The role of leukotriene receptor signaling in inflammation and cancer

TheScientificWorldJournal

Volumn 7, Issue , 2007, Pages 1413-1421

  Massoumi, Ramin ^a   Sjölander, Anita ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

CysLT1 receptor; Leukotrienes; Proliferation; Survival

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CYCLOOXYGENASE 2; LEUKOTRIENE RECEPTOR; PROSTAGLANDIN; PROSTAGLANDIN E2;

CANCER; CARCINOGENICITY; CELL ADHESION; CELL PROLIFERATION; CELL SURVIVAL; COMPARATIVE STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; INFLAMMATION; INTESTINE CELL; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; SIGNAL TRANSDUCTION; TISSUE MICROARRAY;

CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; INFLAMMATION; NEOPLASMS; PROSTAGLANDINS; RECEPTORS, LEUKOTRIENE; SIGNAL TRANSDUCTION;

EID: 34548809284     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2007.200     Document Type: Review

References (63)

1. Ikai, K. (1999) Psoriasis and the arachidonic acid cascade. J. Dermatol. Sci. 21, 135-146.
2. Sperling, R.I. (1995) Eicosanoids in rheumatoid arthritis. Rheum. Dis. Clin. North Am. 21, 741-758.
3. 4 by colonic mucosa in inflammatory bowel disease. Gastroenterology 86, 453-460.
4. Hendel, J. and Nielsen, O.H. (1997) Expression of cyclooxygenase-2 mRNA in active inflammatory bowel disease. Am. J. Gastroenterol. 92, 1170-1173.
5. Sharon, P., Ligumsky, M., Rachmilewitz, D., and Zor, U. (1978) Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine. Gastroenterology 75, 638-640.
6. Ekbom, A., Helmick, C., Zack, M., and Adami, H.O. (1990) Ulcerative colitis and colorectal cancer. A population-based study. N. Engl. J. Med. 323, 1228-1233.
7. Eberhart, C.E., Coffey, R.J., Radhika, A., Giardiello, F.M., Ferrenbach, S., and DuBois, R.N. (1994) Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107, 1183-1188.
8. Kargman, S.L., O'Neill, G.P., Vickers, P.J., Evans, J.F., Mancini, J.A., and Jothy, S. (1995) Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res. 55, 2556-2559.
9. Rigas, B., Goldman, I.S., and Levine, L. (1993) Altered eicosanoid levels in human colon cancer. J. Lab. Clin. Med. 122, 518-523.
10. Dempke, W., Rie, C., Grothey, A., and Schmoll, H.J. (2001) Cyclooxygenase-2: a novel target for cancer chemotherapy? J. Cancer Res. Clin. Oncol. 127, 411-417.
11. Tsuji, S., Kawano, S., Sawaoka, H., Takei, Y., Kobayashi, I., Nagano, K., Fusamoto, H., and Kamada, T. (1996) Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines. Prostaglandins Leukot. Essent. Fatty Acids 55, 179-183.
12. Tsuji, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M., and DuBois, R.N. (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93, 705-716.
13. Cuzzocrea, S., Rossi, A., Serraino, I., Mazzon, E., Di Paola, R., Dugo, L., Genovese, T., Calabro, B., Caputi, A.P., and Sautebin, L. (2003) 5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan. J. Leukoc. Biol. 73, 739-746.
14. Cuzzocrea, S., Rossi, A., Mazzon, E., Di Paola, R., Genovese, T., Muia, C., Caputi, A.P., and Sautebin, L. (2005) 5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration. Lab. Invest. 85, 808-822.
15. Hendel, J., Ahnfelt-Ronne, I., and Nielsen, O.H. (2002) Expression of 5-lipoxygenase mRNA is unchanged in the colon of patients with active inflammatory bowel disease. Inflamm. Res. 51, 423-426.
16. Steele, V.E., Holmes, C.A., Hawk, E.T., Kopelovich, L., Lubet, R.A., Crowell, J.A., Sigman, C.C., and Kelloff, G.J. (1999) Lipoxygenase inhibitors as potential cancer chemopreventives. Cancer Epidemiol. Biomarkers Prev. 8, 467-483
17. Avis, I., Hong, S.H., Martinez, A., Moody, T., Choi, Y.H., Trepel, J., Das, R., Jett, M., and Mulshine, J.L. (2001) Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions. FASEB J. 15, 2007-2009.
18. Romano, M., Catalano, A., Nutini, M., D'Urbano, E., Crescenzi, C., Claria, J., Libner, R., Davi, G., and Procopio, A. (2001) 5-Lipoxygenase regulates malignant mesothelial cell survival: involvement of vascular endothelial growth factor. FASEB J. 15, 2326-2336.
19. 4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas. Gastroenterology 124, 57-70.
20. Öhd, J.F., Wikström, K., and Sjölander, A. (2000) Leukotrienes induce cell-survival signaling in intestinal epithelial cells. Gastroenterology 119, 1007-1018.
21. Peters-Golden, M. (1998) Cell biology of the 5-lipoxygenase pathway. Am. J. Respir. Crit. Care Med. 157, S227-232.
22. 4 that mediates chemotaxis. Nature 387, 620-624.
23. Huang, W.W., Garcia-Zepeda, E.A., Sauty, A., Oettgen, H.C., Rothenberg, M.E., and Luster, A.D. (1998) Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils. J. Exp. Med. 188, 1063-1074.
