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Volumn 16, Issue 48, 2010, Pages 6035-6043

Oxidative stress and antioxidants in hepatic pathogenesis

Author keywords

Alcohol; Antioxidant; Chronic liver disease; Hepatitis B virus; Hepatitis B virus X protein; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CURCUMIN; DNA; SILYMARIN;

EID: 78650780107     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v16.i48.6035     Document Type: Review
Times cited : (199)

References (129)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132: 2557-2576
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 0019451351 scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan
    • Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 1981; 2: 1129-1133
    • (1981) Lancet , vol.2 , pp. 1129-1133
    • Beasley, R.P.1    Hwang, L.Y.2    Lin, C.C.3    Chien, C.S.4
  • 4
    • 0035888074 scopus 로고    scopus 로고
    • Estimating the world cancer burden: Globocan 2000
    • Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001; 94: 153-156
    • (2001) Int J Cancer , vol.94 , pp. 153-156
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3    Pisani, P.4
  • 5
    • 58849143425 scopus 로고    scopus 로고
    • The epidemiology of hepatocellular cancer: From the perspectives of public health problem to tumor biology
    • Caldwell S, Park SH. The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology. J Gastroenterol 2009; 44 Suppl 19: 96-101
    • (2009) J Gastroenterol , vol.44 , Issue.SUPPL 19 , pp. 96-101
    • Caldwell, S.1    Park, S.H.2
  • 6
    • 0037325438 scopus 로고    scopus 로고
    • Natural history and prognosis of hepatitis B
    • Fattovich G. Natural history and prognosis of hepatitis B. Semin Liver Dis 2003; 23: 47-58
    • (2003) Semin Liver Dis , vol.23 , pp. 47-58
    • Fattovich, G.1
  • 7
    • 0031985778 scopus 로고    scopus 로고
    • Hepatitis B virus X protein interferes with cellular DNA repair
    • Becker SA, Lee TH, Butel JS, Slagle BL. Hepatitis B virus X protein interferes with cellular DNA repair. J Virol 1998; 72: 266-272
    • (1998) J Virol , vol.72 , pp. 266-272
    • Becker, S.A.1    Lee, T.H.2    Butel, J.S.3    Slagle, B.L.4
  • 8
    • 0029897214 scopus 로고    scopus 로고
    • Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system
    • Kazantsev A, Mu D, Nichols AF, Zhao X, Linn S, Sancar A. Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system. Proc Natl Acad Sci USA 1996; 93: 5014-5018
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5014-5018
    • Kazantsev, A.1    Mu, D.2    Nichols, A.F.3    Zhao, X.4    Linn, S.5    Sancar, A.6
  • 10
    • 0001655748 scopus 로고
    • Hepatitis B virus X protein inhibits p53 sequencespecific DNA binding, transcriptional activity, and association with transcription factor ERCC3
    • Wang XW, Forrester K, Yeh H, Feitelson MA, Gu JR, Harris CC. Hepatitis B virus X protein inhibits p53 sequencespecific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci USA 1994; 91: 2230-2234
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2230-2234
    • Wang, X.W.1    Forrester, K.2    Yeh, H.3    Feitelson, M.A.4    Gu, J.R.5    Harris, C.C.6
  • 11
    • 31944438515 scopus 로고    scopus 로고
    • Effects of hepatitis B virus X protein on the development of liver cancer
    • Zhang X, Zhang H, Ye L. Effects of hepatitis B virus X protein on the development of liver cancer. J Lab Clin Med 2006; 147: 58-66
    • (2006) J Lab Clin Med , vol.147 , pp. 58-66
    • Zhang, X.1    Zhang, H.2    Ye, L.3
  • 12
    • 33646337650 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus
    • Chan HL, Sung JJ. Hepatocellular carcinoma and hepatitis B virus. Semin Liver Dis 2006; 26: 153-161
    • (2006) Semin Liver Dis , vol.26 , pp. 153-161
    • Chan, H.L.1    Sung, J.J.2
  • 13
    • 0036292006 scopus 로고    scopus 로고
    • Molecular mechanism of viral hepatocarcinogenesis
    • Koike K, Tsutsumi T, Fujie H, Shintani Y, Kyoji M. Molecular mechanism of viral hepatocarcinogenesis. Oncology 2002; 62 Suppl 1: 29-37
    • (2002) Oncology , vol.62 , Issue.SUPPL 1 , pp. 29-37
    • Koike, K.1    Tsutsumi, T.2    Fujie, H.3    Shintani, Y.4    Kyoji, M.5
  • 15
    • 0346671161 scopus 로고    scopus 로고
    • Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis
    • Zhu H, Wang Y, Chen J, Cheng G, Xue J. Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis. Exp Mol Pathol 2004; 76: 44-50
    • (2004) Exp Mol Pathol , vol.76 , pp. 44-50
    • Zhu, H.1    Wang, Y.2    Chen, J.3    Cheng, G.4    Xue, J.5
  • 16
    • 0037084160 scopus 로고    scopus 로고
    • The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice
    • Hildt E, Munz B, Saher G, Reifenberg K, Hofschneider PH. The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice. EMBO J 2002; 21: 525-535
