Orexins in the brain-gut axis

Endocrine Reviews

Volumn 23, Issue 1, 2002, Pages 1-15

  Kirchgessner, Annette L ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NEUROPEPTIDE; NEUROPEPTIDE RECEPTOR; OREXIN; OREXIN RECEPTOR; UNCLASSIFIED DRUG;

AROUSAL; BRAIN; ENDOCRINE CELL; ENERGY BALANCE; FEEDING BEHAVIOR; FOOD INTAKE; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL SECRETION; GUINEA PIG; HYPOTHALAMUS; INTESTINE INNERVATION; NONHUMAN; PANCREAS; PRIORITY JOURNAL; REVIEW; SPINAL CORD NERVE CELL; VAGUS NERVE DORSAL NUCLEUS;

EID: 0036185058     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/edrv.23.1.0454     Document Type: Review

References (158)

1. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
2. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
3. Neurons containing hypocretin (orexin) project to multiple neuronal systems
4. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
5. Input-output organization in the hypothalamus relating to food intake behavior
6. The lateral hypothalamic area revisited: Neuroanatomy, body weight regulation, neuroendocrinology and metabolism
7. The lateral hypothalamic area revisited: Ingestive behavior
8. The effect of the orexins on food intake: Comparison with neuropeptide Y, melanin-concentrating hormone and galanin
9. Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats
10. Feeding response to central orexins
11. Food intake elicited by central administration of orexins/hypocretins: Identification of hypothalamic sites of action
12. Inhibition of food intake by central injection of anti-orexin antibody in fasted rats
13. Widespread distribution of orexin in rat brain and its regulation upon fasting
14. The hypocretins: Excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding
15. To eat or to sleep? Orexin in the regulation of feeding and wakefulness
16. Hypocretin (orexin) deficiency in human narcolepsy
17. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
18. Reduced number of hypocretin neurons in human narcolepsy
19. Genetic ablation of orexins neurons in mice results in narcolepsy, hypophagia, and obesity
20. Nutrient tasting and signaling mechanisms in the gut. II. The intestine as a sensory organ: Neural, endocrine, and immune responses
21. Afferent signals regulating food intake
22. Cholecystokinin and satiety: Current perspectives
23. The role of gastrointestinal vagal afferents in the control of food intake: Current prospects
24. Functional anatomy of the enteric nervous system
25. Orexin synthesis and response in the gut
26. Glutamatergic enteric neurons
27. Systems and molecular genetic approaches converge to tackle learning and memory
28. Neuropeptide Y, and human pancreatic polypeptide stimulate feeding behavior in rats
29. Peptidergic regulation of gastrointestinal motility in rodents
30. Ghrelin is a growth-hormone releasing acylated peptide from the stomach
31. Galanin-like immunoreactivity in enteric neurons of the human colon
32. Galanin: Stimulation of feeding by medial hypothalamic injection of this novel peptide
33. Hypothalamic CART is a new anorectic peptide regulated by leptin
34. CART peptide analysis by Western blotting
35. Identification and characterization of glucoresponsive neurons in the enteric nervous system
36. The hypocretin/orexin ligand-receptor system: Implications for sleep and sleep disorders
37. The hypocretin/orexin story
38. Narcolepsy: A neurogenerative disease of the hypocretin system?
39. Localization of disinhibition-dementia-parkinsonism-amyotropy complex to 17q21-q22
40. Orexin-A, an hypothalamic peptide with analgesic properties
41. Pre- and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin
42. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
43. Distribution of orexin neurons in the adult rat brain
44. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems
45. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations
46. Immunohistochemical localization and biochemical characterization of hypocretin/orexin-related peptides in the central nervous system of the frog Rana ridibunda
47. Distribution of hypocretin-(orexin) immunoreactivity in the central nervous system of Syrian hamsters (Mesocricetus auratus)
48. Hypothalamic hypocretin (orexin): Robust innervation of the spinal cord
49. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food
50. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
51. Orexin-induced food intake involves neuropeptide Y pathway
52. Evidence that NPY Y1 receptors are involved in the stimulation of feeding by orexins (hypocretins) in sated rats
53. Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats
54. Glucose responding neurons in the nucleus tractus solitarius of the rat: In vitro study
55. Characteristics of glycemia-sensitive neurons in the nucleus tractus solitarii: Possible involvement in nutritional regulation
56. Vagal circuitry mediating cephalic-phase responses to food
57. A new twist in the brain-gut axis
58. Effects of hypothalamic stimulation on activity of dorsomedial medullar neurons that respond to subdiaphragmatic vagal stimulation
59. Lateral and ventromedial hypothalamic influences on hepatic autonomic nerve activity in the rat
60. Ascending projections from the solitary tract nucleus to the hypothalamus: A phaseolus vulgaris lectin tracing study in the rat
61. Distribution of orexin receptor mRNA in the rat brain
62. Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting
63. Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord
64. Differential expression of orexin receptors 1 and 2 in the rat brain
65. Evidence for histaminergic arousal mechanisms in the hypothalamus of cat
66. Hypothalamic and genetic obesity: An appraisal of the autonomic hypothesis and the endocrine hypothesis
67. Effects of PVN galanin on macronutrient selection
68. Stimulation of the paraventricular nucleus modulates the activity of gut-sensitive neurons in the vagal complex
69. Hypothalamic paraventricular nucleus stimulation induced gastric acid secretion and bradycardia suppressed by oxytocin antagonist
70. Oxytocin, oxytocin antagonist, TRG, and hypothalamic paraventricular nucleus effects on gastric motility
71. Orexin-A in the dorsal motor nucleus of the vagus potently increases gastric motor function via orexin 1 receptor in rats
72. Hypothalamic control of food intake in rats and cats
73. Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in rats
74. Stimulation of feeding behavior and food consumption in the goldfish, Carassius auratus, by orexin-A and orexin-B
75. A selective orexin-1 receptor antagonist reduces food consumption in male and female rats
76. SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats
77. Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat
78. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor gene
79. Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight
80. Neuropeptide Y chronically injected into the hypothalamus: Powerful neurochemical inducer of hyperphagia and obesity
81. Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity
82. Melanin-concentrating hormone acutely stimulates feeding but chronic administration has no effect on body weight
83. Mice lacking melanin-concentrating hormone are hypophagic and lean
84. Independent feeding and metabolic actions of orexins in mice
85. Circadian and other rhythmic activity of neurons in the ventromedial nuclei and lateral hypothalamic area
86. Orexin A activates locus coeruleus cell firing and increases arousal in the rat
87. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons
88. Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
89. Hypothalamic orexin expression. Modulation by blood glucose and feeding
90. Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels. Responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract
91. Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area
92. Down-regulation of orexin gene expression by sever obesity in the rats: Studies in Zucker fatty and Zucker diabetic rats and effects of rosiglitazone
93. Glucose inhibition of the glucose-sensitive neurons in the rat lateral hypothalamus
94. Regulation of energy intake and body weight: The glucostatic theory and lipostatic hypothesis
95. Responses of lateral hypothalamic neurons recorded in vitro to moderate changes in glucose concentration
96. Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia
97. Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons
98. Positional cloning of the mouse obese gene and its human homologue
99. Weight reducing effects of the plasma protein encoded by the obese gene
100. Characterization of CART neurons in the rat and human hypothalamus
101. Leptin receptor-and STAT3-immunoreactivities in hypocretin/orexin neurons of the lateral hypothalamus
102. Hypothalamic hypocretin/orexin and neuropeptide Y: Divergent interaction with energy depletion and leptin
103. Leptin regulation of prepro-orexin and orexin receptor mRNA levels in the hypothalamus
104. Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats
105. Beitrage zur physiologie der absonderungen die innervation der magenrüsen beim hunde
106. Role of thought, sight, smell, and taste of food in the cephalic phase of gastric acid secretion in humans
107. Vagal regulation of gastric function involves thyrotropin-releasing hormone in the medullary raphe nuclei and dorsal vagal complex
108. Intracerebroventricular neuropeptide Y increases gastric and pancreatic secretion in the dog
109. Ghrelin stimulates gasric acid secretion and motility in rats
110. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin
111. Fundamentals of neurogastroenterology
112. Outer submucous plexus: An intrinsic nerve network involved in both secretory and motility processes in the intestine of large mammals and humans
113. Innervation of the pancreas by neurons in the gut
114. In situ identification and visualization of neurons that mediate enteric and enteropancreatic reflexes
115. Innervation of the gallbladder: Structure, neurochemical coding, and physiological properties of guinea pig gallbladder ganglia
116. Neuropathy in the brain-in-the-gut
117. Secretomotor function of the dorsal motor nucleus of the vagus
118. Extrinsic nervous control of motility of small and large intestines and related sphincters
119. Extrinsic control of digestive motility
120. Identification of vagal efferent fibers and putative target neurons in the enteric nervous system of the rat
121. Vagal input to the enteric nervous system
122. Orexin receptors are expressed in the adrenal medulla of the rat
123. "Enteric tears": Chloride secretion and its neural regulation
124. Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: Activity-induced expression of Fos immunoreactivity
125. Intrinsic primary afferent neurons of the intestine
126. Glucose sensing in pancreatic β-cells. A model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus
127. Orexin-A and leptin change inversely in fasting non-obese subjects
128. Sensory afferent from the gastrointestinal tract
129. Orexin-containing vagal afferents in the rat enteric nervous system
130. Galanin and orexin A potentiate intracellular calcium responses to cholecystokinin and carbachol in human and rat duodenal enterocytes
131. The pivotal role of John S. Edkins in the discovery of gastrin
132. Gastrointestinal hormones
133. Localization of effects of orexin on fasting motility in the rat duodenum
134. Direct and indirect actions of 5-HT on the discharge of mesenteric afferent fibres innervating the rat jejunum
135. The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis: The local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity
136. Excitatory and inhibitory neuronally-mediated actions of orexin-A and melanin-concentrating hormone (MCH) in human isolated colon
137. Vasoactive intestinal peptide suppresses migrating myoelectric complex of rat small intestine independent of nitric oxide
138. Acute orexin effects on insulin secretion in the rat: In vivo and in vitro studies
139. Nutritional implications of cephalic phase gastrointestinal responses
140. Neurohormonal regulation of the pancreas
141. Sympathetic and cardiovascular actions of orexins in conscious rats
142. Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats
143. Orexins a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner
144. Central administration of orexin A suppresses basal and domperidone stimulated plasma prolactin
145. Effects of orexins on the hypothalamo-pituitary-adrenal system
146. Orexins/hypocretins regulate drinking behaviour
147. Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system
148. Orexins: A role in medullary sympathetic outflow
149. Relationship between sleep patterns and human colonic motor patterns
150. Relationship between enteric migrating motor complex and the sleep cycle
151. Circadian variation in gastric emptying of meals in humans
152. Modulation of the duration of human postprandial motor activity by sleep
153. Circadian coupling between pancreatic secretion and intestinal motility in humans
154. Intravenous infusions of nutrients and sleep in the rat: An ischymetric sleep regulation hypothesis
155. Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat
156. Effect of hyperglycemia on gastric acid secretion during the gastric phase of digestion