5′-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication

Journal of Hepatology

Volumn 34, Issue 3, 2001, Pages 386-394

  Simile, Maria M ^a   Banni, Sebastiano ^b   Angioni, Elisabetta ^b   Carta, Gianfranca ^b   De Miglio, Maria R ^a   Muroni, Maria R ^a   Calvisi, Diego F ^a   Carru, Angelo ^a   Pascale, Rosa M ^a   Feo, Francesco ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Actin; 5 Methylthioadenosine; Antioxidant effect; Collagen 1 (I); Hydroperoxides; Liver cirrhosis; Liver fibrosis; S Adenosyl methionine; Tgf ; Tgf 1

Indexed keywords

5' METHYLTHIOADENOSINE; CARBON TETRACHLORIDE; GLUTATHIONE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; S ADENOSYLMETHIONINE; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1; UNSPECIFIC MONOOXYGENASE; 5'-METHYLTHIOADENOSINE; ANTIOXIDANT; DEOXYADENOSINE DERIVATIVE; ENZYME INHIBITOR; LIPID PEROXIDE; NUCLEOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; AUTOOXIDATION; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROGENESIS; LIPID PEROXIDATION; LIVER FIBROSIS; LIVER INJURY; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; RAT; ACUTE DISEASE; ANIMAL; CELL DIVISION; DRUG ANTAGONISM; DRUG EFFECT; FIBROSIS; GENE EXPRESSION; GENETICS; INTOXICATION; LIVER; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; WISTAR RAT;

ACUTE DISEASE; ANIMALS; ANTIOXIDANTS; CARBON TETRACHLORIDE POISONING; CELL DIVISION; DEOXYADENOSINES; ENZYME INHIBITORS; FIBROSIS; GENE EXPRESSION; LIPID PEROXIDES; LIVER; PROCOLLAGEN-PROLINE DIOXYGENASE; RATS; RATS, WISTAR; S-ADENOSYLMETHIONINE; THIONUCLEOSIDES;

EID: 0034745043     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)00078-7     Document Type: Article

References (62)

1. The pathology of hepatic iron overload: A free radical-mediated process?
2. Effect of dietary lipid and vitamin E on mitochondrial lipid peroxidation and hepatic injury in the bile duct-ligated rat
3. On the role of lipid peroxidation in the pathogenesis of liver damage induced by long-standing cholestasis
4. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis
5. Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis
6. 1 gene expression in the rat liver
7. Biochemical effect of antioxidants on lipid and liver function in experimentally-induced liver damage
8. 4-induced liver cirrhosis by silymarin
9. Polyphenylphosphatidylcholine prevents carbon tetrachloride-induced lipid peroxidation while it attenuates liver fibrosis
10. 4-poisoned liver injury and fibrosis in rats
11. Retinyl palmitate reduces hepatic fibrosis in rats induced by dimethylnitrosamine or pig serum
12. 4-induced cirrhosis: Protective role of adenosine administration
13. Effect of the variations of S-adenosyl-L-methionine liver content on fat accumulation and ethanol metabolism in ethanol-intoxicated rats
14. +)ATPase: Protective effect of S-adenosyl-L-methionine, L-methionine and N-acetylcysteine
15. S-adenosylmethionine in alcoholic liver cirrhosis: A randomized, placebo-controlled, double-blind, multicenter clinical trial
16. S-adenosylmethionine treatment prevents carbon tetrachloride-induced S-adenosylmethionine synthetase inactivation and attenuates liver injury
17. Role of phosphatidylethanolamine methylation in the synthesis of phosphatidyl choline by hepatocytes isolated from choline-deficient rats
18. Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats
19. Protective role of S-adenosyl-L-methionine against acetaminophen induced mortality and hepatotoxicity in mice
20. Protooncogene methylation and expression in regenerating and preneoplastic liver nodules induced in the rat by diethylnitrosamine: Effect of variations of S-adenosyl-L-methionine:S-adenosyl-homocysteine ratio
21. The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis
22. Variations in ornithine decarboxylase activity and S-adenosyl-L-methionine and 5′-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinomas
23. Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells
24. Mechanisms and consequences of the impaired trans-sulphuration pathway in liver disease: Part I. Biochemical implications
25. Comparative effects of L-methionine, S-adenosyl-L-methionine and 5′-methylthioadenosine on the growth of preneoplastic lesions and DNA methylation in rat liver during the early stages of hepato-carcinogenesis
26. Role of polyamines in the control of cell proliferation and differentiation
27. Chiral instability at sulfur of S-adenosylmethione
28. Effect of inhibitors of sperimidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts
29. Inhibition of the synthesis of polyamines and macromolecules by 5′-methylthioadenosine and 5′-alkylthiotubercidins in BHK21 cells
30. Effect of 5′-methylthioadenosine and its analogs on murine lymphoid cell proliferation
31. Effects of 5′deoxy-5′-methylthioadenosine on the metabolism of S-adenosyl methionine
32. Inhibition of the tyrosine kinase activity of the fibroblast growth factor receptor by the methyltransferase inhibitor 5′-methylthioadenosine
33. Inhibition by 5′-methylthioadenosine of cell growth and tyrosine kinase activity stimulated by fibroblast growth factor receptor in human gliomas
34. Sulfoxidation of thioether-containing pesticides by the flavin-adenine dinucleotide-dependent monooxygenase of pig liver microsomes
35. Redox and addition chemistry of quinoid compounds and its biological implications
36. Chemoprevention of rat liver carcinogenesis by S-adenosyl-L-methionine: A long-term study
37. High-performance liquid chromatography analysis of nanomol levels of glutathione, and glutathione disulfide, and related thiols and disulfides
38. Characterization of conjugated diene fatty acids in milk, dairy products, and lamb tissues
39. Detection of conjugated dienes by second derivative ultraviolet spectrophotometry
40. Protein measurement with folinphenol reagent
41. A rapid assay for collagen proline hydroxylase
42. Alterations of ornithine decarboxylase gene during the progression of rat liver carcinogenesis
43. c-myc Amplification in pre-malignant and malignant lesions induced in rat liver by the resistant hepatocyte model
44. c-myc Overexpression and amplification correlate with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain
45. Serum lipoproteins in rats with carbon tetrachloride-induced fatty liver
46. Carbon tetrachloride hepatotoxicity: An example of lethal cleavage
47. Pathological mechanisms in carbon tetrachloride hepatotoxicity
48. Lipid hydroperoxide-induced peroxidation and turnover of endothelial cell phospholipids
49. 5-Methylthioadenosine. Its effects and function in mammalian cells
50. Biochemical genetic analysis of the role of methylthioadenosine phosphorylase in a murine lymphoid cell line
51. Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis
52. Liver regeneration and the effect of exogenous putrescine on regenerative activity after partial hepatectomy in cirrhotic rats
53. A novel approach to study linoleic acid autoxidation: Importance of simultaneous detection of the substrate and its derivative oxidation products
54. Oxidative stress, antioxidants, and alcoholic liver fibrogenesis
55. Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats
56. Stimulation of collagen alpha (I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis?
57. HNE interacts directly with JNK isoforms in human hepatic stellate cells
58. Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcript in carbon tetrachloride-induced rat liver fibrosis
59. Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver
60. Transdifferentiation of stellate cells (Ito cells) to myofibroblasts: A key event in hepatic fibrogenesis
61. Cytokine regulation of hepatic stellate cells in liver fibrosis
62. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myh expression