    • (2002) EMBO J , vol.21 , pp. 525-535
    • Hildt, E.1    Munz, B.2    Saher, G.3    Reifenberg, K.4    Hofschneider, P.H.5
  • 18
    • 0842270038 scopus 로고    scopus 로고
    • Oxidative stress and aging
    • Dröge W. Oxidative stress and aging. Adv Exp Med Biol 2003; 543: 191-200
    • (2003) Adv Exp Med Biol , vol.543 , pp. 191-200
    • Dröge, W.1
  • 20
    • 33645819203 scopus 로고    scopus 로고
    • Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus
    • Choi J, Ou JH. Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol 2006; 290: G847-G851
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Choi, J.1    Ou, J.H.2
  • 21
    • 0036260697 scopus 로고    scopus 로고
    • Cellular response to oxidative stress: Signaling for suicide and survival
    • Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 2002; 192: 1-15
    • (2002) J Cell Physiol , vol.192 , pp. 1-15
    • Martindale, J.L.1    Holbrook, N.J.2
  • 22
    • 33748807185 scopus 로고    scopus 로고
    • Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver cancers
    • Tien Kuo M, Savaraj N. Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver cancers. Mol Carcinog 2006; 45: 701-709
    • (2006) Mol Carcinog , vol.45 , pp. 701-709
    • Tien Kuo, M.1    Savaraj, N.2
  • 23
    • 35948979743 scopus 로고    scopus 로고
    • Cell signaling in oxidative stress-induced liver injury
    • Czaja MJ. Cell signaling in oxidative stress-induced liver injury. Semin Liver Dis 2007; 27: 378-389
    • (2007) Semin Liver Dis , vol.27 , pp. 378-389
    • Czaja, M.J.1
  • 24
    • 0031962151 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis
    • Weltman MD, Farrell GC, Hall P, Ingelman-Sundberg M, Liddle C. Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 1998; 27: 128-133
    • (1998) Hepatology , vol.27 , pp. 128-133
    • Weltman, M.D.1    Farrell, G.C.2    Hall, P.3    Ingelman-Sundberg, M.4    Liddle, C.5
  • 25
    • 71549121960 scopus 로고    scopus 로고
    • High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancerprone liver diseases
    • Nair J, Srivatanakul P, Haas C, Jedpiyawongse A, Khuhaprema T, Seitz HK, Bartsch H. High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancerprone liver diseases. Mutat Res 2010; 683: 23-28
    • (2010) Mutat Res , vol.683 , pp. 23-28
    • Nair, J.1    Srivatanakul, P.2    Haas, C.3    Jedpiyawongse, A.4    Khuhaprema, T.5    Seitz, H.K.6    Bartsch, H.7
  • 26
    • 0034869459 scopus 로고    scopus 로고
    • Oxidative stress-related molecules and liver fibrosis
    • Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol 2001; 35: 297-306
    • (2001) J Hepatol , vol.35 , pp. 297-306
    • Parola, M.1    Robino, G.2
  • 28
    • 15244356690 scopus 로고    scopus 로고
    • Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications
    • Friedman SL. Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol 2004; 1: 98-105
    • (2004) Nat Clin Pract Gastroenterol Hepatol , vol.1 , pp. 98-105
    • Friedman, S.L.1
  • 29
    • 54549111991 scopus 로고    scopus 로고
    • Oxidative and nitrosative stress and fibrogenic response
    • Urtasun R, Conde de la Rosa L, Nieto N. Oxidative and nitrosative stress and fibrogenic response. Clin Liver Dis 2008; 12: 769-790, viii
    • (2008) Clin Liver Dis , vol.12
    • Urtasun, R.1    de la Rosa Conde, L.2    Nieto, N.3
  • 30
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008; 88: 125-172
    • (2008) Physiol Rev , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 31
    • 0032794576 scopus 로고    scopus 로고
    • Cytokines and fibrogenesis
    • Friedman SL. Cytokines and fibrogenesis. Semin Liver Dis 1999; 19: 129-140
    • (1999) Semin Liver Dis , vol.19 , pp. 129-140
    • Friedman, S.L.1
  • 32
    • 20044393839 scopus 로고    scopus 로고
    • NAD(P)H oxidase plays a crucial role in PDGFinduced proliferation of hepatic stellate cells
    • Adachi T, Togashi H, Suzuki A, Kasai S, Ito J, Sugahara K, Kawata S. NAD(P)H oxidase plays a crucial role in PDGFinduced proliferation of hepatic stellate cells. Hepatology 2005; 41: 1272-1281
    • (2005) Hepatology , vol.41 , pp. 1272-1281
    • Adachi, T.1    Togashi, H.2    Suzuki, A.3    Kasai, S.4    Ito, J.5    Sugahara, K.6    Kawata, S.7
  • 34
    • 74149085153 scopus 로고    scopus 로고
    • Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis
    • Liu RM, Gaston Pravia KA. Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic Biol Med 2010; 48: 1-15
    • (2010) Free Radic Biol Med , vol.48 , pp. 1-15
    • Liu, R.M.1    Gaston Pravia, K.A.2
  • 35
    • 0037563386 scopus 로고    scopus 로고
    • Levels of plasma malondialdehyde and erythrocyte antioxidant enzyme activities in patients with chronic hepatitis B
