Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis

Journal of Hepatology

Volumn 59, Issue 4, 2013, Pages 830-841

  Frau, Maddalena ^a   Feo, Francesco ^a   Pascale, Rosa M ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

Epigenetic regulation; Hepatocarcinogenesis; Methionine adenosyltransferase; Prognosis; Progression; S adenosylmethionine; Signal transduction

Indexed keywords

CYCLIN D1; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHIONINE ADENOSYLTRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BCL 2; REACTIVE NITROGEN SPECIES; S ADENOSYLMETHIONINE; TRANSCRIPTION FACTOR E2F1; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURGERY; CANCER SURVIVAL; CELL INFILTRATION; CELL PROLIFERATION; CELL SURVIVAL; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA METHYLATION; DNA REPAIR; DNA STRAND BREAKAGE; DNA SYNTHESIS; DOWN REGULATION; ENZYME ACTIVATION; ENZYME METABOLISM; ENZYME REGULATION; FATTY ACID OXIDATION; GENE OVEREXPRESSION; GENOMIC INSTABILITY; HISTONE MODIFICATION; HUMAN; IMMUNOFLUORESCENCE; LIPID PEROXIDATION; LIPOPROTEIN SECRETION; LIVER CANCER; LIVER CARCINOGENESIS; LIVER RESECTION; LONG TERM CARE; METHYLATION; MICROVASCULARIZATION; MONONUCLEAR CELL; NONALCOHOLIC FATTY LIVER; NONHUMAN; ONCOGENE C MYC; OXIDATIVE STRESS; PHENOTYPE; PLEIOTROPY; POINT MUTATION; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN METHYLATION; REVIEW; SOMATIC MUTATION; STEATOSIS; TRANSCRIPTION REGULATION; UPREGULATION;

5'-METHYLTHIOADENOSINE PHOSPHORYLASE; 5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; 5′-METHYLTHIOADENOSINE; 5′-MTA; ACTIVATOR PROTEIN-1; AKT; ALCOHOLIC STEATOHEPATITIS; AMP ACTIVATED PROTEIN KINASE; AMPK; ANTISENSE OLIGONUCLEOTIDE; AP; AP-1; APEX1; APURINIC/APYRIMIDINIC; ASH; ASO; AUF1; AURICH RNA BINDING FACTOR 1; B-CELL CELL/LYMPHOMA 2; BAK; BAX; BCL2; BCL2 ANTAGONIST KILLER; BCL2-ASSOCIATED X PROTEIN; BETAINE-HOMOCYSTEINE METHYLTRANSFERASE; BHMT; C-MYBL2; CBS; CDC2; CDC28 PROTEIN KINASE B1; CELL DIVISION CYCLE 2; CSK1; CYSTATHIONINE Β-SYNTHASE; DN; DUAL-SPECIFICITY PHOSPHATASE 1; DUSP1; DYSPLASTIC NODULE; EARLY GROWTH RESPONSE PROTEIN-1; EGR-1; ENDONUCLEASE REDOX EFFECTOR APE1/REF-1/APEX1; EPIGENETIC REGULATION; ERK; EXTRACELLULAR SIGNAL-REGULATED KINASE; FAS; FORKHEAD BOX M1B; FOXM1; GENOMIC INSTABILITY; GI; GLYCINE N-METHYLTRANSFERASE; GNMT; GSH; HAMARTIN; HCC; HCC WITH BETTER PROGNOSIS; HCC WITH POORER PROGNOSIS; HCCB; HCCP; HEPATOCARCINOGENESIS; HEPATOCELLULAR CARCINOMA; HEPATOCYTE GROWTH FACTOR; HGF; HIF-1Α; HU ANTIGEN R; HUR; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IKK; INHIBITOR OF APOPTOSIS, X-LINKED; INHIBITOR OF KAPPA LIGHT CHAIN GENE ENHANCER IN B CELLS, KINASE OF; JAK; JANUS KINASE; JUN; LDL; LKB1; LOW DENSITY LIPOPROTEINS; MAFK; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX; MAPK; MAT; MDD; MDM2; METHIONINE ADENOSYLTRANSFERASE; METHYL DEFICIENT DIET; MITOGEN-ACTIVATED PROTEIN KINASE; MOUSE DOUBLE MINUTE 2 HOMOLOG; MRNA-BINDING PROTEINS; MTAP; MTHF-HMT; MTORC2; NASH; NF-KB; NITRIC OXIDE SYNTHASE; NON-ALCOHOLIC STEATOHEPATITIS; NOS; NUCLEAR FACTOR KB; ODC; ORNITHINE DECARBOXYLASE; P90RSK; PARTIAL HEPATECTOMY; PCNA; PFK-2; PH; PHB1; PHOSPHATADYLINOSITOL 3-KINASE; PHOSPHOFRUCTOKINASE 2; PI3K; PIAS1; PP2A; PRMT5; PROGNOSIS; PROGRESSION; PROHIBITIN 1; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN ARGININE METHYLTRANSFERASE 5; PROTEIN INHIBITOR OF ACTIVATED STAT1; PROTEIN PHOSPHATASE 2A; RAS GUANYL RELEASING PROTEIN 3; RASGRP3; RBP; REACTIVE OXYGEN SPECIES; REDUCED GLUTATHIONE; RIBOSOMAL PROTEIN S6 KINASE POLYPEPTIDE 2; ROS; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; S-PHASE KINASE-ASSOCIATED PROTEIN 2; SAH; SAH HYDROXYLASE; SAHH; SAM; SAM DACARBOXYLASE; SDC; SECRETED PHOSPHOPROTEIN 1; SERINE/THREONINE PROTEIN KINASE 11; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; SIGNAL TRANSDUCTION; SKP2; SL; SMR; SMS; SP1; SPECIFICITY PROTEIN 1; SPERMIDINE SYNTHASE; SPERMINE SYNTHASE; SPP1; STAT1; SURROUNDING LIVER; TNFΑ; TSC1; TSC2; TUBERIN; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 6; TUMOR NECROSIS FACTOR Α; UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7; USP7; V-AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOG; V-JUN AVIAN SARCOMA VIRUS 17 ONCOGENE HOMOLOG; V-MAF AVIAN MUSCULOAPONEUROTIC FIBROSARCOMA ONCOGENE FAMILY, PROTEIN K; V-MYB AVIAN MYELOBLASTOSIS VIRAL ONCOGENE HOMOLOG-LIKE 2; VERY LOW DENSITY LIPOPROTEINS; VLDL; XIAP;

ANIMALS; CARCINOMA, HEPATOCELLULAR; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; METHIONINE ADENOSYLTRANSFERASE; MICE; PROGNOSIS; RATS; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; SIGNAL TRANSDUCTION;

EID: 84884417889     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.04.031     Document Type: Review

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