Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1

Gastroenterology

Volumn 143, Issue 3, 2012, Pages

  Martínez López, Nuria ^a   García Rodrgíuez, Juan L ^a   Varela Rey, Marta ^a   Gutiérrez, Virginia ^a   Fernández Ramos, David ^a   Beraza, Naiara ^a   Aransay, Ana M ^a   Schlangen, Karin ^a   Lozano, Juan Jose ^b   Aspichueta, Patricia ^c   Luka, Zigmund ^d   Wagner, Conrad ^d   Evert, Matthias ^e   Calvisi, Diego F ^e   Lu, Shelly C ^f   Mato, José M ^a   Martínez Chantar, María L ^a  

^a CIC BIOGUNE   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF GREIFSWALD   (Germany)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

AMP; CaMKK2; Liver Cancer; Mouse Model

Indexed keywords

AZACITIDINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCINE METHYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIVER KINASE B1; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN MDM2; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RAS GUANYL RELEASING PROTEIN 3; RAS PROTEIN; S6 KINASE; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER PROGNOSIS; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA METHYLATION; ENZYME ACTIVATION; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; HEPATOMA CELL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SURVIVAL TIME; TUMOR GROWTH;

EID: 84865502592     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.05.050     Document Type: Article

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