    • Demirdag K, Yilmaz S, Ozdarendeli A, Ozden M, Kalkan A, Kilic SS. Levels of plasma malondialdehyde and erythrocyte antioxidant enzyme activities in patients with chronic hepatitis B. Hepatogastroenterology 2003; 50: 766-770
    • (2003) Hepatogastroenterology , vol.50 , pp. 766-770
    • Demirdag, K.1    Yilmaz, S.2    Ozdarendeli, A.3    Ozden, M.4    Kalkan, A.5    Kilic, S.S.6
  • 36
    • 6444242588 scopus 로고    scopus 로고
    • Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage
    • Hsieh YH, Su IJ, Wang HC, Chang WW, Lei HY, Lai MD, Chang WT, Huang W. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis 2004; 25: 2023-2032
    • (2004) Carcinogenesis , vol.25 , pp. 2023-2032
    • Hsieh, Y.H.1    Su, I.J.2    Wang, H.C.3    Chang, W.W.4    Lei, H.Y.5    Lai, M.D.6    Chang, W.T.7    Huang, W.8
  • 38
    • 73649145525 scopus 로고    scopus 로고
    • An altered pattern of liver apolipoprotein A-I isoforms is implicated in male chronic hepatitis B progression
    • Yang F, Yin Y, Wang F, Zhang L, Wang Y, Sun S. An altered pattern of liver apolipoprotein A-I isoforms is implicated in male chronic hepatitis B progression. J Proteome Res 2010; 9: 134-143
    • (2010) J Proteome Res , vol.9 , pp. 134-143
    • Yang, F.1    Yin, Y.2    Wang, F.3    Zhang, L.4    Wang, Y.5    Sun, S.6
  • 39
    • 59149098885 scopus 로고    scopus 로고
    • HBx genotype D represses GSTP1 expression and increases the oxidative level and apoptosis in HepG2 cells
    • Niu D, Zhang J, Ren Y, Feng H, Chen WN. HBx genotype D represses GSTP1 expression and increases the oxidative level and apoptosis in HepG2 cells. Mol Oncol 2009; 3: 67-76
    • (2009) Mol Oncol , vol.3 , pp. 67-76
    • Niu, D.1    Zhang, J.2    Ren, Y.3    Feng, H.4    Chen, W.N.5
  • 40
    • 0033850997 scopus 로고    scopus 로고
    • Antioxidant defense in children with chronic viral hepatitis B and C
    • Chrobot AM, Szaflarska-Szczepanik A, Drewa G. Antioxidant defense in children with chronic viral hepatitis B and C. Med Sci Monit 2000; 6: 713-718
    • (2000) Med Sci Monit , vol.6 , pp. 713-718
    • Chrobot, A.M.1    Szaflarska-Szczepanik, A.2    Drewa, G.3
  • 41
    • 27844562708 scopus 로고    scopus 로고
    • Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection
    • Bolukbas C, Bolukbas FF, Horoz M, Aslan M, Celik H, Erel O. Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect Dis 2005; 5: 95
    • (2005) BMC Infect Dis , vol.5 , pp. 95
    • Bolukbas, C.1    Bolukbas, F.F.2    Horoz, M.3    Aslan, M.4    Celik, H.5    Erel, O.6
  • 42
    • 33751072935 scopus 로고    scopus 로고
    • Bioenergetics and the formation of mitochondrial reactive oxygen species
    • Adam-Vizi V, Chinopoulos C. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci 2006; 27: 639-645
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 639-645
    • Adam-Vizi, V.1    Chinopoulos, C.2
  • 43
    • 2442452762 scopus 로고    scopus 로고
    • Human hepatitis B virus-X protein alters mitochondrial function and physiology in human liver cells. J
    • Lee YI, Hwang JM, Im JH, Lee YI, Kim NS, Kim DG, Yu DY, Moon HB, Park SK. Human hepatitis B virus-X protein alters mitochondrial function and physiology in human liver cells. J Biol Chem 2004; 279: 15460-15471
    • (2004) Biol Chem , vol.279 , pp. 15460-15471
    • Lee, Y.I.1    Hwang, J.M.2    Im, J.H.3    Lee, Y.I.4    Kim, N.S.5    Kim, D.G.6    Yu, D.Y.7    Moon, H.B.8    Park, S.K.9
  • 44
    • 0342905085 scopus 로고    scopus 로고
    • Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential
    • Rahmani Z, Huh KW, Lasher R, Siddiqui A. Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential. J Virol 2000; 74: 2840-2846
    • (2000) J Virol , vol.74 , pp. 2840-2846
    • Rahmani, Z.1    Huh, K.W.2    Lasher, R.3    Siddiqui, A.4
  • 45
    • 0033604446 scopus 로고    scopus 로고
    • Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death
    • Takada S, Shirakata Y, Kaneniwa N, Koike K. Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death. Oncogene 1999; 18: 6965-6973
    • (1999) Oncogene , vol.18 , pp. 6965-6973
    • Takada, S.1    Shirakata, Y.2    Kaneniwa, N.3    Koike, K.4
  • 46
    • 77951254206 scopus 로고    scopus 로고
    • HBx targeting to mitochondria and ROS generation are necessary but insufficient for HBV-induced cyclooxygenase-2 expression
    • Lim W, Kwon SH, Cho H, Kim S, Lee S, Ryu WS, Cho H. HBx targeting to mitochondria and ROS generation are necessary but insufficient for HBV-induced cyclooxygenase-2 expression. J Mol Med 2010; 88: 359-369
    • (2010) J Mol Med , vol.88 , pp. 359-369
    • Lim, W.1    Kwon, S.H.2    Cho, H.3    Kim, S.4    Lee, S.5    Ryu, W.S.6    Cho, H.7
  • 47
    • 8644274040 scopus 로고    scopus 로고
