S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model

Hepatology

Volumn 50, Issue 2, 2009, Pages 462-471

  Lu, Shelly C ^a   Ramani, Komal ^a   Ou, Xiaopeng ^a   Lin, Mark ^a   Yu, Victor ^a   Ko, Kwangsuk ^a   Park, Ryan ^a   Bottiglieri, Teodoro ^b   Tsukamoto, Hidekazu ^a,c   Kanel, Gary ^a,c   French, Samuel W ^a,d   Mato, José M ^e   Moats, Rex ^a   Grant, Edward ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^d HARBOR UCLA MEDICAL CENTER   (United States)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLTRANSFERASE; S ADENOSYLMETHIONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CHRONIC DRUG ADMINISTRATION; CONTINUOUS INFUSION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME INDUCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TUMOR VASCULARIZATION; ANIMAL; AUGUST COPENHAGEN IRISH RAT; CELL DEATH; DIET SUPPLEMENTATION; DISEASE COURSE; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER TUMOR; TUMOR CELL LINE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL DEATH; CELL LINE, TUMOR; DIETARY SUPPLEMENTS; DISEASE PROGRESSION; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAPERITONEAL; LIVER NEOPLASMS, EXPERIMENTAL; MALE; RATS; RATS, INBRED ACI; S-ADENOSYLMETHIONINE;

EID: 68949180034     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22990     Document Type: Article

