Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation

Drug Metabolism and Disposition

Volumn 40, Issue 10, 2012, Pages 1984-1992

  Ji, Yuan ^a   Nordgren, Kendra K S ^a   Chai, Yubo ^a   Hebbring, Scott J ^a   Jenkins, Gregory D ^b   Abo, Ryan P ^a   Peng, Yi ^c   Pelleymounter, Linda L ^a   Moon, Irene ^a   Eckloff, Bruce W ^a   Chai, Xiaoshan ^a   Zhang, Jianping ^a,d   Fridley, Brooke L ^b   Yee, Vivien C ^c   Wieben, Eric D ^a   Weinshilboum, Richard M ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d JINAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE HOMOCYSTEINE METHYLTRANSFERASE; FOLIC ACID; GLYCINE METHYLTRANSFERASE; LIVER PROTEIN; MESSENGER RNA; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; METHIONINE ADENOSYLTRANSFERASE 1A; UNCLASSIFIED DRUG;

ADULT; AMINO ACID METABOLISM; ARTICLE; CONTROLLED STUDY; ETHNICITY; FEMALE; FUNCTIONAL GENOMICS; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; GLYCINE METHYLTRANSFERASE GENE; HUMAN; HUMAN TISSUE; LIVER BIOPSY; METABOLIC REGULATION; METHIONINE ADENOSYLTRANSFERASE 1A GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METHYLATION; QUANTITATIVE ANALYSIS; REPORTER GENE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

AFRICAN AMERICANS; ASIAN CONTINENTAL ANCESTRY GROUP; BIOPSY; BLOTTING, WESTERN; EUROPEAN CONTINENTAL ANCESTRY GROUP; FOLIC ACID; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; GENETIC ASSOCIATION STUDIES; GENOMICS; GENOTYPE; GLYCINE N-METHYLTRANSFERASE; HEK293 CELLS; HEP G2 CELLS; HUMANS; LIVER; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; S-ADENOSYLMETHIONINE; SEQUENCE ANALYSIS, DNA; TRANSFECTION;

EID: 84866447850     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.046953     Document Type: Article

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