    • The enigmatic X gene of hepatitis B virus
    • Bouchard MJ, Schneider RJ. The enigmatic X gene of hepatitis B virus. J Virol 2004; 78: 12725-12734
    • (2004) J Virol , vol.78 , pp. 12725-12734
    • Bouchard, M.J.1    Schneider, R.J.2
  • 48
    • 0034774463 scopus 로고    scopus 로고
    • Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress
    • Waris G, Huh KW, Siddiqui A. Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol Cell Biol 2001; 21: 7721-7730
    • (2001) Mol Cell Biol , vol.21 , pp. 7721-7730
    • Waris, G.1    Huh, K.W.2    Siddiqui, A.3
  • 49
    • 34249945923 scopus 로고    scopus 로고
    • Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress
    • Chen J, Siddiqui A. Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress. J Virol 2007; 81: 6757-6760
    • (2007) J Virol , vol.81 , pp. 6757-6760
    • Chen, J.1    Siddiqui, A.2
  • 50
    • 0142107344 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces TNF-alpha expression via downregulation of selenoprotein P in human hepatoma cell line, HepG2
    • Yi YS, Park SG, Byeon SM, Kwon YG, Jung G. Hepatitis B virus X protein induces TNF-alpha expression via downregulation of selenoprotein P in human hepatoma cell line, HepG2. Biochim Biophys Acta 2003; 1638: 249-256
    • (2003) Biochim Biophys Acta , vol.1638 , pp. 249-256
    • Yi, Y.S.1    Park, S.G.2    Byeon, S.M.3    Kwon, Y.G.4    Jung, G.5
  • 53
    • 69249086613 scopus 로고    scopus 로고
    • Investigation of oxidative stress and antioxidant defense in patients with hepatitis B virus infection and the effect of interferon-alpha plus lamivudine combination therapy on oxidative stress
    • Acar A, Görenek L, Aydin A, Eyigün CP, Eken A, Sayal A, Pahsa A. [Investigation of oxidative stress and antioxidant defense in patients with hepatitis B virus infection and the effect of interferon-alpha plus lamivudine combination therapy on oxidative stress] Mikrobiyol Bul 2009; 43: 411-23
    • (2009) Mikrobiyol Bul , vol.43 , pp. 411-423
    • Acar, A.1    Görenek, L.2    Aydin, A.3    Eyigün, C.P.4    Eken, A.5    Sayal, A.6    Pahsa, A.7
  • 56
    • 0031757422 scopus 로고    scopus 로고
    • The P450 catalytic cycle and oxygenation mechanism
    • Lewis DF, Pratt JM. The P450 catalytic cycle and oxygenation mechanism. Drug Metab Rev 1998; 30: 739-786
    • (1998) Drug Metab Rev , vol.30 , pp. 739-786
    • Lewis, D.F.1    Pratt, J.M.2
  • 58
    • 0026022322 scopus 로고
    • The involvement of free radicals in the mechanisms of monooxygenases
    • White RE. The involvement of free radicals in the mechanisms of monooxygenases. Pharmacol Ther 1991; 49: 21-42
    • (1991) Pharmacol Ther , vol.49 , pp. 21-42
    • White, R.E.1
  • 60
    • 0029786269 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis
    • Eliasson E, Kenna JG. Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. Mol Pharmacol 1996; 50: 573-582
    • (1996) Mol Pharmacol , vol.50 , pp. 573-582
    • Eliasson, E.1    Kenna, J.G.2
  • 62
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    • Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ, Robertson GR. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest 2000; 105: 1067-1075
    • (2000) J Clin Invest , vol.105 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4    Gonzalez, F.J.5    Robertson, G.R.6
  • 63
    • 0035196704 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxi- dative stress
    • Robertson G, Leclercq I, Farrell GC. Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxi- dative stress. Am J Physiol Gastrointest Liver Physiol 2001; 281: G1135-G1139
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281
    • Robertson, G.1    Leclercq, I.2    Farrell, G.C.3
  • 64
    • 77249093012 scopus 로고    scopus 로고
    • The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat
    • Ronis MJ, Korourian S, Blackburn ML, Badeaux J, Badger TM. The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat. Alcohol 2010; 44: 157-169
    • (2010) Alcohol , vol.44 , pp. 157-169
    • Ronis, M.J.1    Korourian, S.2    Blackburn, M.L.3    Badeaux, J.4    Badger, T.M.5
  • 65
    • 74549209572 scopus 로고    scopus 로고
    • Chronic ethanol consumption induces global hepatic protein hyperacetylation
    • Shepard BD, Tuma DJ, Tuma PL. Chronic ethanol consumption induces global hepatic protein hyperacetylation. Alcohol Clin Exp Res 2010; 34: 280-291
    • (2010) Alcohol Clin Exp Res , vol.34 , pp. 280-291
    • Shepard, B.D.1    Tuma, D.J.2    Tuma, P.L.3
  • 66
    • 67649968443 scopus 로고    scopus 로고
    • Oxidative stress and alcoholic liver disease
    • Wu D, Cederbaum AI. Oxidative stress and alcoholic liver disease. Semin Liver Dis 2009; 29: 141-154
    • (2009) Semin Liver Dis , vol.29 , pp. 141-154
