., Zhang, Y., Hoon, M. A., Chandrashekar, J., Erlenbach, I., Ryba, N. J., and Zuker, C. S. (2003) Cell 31, 255-266
49. Pin, J. P., Kniazeff, J., Liu, J., Binet, V., Goudet, C., Rondard, P., and Prezeau, L. (2005) FEBS J. 272, 2947-2955
50. Springael, J. Y., Le Minh, P. N., Urizar, E., Costagliola, S., Vassart, G., and Parmentier, M. (2006) Mol. Pharmacol. 69, 1652-1661
51. Rinaldi-Carmona, M., Le Duigou, A., Oustric, D., Barth, F., Bouaboula, M., Carayon, P., Casellas, P., and Le Fur, G. (1998) J. Pharmacol. Exp. Ther. 287, 1038-1047
52. Leterrier, C., Bonnard, D., Carrel, D., Rossier, J., and Lenkei, Z. (2004) J. Biol. Chem. 279, 36013-36021
53. Leterrier, C., Laine, J., Darmon, M., Boudin, H., Rossier, J., and Lenkei, Z. (2006) J. Neurosci. 26, 3141-3153
54. Rodgers, R. J., Ishii, Y., Halford, J. C., and Blundell, J. E. (2002) Neuropeptides 36, 303-325
55. Ishii, Y., Blundell, J. E., Halford, J. C., Upton, N., Porter, R., Johns, A., Jeffrey, P., Summerfield, S., and Rodgers, R. J. (2005) Behav. Brain Res. 157, 331-341
56. Harris, G. C., Wimmer, M., and Aston-Jones, G. (2005) Nature 437, 556-559
57. Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., and de Lecea, L. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 19168-19173
58. Mackie, K. (2005) Life Sci. 77, 1667-1673
59. Kearn, C. S., Blake-Palmer, K., Daniel, E., Mackie, K., and Glass, M. (2005) Mol. Pharmacol. 67, 1697-1704