Synergistic regulation of β2-adrenergic receptor sequestration: Intracellular complement of β-adrenergic receptor kinase and β-arrestin determine kinetics of internalization

Molecular Pharmacology

Volumn 51, Issue 5, 1997, Pages 800-808

  Ménard, Luc ^a,b   Ferguson, Stephen S G ^a   Zhang, Jie ^a   Lin, Fang Tsyr ^a   Lefkowitz, Robert J ^a   Caron, Marc G ^a   Barak, Larry S ^a,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; COMPLEMENTARY DNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; MUTANT PROTEIN; PROTEIN KINASE; RETINA S ANTIGEN; BETA ADRENERGIC RECEPTOR KINASE; BETA ARRESTIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DESENSITIZATION; EMBRYO; ENDOCYTOSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; ANIMAL; CELL FRACTIONATION; CELL LINE; CELL STRAIN COS1; CHO CELL; HAMSTER; KINETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; ARRESTINS; BETA-ADRENERGIC RECEPTOR KINASE; CELL LINE; CHO CELLS; COS CELLS; CRICETINAE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOCYTOSIS; HUMANS; KINETICS; PHOSPHORYLATION; RECEPTORS, ADRENERGIC, BETA-2; SUBCELLULAR FRACTIONS; TUMOR CELLS, CULTURED;

EID: 0030609874     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.5.800     Document Type: Article

References (35)