    • Wu, D.1    Cederbaum, A.I.2
  • 67
    • 0028170464 scopus 로고
    • Effect of ethanol treatment on indices of cumulative oxidative stress
    • Bondy SC, Guo SX. Effect of ethanol treatment on indices of cumulative oxidative stress. Eur J Pharmacol 1994; 270: 349-355
    • (1994) Eur J Pharmacol , vol.270 , pp. 349-355
    • Bondy, S.C.1    Guo, S.X.2
  • 69
    • 0035029397 scopus 로고    scopus 로고
    • Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells
    • Svegliati-Baroni G, Ridolfi F, Di Sario A, Saccomanno S, Bendia E, Benedetti A, Greenwel P. Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells. Hepatology 2001; 33: 1130-1140
    • (2001) Hepatology , vol.33 , pp. 1130-1140
    • Svegliati-Baroni, G.1    Ridolfi, F.2    di Sario, A.3    Saccomanno, S.4    Bendia, E.5    Benedetti, A.6    Greenwel, P.7
  • 70
    • 12844288099 scopus 로고    scopus 로고
    • Alcoholic fatty liver: Its pathogenesis and mechanism of progression to inflammation and fibrosis
    • Lieber CS. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol 2004; 34: 9-19
    • (2004) Alcohol , vol.34 , pp. 9-19
    • Lieber, C.S.1
  • 72
    • 0025312660 scopus 로고
    • The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism
    • Cunningham CC, Coleman WB, Spach PI. The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism. Alcohol Alcohol 1990; 25: 127-136
    • (1990) Alcohol Alcohol , vol.25 , pp. 127-136
    • Cunningham, C.C.1    Coleman, W.B.2    Spach, P.I.3
  • 73
    • 0021021532 scopus 로고
    • Increased chemiluminescence and superoxide production in the liver of chronically ethanol-treated rats
    • Boveris A, Fraga CG, Varsavsky AI, Koch OR. Increased chemiluminescence and superoxide production in the liver of chronically ethanol-treated rats. Arch Biochem Biophys 1983; 227: 534-541
    • (1983) Arch Biochem Biophys , vol.227 , pp. 534-541
    • Boveris, A.1    Fraga, C.G.2    Varsavsky, A.I.3    Koch, O.R.4
  • 74
    • 0028332490 scopus 로고
    • Increased production of reactive oxygen species by rat liver mitochondria after chronic ethanol treatment
    • Kukiełka E, Dicker E, Cederbaum AI. Increased production of reactive oxygen species by rat liver mitochondria after chronic ethanol treatment. Arch Biochem Biophys 1994; 309: 377-386
    • (1994) Arch Biochem Biophys , vol.309 , pp. 377-386
    • Kukiełka, E.1    Dicker, E.2    Cederbaum, A.I.3
  • 75
    • 37349010629 scopus 로고    scopus 로고
    • DNA damage in peripheral blood lymphocytes of patients with cirrhosis related to alcohol abuse or to hepatitis B and C viruses
    • Grossi S, Sumberaz A, Gosmar M, Mattioli F, Testino G, Martelli A. DNA damage in peripheral blood lymphocytes of patients with cirrhosis related to alcohol abuse or to hepatitis B and C viruses. Eur J Gastroenterol Hepatol 2008; 20: 22-25
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 22-25
    • Grossi, S.1    Sumberaz, A.2    Gosmar, M.3    Mattioli, F.4    Testino, G.5    Martelli, A.6
  • 77
    • 0032823769 scopus 로고    scopus 로고
    • Antioxidant defence mechanisms: From the beginning to the end (of the beginning)
    • Halliwell B. Antioxidant defence mechanisms: from the beginning to the end (of the beginning). Free Radic Res 1999; 31: 261-272
    • (1999) Free Radic Res , vol.31 , pp. 261-272
    • Halliwell, B.1
  • 78
    • 0010471495 scopus 로고
    • Cellular defenses against damage from reactive oxygen species
    • Yu BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994; 74: 139-162
    • (1994) Physiol Rev , vol.74 , pp. 139-162
    • Yu, B.P.1
  • 79
    • 0030806863 scopus 로고    scopus 로고
    • Superoxide anion radical (O2-.), superoxide dismutases, and related matters
    • Fridovich I. Superoxide anion radical (O2-.), superoxide dismutases, and related matters. J Biol Chem 1997; 272: 18515-18517
    • (1997) J Biol Chem , vol.272 , pp. 18515-18517
    • Fridovich, I.1
  • 81
    • 0028260177 scopus 로고
    • Purification and characterization of a substrate protein for mitochondrial ATP-dependent protease in bovine adrenal cortex
    • Watabe S, Kohno H, Kouyama H, Hiroi T, Yago N, Nakazawa T. Purification and characterization of a substrate protein for mitochondrial ATP-dependent protease in bovine adrenal cortex. J Biochem 1994; 115: 648-654
    • (1994) J Biochem , vol.115 , pp. 648-654
    • Watabe, S.1    Kohno, H.2    Kouyama, H.3    Hiroi, T.4    Yago, N.5    Nakazawa, T.6
  • 82
    • 1842295744 scopus 로고    scopus 로고
    • Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation
    • Jin DY, Chae HZ, Rhee SG, Jeang KT. Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. J Biol Chem 1997; 272: 30952-30961
    • (1997) J Biol Chem , vol.272 , pp. 30952-30961
