Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 280, Issue 2 43-2, 2001, Pages

  Yang, Heping ^a   Huang, Zong Zhi ^a   Zeng, Zhaohui ^a   Chen, Changjin ^a   Selby, Robert R ^b   Lu, Shelly C ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Methionine adenosyltransferase 1A; S adenosylmethionine; Transcriptional regulation; Transient transfection

Indexed keywords

HISTONE; HISTONE DEACETYLASE INHIBITOR; LUCIFERASE; METHIONINE ADENOSYLTRANSFERASE; METHIONINE ADENOSYLTRANSFERASE 2A; S ADENOSYLMETHIONINE; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; GENE CONSTRUCT; GENE EXPRESSION; HEP 2 CELL; HUMAN; HUMAN CELL; LIVER CANCER; LIVER CELL CARCINOMA; MAT1A GENE; MAT2A GENE; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

EID: 0035023213     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.280.2.g184     Document Type: Article

References (31)

1. Alvarez L, Corrales F, Martin-Duce A, and Mato JM. Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies. Biochem J 293: 481-486, 1993.
2. Boyes J and Bird A. Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein. EMBO J 11: 327-333, 1992.
3. Cabrero C, Puerta J, and Alemany S. Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver. Eur J Biochem 170: 299-304, 1987.
4. Cai J, Huang ZZ, and Lu SC. Differential regulation of γ-glutamylcysteine synthetase heavy and light subunit gene expression. Biochem J 326: 167-172, 1997.
5. Cai J, Mao Z, Hwang JJ, and Lu SC. Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. Cancer Res 58: 1444-1450, 1998.
6. Cai J, Sun WM, Hwang JJ, Stain S, and Lu SC. Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance. Hepatology 24: 1090-1097, 1996.
7. Chomczynski P and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
8. De La Rosa J, Ostrowski J, Hryniewicz MM, Kredich NM, Kotb M, LeGros HL Jr, Valentine M, and Geller AM Chromosomal localization and catalytic properties of the recombinant α subunit of human lymphocyte methionine adenosyltransferase. J Biol Chem 270: 21860-21868, 1995.
9. Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem 1: 228-237, 1990.
10. Garcea R, Daino L, Pascale R, Simile MM, Puddu M, Ruggiu ME, Seddaiu MA, Satta G, Sequenza MJ, and Feo F. Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine:S-adenosylhomocysteine ratio. Carcinogenesis 10: 1183-1192, 1989.
11. Gil B, Casado M, Pajares M, Boscá L, Mato JM, Martín-Sanz P, and Alvarez L. Differential expression pattern of methionine adenosyltransferase isoenzymes during rat liver development. Hepatology 24: 876-881, 1996.
12. Horikawa S, Ozasa H, Ota K, and Tsukada K. Immunohistochemical analysis of rat methionine adenosyltransferase isozymes in developmental liver. FEBS Lett 330: 307-311, 1993.
13. Horikawa S and Tsukada K. Molecular cloning and developmental expression of a human kidney methionine adenosyltransferase. FEBS Lett 312: 37-41, 1992.
14. Huang ZZ, Mao Z, Cai J, and Lu SC. Changes in methionine adenosyltransferase during liver regeneration in the rat. Am J Physiol Gastrointest Liver Physiol 275: G14-G21, 1998.
15. Huang ZZ, Mato JM, Kanel G, and Lu SC. Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression. Hepatology 29: 1471-1478, 1999.
16. Jones PL, Veenstra GJC, Wade PA, Vermaak D, Kass SU, Landsberger N, Strouboulis J, and Wolff AP. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19: 187-191, 1998.
17. Kotb M, Mudd SH, Mato JM, Geller AM, Kredich NM, Chou JY, and Cantoni GL. Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products. Trends Genet 13: 51-52, 1997.
18. Liau MC, Chang CF, Belanger L, and Grenier A. Correlation of isozyme patterns of S-adenosylmethionine synthetase with fetal stages and pathologic states of the liver. Cancer Res 39: 162-169, 1979.
19. Lu SC. Methionine adenosyltransferase and liver disease: it's all about SAM. Gastroenterology 114: 403-407, 1998.
20. Lu SC. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J 13: 1169-1183, 1999.
21. Lu SC, Huang ZZ, Yang HP, Mato JM, Avila MA, and Tsukamoto H. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in the alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol 279: G178-G185, 2000.
22. Mao Z, Liu S, Cai J, Huang ZZ, and Lu SC. Cloning and functional characterization of the 5′-flanking region of human methionine adenosyltransferase 2A gene. Biochem Biophys Res Commun 248: 479-484, 1998.
23. Mato JM, Alvarez L, Ortiz P, and Pajares MA. S-adenosylmethionine synthesis: molecular mechanisms and clinical implications. Pharmacol Ther 73: 265-280, 1997.
24. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, and Bird A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393: 386-389, 1998.
25. Okada G, Teraoka H, and Tsukada K. Multiple species of mammalian S-adenosylmethionine synthetase. Partial purification and characterization. Biochemistry 20: 934-940, 1981.
26. Pajares MA, Duran C, Corrales F, Pliego M, and Mato JM. Modulation of rat liver S-adenosylmethionine synthetase activity by glutathione. J Biol Chem 267: 17598-17605, 1992.
27. Razin A. CpG methylation, chromatin structure and gene silencing - a three-way connection. EMBO J 17: 4905-4908, 1998.
28. Sambrook J, Fritsch EF, and Maniatis T. Molecular Cloning: A Laboratory Manual (2nd ed.). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989.
29. Sullivan DM and Hoffman J. Fractionation and kinetic properties of rat liver and kidney methionine adenosyltransferase isozymes. Biochemistry 22: 1636-1641, 1983.
30. Tobeña R, S, Horikawa Calvo V, and Alemany S. Interleukin-2 induces γ-S-adenosyl-L-methionine synthetase gene expression during T-lymphocyte activation. Biochem J 319: 929-933, 1996.
31. Zeng ZH, Huang ZZ, Chen CJ, Yang HP, Mao Z, and Lu SC. Molecular cloning and functional characterization of the 5′-flanking region of human methionine adenosyltransferase 1A gene. Biochem J 346: 475-482, 2000.