References (34)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000 Int J Cancer 2001;94:153-156.
2. Sypsa V, Touloumi G, Papatheodoridis GV, Tassopoulos NC, Ketikoglou I, Vafiadis I, et al. Future trends of HCV-related cirrhosis and hepatocellular carcinoma under the currently available treatments. J Viral Hep 2005;12:543-550. (Pubitemid 41224261)
3. Yeh FS, Yu MC, Mo CC, Luo S, Tong MJ, Henderson BE. Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi, China. Cancer Res 1989;49:2506-2509. (Pubitemid 19125586)
4. Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-390.
5. Takai K, Okuno M, Yasuda I, Matsushima-Nishiwaki R, Uematsu T, Tsurumi H, et al. Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma. Updated analysis of the long-term follow-up data. Intervirology 2005;48:39-45.
6. Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. HEPATOLOGY 2007;45:1306-1312. (Pubitemid 46775795)
7. Martínez-Chantar ML, Corrales FJ, Martínez-Cruz LA, García-Trevijano ER, Huang ZZ, Chen L, et al. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J 2002;16:1292-1294.
8. Pascale RM, Marras V, Simile MM, Daino L, Pinna G, Bennati S, et al. Chemoprevention of rat liver carcinogenesis by S-adenosyl-L-methionine: a long-term study. Cancer Res 1992;52:4979-4986.
9. Pascale RM, Simile MM, De Miglio MR, Nufris A, Daino L, Seddaiu MA, et al. Chemoprevention by S-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid. Carcinogenesis 1995;16:427-430.
10. Ansorena E, García-Trevijano ER, Martiacute;nez-Chantar ML, Huang ZZ, Chen LX, Mato JM, et al. S-adenosylmethionine and methylthioadenosine are anti-apoptotic in cultured rat hepatocytes but pro-apoptotic in human hepatoma cells. HEPATOLOGY 2002;35:274-280. (Pubitemid 34106365)
11. Yang HP, Sadda MR, Li M, Zeng Y, Chen LX, Bae WJ, et al. S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: role of protein phosphatase 1 and Bcl-xS. HEPATOLOGy 2004;40:221-231. (Pubitemid 38868941)
12. Mato JM, Lu SC. S-adenosylmethionine. In: Coates PM, Blackman MR, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. 1st ed. Marcel Dekker: New York, 2005;1-7.
13. McKillop IH, Schmidt CM, Cahill PA, Sitzmann JV. Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma. HEPATOLOGY 1997;26:1484-1491.
14. Tsukamoto H, Reidelberger RD, French SW, Largman C. Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am J Physiol 1984;247:R595-R599.
15. Lee TD, Sadda ME, Mendler MH, Bottiglieri T, Kanel G, Mato JM, et al. Abnormal hepatic methionine and GSH metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res 2004;28:173-181. (Pubitemid 38114037)
16. Ko KS, Yang HP, Noureddin M, Iglesia-Ara A, Xia M, Wagner C, et al. Changes in S-adenosylmethionine and glutathione homeostasis during endotoxemia in mice. Lab Invest 2008;88:1121-1129.
17. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997;88:277-285. (Pubitemid 28015876)
18. Yuan JM, Lu SC, Van Den Berg D, Govindarajan S, Zhang ZQ, Mato JM, et al. Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma. HEPATOLOGY 2007;46:749-758. (Pubitemid 47436121)
19. Okita K, Sakaida I, Hino K. Current strategies for chemoprevention of hepatocellular carcinoma. Oncology 2002;62(Suppl 1):24-28. (Pubitemid 34702016)
20. Chen L, Zeng Y, Yang HP, Lee TD, French SW, Corrales FJ, et al. Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A. FASEB J 2004. doi:10.1096/fj.03-1204fje.
21. Martínez-Chantar ML, Vázquez-Chantada M, Garnacho-Echevarria M, Latasa MU, Varela-Rey M, Dotor J, et al. S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase. Gastroenterology 2006;131:223-232. (Pubitemid 44040917)
22. Lu SC, Alvarez L, Huang ZZ, Chen LX, An W, Corrales FJ, et al. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A 2001;98:5560-5565.
23. Garcea R, Daino L, Pascale R, Simile MM, Puddu M, Ruggiu ME, et al. Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine:S-adenosylhomocysteine ratio. Carcinogenesis 1989; 10:1183-1192. (Pubitemid 19177218)
24. Iglesias Ara A, Xia M, Ramani K, Mato JM, Lu SC. S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation. HEPATOLOGY 2008;47:1655-1666. (Pubitemid 351702748)
25. Chen H, Xia M, Lin M, Yang HP, Kuhlenkamp J, Li T, et al. Role of methionine adenosyltransferase 2A and S-adenosylemthionine in mitogen-induced growth of human colon cancer cells. Gastroenterology 2007;133:207-218.
26. Ramani K, Yang HP, Xia M, Iglesias Ara A, Mato JM, Lu SC. Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2β. HEPATOLOGY 2008;47:521-531. (Pubitemid 351280720)
27. Pascale RM, Simile MM, Satta G, Seddaiu MA, Daino L, Pinna G, et al. Comparative effects of L-methionine, S-adenosylmethionine and 5′-methylthioadenosine on the growth of preneoplastic lesions and DNA methylation during the early stages of hepatocarcinogenesis. Anticancer Res 1991;11:1617-1624.
28. Martinez-Chantar ML, Vázquez-Chantada M, Ariz U, Martínez N, Varela M, Luka Z, et al. Loss of the GNMT gene leads to steatosis and hepatocellular carcinoma in mice. HEPATOLOGY 2008;47:1191-1199.
29. Rountree CB, Senadheera S, Mato JM, Crooks GM, Lu SC. Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A deficient mice. HEPATOLOGY 2008;47:1288-1297. (Pubitemid 351547915)
30. Tomasi ML, Iglesias Ara A, Yang H, Ramani K, Feo F, Pascale MR, et al. S-adenosylmethionine regulates Apurinic/Apyrimidinic Endonuclease 1 stability: implication in hepatocarcinogenesis. Gastroenterology 2009;136:1025-1036.
31. Kato M, Shinozawa T, Kato S, Awaya A, Terada T. Increased midkine expression in hepatocellular carcinoma: immunohistochemical and in situ hybridization analyses. Arch Pathol Lab Med 2000;124:848-852. (Pubitemid 30397568)
32. Kim SJ, Tae Kim KT, Jeong JS. PDGFR-α expression in preneoplastic and neoplastic hepatocellular lesions: a rat model N-nitrosomorpholine stop experiment. The Korean Journal of Pathology 2006;40:354-360.
33. Vendemiale G, Altomare E, Trizio T, Le Grazie C, Di Padova C, Salerno MT, et al. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol 1989;24:407-415. (Pubitemid 19141425)
34. Mato JM, Cámara J, Fernández de Paz J, Caballería L, Coll S, Caballero A, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-1089. (Pubitemid 29278753)