MT-stabilizer, dictyostatin, exhibits prolonged brain retention and activity: Potential therapeutic implications

ACS Medicinal Chemistry Letters

Volumn 4, Issue 9, 2013, Pages 886-889

  Brunden, Kurt R ^a   Gardner, Nicola M ^c   James, Michael J ^a   Yao, Yuemang ^a   Trojanowski, John Q ^a   Lee, Virginia M Y ^a   Paterson, Ian ^c   Ballatore, Carlo ^a,b   Smith, Amos B ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Blood brain barrier; dictyostatin; discodermolide; microtubule; pharmacokinetics; tauopathy

Indexed keywords

DICTYOSTATIN; DISCODERMOLIDE; NATURAL PRODUCT; STABILIZING AGENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; LIQUID CHROMATOGRAPHY; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

MUS; MUS MUSCULUS;

EID: 84884220993     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400233e     Document Type: Article

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