    • Jin, D.Y.1    Chae, H.Z.2    Rhee, S.G.3    Jeang, K.T.4
  • 83
  • 84
    • 0001015125 scopus 로고    scopus 로고
    • Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate
    • Seo MS, Kang SW, Kim K, Baines IC, Lee TH, Rhee SG. Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. J Biol Chem 2000; 275: 20346-20354
    • (2000) J Biol Chem , vol.275 , pp. 20346-20354
    • Seo, M.S.1    Kang, S.W.2    Kim, K.3    Baines, I.C.4    Lee, T.H.5    Rhee, S.G.6
  • 87
    • 38349011007 scopus 로고    scopus 로고
    • Curcumin: Preventive and therapeutic properties in laboratory studies and clinical trials
    • Strimpakos AS, Sharma RA. Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal 2008; 10: 511-545
    • (2008) Antioxid Redox Signal , vol.10 , pp. 511-545
    • Strimpakos, A.S.1    Sharma, R.A.2
  • 90
    • 60149098487 scopus 로고    scopus 로고
    • Supplementation of curcumin and vitamin E enhances oxidative stress, but restores hepatic histoarchitecture in hypothyroid rats
    • Subudhi U, Das K, Paital B, Bhanja S, Chainy GB. Supplementation of curcumin and vitamin E enhances oxidative stress, but restores hepatic histoarchitecture in hypothyroid rats. Life Sci 2009; 84: 372-379
    • (2009) Life Sci , vol.84 , pp. 372-379
    • Subudhi, U.1    Das, K.2    Paital, B.3    Bhanja, S.4    Chainy, G.B.5
  • 91
    • 53949090765 scopus 로고    scopus 로고
    • NF-kappaB signaling pathway and its therapeutic implications in human diseases
    • Sarkar FH, Li Y, Wang Z, Kong D. NF-kappaB signaling pathway and its therapeutic implications in human diseases. Int Rev Immunol 2008; 27: 293-319
    • (2008) Int Rev Immunol , vol.27 , pp. 293-319
    • Sarkar, F.H.1    Li, Y.2    Wang, Z.3    Kong, D.4
  • 92
    • 0028867742 scopus 로고
    • Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]
    • Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected] J Biol Chem 1995; 270: 24995-25000
    • (1995) J Biol Chem , vol.270 , pp. 24995-25000
    • Singh, S.1    Aggarwal, B.B.2
  • 93
    • 0033996571 scopus 로고    scopus 로고
    • Protective effect of curcumin in rat liver injury induced by carbon tetrachloride
    • Park EJ, Jeon CH, Ko G, Kim J, Sohn DH. Protective effect of curcumin in rat liver injury induced by carbon tetrachloride. J Pharm Pharmacol 2000; 52: 437-440
    • (2000) J Pharm Pharmacol , vol.52 , pp. 437-440
    • Park, E.J.1    Jeon, C.H.2    Ko, G.3    Kim, J.4    Sohn, D.H.5
  • 95
    • 0042859806 scopus 로고    scopus 로고
    • Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase
    • Amin MA, Volpert OV, Woods JM, Kumar P, Harlow LA, Koch AE. Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase. Circ Res 2003; 93: 321-329
    • (2003) Circ Res , vol.93 , pp. 321-329
    • Amin, M.A.1    Volpert, O.V.2    Woods, J.M.3    Kumar, P.4    Harlow, L.A.5    Koch, A.E.6
  • 96
    • 77649189669 scopus 로고    scopus 로고
    • Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction
    • Bao W, Li K, Rong S, Yao P, Hao L, Ying C, Zhang X, Nussler A, Liu L. Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction. J Ethnopharmacol 2010; 128: 549-553
    • (2010) J Ethnopharmacol , vol.128 , pp. 549-553
    • Bao, W.1    Li, K.2    Rong, S.3    Yao, P.4    Hao, L.5    Ying, C.6    Zhang, X.7    Nussler, A.8    Liu, L.9
  • 98
    • 64849103315 scopus 로고    scopus 로고
    • Effects of intensive insulin therapy on plasma nitric oxide and endothelin-1 levels in patients undergoing cardiac surgery under cardiopulmonary bypass
    • Ma C, Liu WY, Cui Q, Gu CH, Dou YW, Zhao R, Chen M, Zheng X. [Effects of intensive insulin therapy on plasma nitric oxide and endothelin-1 levels in patients undergoing cardiac surgery under cardiopulmonary bypass] Zhonghua Waike Zazhi 2008; 46: 443-445
    • (2008) Zhonghua Waike Zazhi , vol.46 , pp. 443-445
    • Ma, C.1    Liu, W.Y.2    Cui, Q.3    Gu, C.H.4    Dou, Y.W.5    Zhao, R.6    Chen, M.7    Zheng, X.8
  • 100
    • 0036842061 scopus 로고    scopus 로고
    • Effects of environmental changes on expression of the oligopeptide permease (opp) genes of Borrelia burgdorferi
    • Wang XG, Lin B, Kidder JM, Telford S, Hu LT. Effects of environmental changes on expression of the oligopeptide permease (opp) genes of Borrelia burgdorferi. J Bacteriol 2002; 184: 6198-6206
    • (2002) J Bacteriol , vol.184 , pp. 6198-6206
    • Wang, X.G.1    Lin, B.2    Kidder, J.M.3    Telford, S.4    Hu, L.T.5
  • 101
    • 76749084248 scopus 로고    scopus 로고
    • Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage
    • Shaker E, Mahmoud H, Mnaa S. Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage. Food Chem Toxicol 2010; 48: 803-806
    • (2010) Food Chem Toxicol , vol.48 , pp. 803-806
    • Shaker, E.1    Mahmoud, H.2    Mnaa, S.3
