Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors

Molecular Pharmacology

Volumn 52, Issue 1, 1997, Pages 172-179

  Jakubík, Jan ^a   Bačáková, Lucie ^a   El Fakahany, Esam E ^b   Tuček, Stanislav ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALCURONIUM; ARECAIDINE PROPARGYL ESTER; ARECOLINE; BETHANECHOL; BRUCINE; CARBACHOL; FURTRETHONIUM; LIGAND; METHYLFURTRETHONIUM; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR; OXOTREMORINE; OXOTREMORINE M; PILOCARPINE; RECEPTOR SUBTYPE; STRYCHNINE; VINBURNINE; VINCAMINE; [4 [(3 CHLOROPHENYL)CARBAMOYLOXY] 2 BUTYNYL]TRIMETHYLAMMONIUM;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING KINETICS; CHO CELL; CHOLINERGIC SYNAPSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY;

EID: 1842333847     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.1.172     Document Type: Article

References (29)

1. Henis, Y. I., Y. Kloog, and M. Sokolovsky. Allosteric interactions of muscarinic receptors and their regulation by other membrane proteins, in The Muscarinic Receptors (J. H. Brown, ed.). Humana Press, Clifton, NJ, 377-418 (1989).
2. Lee, N. H., and E. E. El-Fakahany. Allosteric antagonists of the muscarinic acetylcholine receptor. Biochem. Pharmacol. 42:199-205 (1991).
3. Tuček, S., and J. Proška. Allosteric modulation of muscarinic acetylcholine receptors. Trends Pharmacol. Sci. 16:205-212 (1995).
4. Nedoma, J., S. Tuček, S. Shelkovnikov, and A. Danilov. Allosteric effects of gallamine and alcuronium on muscarinic receptors, in Synaptic Transmitters and Receptors (S. Tuček, ed.). Academia, Prague/Wiley, Chichester, 108-112 (1987).
5. Tuček, S., J. Musílková, J. Nedoma, J. Proška, S. Shelkovnikov, and J. Vorlíček. Positive cooperativity in the binding of alcuronium and N-methylscopolamine to muscarinic acetylcholine receptors. Mol. Pharmacol. 38:674-680 (1990).
6. 5 muscarinic acetylcholine receptors. J. Pharmacol. Exp. Ther. 274:1077-1083 (1995).
7. Dong, G. Z., K. Kameyama, A. Rinken, and T. Haga. Ligand binding properties of muscarinic acetylcholine receptor subtypes (m1-m5) expressed in baculovirus-infected insect cells. J. Pharmacol. Exp. Ther. 274: 378-384 (1995).
8. Dong, G. Z., T. Haga, H. Itokawa, and F. Mizobe. Allosteric binding of 9-methoxy-alpha-lapachone and alcuronium to the muscarinic acetylcholine receptor m2 subtype. Biomed. Res. 16:327-335 (1995).
9. Hejnová, L., S. Tuček, and E. E. El-Fakahany. Positive and negative allosteric interactions on muscarinic receptors. Eur. J. Pharmacol. 291: 427-430 (1995).
10. Tuček, S., J. Proška, L. Hejnová, and E. E. El-Fakahany. Allosteric interactions between alcuronium and ligands binding to the classical binding site on cardiac muscarinic receptors. Life Sci. 56:1009 (1995).
11. Lazareno, S., and N. J. M. Birdsall. Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors. Mol. Pharmacol. 48:362-378 (1995).
12. Proška, J., and S. Tuček. Competition between positive and negative allosteric effectors on muscarinic receptors. Mol. Pharmacol. 48:696-702 (1995).
13. Proška, J., and S. Tuček. Positive allosteric action of eburnamonine on cardiac muscarinic acetylcholine receptors. Eur. J. Pharmacol. 305:201-205 (1996).
14. 1 selective muscarinic agonists: synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines. J. Med. Chem. 35: 2274-2283 (1992).
15. 1 receptors. J. Pharmacol. Exp. Ther. 269:271-281 (1994).
16. 1 muscarinic agonist xanomeline (LY246708/NNC11-0232). J. Pharmacol. Exp. Ther. 269:282-289 (1994).
17. Buckley, N. J., T. I. Bonner, C. M. Buckley, and M. R. Brann. Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol. Pharmacol. 35:469-476 (1989).
18. Proška, J., and S. Tuček. Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic acetylcholine receptors. Mol. Pharmacol. 45:709-717 (1994).
19. Jakubík, J., and S. Tuček. Two populations of muscarinic binding sites in the chick heart distinguished by affinities for ligands and selective inactivation. Br. J. Pharmacol. 113:1529-1537 (1994).
20. Jakubík, J., and S. Tuček. Protection by alcuronium of muscarinic receptors against chemical inactivation and location of the allosteric binding site for alcuronium. J. Neurochem. 63:1932-1940 (1994).
21. Ehlert, F. J. Estimation of the affinities of allosteric ligands using radio-ligand binding and pharmacological null methods. Mol. Pharmacol. 83: 187-194 (1988).
22. Clark, A. L., and F. Mitchelson. The inhibitory effect of gallamine on muscarinic receptors. Br. J. Pharmacol. 58:323-331 (1976).
23. Stockton, J. M., N. J. M. Birdsall, A. S. V. Burgen, and E. C. Hulme. Modification of the binding properties of muscarinic receptors by gallamine. Mol. Pharmacol. 23:551-557 (1983).
24. Nedoma, J., N. A. Dorofeeva, S. Tuček, S. A. Shelkovnikov, and A. F. Danilov. Interaction of the neuromuscular blocking drugs alcuronium, decamethonium, gallamine, pancuronium, ritebronium, tercuronium and d-tubocurarine with muscarinic acetylcholine receptors in the heart and ileum. Naunyn-Schmiedeberg's Arch. Pharmacol. 329:176-181 (1985).
25. 2 muscarine receptors. Mol. Pharmacol. 46:105-114 (1994).
26. Ehlert, F. J. 'Inverse agonists,' cooperativity and drug action at benzodiazepine receptors. Trends Pharmacol. Sci. 7:28-32 (1986).
27. Birdsall, N. J. M., F. Cohen, S. Lazareno, and H. Matsui. Allosteric regulation of G-protein-linked receptors. Biochem. Soc. Trans. 23:108-111 (1995).
28. Kharkevich, D. A., and V. A. Shorr. Antimuscarinic and ganglion-blocking activity of neuromuscular blocking agents, in New Neuromuscular Blocking Agents (Handbook of Experimental Pharmacology (D. A. Kharkevich, ed). Vol. 79. Springer-Verlag, Berlin, 191-224 (1986).
29. Jakubík, J., L. Bačáková, V. Lisá, E. E. El-Fakahany, and S. Tuček. Activation of muscarinic acetylcholine receptors via their allosteric binding sites. Proc. Natl. Acad. Sci. USA 93:8705-8709 (1996).