24. 4 receptor-transfected cells. J. Biol. Chem. 174, 8597-8603
25. 4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nat. Immunol. 4, 965-973
26. 4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness. J. Immunol. 176, 3157-3164.
27. 4. Nat. Immunol. 4, 974-981.
28. 4 receptor 1 in allergen-induced airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 172, 161-167.
29. 1 receptor. Nature 399, 789-793.
30. Heise, C.E. et al. (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275, 30531-30536.
31. Nielsen, C.K., Campbell, J.I., Öhd, J.F., Mörgelin, M., Riesbeck, K., Landberg, G., and Sjölander A. (2005) A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. Cancer Res. 65, 732-742.
32. 1R. Proc. Natl. Acad. Sci. U. S. A. 100, 11589-11593.
33. Austen, K.F. (2005) The mast cell and the cysteinyl leukotrienes. Novartis Found. Symp. 271, 166-175.
34. 4-induced activation and translocation of the G-protein alpha i3-subunit in human epithelial cells. Biochem. Biophys. Res. Commun. 226, 413-419.
35. 4 receptor solubilized in an active form. Association and dissociation with an islet-activating protein-sensitive guanine nucleotide-binding protein. J. Biol. Chem. 265, 21237-21241.
36. Offermanns, S. (2003) G-proteins as transducers in transmembrane signalling. Prog. Biophys. Mol. Biol. 83, 101-130.
37. 2+. J. Biol. Chem. 265, 20976-20981.
38. 4 triggers an association between β/γ subunits and phosphlipase C-γ1 in intestinal epithelial cells. J. Biol. Chem. 275, 9849-9853.
39. 4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. Cell Calcium 24, 9-16.
40. 1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. J. Cell Sci. 118, 5625-5636.
41. 4 in differentiated U937 cells. Prostaglandins Other Lipid Mediat. 71, 235-251.
42. 1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras. Biochem. Pharmacol. 67, 1569-1577.
43. 4 activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells. J. Cell Sci. 115, 1883-1893.
44. Li, M., Wu, X., and Xu, X.C. (2001) Induction of apoptosis by cyclo-oxygenase-2 inhibitor NS398 through a cytochrome C-dependent pathway in esophageal cancer cells. Int. J. Cancer 93, 218-223.
45. Sun, Y., Tang, X.M., Half, E., Kuo, M.T., and Sinicrope, F.A. (2002) Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res. 62, 6323-6328.
46. 4 involves the prevention of caspase 8 activation and Bid cleavage. Biochem. J. 371, 115-124.
47. Wikström, K., Öhd, J.F., and Sjölander, A. (2003) Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2. Biochem. Biophys. Res. Commun. 302, 330-335.
48. 4 induces β-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells. J. Biol. Chem. 281, 6776-6784.
49. Shin, S.Y., Kim, C.G., Jho, E.H., Rho, M.S., Kim, Y.S., Kim, Y.H., and Lee, Y.H. (2004) Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin. Cancer Lett. 212, 225-231.
50. Dormond, O., Foletti, A., Paroz, C., and Ruegg, C. (2001) NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis. Nat. Med. 7, 1041-1047.
51. 2 and upregulation of alpha2beta1-integrin. Exp. Cell Res. 289, 342-351.
52. Sanders, D.S. (2005) Mucosal integrity and barrier function in the pathogenesis of early lesions in Crohn's disease. J. Clin. Pathol. 58, 568-572.
53. Freeman, H.J. (2005) Collagenous mucosal inflammatory diseases of the gastrointestinal tract. Gastroenterology 129, 338-350.
54. 4 affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events. J. Cell Sci. 114, 1925-1934.
55. 4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. J. Biol. Chem. 280, 13538-13544.
56. 4 mediates survival and proliferation via separate but parallel pathways in the human intestinal epithelial cell line Int 407. J. Biol. Chem. 278, 45577-45585.
57. Chen, R.H., Chung, J., and Blenis, J. (1991) Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction. Mol. Cell Biol. 11, 1861-1867.
58. 1 receptor signalling in intestinal epithelial cells. Oncogene 25, 6660-6665.
59. Hu, H., Chen, G., Zhang, J.M., Zhang, W.P., Zhang, L., Ge, Q.F., Yao, H.T., Ding, W., Chen, Z., and Wei, E.Q. (2005) Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors. Acta Pharmacol. Sin. 26, 685-690.
60. Fang, S.H., Zhou, Y., Chu, L.S., Zhang, W.P., Wang, M.L., Yu, G.L., Peng, F., and Wei, E.Q. (2007) Spatio-temporal expression of cysteinyl leukotriene receptor-2 mRNA in rat brain after focal cerebral ischemia. Neurosci. Lett. 412, 78-83.
61. 4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer. J. Pharmacol. Sci. 103, 24-32.
62. Ding, X.Z., Talamonti, M.S., Bell, R.H. Jr., and Adrian, T.E. (2005) A novel anti-pancreatic cancer agent, LY293111. Anticancer Drugs 16, 467-473.
63. 4 plays a pivotal role in CD40-dependent activation of chronic B lymphocytic leukemia cells. Blood 105, 1274-1279.