1. Ferguson, S. S., L. S. Barak, J. Zhang, and M. G. Caron. G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins. Can. J. Physiol. Pharmacol. 74:1095-1110 (1996).
2. Hertel, C., and J. P. Perkins. Receptor-specific mechanisms of desensitization of beta-adrenergic receptor function. Mol. Cell Endocrinol. 37:245-256 (1984).
3. Chuang, D. M., L. Farber, W. J. Kinnier, and E. Costa. Beta-adrenergic receptors from frog erythrocytes: receptor internalization as a mechanism for receptor desensitization. Adv. Biochem. Psychopharmacol. 21:143-150 (1980).
4. Hertel, C., M. Staehelin, and J. P. Perkins. Evidence for intravesicular beta-adrenergic receptors in membrane fractions from desensitized cells: binding of the hydrophilic ligand CGP-12177 only in the presence of alamethicin. J. Cyclic Nucleotide Protein Phosphorylation Res. 9:119-128 (1983).
5. Perkins, J. P., W. P. Hausdorff, and R. J. Lefkowitz. Mechanisms of ligand-induced desensitization of beta-adrenergic receptors, in The β-Adrenergic Receptors (J. P. Perkins, ed.). The Humana Press, Totowa, NJ, 73-124 (1991).
6. 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J. Biol. Chem. 264:12657-12665 (1989).
7. Benovic, J. L., A. DeBlasi, W. C. Stone, M. Caron, and R. J. Lefkowitz. β-Adrenergic receptor kinase. primary structure delineates a multigene family. Science (Washington D. C.) 246:235-246 (1989).
8. Lohse, M. J., S. Andexinger, J. Pitcher, S. Trukawinski, J. Codina, J. Faure, M. Caron, and R. J. Lefkowitz. Receptor-specific desensitization with purified proteins. J. Biol. Chem. 267:8558-8564 (1992).
9. Gurevich, V. V., S. B. Dion, J. J. Onorato, J. Ptasienski, C. M. Kim, R. Sterne-Marr, M. M. Hosey, and J. L. Benovic. Arrestin interactions with G protein-coupled receptors: direct binding studies of wild type and mutant arrestins with rhodopsin, β2-adrenergic, and m2 muscarinic cholinergic receptors. J. Biol. Chem. 270:720-731 (1995).
10. Chen, C. Y., S. B. Dion, C. M. Kim, and J. L. Benovic. β-adrenergic receptor kinase: agonist-dependent receptor binding promotes kinase activation. J. Biol. Chem. 268:7825-7831 (1993).
11. Ferguson, S. S., L. Ménard, L. S. Barak, W. J. Koch, A. M. Colapietro, and M. G. Caron. Role of phosphorylation in agonist-promoted β2-adrenergic receptor sequestration: rescue of a sequestration-defective mutant receptor by βARK1. J. Biol. Chem. 270:24782-24789 (1995).
12. Ferguson, S. S., W. E. Downey 3rd, A. M. Colapietro, L. S. Barak, L. Ménard, and M. G. Caron. Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science (Washington D. C.) 271:363-366 (1996).
13. Tsuga, H., K. Kameyama, T. Haga, H. Kurose, and T. Nagao. Sequestration of muscarinic acetylcholine receptor m2 subtypes: facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2. J. Biol. Chem. 269:32522-32527 (1994).
14. Ménard, L., S. S. G. Ferguson, L. S. Barak, L. Bertrand, R. T. Premont, A. M. Colapietro, R. J. Lefkowitz, and M. G. Caron. Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. Biochemistry 35:4155-4160 (1996).
15. 2-adrenergic receptor delays onset of agonist-promoted desensitization. Nature (Lond.) 333:370-373 (1988).
16. 2-adrenergic receptor desensitization: delineation with specific inhibitors. J. Biol. Chem. 265:3202-3208 (1990).
17. 2-adrenergic receptor sequestration. J. Biol. Chem. 269:2790-2795 (1994).
18. Barak, L. S., L. Ménard, S. S. Ferguson, A. M. Colapietro, and M. G. Caron. The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor. Biochemistry 34:15407-15414 (1995).
19. Yu, S. S., R. J. Lefkowitz, and W. P. Hausdorff. β-Adrenergic receptor sequestration: a potential mechanism of receptor resensitization. J. Biol. Chem. 268:337-341 (1993).
20. Sibley, D. A., R. H. Strasser, J. L. Benovic, K. Daniel, and R. J. Lefkowitz. Phosphorylation/dephosphorylation of the β-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. Proc. Natl. Acad. Sci. USA 83:9408-9412 (1986).
21. Sibley, D. A., J. L. Benovic, M. Caron, and R. J. Lefkowitz. Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways. Endocr. Rev. 9:38-56 (1988).
22. 2-adrenergic receptors permit receptor resensitization. Mol. Pharmacol. 47:666-676 (1995).
23. Arriza, J. L., T. M. Dawson, R. B. Simerly, L. J. Martin, M. G. Caron, S. H. Snyder, and R. J. Lefkowitz. The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. J. Neurosci. 12:4045-4055 (1992).
24. Dawson, T. M., J. L. Arriza, D. E. Jaworsky, F. F. Borisy, H. Attramadal, R. J. Lefkowitz, and G. V. Ronnett. beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. Science (Washington D. C.) 259:825-829 (1993).
25. Lefkowitz, R. J., J. Inglese, W. J. Koch, J. Pitcher, H. Attramadal, and M. G. Caron. G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. Cold Spring Harb. Symp. Quant. Biol. 57:127-133 (1992).
26. Zhang, J., S. S. G. Ferguson, L. S. Barak, and M. G. Caron. Dynamin and β-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. J. Biol. Chem. 271:18302-18305 (1996).
27. von Zastrow, M., and B. K. Kobilka. Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization. J. Biol. Chem. 269:18448-18452 (1994).
28. 2-adrenergic receptor coupling and sequestration. J. Biol. Chem. 269:26215-26219 (1996).
29. Waldo, G. L., J. K. Northup, J. P. Perkins, and T. K. Harden. Characterization of an altered membrane form of the β-adrenergic receptor produced during agonist-induced desensitization. J. Biol. Chem. 258:13900-13908 (1983).
30. von Zastrow, M., and B. K. Kobilka. Ligand-regulated internalization and recycling of human β2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors. J. Biol. Chem. 267:3530-3538 (1992).
31. 2-adrenergic receptor. Nature (Lond.) 383:447-450 (1996).
32. 2-adrenergic receptor extending the ternary complex model. J. Biol. Chem. 268:4625-4636 (1993).
33. Krueger, K. M., Y. Daaka, J. A. Pitcher, and R. J. Lefkowitz. The role of sequestration in G protein-coupled receptor resensitization-regulation of β(2)-adrenergic receptor dephosphorylation by vesicular acidification. J. Biol. Chem. 272:5-8 (1997).
34. 1-adrenergic receptors in the failing human heart. Circulation 87:454-463 (1993).
35. Lohse, M. J. G-protein-coupled receptor kinases and the heart. Trends Cardiovasc. Med. 5:63-68 (1995).