  • 102
    • 25644448238 scopus 로고    scopus 로고
    • A review of the bioavailability and clinical efficacy of milk thistle phytosome: A silybin-phosphatidylcholine complex (Siliphos)
    • Kidd P, Head K. A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Altern Med Rev 2005; 10: 193-203
    • (2005) Altern Med Rev , vol.10 , pp. 193-203
    • Kidd, P.1    Head, K.2
  • 103
    • 0037100493 scopus 로고    scopus 로고
    • An international taxonomy for errors in general practice: A pilot study
    • Makeham MA, Dovey SM, County M, Kidd MR. An international taxonomy for errors in general practice: a pilot study. Med J Aust 2002; 177: 68-72
    • (2002) Med J Aust , vol.177 , pp. 68-72
    • Makeham, M.A.1    Dovey, S.M.2    County, M.3    Kidd, M.R.4
  • 104
    • 27444438669 scopus 로고    scopus 로고
    • Silymarin treatment of viral hepatitis: A systematic review
    • Mayer KE, Myers RP, Lee SS. Silymarin treatment of viral hepatitis: a systematic review. J Viral Hepat 2005; 12: 559-567
    • (2005) J Viral Hepat , vol.12 , pp. 559-567
    • Mayer, K.E.1    Myers, R.P.2    Lee, S.S.3
  • 105
    • 33846519345 scopus 로고    scopus 로고
    • Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine
    • Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res 2006; 124: 491-504
    • (2006) Indian J Med Res , vol.124 , pp. 491-504
    • Pradhan, S.C.1    Girish, C.2
  • 106
    • 40949143283 scopus 로고    scopus 로고
    • Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic mice
    • Wu YF, Fu SL, Kao CH, Yang CW, Lin CH, Hsu MT, Tsai TF. Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic mice. Cancer Res 2008; 68: 2033-2042
    • (2008) Cancer Res , vol.68 , pp. 2033-2042
    • Wu, Y.F.1    Fu, S.L.2    Kao, C.H.3    Yang, C.W.4    Lin, C.H.5    Hsu, M.T.6    Tsai, T.F.7
  • 107
    • 0037109597 scopus 로고    scopus 로고
    • Milk thistle for the treatment of liver disease: A systematic review and meta-analysis
    • Jacobs BP, Dennehy C, Ramirez G, Sapp J, Lawrence VA. Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. Am J Med 2002; 113: 506-515
    • (2002) Am J Med , vol.113 , pp. 506-515
    • Jacobs, B.P.1    Dennehy, C.2    Ramirez, G.3    Sapp, J.4    Lawrence, V.A.5
  • 108
    • 0033046517 scopus 로고    scopus 로고
    • Determination of silymarine in the extract from the dried silybum marianum fruits by high performance liquid chromatography and capillary electrophoresis
    • Quaglia MG, Bossù E, Donati E, Mazzanti G, Brandt A. Determination of silymarine in the extract from the dried silybum marianum fruits by high performance liquid chromatography and capillary electrophoresis. J Pharm Biomed Anal 1999; 19: 435-442
    • (1999) J Pharm Biomed Anal , vol.19 , pp. 435-442
    • Quaglia, M.G.1    Bossù, E.2    Donati, E.3    Mazzanti, G.4    Brandt, A.5
  • 109
    • 33847265733 scopus 로고    scopus 로고
    • Silybin and silymarin--new and emerging applications in medicine
    • Gazák R, Walterová D, Kren V. Silybin and silymarin--new and emerging applications in medicine. Curr Med Chem 2007; 14: 315-338
    • (2007) Curr Med Chem , vol.14 , pp. 315-338
    • Gazák, R.1    Walterová, D.2    Kren, V.3
  • 110
    • 0035211762 scopus 로고    scopus 로고
    • The use of silymarin in the treatment of liver diseases
    • Saller R, Meier R, Brignoli R. The use of silymarin in the treatment of liver diseases. Drugs 2001; 61: 2035-2063
    • (2001) Drugs , vol.61 , pp. 2035-2063
    • Saller, R.1    Meier, R.2    Brignoli, R.3
  • 111
    • 0032715311 scopus 로고    scopus 로고
    • Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis
    • Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. J Immunol 1999; 163: 6800-6809
    • (1999) J Immunol , vol.163 , pp. 6800-6809
    • Manna, S.K.1    Mukhopadhyay, A.2    Van, N.T.3    Aggarwal, B.B.4
  • 113
    • 52049116999 scopus 로고    scopus 로고
    • Green tea catechins and cardiovascular health: An update
    • Babu PV, Liu D. Green tea catechins and cardiovascular health: an update. Curr Med Chem 2008; 15: 1840-1850
    • (2008) Curr Med Chem , vol.15 , pp. 1840-1850
    • Babu, P.V.1    Liu, D.2
  • 114
    • 0026695822 scopus 로고
    • Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: Possible role in cancer chemoprevention
    • Khan SG, Katiyar SK, Agarwal R, Mukhtar H. Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention. Cancer Res 1992; 52: 4050-4052
    • (1992) Cancer Res , vol.52 , pp. 4050-4052
    • Khan, S.G.1    Katiyar, S.K.2    Agarwal, R.3    Mukhtar, H.4
  • 115
    • 31544477698 scopus 로고    scopus 로고
    • Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: Modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine
    • Luo H, Tang L, Tang M, Billam M, Huang T, Yu J, Wei Z, Liang Y, Wang K, Zhang ZQ, Zhang L, Wang JS. Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. Carcinogenesis 2006; 27: 262-268
    • (2006) Carcinogenesis , vol.27 , pp. 262-268
    • Luo, H.1    Tang, L.2    Tang, M.3    Billam, M.4    Huang, T.5    Yu, J.6    Wei, Z.7    Liang, Y.8    Wang, K.9    Zhang, Z.Q.10    Zhang, L.11    Wang, J.S.12
  • 116
    • 0034284989 scopus 로고    scopus 로고
    • Specific induction of glutathione S-transferase GSTM2 subunit expression by epigallocatechin gallate in rat liver
    • Chou FP, Chu YC, Hsu JD, Chiang HC, Wang CJ. Specific induction of glutathione S-transferase GSTM2 subunit expression by epigallocatechin gallate in rat liver. Biochem Pharmacol 2000; 60: 643-650
    • (2000) Biochem Pharmacol , vol.60 , pp. 643-650
    • Chou, F.P.1    Chu, Y.C.2    Hsu, J.D.3    Chiang, H.C.4    Wang, C.J.5
  • 117
    • 0034986020 scopus 로고    scopus 로고
    • Free radical scavenging by green tea polyphenols
    • Zhao B, Guo Q, Xin W. Free radical scavenging by green tea polyphenols. Methods Enzymol 2001; 335: 217-231
    • (2001) Methods Enzymol , vol.335 , pp. 217-231
    • Zhao, B.1    Guo, Q.2    Xin, W.3
  • 118
    • 41049085144 scopus 로고    scopus 로고
    • Green tea extract and its major component epigallocatechin gallate inhibits hepatitis B virus in vitro
    • Xu J, Wang J, Deng F, Hu Z, Wang H. Green tea extract and its major component epigallocatechin gallate inhibits hepatitis B virus in vitro. Antiviral Res 2008; 78: 242-249
    • (2008) Antiviral Res , vol.78 , pp. 242-249
    • Xu, J.1    Wang, J.2    Deng, F.3    Hu, Z.4    Wang, H.5
  • 119
    • 0035285946 scopus 로고    scopus 로고
    • Vitamin E: Action, metabolism and perspectives
    • Herrera E, Barbas C. Vitamin E: action, metabolism and perspectives. J Physiol Biochem 2001; 57: 43-56
    • (2001) J Physiol Biochem , vol.57 , pp. 43-56
    • Herrera, E.1    Barbas, C.2
  • 121
    • 0027269680 scopus 로고
    • Differential depletion of carotenoids and tocopherol in liver disease
    • Leo MA, Rosman AS, Lieber CS. Differential depletion of carotenoids and tocopherol in liver disease. Hepatology 1993; 17: 977-986
    • (1993) Hepatology , vol.17 , pp. 977-986
    • Leo, M.A.1    Rosman, A.S.2    Lieber, C.S.3
  • 122
    • 17044407548 scopus 로고    scopus 로고
    • Oxidative stress and antioxidant status in patients with alcoholic liver disease
    • Masalkar PD, Abhang SA. Oxidative stress and antioxidant status in patients with alcoholic liver disease. Clin Chim Acta 2005; 355: 61-65
    • (2005) Clin Chim Acta , vol.355 , pp. 61-65
    • Masalkar, P.D.1    Abhang, S.A.2
  • 124
    • 0032407621 scopus 로고    scopus 로고
    • Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1
    • Sakurai K, Cederbaum AI. Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1. Mol Pharmacol 1998; 54: 1024-1035
    • (1998) Mol Pharmacol , vol.54 , pp. 1024-1035
    • Sakurai, K.1    Cederbaum, A.I.2
  • 125
    • 22244483452 scopus 로고    scopus 로고
    • Effects of antioxidant vitamins on glutathione depletion and lipid peroxidation induced by restraint stress in the rat liver
    • Zaidi SM, Al-Qirim TM, Banu N. Effects of antioxidant vitamins on glutathione depletion and lipid peroxidation induced by restraint stress in the rat liver. Drugs R D 2005; 6: 157-165
    • (2005) Drugs R D , vol.6 , pp. 157-165
    • Zaidi, S.M.1    Al-Qirim, T.M.2    Banu, N.3
  • 126
    • 72149118439 scopus 로고    scopus 로고
    • The role of vitamin C as antioxidant in protection of oxidative stress induced by imidacloprid
    • El-Gendy KS, Aly NM, Mahmoud FH, Kenawy A, El-Sebae AK. The role of vitamin C as antioxidant in protection of oxidative stress induced by imidacloprid. Food Chem Toxicol 2010; 48: 215-221
    • (2010) Food Chem Toxicol , vol.48 , pp. 215-221
    • El-Gendy, K.S.1    Aly, N.M.2    Mahmoud, F.H.3    Kenawy, A.4    El-Sebae, A.K.5
  • 127
    • 26044457028 scopus 로고    scopus 로고
    • Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver
    • Bansal AK, Bansal M, Soni G, Bhatnagar D. Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. Chem Biol Interact 2005; 156: 101-111
    • (2005) Chem Biol Interact , vol.156 , pp. 101-111
    • Bansal, A.K.1    Bansal, M.2    Soni, G.3    Bhatnagar, D.4
  • 128
    • 77149160102 scopus 로고    scopus 로고
    • Influence of vitamin E on alcohol- induced changes in antioxidant defenses in mice liver
    • Kaur J, Shalini S, Bansal MP. Influence of vitamin E on alcohol- induced changes in antioxidant defenses in mice liver. Toxicol Mech Methods 2010; 20: 82-89
    • (2010) Toxicol Mech Methods , vol.20 , pp. 82-89
    • Kaur, J.1    Shalini, S.2    Bansal, M.P.3


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